有機雙鋰試劑分子內化學鍵切斷：反應、機理與套用

《有機雙鋰試劑分子內化學鍵切斷：反應、機理與套用》是席振峰為項目負責人，北京大學為依託單位的面上項目。

基本介紹

• 中文名：有機雙鋰試劑分子內化學鍵切斷：反應、機理與套用
• 項目類別 ：面上項目
• 項目負責人：席振峰
• 依託單位 ：北京大學

科研成果

序號	標題	類型
1	Isolation, Structural Characterization and Synthetic Application of Oxy-cyclopentadienyl Dianions	期刊論文
2	Zirconium- and Silicon-Containing Intermediates with Three Fused Rings in a Zirconocene-Mediated Intermolecular Coupling Reaction	期刊論文
3	Iterative Dianion Relay Along the Ring: Formation of gem-Bis(trimethylsilyl) Cyclopentenones from 2,5-Bis(trimethylsilyl) Oxy-cyclopentadienyl Dianions and Acid Chlorides	期刊論文
4	One-pot Multi-Component Synthesis of Azaindoles and Pyrroles from One Molecule of Si-Tethered Diyne and Three or Two Molecules of Organonitriles Mediated by Zirconocence	期刊論文
5	Synthesis of benzothiophene derivatives from dilithio reagents, sulfur, and electrophiles via electrophilic cyclization	期刊論文
6	Palladium-Catalyzed Synthesis of Benzosilolo[2,3-b]indoles via Cleavage of a C(sp(3))-Si Bond and Consequent Intramolecular C(sp(2))-Si Coupling	期刊論文
7	Opening the Silole Ring: Efficient and Specific Cleavage of the endo-C(sp2)-Si Bond with AcOH/ROH System	期刊論文
8	Efficient One-pot Synthesis of N-Containing Heterocycles by Multi-Component Coupling of Silicon-tethered Diynes, Nitriles and Isocyanides via Intramolecular Cyclization of Iminoacyl-Zr Intermediates	期刊論文
9	Formation of α-Lithio Siloles from Silylated 1,4-Dilithio-1,3-butadienes: Mechanism and Applications	期刊論文
10	One-pot Synthesis of Pyrrolo[3,2-d]pyridazines and Pyrrole-2,3-diones via Zirconocene-mediated Four-component Coupling of Si-tethered Diyne, Nitriles and Azide	期刊論文
11	Selective synthesis of dibenzo[a,c]cyclooctatetraenes via palladium-catalyzed [4+4] cyclic homocoupling of borylvinyl iodobenzene derivatives	期刊論文
12	Efficient One-Pot Synthesis of 2,3-Dihydropyrimidinthiones via Multicomponent Coupling of Terminal Alkynes, Elemental Sulfur and Carbodiimides	期刊論文
13	Cleavage and Re-organization of Zr-C/Si-C Bonds Leading to Zr/Si-N Organometallic and Heterocyclic Compounds	期刊論文
14	Zirconocene and Si-Tethered Diynes: A Happy Match Directed toward Organometallic Chemistry and Organic Synthesis	期刊論文
15	StaStar-shaped Silacyclobutene- Containing π-Systems: Synthesis and Optical Properties	期刊論文
16	Organo-di-lithio Reagents: Reaction and Synthetic Applications	期刊論文
17	Synthesis of functionalized siloles from Si-tethered diynes	期刊論文
18	Hydride-induced Novel Cyclization of Dienedinitriles Leading to Multi-functionalized Cyclopentadienes	期刊論文
19	Formation of Zirconocenes Containing Vinyl-imine and Keteniminate Species from Zirconacycles and Diphenylacetonitrile	期刊論文
20	Isolation and X-ray Structure of a Trimeric 1,4-Dilithio-1, 3-butadiene and a Dimeric Me3Si-substituted 1,4-dilithio-1,3-butadiene	期刊論文
21	Hydride-Induced Cleavage of C-O Bond in Pyran Ring of 2-Pyranylidene Carbene Complexes Followed by Ring Closure of Unsaturated Acylmetalates and Reductive Elimination: Mechanism and Synthetic Application	期刊論文
22	One-Pot Selective Syntheses of 5-Azaindoles through Zirconocene-Mediated Multicomponent Reactions with Three Different Nitrile Components and One Alkyne Component	期刊論文

項目摘要

金屬促進的切斷化學鍵的新反應、新模式以及基於化學鍵切斷的有機合成方法學研究具有重要的理論意義和套用價值。本項目擬在以往工作的基礎上，開展如下3個方面的研究：（1）合成多種具有不同取代基（包括有機矽，有機鍺以及有機錫等）的1，4-雙鹵代-1，3-丁二烯類衍生物，並研究這些化合物的鋰化條件實現高產率高選擇性雙鋰化；（2）摸索反應條件，研究這些雙鋰化合物的分子內化學鍵切斷反應和反應機理，生成鋰代矽雜（錫雜、鍺雜）環戊二烯衍生物，並在此基礎上進一步研究新型功能性化合物包括一些含有矽雜（錫雜、鍺雜）環戊二烯單元的pi-共軛體系的合成方法學；（3）總結歸納從1，4-二鋰-1，3-丁二烯類衍生物生成鋰代矽雜（錫雜、鍺雜）環戊二烯衍生物的有關反應規律，總結歸納C-Si, C-Ge, C-Sn在該反應體系中被切斷的特性，深入認識反應類型。