朱要宏

朱要宏，女，1970年11月生，內蒙古集寧人，博士，中國農業大學動物醫學院教授、博士生導師，教育部“新世紀優秀人才支持計畫”入選者，長期從事獸醫產科學、動物營養與免疫學等領域的教學、科研和臨床工作。

基本介紹

• 中文名：朱要宏
• 出生日期：1970年11月
• 畢業院校：瑞典農業科學大學
• 學位/學歷：博士
• 專業方向：獸醫產科學、動物營養與免疫學
• 任職院校：中國農業大學

研究方向

動物乳房炎發病機理、診斷與防控技術研究；

動物子宮內膜炎診斷與防墊酷循控技術研究；

動物源性大腸桿菌病和沙門菌病防控技術研究與示範；

益生菌調控動物微生態環境與黏膜免疫的套用研究。

人物經歷

2017.12 - 至今，任中國農業大學動物套鑽乘駝醫學院教授，從事教學與科研工作。

2009.12 - 2017.12，任中國農業大學動物醫學院副教授，從事教學與科研工作。

2007.12 - 2009.12，任中國農業大學動物醫學院講師，從事教學與科研工作。

2002.10 - 2007.10，赴瑞典農業科學大學，攻讀並獲得獸醫產科學博士學位。

2000.09 - 2002.08，赴瑞典農業科學大學，攻讀並獲得動物營養學碩士學位。

1999.02 - 2000.01，赴丹麥奧胡斯大學動物健康與生物科學系進修歸諒企汗學習。

1993.07 - 1999.01，於北京大發正大有限公司技術部從事技術服務工作。

1988.09 - 1993.07，於中國農業大頁踏踏學攻讀並獲得獸醫學士學位。

講授課程

主講本科生課程“獸醫產科學”乃盛良,研究生課程“獸醫產科學專題”,參講“動物營養與免疫學專題”、“臨床獸醫學專業甩兵Seminar”等。

學術成果

科研項目

主持國家自然熱己舟科學基金項目2項，公益性行業（農業）科研專項課題1項，“十三五”國家重點研發計畫項目任務1項，教育部“新世紀優秀人才支持計畫”等國家（省部）級科研項目10餘項；參與完成瑞典環境與農業科學研究委員會資助項目2項。

發表論文

已發表SCI收錄論文29篇，其中以第一或通訊作者在“Frontiers in cellular and infection microbiology”、“Veterinary Research”、“Journal of Animal Science”等刊物發表SCI收錄論文23篇。其代表論文有：

1.Zhang W，Zhu YH，Yang GY, Liu X, Xia B, Hu X, Su JH, Wang JF. 2018. Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis. Front Microbiol. 8:2705. (SCI IF = 4.08)

2.Yu J, Zhu YH, Yang GY, Zhang W, Zhou D, Su JH, Wang JF. 2017 Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses. Vet. Microbiol. 210:91-100. (SCI IF = 2.63)

3.Yang GY, Yu J, Su JH, Jiao LG, Liu X, Zhu YH*. 2017. Oral administration of Lactobacillus rhamnosus GG ameliorates Salmonella Infantis-induced inflammation in a pig model via activation of the IL-22BPIL-22STAT3 pathway. Front. Cell. Infect. Microbiol. 7:323. (SCI IF = 4.92)

4. hang W, Zhu YH*, Zhou D, Wu Q, Song D, Dicksved J, Wang JF. 2017. Oral administration of a select mixture of Bacillus probiotics affects the gut microbiota and goblet cell function following Escherichia coli challenge in newly weaned pigs of genotype MUC4 that are supposed to be enterotoxigenic E. coli F4abac receptor negative. Appl. Environ. Microbiol. 83: e02747 (SCI IF = 4.49)

5.Yang GY, Zhu YH，Zhang W, Zhou D, Zhai CC, Wang JF. 2016. Influence of orally fed a select mixture of Bacillus probiotics on intestinal T-cell migration in weaned MUC4 resistant pigs following Escherichia coli challenge. Vet. Res. 47:71. (SCI IF = 3.85)

6.Wu Q, Liu MC, Yang J, Wang JF, Zhu YH*. 2016. Lactobacillus rhamnosus GR-1 ameliorates Escherichia coli–induced inflammation and cell damage via attenuation of ASC-independent NLRP3 inflammasome activation. Appl. Environ. Microbiol. 82:1173-1182. (SCI IF = 4.49)

