朱融融，女，同濟大學生命科學與技術學院博士，教授，碩士、博士生導師。2019年獲國家自然科學基金優秀青年科學基金資助。
基本介紹
- 中文名：朱融融
- 畢業院校：同濟大學
- 學位/學歷：博士
- 專業方向：納米材料促進脊髓損傷修復和神經再生及其機制研究
- 職務：碩士、博士生導師
- 主要成就：獲國家自然科學基金優秀青年科學基金資助
人物經歷,研究領域與方向,研究領域,研究方向,科研項目,發表文章,
人物經歷
現任同濟大學生命科學與技術學院教授，碩士/博士生導師，上海生物化學與分子生物學學會理事。2002年畢業於同濟大學環境科學與技術學院；2007年獲得同濟大學生命科學與技術學院博士學位。2009年赴美國石溪大學作訪問學者。已主持或參與國家、省部級項目10餘項，已發表被SCI摘錄的學術論文40餘篇，申請專利5項，其中授權國際專利1項。
研究領域與方向
研究領域
納米生物醫藥，具體內容為：
納米材料在促進神經再生促進脊髓損傷修復和治療神經退行性疾病領域的套用和機制分析
納米材料維持胚胎幹細胞乾性以及誘導定向分化的研究。
納米材料在促進神經再生促進脊髓損傷修復和治療神經退行性疾病領域的套用和機制分析
納米材料維持胚胎幹細胞乾性以及誘導定向分化的研究。
研究方向
1、納米材料促進脊髓損傷修復和神經再生及其機制研究
2、納米材料維持幹細胞乾性和誘導定向分化的作用機制
3、納米材料搭載小分子在神經退行性疾病治療上的套用
4、納米載藥體系套用於腫瘤靶向治療
2、納米材料維持幹細胞乾性和誘導定向分化的作用機制
3、納米材料搭載小分子在神經退行性疾病治療上的套用
4、納米載藥體系套用於腫瘤靶向治療
科研項目
1、國家自然科學基金面上項目，81873994，LDH-NT3@外泌體激活內源性神經幹細胞修復脊髓損傷及其機制研究，2019/01-2022/12，57萬元，在研，主持；
2、國家自然科學基金面上項目，81671105，大麻素受體CB2作為帕金森病治療新靶點的作用及其分子機制研究，2017/01-2020/12，52萬元，在研，主持；
2、國家重大科研儀器研製項目（31727801）（子課題）高分辨自由流電泳-線上檢測儀器裝備技術的研製，88萬元，主持，2013.01-2015.12
3. 國家重點研發計畫——課題三子課題，2016YFA0100800，基於動員內源性神經幹細胞修復脊髓損傷的機制與轉化研究，2016/07-2021/07，100萬，主持
4、中央高校基本科研業務費學科交叉類（面上）項目 20萬元 （主持）超聲刺激內源性神經幹細胞修復脊髓損傷機理研究 2017.01-2018.12
5、國家自然科學青年基金，“基於大麻素受體CB1的固體脂質納米粒治療抑鬱症研究”,2013-2016，23萬，主持
6、中央高校基本科研業務費學科交叉類（面上）項目，“Avastin介導的LDH@SiO2-DOX納米複合藥物載體抗肺癌機制研究”， 2015-2016，20萬，主持
7、國家博士點基金“納米TiO2對亞單位疫苗的佐劑效應”，20090072120019，2010年1月~2012年12月，主持
8、中央高校基本科研業務費基礎研究人才培養計畫,‘SLN-薑黃素治療哮喘及其信號通路研究’2011-2012,主持；
9、上海市教委晨光計畫“蛋白酶分子水平多尺度納米TiO2生物效應研究”，2008CG26，2007年12月~2010年12月，主持；
10、09年度校優青資助“羥基化金紅石型納米TiO2作為免疫佐劑的研究”，2000144024；2009年12月~2011年12月，主持；
11、973項目“心臟中內源性H2S生成調控及其傳遞”， 2010CB912604,項目骨幹；
2、國家自然科學基金面上項目，81671105，大麻素受體CB2作為帕金森病治療新靶點的作用及其分子機制研究，2017/01-2020/12，52萬元，在研，主持；
2、國家重大科研儀器研製項目（31727801）（子課題）高分辨自由流電泳-線上檢測儀器裝備技術的研製，88萬元，主持，2013.01-2015.12
3. 國家重點研發計畫——課題三子課題，2016YFA0100800，基於動員內源性神經幹細胞修復脊髓損傷的機制與轉化研究，2016/07-2021/07，100萬，主持
4、中央高校基本科研業務費學科交叉類（面上）項目 20萬元 （主持）超聲刺激內源性神經幹細胞修復脊髓損傷機理研究 2017.01-2018.12
5、國家自然科學青年基金，“基於大麻素受體CB1的固體脂質納米粒治療抑鬱症研究”,2013-2016，23萬，主持
6、中央高校基本科研業務費學科交叉類（面上）項目，“Avastin介導的LDH@SiO2-DOX納米複合藥物載體抗肺癌機制研究”， 2015-2016，20萬，主持
7、國家博士點基金“納米TiO2對亞單位疫苗的佐劑效應”，20090072120019，2010年1月~2012年12月，主持
8、中央高校基本科研業務費基礎研究人才培養計畫,‘SLN-薑黃素治療哮喘及其信號通路研究’2011-2012,主持；
9、上海市教委晨光計畫“蛋白酶分子水平多尺度納米TiO2生物效應研究”，2008CG26，2007年12月~2010年12月，主持；
10、09年度校優青資助“羥基化金紅石型納米TiO2作為免疫佐劑的研究”，2000144024；2009年12月~2011年12月，主持；
11、973項目“心臟中內源性H2S生成調控及其傳遞”， 2010CB912604,項目骨幹；
發表文章
1.Zhang B#, Yan W#, Zhu Y, Yang W, Le W, Chen B*, Zhu R*, Cheng L*. Nanomaterials in Neural-Stem-Cell-Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases. Adv Mater. 2018 Mar 15:e1705694.
