朱明昭，男，漢族，中國科學院生物物理所研究員，獲中科院“百人計畫”資助。
基本介紹
- 中文名：朱明昭
- 國籍：中國
- 民族：漢族
- 性別：男
簡歷,研究方向,代表性論文,參考資料,
簡歷
1994-1998，北京大學生命科學學院生物技術系，理學學士學位；
1998-2003，中國醫學科學院基礎醫學研究所，理學博士學位；
2004-2008, 芝加哥大學病理系，博士後；
2009，芝加哥大學病理系，研究助理教授；
2009年10月，中國科學院生物物理所研究員，獲中科院“百人計畫”資助。
研究方向
1.淋巴器官的發育、穩態、重塑和功能
淋巴器官是免疫系統中最基本和最重要的組織結構之一。在淋巴器官中，各種基質細胞（上皮細胞、內皮細胞、成纖維細胞等）形成豐富多樣、複雜有序的免疫微環境，對於各種免疫細胞的發育和功能至關重要。我們利用多種基因工程小鼠，圍繞胸腺、淋巴結、Peyer’s Patch等重要淋巴器官，研究它們的發育、穩態和重塑的細胞和分子機制，研究淋巴器官中重要基質細胞的發育分化和穩態平衡的細胞和分子機制，研究淋巴器官各種微環境對主要免疫細胞發育、分化、活化、遷移等各種細胞行為的影響和作用機制，揭示淋巴器官微環境在自身免疫、感染免疫和腫瘤免疫等方面的生理和病理意義。
2.免疫細胞的發育、分化和功能
免疫細胞是機體免疫系統許多基本功能實現的重要效應細胞。免疫細胞的發育、分化和活化的過程，是淋巴器官微環境（外因）與免疫（祖）細胞（內因）相互作用，相互影響，外因與內因協同決定細胞行為和命運的鮮明體現。我們以T細胞和固有淋巴細胞（innate lymphoid cell）為主要對象，從外因和內因兩個方面，研究它們發育、分化、活化等行為命運調控的細胞和分子機制，揭示其生理和病理意義。
3.疫苗免疫學
疫苗是人為操縱機體免疫系統功能的重要方式之一，既是推動免疫學理論發展的有力工具，也是免疫學理論研究的轉化套用載體。我們一方面以腫瘤和重大傳染性疾病為對象，致力於新型治療性疫苗的研製；另一方面以疫苗為工具，努力探索T細胞免疫應答和免疫記憶調控的細胞和分子機制。
代表性論文
1.Wang, Z., Wang, W., Chai, Q., Zhu, M.* Langerhans cells control lymphatic vessel function during inflammation via LIGHT-LTbetaR signaling. J Immunol (Accept) (2019)
2.Wang, Z., Chai, Q., and Zhu, M.* Differential roles of LTbetaR in endothelial cell subsets for lymph node organogenesis and maturation. J Immunol 201, 69-76. (2018)
3.Wang, W., Liu, Z., Zhou, X., Guo, Z., Zhang, J., Zhu, P., Yao, S., and Zhu, M.* Ferritin nanoparticle-based SpyTag/SpyCatcher-enabled click vaccine for tumor immunotherapy. Nanomedicine 16, 69-78. (2018)
4.Liu, X., Liu, L., Ren, Z., Yang, K., Xu, H., Luan, Y., Fu, K., Guo, J., Peng, H., Zhu, M.*, and Fu, Y. X.* Dual targeting of innate and adaptive checkpoints on tumor cells limits immune evasion. Cell Rep 24, 2101-2111. (2018)
5.Jin, C., and Zhu, M.* RelB intrinsically regulates the development and function of medullary thymic epithelial cells. Science China Life Sciences 61(9):1039-1048. (2018)
6.Jin, L., Guo, X., Shen, C., Hao, X., Sun, P., Li, P., Xu, T., Hu, C., Rose, O., Zhou, H., Yang, M., Qin, C.-F., Guo, J., Peng, H., Zhu, M., Cheng, G., Qi, X., and Lai, R. Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor. Nature Immunology 19, 342-353. (2018)
7.Yang, K., Liang, Y., Sun, Z., Xue, D., Xu, H., Zhu, M., Fu, Y. X., and Peng, H. T cell-derived lymphotoxin is essential for anti-HSV-1 humoral immune response. J Virol 92(14). pii: e00428-18. (2018)
8.Yang, K., Liang, Y., Sun, Z., Liu, L., Liao, J., Xu, H., Zhu, M., Fu, Y.-X., and Peng, H. T cell-derived lymphotoxin limits Th1 response during HSV-1 infection. Scientific Reports 8, 17727. (2018)
9.Liu, Z., Zhou, C., Qin, Y., Wang, Z., Wang, L., Wei, X., Zhou, Y., Li, Q., Zhou, H., Wang, W., Fu, Y.-X.*, Zhu, M.*, and Liang, W.* Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine.Cell Discovery 3, 17007. (2017)
10.Wu, W., Shi, Y., Xia, H., Chai, Q., Jin, C., Ren, B., and Zhu, M.* Epithelial LTbetaR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice.Scientific reports 7, 44481. (2017)
11.Tang, H., Zhu, M., Qiao, J., Fu, YX. Lymphotoxin signaling in tertiary lymphoid structures and immunotherapy. Cell Mol Immunol 14(10):809-818. (2017)
