李卓玉(山西大學生命科學學院院長)

李卓玉(山西大學生命科學學院院長)

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李卓玉，女，山西大學生命科學學院教授（二級），博士生導師。現任山西大學生命科學學院院長，黨委副書記，山西大學生物技術研究所所長。李卓玉教授於2002.03在德國Kaiserslautern大學生物化學系，並獲得理學博士學位，2003.09至2009.09進入英國鄧迪大學生物醫學中心從腫瘤病因及分子干預研究。在此期間主要聚焦在大腸癌Wnt信號通路、細胞骨架運動和腫瘤細胞的浸潤等領域的研究。2009年秋全職回到山西大學工作，並於2010年入選“山西省海外引進百人計畫”。

基本介紹

  • 中文名：李卓玉
  • 國籍：中國
  • 民族：漢族
  • 出生地：山西太原
  • 畢業院校：德國Kaiserslautern大學
  • 職稱：山西大學生命科學學院教授
  • 職務：山西大學生命科學學院院長，黨委副書記
主要研究方向,教育背景,工作經歷,社會任職,獲得榮譽,專利,論文發表,

主要研究方向

李卓玉教授課題組主要圍繞結腸癌發病機理進行深入系統的研究，包括：腫瘤標靶分子的揭示及其外源分子干預、細胞周期與凋亡、細胞遷移和癌症轉移、腫瘤信號傳導、腫瘤免疫調控等；在分子、細胞、模式動物和人體標本等多個層次進行關鍵基因和蛋白的調控機制研究，為腫瘤的預防和治療發現新型診斷/預後的分子標誌物以及天然產物候選藥物。

教育背景

1997.04-2002.03 德國Kaiserslautern大學攻讀博士學位
1993.09-1996.06 山西大學攻讀在職碩士究生
1982.09-1986.06 山西大學攻讀學士學位

工作經歷

2017年 山西大學生命科學學院院長
2009至2016年 山西大學生物技術研究所 所長
2003年至2009年 英國鄧迪大學生物醫學中心 博士後

社會任職

中國生物化學與分子生物學會山西省生物化學與分子生物學會理事
《中國細胞生物學學報》編輯
山西大學學報編委

獲得榮譽

2016年: 山西省高等學校科學技術成果獎自然科學類一等獎
2016年：中國產學研合作個人創新獎
2014年：全國優秀科技工作者
2014年：第六屆“山西省十佳中青年優秀科技工作者”
2013年：第七屆山西省優秀科技工作者
2013年：浙江省“錢江學者”
2013年：山西省“131”領軍人才
2012年：山西省學術技術帶頭人
2010年：山西省“百人計畫”海外引進人才
2010年: 山西省科技奉獻獎“先進個人二等獎”（山西省科協）
2010年：山西省自然科學三等獎（山西省科技廳）

專利

（1）冬葵子活性蛋白的製備方法和套用：201410238318.3
（2）一種地木耳抗腫瘤多糖及其製備方法和套用：201410459857.X
（3）一種地皮菜水應激蛋白基因及其重組蛋白的製備和套用: 2013-1-0291766.5
（4）一種胰蛋白酶抑制劑及其製備方法和套用：2012-1-0012186.3
（5）一種穀糠抗腫瘤活性蛋白及其製備方法和套用：2012-1-0084106
（6）一種胰蛋白酶抑制劑活性片段衍生物及其製備方法和套用：2011-1-0313113.3
（7）力生長因子多肽及其製備方法和用途：2010-1-0224435.6
（8）一種植物源農藥及其生產方法和套用：2010-1-0259258.5

