基本介紹
- 中文名：朱書高
- 畢業院校：浙江大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：有機化學
- 任職院校：南昌大學化學學院
研究方向,個人經歷,學術成果,
研究方向
活性天然產物及其類似物的合成，過渡金屬催化的反應方法學研究，胰島素類似物的設計合成以及活性研究
個人經歷
科研經歷
2019.6-至今南昌大學化學學院特聘教授
2017.3-2019.2University of Utah（猶他大學）博士後導師：Prof. Danny Hung-Chieh Chou
2015.8-2017.2 Rice University（萊斯大學）博士後導師：Prof. K. C. Nicolaou
2012.8-2015.6中科院上海有機化學研究所博士後導師：李昂研究員
教育背景
2007.9-2012.7浙江大學理學院化學系有機化學博士導師：黃憲教授
2003.9-2007.7武漢大學化學與分子科學學院理學學士導師：周翔教授
學術成果
代表性論文：
Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.
K. C. Nicolaou,* P. Chen,S. Zhu,Q. Cai,R. D. Erande, R. Li, H. Sun, K. K. Pulukuri, S. Rigol, M. Aujay, J. Sandoval, and J. Gavrilyuk.J. Am. Chem. Soc.2017,139, 15467.
(these authorscontributed equally to this work).
Asymmetric Total Synthesis of Lonicerine, Aspidodasicarpine, and the Proposed Structure of Lanciferine.
Y. Li,S. Zhu,J. Li, and A. Li*,J. Am. Chem. Soc.2016,138, 3982.(these authors contributed equally to this work).
· Top 20 Most Read articles in the year.
· Highlighted bySynfacts2016,12, 549.
Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C.
K. C. Nicolaou,* Q. Cai, H. Sun, B. Qin, andS. Zhu,J. Am. Chem. Soc.2016,138, 3118.
Gold-Catalyzed Cyclization of 3-(2′-Azidoaryl)-1-arylpropargyl Carbonates or 3-Aryl-1-(2′-azidoaryl)propargyl Carbonates to Produce Quinolines.
S. Zhu,L. Wu,*X. Huang,J. Org. Chem.,2013,78, 9120.
· Top 20 Most Read articles for the previous month.
Synthesis of Polycyclic Isoindoline Derivatives via Tandem Pd-Catalyzed Coupling, Propargyl–Allenyl Isomerization, [4 + 2] Cycloaddition and Aromatization Reaction.
S. Zhu,J. Cao,L. Wu,*X. Huang,J. Org. Chem.,2012,77, 10409.
Palladium-Catalyzed Sequential Reaction via Sonogashira Coupling, Isomerization, Claisen Rearrangement and [4+2] Cycloaddtion Sequence for the Rapid Synthesis of Tricyclo[3.2.1.0]oct-3-ene Derivatives.
S. Zhu,L. Wu,*X. Huang,RSC Adv.2012,2, 132.
Palladium(0)-Catalyzed Cyclization of Functionalized Propargylic compounds and Tandem Schmittel Cyclization Reaction: A Facile Synthesis of Polycyclic Benzo[b]fluorene Derivatives via Allene Intermediate.
S. Zhu,L. Wu,*X. Huang,Organic & Biomolecular Chemistry,2012,10,3696.
Palladium-Catalyzed Sequential Reactions via Allene Intermediates for the Rapid Synthesis of Fused PolycyclicPyrrole Derivatives.
X. Huang,*S. Zhu,R. Shen,Adv. Synth. Catal.2009,351, 3118.
Gold(I)-Catalyzed Decarboxylation of Propargyl Carbonates: Reactivity Reversal of the Gold Catalyst from p-Lewis Acidity to s-Lewis Acidity.
R. Shen,* J. Yang,S. Zhu, C. Chen, L. Wu,Adv. Synth. Catal.2015,357, 1257.
Chemoselective Synthesis of Highly Substituted 1,2-Allenyl Ketones, Furans, and 2-Alkynyl Ketones from Reaction of Lithium Selenolates with 1-(1-Alkynyl)cyclopropyl Ketones and Electrophiles.
J. Xu,S. Zhu, L. Wu,* X. Huang,Organic & Biomolecular Chemistry,2012,10,3705.
Unexpected Pd-Catalyzed Coupling, Propargyl-Allenyl Isomerization and Alder-Ene Reaction: Facile Synthesis of Some Not Readily Available 2,3-Dihydrofuran Derivatives.
R. Shen,S Zhu, X.Huang*,J. Org. Chem.2009,74, 4118.
Pd-catalyzed sequential reaction for the synthesis of fused tricyclic compounds containing a dihydrofuran or isobenzofuranone unit.
R. Shen,S. Zhu, Q Xia, L. Wu, X. Huang*,Chin. Chem. Lett.2009,20,165.
Specific Recognition of Loop DNA by Dicationic Porphyrins.
X. Weng, J. Huang, S. Wu, L. Ren, L. Weng,S. Zhu,X. Zhou*,Chem. Biodiversity.2007, 4, 1501.
Synthesis and Biological Studies of Inducible DNA Cross-Linking Agents.
X. Weng, L. Ren, L. Weng, J. Huang,S. Zhu,X. Zhou*,L. Weng,Angew. Chem. Int. Ed.2007,46, 8020.
專利：
1. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogs Thereof.
K. C. Nicolaou,* P. Chen,S. Zhu,Q Cai. PCT Int. Appl. (2019), WO 2019036537 A1 20190221.