7.Cai DJ, Song QJ, Wang JF, Zhu YH*. 2016. Genomic characterization of three bovine viral diarrhea virus isolates from cattle. Arch. Virol. 161:3589-3592 (SCI IF = 2.25)

8.Zhou D，Zhu YH，Zhang W, Wang ML, Fan WY, Song D, Yang GY, Jensen BB, Wang JF. 2015. Oral administration of a select mixture of Bacillus probiotics generates Tr1 cells in weaned F4abacR− pigs challenged with an F4ETECVTEC/EPEC strain. Vet. Res. 46:95. (SCI IF = 3.85)

9.Zhang W, Zhu YHYang JC, Yang GY, Zhou D, Wang JF. 2015. A selected Lactobacillus rhamnosus strain promotes EGFR-independent Akt activation in an enterotoxigenic Escherichia coli K88-Infected IPEC-J2 cell model. PLoS One. 10:e0125717. (SCI IF = 4.02)

10.Wu Q, Yao HD, Tan SR, Zhang ZW, Zhu YH*, Xu SW. 2014. Possible correlation of selenoprotein W with inflammation factors in chicken skeletal muscles. Biol. Trace Elem. Res. 161:167-172. (SCI IF = 1.66)

11.Zhang FJ, Weng XG, Wang JF, Zhou D, Zhang W, Zhai CC, Hou YX, Zhu YH*. 2014. Effects of temperature-humidity index and chromium supplementation on antioxidant capacity, heat shock protein 72, and cytokine responses of lactating cows. J. Anim. Sci. 92:3026-3034. (SCI IF = 2.55)

12.Zhu YH, Li XQ, Zhang W, Zhou D, Liu HY, Wang JF. 2014. Dose-dependent effects of Lactobacillus rhamnosus on serum interleukin-17 production and intestinal T-cell responses in pigs challenged with Escherichia coli. Appl. Environ. Microbiol. 80:1787-1798. (SCI IF = 4.49)

13.Li XQ, Zhu YH, Zhang HF, Yue Y, Cai ZX, Lu QP, Zhang L, Weng XG, Zhang FJ, Zhou D, Yang JC, Wang JF. 2012. Risks associated with high-dose Lactobacillus rhamnosus in an Escherichia coli model of piglet diarrhoea: intestinal microbiota and immune imbalances. PLoS One. 7:e40666. (SCI IF = 4.02)

14.Zhu YH, Liu PQ, Weng XG, Zhuge ZY, Zhang R, Ma JL, Qiu XQ, Li RQ, Zhang XL, Wang JF. 2012. Pheromonicin-SA affects mRNA expression of toll-like receptors, cytokines, and lactoferrin by Staphylococcus aureus–infected bovine mammary epithelial cells. J. Dairy Sci. 95:759-764. (SCI IF = 3.08)

15.Zhuge ZY，Zhu YH， Liu PQ, Yan XD, Yue Y, Weng XG, Zhang R, Wang JF. 2012. Effects of Astragalus Polysaccharide on Immune Responses of Porcine PBMC Stimulated with PRRSV or CSFV. PLoS One. 7:e29320. (SCI IF = 4.02)

16.Ma JL Zhu YH, Zhang L, Zhuge ZY, Liu PQ, Yan XD, Gao HS, Wang JF. 2011. Serum concentration and mRNA expression in milk somatic cells of toll-like receptor 2, toll-like receptor 4, and cytokines in dairy cows following intramammary inoculation with Escherichia coli. J. Dairy Sci. 94:5903-5912. (SCI IF = 3.08)

17.Li X， Zhu YH， Liu P, Zhuge Z, Su G, Wang J. 2010. Assessment of genetic diversity in Chinese eared pheasant using fluorescent-AFLP markers. Mol. Phylogenet. Evol. 57: 429-433. (SCI IF = 3.87)

18.Zhang L, Xu YQ, Liu HY, Lai T, Ma JL, Wang JF, Zhu YH*. 2010. Evaluation of Lactobacillus rhamnosus GG using an Escherichia coli K88 model of piglet diarrhoea: Effects on diarrhoea incidence, faecal microflora and immune responses. Vet. Microbiol. 141:142-148. (SCI IF = 3.12)