2.Wang Z, Liang P, He X, Wu B, Liu Q, Xu Z, Wu H, Liu Z, Qian Y, Wang S*, Zhu R*. Etoposide loaded layered double hydroxide nanoparticles reversing chemoresistance and eradicating human glioma stem cells in vitro and in vivo. Nanoscale. 2018 Jul 13;10(27):13106-13121.
3.Jing G, Wang Z, Zhuang X, He X, Wu H, Wang Q, Cheng L, Liu Z, Wang S*, Zhu R*. Suspended graphene oxide nanosheets maintain the self-renewal of mouse embryonic stem cells via down-regulating the expression of Vinculin. Biomaterials. 2018 Jul;171:1-11.
4.Rongrong Zhu#, Zhaoqi Wang#, Yechang Qian*, Shilong Wang*, Efficient VEGF targeting delivery of DOX using bevacizumab conjugated SiO2@LDH for anti-neuroblastoma therapy[J]. Acta Biomaterialia, 2017,63:163-180.
5.Yanjing Zhu#; Rongrong Zhu#*; Mei Wang; Bin Wu; Xiaolie He; Yechang Qian*; Shilong Wang* Anti-metastatic and Anti-angiogenic activities of Core-shell SiO2@LDH loaded with Etoposide in Non-small Cell Lung Cancer. Advanced Science 2016, 3(11): 3(11): 1600229，封面文章.
6.Xiaolie He, # Yanjing Zhu, # Mei Wang, Guoxin Jing, Rongrong Zhu*, and Shilong Wang*. Antidepressant effects of curcumin and hU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. Int J Nanomedicine. 2016
7.Zhu, Rongrong; Wang, Qingxiu; Zhu, Yanjing; Wang, Zhaoqi; Zhang, Haixia; Wu, Bin; Wu, Xianzheng; Wang, Shilong, pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on non-small cell lung cancer., Acta Biomaterialia,2016,29:320-332
8.Youjun Wu1, Rongrong Zhu1, Xiaoyu Sun1, Zhaoqi Wang1, Wenrui Wang1, Mei Wang1, Hui Liu2* & Shilong Wang1*,Size dependent effects of layered double hydroxide nanoparticles on cellular functions of mouse embryonic stem cells, Nanomedicine, 2015. 1743-5889,
9.Yanjing Zhu, Youjun Wu, Haixia Zhang, Zhaoqi Wang, Yechang Qia*, Shilong Wang*，Rongrong Zhu*, The enhanced anti-metastasis efficiency of etoposide by the delivery of LDH nanoparticles through caveolae-mediated cellular uptake and the regulation of mTOR/AKT and STAT pathways, J. Biomed.Nanotechnol. 2015,11（12），2158-2168,
10.Youjun Wu, Rongrong Zhu, Yang Zhou, Jun Zhang, Wenrui Wang, Xiaoyu Sun,Xianzheng Wu, Liming Cheng, Jing Zhang* and Shilong Wang*,Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cellsthrough the PI3K signaling pathway, Nanoscale, 2015, 7, 11102–11114
11.Jiao Wang, Haoyue Wang, Rongrong Zhu, Qiang Liu, Jian Fei*,Shilong Wang *,Anti- inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1b transgenic mice subjected to the lipopolysaccharide-induced sepsis. Biomaterials ,2015,53, 475-483.
