《有機磷酸酯對磷脂S1P合成代謝的影響機制及其毒理效應》是北京大學為項目負責人，胡建英為依託單位的面上項目。
基本介紹
- 中文名：有機磷酸酯對磷脂S1P合成代謝的影響機制及其毒理效應
- 項目類別：面上項目
- 項目負責人 ：胡建英
- 依託單位 ：北京大學
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Organophosphorus Flame Retardants in Pregnant Women and Their Transfer to Chorionic Villi | 期刊論文 | Zhao Fanrong(#); Chen Mo; Gao Fumei; Shen Huan; Hu Jianying(*) |
2 | Association of Aryl Organophosphate Flame Retardants Triphenyl Phosphate and 2-Ethylhexyl Diphenyl Phosphate with Human Blood Triglyceride and Total Cholesterol Levels | 期刊論文 | Zhao, Fanrong(#); Li, Yu; Zhang, Shiyi; Ding, Mengyu; Hu, Jianying(*) |
3 | Occurrence and Maternal Transfer of Chlorinated Bisphenol A and Nonylphenol in Pregnant Women and Their Matching Embryos | 期刊論文 | Chen, Mo(#); Fan, Zhanlan; Zhao, Fanrong; Gao, Fumei; Mu, Di; Zhou, Yuyin; Shen, Huan; Hu, Jianying(*) |
4 | Screening of house dust from Chinese homes for chemicals with liver x receptors binding activities and characterization of atherosclerotic activity using an in vitro macrophage cell line and apoe-/- mice | 期刊論文 | Wenxin Hu(#); Yingting Jia; Qiyue Kang,; Hui Peng,; Haojia Ma,; Shiyi Zhang; Youhei Hiromori; Tomoki Kimura; Tsuyoshi Nakanishi; Lemin Zheng; Yifu Qiu; Zhaobin Zhang; Yi Wan; JianyingHu(*) |
5 | Activation of Peroxisome Proliferator-Activated Receptor Gamma and Disruption of Progesterone Synthesis of 2-Ethylhexyl Diphenyl Phosphate in Human Placental Choriocarcinoma Cells: Comparison with Triphenyl Phosphate | 期刊論文 | Hu Wenxin(#); Gao Fumei; Zhang Hong; Hiromori Youhei; Arakawa Shuhei; Nagase Hisamitsu; Nakanishi Tsuyoshi; Hu Jianying(*) |
6 | Levels of Blood Organophosphorus Flame Retardants and Association with Changes in Human Sphingolipid Homeostasis | 期刊論文 | Zhao, Fanrong(#); Wan, Yi; Zhao, Haoqi; Hu, Wenxin; Mu, Di; Webster, Thomas F.; Hu, Jianying(*) |
7 | Levels of Phthalate Metabolites in Urine of Pregnant Women and Risk of Clinical Pregnancy Loss | 期刊論文 | Mu, Di(#); Gao, Fumei; Fan, Zhanlan; Shen, Huan(*); Peng, Hui; Hu, Jianying(*) |
8 | Urinary biomarkers for assessment of human exposure to monomeric aryl phosphate flame retardants | 期刊論文 | Zhao, Fanrong(#); Kang, Qiyue; Zhang, Xiaohua; Liu, Jiaying; Hu, Jianying(*) |
項目摘要
動脈粥樣硬化是最常見的血管疾病，人體內磷酯信號小分子S1P合成代謝的異常對動脈粥樣硬化的發生髮展以及心血管的健康產生重要影響。本項目以揭示有機磷酸酯類物質對磷脂合成代謝影響機制及其毒理效應作為研究目標，通過建立血液樣品中磷脂S1P代謝合成相關物質和有機磷酸酯類物質的監測方法，評價人群有機磷酸酯類物質的暴露水平對人體磷脂S1P水平的影響，並結合小鼠暴露實驗弄清有機磷酸酯對磷脂S1P合成代謝的影響；研究有機磷酸酯類物質與PPARγ、磷脂S1P受體的結合活性和結構特徵，從細胞水平上闡明有機磷酸酯類物質對磷脂S1P合成代謝和對泡沫細胞形成和內皮細胞粘附功能的影響及其機制，為該類物質的風險評價提供毒理學基礎。