論文發表

  1. Li Z*, Näthke IS.Tumor-associated NH2-terminal fragments are the most stable part of the Adenomatous Polyposis Coli protein and can be regulated by interactions with COOH-terminal domains, Cancer Research , 2005; 65 (12): 5195-5204. IF: 9.234
  2. Zhuoyu Li*, Karin Kroboth, Ian P Newton, Inke S Nathke. Novel self-association of NH2-terminal regions of the Adenomatous polyposis coli protein regulates APC cluster formation and cell migration. Journal of Cell Science , 2008, 121: 1916-1925. IF: 6.290
  3. Dina Dikovskaya, Zhuoyu Li*, Ian P Newton, Iain Davision, Paul Clacke and Inke S Nathke. Microtubule assmbly by the Apc protein is regulated by importin-β-RanGTP. Journal of Cell Scienc e. 2010, 123:1242-1253. IF: 6.290
  4. Zhuoyu Li*, Wenling Li, Wensi Li, Li Song, Cilia. adenomatous polyposis coli and associated diseases. Oncogene . 2012, 31(12):1475-83. IF: 7.932
  5. Zongwei Li, Zhuoyu Li*. Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks. BBA-reviews on cancer .2012，1826(1):13-22．IF:8.8
  6. Zongwei Li, Peng Yang, Zhuoyu Li*. The multifaceted regulation and functions of PKM2 in tumor progression. BBA-reviews on cancer . 2014, 24;1846(2):285-296. IF: 8.8
  7. Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang,Peng Yang, Zhuoyu Li*. GRP78 enhances the glutamine metabolismto support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget . 2014, 30;5(14):5369-5380. IF: 6.6
  8. Haili Wu, Peng Yang, Wanglai Hu, Yingying Wang, Yangxu Lu,Lichao Zhang, Yongsheng Fan, Hong Xiao, Zhuoyu Li*. Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability. Oncotarget , 2016, 7 (47): 78069-78082. IF: 5.008
  9. Xiaoting Jin, Meilan Chen, Ruijin Li,Quan An, Li Song, Yi Zhao, Hong Xiao, Long Cheng, Zhuoyu Li*.Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology . 2016, 90 (8), 1929-38. IF: 6.637
  10. Zongwei Li, Ming Zhuang, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li*. Acetylation modification regulates GRP78 secretion in colon cancer cells, Scientific Reports . 2016,6,1-11. IF:5.228
  11. Xiaoqin La, Lichao Zhang, Zhuoyu Li*, Peng Yang, Yingying Wang. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget , 2017, doi:10.18632/oncotarget.14959. IF: 5.008
  12. Peng Yang, Zongwei Li, Hanqing Li, Yangxu Lu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. Cellular Signalling . 2015, 27, 1525-1532. IF:4.471
  13. Zongwei Li, YingyingWang, Ian P. Newton, Lichao Zhang, Pengyu Ji, Zhuoyu Li*. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ. Cellular Signalling . 2015, 27, 1237–1245. IF:4.471
  14. Yingying Wang , Haili Wu, Zongwei Li, Peng Yang, Zhuoyu Li*. A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. Exp Cell Res . 2016, 351(1):24-35.IF: 3.378
  15. Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li* and Zhuoyu Li*.Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC Biotechnol . 2016; 16(1):65. IF: 2.452
  16. Peng Yang#, Zongwei Li#*, Lichao Zhang, Hanqing Li, Zhuoyu Li*. Analysis of metabonomic profiling alterations in a mouse model of colitis-associated cancer and 2-deoxy-D-glucose treatment. RSC Advances . 2016, 6, 58862. IF: 3.814
  17. Xiaoting Jin, Ruijun Su, Ruijin Li, Li Song, Meilan Chen, Long Cheng, Zhuoyu Li*. Amelioration of particulate matter-induced oxidative damage byvitamin c and quercetin in human bronchial epithelial cells. Chemosphere .2016,144,459-466.IF:3.698