12.Jiao Wang1, Rongrong Zhu1, Dongmei Sun1, Xiaoyu Sun1, Zhengsong Geng1, Hui Liu2*, Shi-Long Wang1* Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-inflammatory Activities Superior to Those of Curcumin through the NF-B Signaling Pathway, J. Biomed.Nanotechnol. 2015,Vol. 11, 403–415
13.Jiao Wang1, Rongrong Zhu1, Xiaoyu Sun1, Yanjing Zhu1, Hui Liu2*, Shi-long Wang1* Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria-mediated apoptosis pathway. Int J Nanomedicine. 2014:9 3987–3998.
14.Rongrong Zhu, Yanjing Zhu, Min Zhang, Yu Xiao, Xiling Du, Hui Liu, ShilongWang*, The induction of maturation on dendritic cells by TiO2 and Fe3O4@TiO2 nanoparticles via NF-κB signaling pathway，Materials Science and Engineering C 39 (2014) 305–314
15.Jin Wang, Rongrong Zhu,Bo Gao,Bin Wu,Kun Li, Xiaoyu Sun,Hui Liu*, Shilong Wang*, The DNA vaccine delivery function of SiO2@ LDH Nanoparticleson the activation of macrophage for the anti-HBV immune response enhancement through NF-κB signaling pathway, Biomaterials, 2014, 35， 466-478，
16.Rongrong Zhu, Xianzheng Wu, Yu Xiao, Bo Gao, Qian Xie, Hui Liu, and Shilong Wang*,，Synergetic Effect of SLN-Curcumin and LDH-5-Fu on SMMC-7721 Liver Cancer Cell Line, Cancer Biother Radiopharm. 2013 Oct;28(8):579-87.
17.Wenrui Wang#, Rongrong Zhu#, Qian Xie, Ang Li, Yu Xiao, Kun Li, Hui Liu, Daxiang Cui, Yihan Chen, Shilong Wang. Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in Solid lipid nanoparticles. International journal of nanomedcine. 2012:7 3667–3677
2.Wang Z, Liang P, He X, Wu B, Liu Q, Xu Z, Wu H, Liu Z, Qian Y, Wang S*, Zhu R*. Etoposide loaded layered double hydroxide nanoparticles reversing chemoresistance and eradicating human glioma stem cells in vitro and in vivo. Nanoscale. 2018 Jul 13;10(27):13106-13121.
3.Jing G, Wang Z, Zhuang X, He X, Wu H, Wang Q, Cheng L, Liu Z, Wang S*, Zhu R*. Suspended graphene oxide nanosheets maintain the self-renewal of mouse embryonic stem cells via down-regulating the expression of Vinculin. Biomaterials. 2018 Jul;171:1-11.
4.Rongrong Zhu#, Zhaoqi Wang#, Yechang Qian*, Shilong Wang*, Efficient VEGF targeting delivery of DOX using bevacizumab conjugated SiO2@LDH for anti-neuroblastoma therapy[J]. Acta Biomaterialia, 2017,63:163-180.
5.Yanjing Zhu#; Rongrong Zhu#*; Mei Wang; Bin Wu; Xiaolie He; Yechang Qian*; Shilong Wang* Anti-metastatic and Anti-angiogenic activities of Core-shell SiO2@LDH loaded with Etoposide in Non-small Cell Lung Cancer. Advanced Science 2016, 3(11): 3(11): 1600229，封面文章.