12.Shi, Y., Wu, W., Chai, Q., Li, Q., Hou, Y., Xia, H., Ren, B., Xu, H., Guo, X., Jin, C., Lv, M., Wang, Z., Fu, Y., and Zhu, M.* LTbetaR controls thymic portal endothelial cells for hematopoietic progenitor cell homing and T cell regeneration. Nature Communications 7, 12369. (2016)
13.Liu, Z., Zhou, H., Wang, W., Fu, Y.-X., and Zhu, M.* A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice. OncoImmunology 5, e1147641. (2016)
14.Lv, M., Wu, W., Zhang, Y., and Zhu, M.* Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon. Scientific reports 5, 12954. (2015)
15.Liu, Z., Zhou, H., Wang, W., Tan, W., Fu, Y. X., and Zhu, M.* A novel method for synthetic vaccine construction based on protein assembly. Scientific reports 4, 7266. (2014)
16.Shi, Y., and Zhu, M.* Medullary thymic epithelial cells, the indispensable player in central tolerance. Sci China Life Sci 56, 392-398. (2013)
17.Zhu, M.*, and Fu, Y. Proinflammatory IL-17 induces iBALT development. Cell Mol Immunol 9, 101-102. (2012)
18.Zhu, M.*, Yang, Y., Wang, Y., Wang, Z., and Fu, Y.-X. LIGHT Regulates Inflamed Draining Lymph Node Hypertrophy. J Immunol 186, 7156-7163. (2011)
19.Zhu, M., and Fu, Y.-X. The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling. Immunol Rev 244, 75-84. (2011)
20.Zhu, M.*, and Fu, Y.-X.* Deflating the Lymph Node. Immunity 34, 8-10. (2011)
21.Zhu, M.*, and Fu, Y. The complicated role of NF-kappaB in T-cell selection. Cell Mol Immunol 7, 89-93. (2010)
22.Zhu, M.*, Brown, N. K., and Fu, Y.-X.* Direct and indirect roles of the LT[beta]R pathway in central tolerance induction. Trends in Immunology 31, 325-331. (2010)
23.Wang, Y., Zhu, M., Yu, P., and Fu, Y. X. Promoting immune responses by LIGHT in the face of abundant regulatory T cell inhibition. J Immunol 184, 1589-1595. (2010)
24.Zhou, P., Fang, X., McNally, B. A., Yu, P., Zhu, M., Fu, Y. X., Wang, L., Liu, Y., and Zheng, P. Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.Proc Natl Acad Sci U S A 106, 17134-17139. (2009)
25.Wang, Y., Zhu, M., Miller, M., and Fu, Y. X. Immunoregulation by tumor necrosis factor superfamily member LIGHT. Immunol Rev 229, 232-243. (2009)
26.Zhu, M.*, and Fu, Y. X.* Coordinating development of medullary thymic epithelial cells. Immunity 29, 386-388. (2008)
27.Zhu, M., Chin, R. K., Tumanov, A. V., Liu, X., and Fu, Y. X. Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla. J Immunol 179, 8069-8075. (2007)
28.Li, J., Li, Y., Yao, J. Y., Jin, R., Zhu, M. Z., Qian, X. P., Zhang, J., Fu, Y. X., Wu, L., Zhang, Y., and Chen, W. F. Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice. Proc Natl Acad Sci U S A104, 18175-18180. (2007)
29. Zhu, M., Chin, R. K., Christiansen, P. A., Lo, J. C., Liu, X., Ware, C., Siebenlist, U., and Fu, Y. X. NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway.J Clin Invest 116, 2964-2971. (2006)
30. Chin, R. K.#, Zhu, M.#, Christiansen, P. A., Liu, W., Ware, C., Peltonen, L., Zhang, X., Guo, L., Han, S., Zheng, B., and Fu, Y. X. Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagen. J Immunol 177, 290-297. (2006)