  18. Xiaoting Jin, Li Song, Zhuoyu Li*, Ian P. Newton, Meirong Zhao M, Weiping Liu. DichlorodiphenyldichloroethyleneDichlorodi exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells.Environ Toxicol . 2016, 29, 350-359.IF:2.868
  19. Jiangying Shi, Shuhua Shan, Zongwei Li, Hanqing Li, Xinfeng Li, Zhuoyu Li*.Bound polyphenol from foxtail millet bran induces apoptosis in HCT-116 cell through ROS generation. Journal of functional foods. 2015, 17, 958-968.IF:3.973
  20. Peng Yang, Zongwei Li, Yingying Wang, Lichao Zhang, Haili Wu, Zhuoyu Li*. Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells. Biochemical and Biophysical Research Communications . 2015, 459(2), 327-332. IF:2.371
  21. Shuhua Shan, Jiangying Shi, Zhen Li,Huixiang Gao, Tonglin Shi, Zongwei Li, Zhuoyu Li*.Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation. Food Funct . 2015, 8; 6(7): 2331-2338.IF:2.686
  22. Min Guo, Guobin Ding, Songjia Guo, Zhuoyu Li*, Liangqi Zhao, Ke Li, Xiangrong Guo. Isolation and antitumor efficacy evaluation of a polysaccharide from Nostoc commune Vauch. Food Funct . 2015, 6, 3035-3044. IF: 2.686
  23. Tonglin Shi, Lichao Zhang, Zhuoyu Li*, Ian P Newton Quanbin Zhang. Expression, purification and renaturation of truncated human integrin β1 from inclusion bodies of Escherichia coli.Protein Expr Purif .2015 Mar; 107:13-9. IF:1.407
  24. Songjia Guo, ShuhuaShan,Xiaoting Jin,Zongwei Li, Zhuoyu Li*, LichaoZhao, Quan An, Wei Zhang. Water Stress Proteins from Nostoc commune Vauch. Exhibit Anti-Colon cancer activities in Vitro and in Vivo.J Agric Food Chem .2015 Jan 14;63(1):150-9.IF:2.857
  25. Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li*, Zhuoyu Li*, Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion viaautocrine TGF-β/Smad2/3 signaling. Int J Biochem Cell Biol . 2015, 2015, 64, 202-211. IF:3.905
  26. Li Song, Meirong Zhao, Jianxin Liu, Zhuoyu Li*,Hong Xiao, Weiping Liu. p, p’-Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways. Toxicology Research . 2015, 4, 1214–1224. IF:2.161
  27. Li Song, Zhuoyu Li*, Wei-Ping Liu, Mei-Rong Zhao. Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biology & Therapy . 2015, 16, 1–7. IF:2.921
  28. Li Song, Jiao Chang and Zhuoyu Li*.A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKTmediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food& Function .2016, 7(2):843-54.IF:2.686
  29. Tonglin Shi, Zongwei Li, Quanbin Zhang, Dawen Zheng and Zhuoyu Li*. Pluronic F127 as a drug vehicle used in chick embryo chorioallantoic membrane shell-less model.Pak J Pharm Sci.2015,28,1997-1999.IF:0.581
  30. Tonglin Shi,Cao Zhao Zhuoyu Li*,Quanbin Zhang,Xiaoting Jin. Bisphenol a exposure promote the migration of NCM460 cells via estrogen receptor-mediated integrin β1/MMP-9 pathway.Environ Toxicol .2014 2016 Jul;31(7):799-807 .IF:2.868
  31. Li Song, Jianxin Liu, Zhuoyu Li*, 2016 Jul;31(7):799-807Meirong Zhao, Weiping Liu. P’-dichlorodiphenyl-dichloroethylene induces colorectal Adenocarcinoma Cell Proliferation through Oxidative Stress.PLoS One . 2014, 11;9(11):e112700.IF:3.057
  32. Shuhua Shan, Zongwei Li, Songjia Guo, Zhuoyu Li*, Tonglin Shi, Jiangying Shi. A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer. Journal of functional foods . 2014, 10:444-455.IF:3.973