6.Xiaolie He, # Yanjing Zhu, # Mei Wang, Guoxin Jing, Rongrong Zhu*, and Shilong Wang*. Antidepressant effects of curcumin and hU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression. Int J Nanomedicine. 2016
7.Zhu, Rongrong; Wang, Qingxiu; Zhu, Yanjing; Wang, Zhaoqi; Zhang, Haixia; Wu, Bin; Wu, Xianzheng; Wang, Shilong, pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on non-small cell lung cancer., Acta Biomaterialia,2016,29:320-332
8.Youjun Wu1, Rongrong Zhu1, Xiaoyu Sun1, Zhaoqi Wang1, Wenrui Wang1, Mei Wang1, Hui Liu2* & Shilong Wang1*,Size dependent effects of layered double hydroxide nanoparticles on cellular functions of mouse embryonic stem cells, Nanomedicine, 2015. 1743-5889,
9.Yanjing Zhu, Youjun Wu, Haixia Zhang, Zhaoqi Wang, Yechang Qia*, Shilong Wang*，Rongrong Zhu*, The enhanced anti-metastasis efficiency of etoposide by the delivery of LDH nanoparticles through caveolae-mediated cellular uptake and the regulation of mTOR/AKT and STAT pathways, J. Biomed.Nanotechnol. 2015,11（12），2158-2168,
10.Youjun Wu, Rongrong Zhu, Yang Zhou, Jun Zhang, Wenrui Wang, Xiaoyu Sun,Xianzheng Wu, Liming Cheng, Jing Zhang* and Shilong Wang*,Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cellsthrough the PI3K signaling pathway, Nanoscale, 2015, 7, 11102–11114
11.Jiao Wang, Haoyue Wang, Rongrong Zhu, Qiang Liu, Jian Fei*,Shilong Wang *,Anti- inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1b transgenic mice subjected to the lipopolysaccharide-induced sepsis. Biomaterials ,2015,53, 475-483.
12.Jiao Wang1, Rongrong Zhu1, Dongmei Sun1, Xiaoyu Sun1, Zhengsong Geng1, Hui Liu2*, Shi-Long Wang1* Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-inflammatory Activities Superior to Those of Curcumin through the NF-B Signaling Pathway, J. Biomed.Nanotechnol. 2015,Vol. 11, 403–415
13.Jiao Wang1, Rongrong Zhu1, Xiaoyu Sun1, Yanjing Zhu1, Hui Liu2*, Shi-long Wang1* Intracellular uptake of etoposide-loaded solid lipid nanoparticles induces an enhancing inhibitory effect on gastric cancer through mitochondria-mediated apoptosis pathway. Int J Nanomedicine. 2014:9 3987–3998.
14.Rongrong Zhu, Yanjing Zhu, Min Zhang, Yu Xiao, Xiling Du, Hui Liu, ShilongWang*, The induction of maturation on dendritic cells by TiO2 and Fe3O4@TiO2 nanoparticles via NF-κB signaling pathway，Materials Science and Engineering C 39 (2014) 305–314
15.Jin Wang, Rongrong Zhu,Bo Gao,Bin Wu,Kun Li, Xiaoyu Sun,Hui Liu*, Shilong Wang*, The DNA vaccine delivery function of SiO2@ LDH Nanoparticleson the activation of macrophage for the anti-HBV immune response enhancement through NF-κB signaling pathway, Biomaterials, 2014, 35， 466-478，
16.Rongrong Zhu, Xianzheng Wu, Yu Xiao, Bo Gao, Qian Xie, Hui Liu, and Shilong Wang*,，Synergetic Effect of SLN-Curcumin and LDH-5-Fu on SMMC-7721 Liver Cancer Cell Line, Cancer Biother Radiopharm. 2013 Oct;28(8):579-87.
17.Wenrui Wang#, Rongrong Zhu#, Qian Xie, Ang Li, Yu Xiao, Kun Li, Hui Liu, Daxiang Cui, Yihan Chen, Shilong Wang. Enhanced bioavailability and efficiency of curcumin for the treatment of asthma by its formulation in Solid lipid nanoparticles. International journal of nanomedcine. 2012:7 3667–3677