19.Zhu YH, Magnusson U, Fossum C, Berg M. 2008. Escherichia coli inoculation of porcine mammary glands affects local mRNA expression of Toll-like receptors and regulatory cytokines. Vet. Immunol. Immunopathol. 125:182-189. (SCI IF = 1.96)

20.Zhu YH, Berg M, Fossum C, Magnusson U. 2007a. Proinflammatory cytokine mRNA expression in mammary tissue of sows following intramammary inoculation with Escherichia coli. Vet. Immunol. Immunopathol. 116:98-103. (SCI IF = 1.96)

21. Zhu YH, Fossum C, Berg M, Magnusson U. 2007b. Morphometric analysis of proinflammatory cytokines in mammary glands of sows suggests an association between clinical mastitis and local production of IL-1beta, IL-6 and TNF-alpha. Vet. Res. 38:871-882. (SCI IF = 4.13)

主要著作

1.朱要宏（主編）．犬貓臨床用藥手冊（第2版）．北京：中國農業出版社，2018.

2.朱要宏（主編）．犬貓臨床用藥手冊（第1版）．北京：中國農業出版社，2015.

3.朱要宏（副主編之一）．小動物內科學. 王九峰主編. 北京：中國農業出版社，2013.

4.朱要宏（副主編之一）．動物保護學. 趙興波主編. 北京：中國農業大學出版社，2011.

3.Yang GY, Yu J, Su JH, Jiao LG, Liu X, Zhu YH*. 2017. Oral administration of Lactobacillus rhamnosus GG ameliorates Salmonella Infantis-induced inflammation in a pig model via activation of the IL-22BPIL-22STAT3 pathway. Front. Cell. Infect. Microbiol. 7:323. (SCI IF = 4.92)

4. hang W, Zhu YH*, Zhou D, Wu Q, Song D, Dicksved J, Wang JF. 2017. Oral administration of a select mixture of Bacillus probiotics affects the gut microbiota and goblet cell function following Escherichia coli challenge in newly weaned pigs of genotype MUC4 that are supposed to be enterotoxigenic E. coli F4abac receptor negative. Appl. Environ. Microbiol. 83: e02747 (SCI IF = 4.49)

5.Yang GY, Zhu YH，Zhang W, Zhou D, Zhai CC, Wang JF. 2016. Influence of orally fed a select mixture of Bacillus probiotics on intestinal T-cell migration in weaned MUC4 resistant pigs following Escherichia coli challenge. Vet. Res. 47:71. (SCI IF = 3.85)

6.Wu Q, Liu MC, Yang J, Wang JF, Zhu YH*. 2016. Lactobacillus rhamnosus GR-1 ameliorates Escherichia coli–induced inflammation and cell damage via attenuation of ASC-independent NLRP3 inflammasome activation. Appl. Environ. Microbiol. 82:1173-1182. (SCI IF = 4.49)

7.Cai DJ, Song QJ, Wang JF, Zhu YH*. 2016. Genomic characterization of three bovine viral diarrhea virus isolates from cattle. Arch. Virol. 161:3589-3592 (SCI IF = 2.25)

8.Zhou D，Zhu YH，Zhang W, Wang ML, Fan WY, Song D, Yang GY, Jensen BB, Wang JF. 2015. Oral administration of a select mixture of Bacillus probiotics generates Tr1 cells in weaned F4abacR− pigs challenged with an F4ETECVTEC/EPEC strain. Vet. Res. 46:95. (SCI IF = 3.85)

9.Zhang W, Zhu YHYang JC, Yang GY, Zhou D, Wang JF. 2015. A selected Lactobacillus rhamnosus strain promotes EGFR-independent Akt activation in an enterotoxigenic Escherichia coli K88-Infected IPEC-J2 cell model. PLoS One. 10:e0125717. (SCI IF = 4.02)

10.Wu Q, Yao HD, Tan SR, Zhang ZW, Zhu YH*, Xu SW. 2014. Possible correlation of selenoprotein W with inflammation factors in chicken skeletal muscles. Biol. Trace Elem. Res. 161:167-172. (SCI IF = 1.66)