  33. Li song, Junyu Zhao, Xiaotiing Jin, Zhuoyu Li*, Ian P Newton, Weiping Liu, Hong xiao, Meirong Zhao. The organochlorine p,p'- dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/β-catenin signaling. Toxicol Lett . 2014, 17; 229(1):284-91. IF:3.522
  34. Li Song, Yuxin Jia, Wensi Zhu, Ian P Newton, Zhuoyu Li*, Wenlin Li. N-terminal trunctions of adenomatous polyposis coli are associated with primary cilia defects. Int J Biochem Cell Biol . 2014, 21; 55C:79-86.IF:3.905
  35. Yanan Peng, Zongwei li, Peng Yang, Ian P Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li*. Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts. Biochem Biophys Res Commun . 2014, 15; 451(1):68-73.IF:2.371
  36. Haili wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng fan, Zhuoyu Li*. PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells. Cell Signal . 2014, 26(11):2397-405. IF:4.191
  37. Xaioting Jin, Meilan Chen, Li Song, Hanqing Li, Zhuoyu Li*. The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma. Toxicology . 2014, 322:99-108.IF:3.817
  38. Xiaoting Jin, Li Song, Junyu Zhao, Zhuoyu Li*, Meirong Zhao, Weiping Liu. Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular. Toxicology letters . 2014, 225:158-166. IF:3.522
  39. Peng Yang, Zongwei Li, Rong Fu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 facilites colon cancer migration via the modulation of STAT3 signaling. Cell Signal . 2014, 26(9):1853-1862.IF:4.191
  40. Shuahua Shan, Zongwei Li, Ian P. Newton, Chao Zhao, Zhuoyu Li*, Maolin Guo. A novel protein extraxted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells. Toxicology letters . 2014, 227:129-138.IF:3.522
  41. Zongwei Li, Lichao Zhang, Hanqing Li, Shuhua Shan, Zhuoyu Li*. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Rep. 2014, 47(8):445-450.IF:2.782
  42. Zongwei Li, Chao Zhao, Zhuoyu Li * , Yarui Zhao, Shuhua Shan, Tonglin Shi, Jianguo Li. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. Int J Biochem Cell Biol .2014, 47, 68-75. IF:3.905
  43. Xiaoting Jin, Li Song, Xiangyuan Liu, Meilian Chen, Zhuoyu Li*, Long Cheng, Hua Ren. Protective efficacy of Vitamins C and E on p,p’ -DDT-induced cytotoxicity via the ROS–mediated mitochondrial pathway and NF-kB/FasL pathway. PLoS One . 2014, 9(12):e113257. IF:3.057
  44. Yanan Peng, Zongwei Li, Zhuoyu Li*. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer associated fibroblasts. Biochemical and Biophysical Research Communications . 2013, 440(4):558-63.IF:2.371
  45. Zongwei Li, Lichao Zhang,Yarui Zhao,Hanqing Li,Hong Xiao,Rong Fu, Zhuoyu Li*. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion.Int J Biochem Cell Biol.2013, 45(5):987-994.IF:3.905
  46. Cui Wang, Zhuoyu Li*, Quan Zhang, Meirong Zhao, Weipiing Liu. Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications of chairality in risk assessment of POPs metabolisms. Environ Sci Technol . 2013, 6; 47(8):3909-3917. IF:5.393
  47. Scott A Nelson, Zhuoyu Li*, Ian P Newton，David Schiffmann，Cornelis J. Weijer，Paul L. Appleton，Inke S. N?thke. Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Disease Models & Mechanisms . 2012, 5(5):1-7. IF:4.316
  48. Lixi Niu, Chenyun Guo, Jingming Yuan, Zhuoyu Li*. Potential roles of recombinant acetylcholine receptor α subunit 1-211 in immunoadsorbent and DNA immunization.J Immunol Methods. 2011, 30; 372(1-2):14-21. IF:1.858

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