11.Zhang FJ, Weng XG, Wang JF, Zhou D, Zhang W, Zhai CC, Hou YX, Zhu YH*. 2014. Effects of temperature-humidity index and chromium supplementation on antioxidant capacity, heat shock protein 72, and cytokine responses of lactating cows. J. Anim. Sci. 92:3026-3034. (SCI IF = 2.55)

12.Zhu YH, Li XQ, Zhang W, Zhou D, Liu HY, Wang JF. 2014. Dose-dependent effects of Lactobacillus rhamnosus on serum interleukin-17 production and intestinal T-cell responses in pigs challenged with Escherichia coli. Appl. Environ. Microbiol. 80:1787-1798. (SCI IF = 4.49)

13.Li XQ, Zhu YH, Zhang HF, Yue Y, Cai ZX, Lu QP, Zhang L, Weng XG, Zhang FJ, Zhou D, Yang JC, Wang JF. 2012. Risks associated with high-dose Lactobacillus rhamnosus in an Escherichia coli model of piglet diarrhoea: intestinal microbiota and immune imbalances. PLoS One. 7:e40666. (SCI IF = 4.02)

14.Zhu YH, Liu PQ, Weng XG, Zhuge ZY, Zhang R, Ma JL, Qiu XQ, Li RQ, Zhang XL, Wang JF. 2012. Pheromonicin-SA affects mRNA expression of toll-like receptors, cytokines, and lactoferrin by Staphylococcus aureus–infected bovine mammary epithelial cells. J. Dairy Sci. 95:759-764. (SCI IF = 3.08)

15.Zhuge ZY，Zhu YH， Liu PQ, Yan XD, Yue Y, Weng XG, Zhang R, Wang JF. 2012. Effects of Astragalus Polysaccharide on Immune Responses of Porcine PBMC Stimulated with PRRSV or CSFV. PLoS One. 7:e29320. (SCI IF = 4.02)

16.Ma JL Zhu YH, Zhang L, Zhuge ZY, Liu PQ, Yan XD, Gao HS, Wang JF. 2011. Serum concentration and mRNA expression in milk somatic cells of toll-like receptor 2, toll-like receptor 4, and cytokines in dairy cows following intramammary inoculation with Escherichia coli. J. Dairy Sci. 94:5903-5912. (SCI IF = 3.08)

17.Li X， Zhu YH， Liu P, Zhuge Z, Su G, Wang J. 2010. Assessment of genetic diversity in Chinese eared pheasant using fluorescent-AFLP markers. Mol. Phylogenet. Evol. 57: 429-433. (SCI IF = 3.87)

18.Zhang L, Xu YQ, Liu HY, Lai T, Ma JL, Wang JF, Zhu YH*. 2010. Evaluation of Lactobacillus rhamnosus GG using an Escherichia coli K88 model of piglet diarrhoea: Effects on diarrhoea incidence, faecal microflora and immune responses. Vet. Microbiol. 141:142-148. (SCI IF = 3.12)

19.Zhu YH, Magnusson U, Fossum C, Berg M. 2008. Escherichia coli inoculation of porcine mammary glands affects local mRNA expression of Toll-like receptors and regulatory cytokines. Vet. Immunol. Immunopathol. 125:182-189. (SCI IF = 1.96)

20.Zhu YH, Berg M, Fossum C, Magnusson U. 2007a. Proinflammatory cytokine mRNA expression in mammary tissue of sows following intramammary inoculation with Escherichia coli. Vet. Immunol. Immunopathol. 116:98-103. (SCI IF = 1.96)

21. Zhu YH, Fossum C, Berg M, Magnusson U. 2007b. Morphometric analysis of proinflammatory cytokines in mammary glands of sows suggests an association between clinical mastitis and local production of IL-1beta, IL-6 and TNF-alpha. Vet. Res. 38:871-882. (SCI IF = 4.13)

主要著作

1.朱要宏（主編）．犬貓臨床用藥手冊（第2版）．北京：中國農業出版社，2018.

2.朱要宏（主編）．犬貓臨床用藥手冊（第1版）．北京：中國農業出版社，2015.

3.朱要宏（副主編之一）．小動物內科學. 王九峰主編. 北京：中國農業出版社，2013.

4.朱要宏（副主編之一）．動物保護學. 趙興波主編. 北京：中國農業大學出版社，2011.