曹鵬秀，博士，河北師範大學生命科學學院教師。
基本介紹
- 中文名：曹鵬秀
- 畢業院校：中國科學院遺傳與發育生物學研究所
- 學位/學歷：博士
- 職業：教師
- 任職院校：河北師範大學生命科學學院
人物經歷,主講課程,研究方向,發表論文,
人物經歷
1998-2002，河北師範大學生命科學學院，獲得理學學士學位
2002-2007，中國科學院遺傳與發育生物學研究所，獲得理學博士學位
2008-2017，美國CaseWestern Reserve University、Cleveland
Clinic和Universityof Michigan 等高校或研究所，進行博士後研究
2018-今，河北師範大學，講師
主講課程
《組織學與解剖學》、《組織學與解剖學實驗》和《生物信息學》。
研究方向
(1) 鐵代謝影響肺纖維化進程分子機制研究及有效治療策略和藥物的開發及篩選；
(2) 霧霾引起肺部重塑的機制研究和干預策略；
(3) 吸菸致肺部疾病機制研究及分子治療策略。
發表論文
1. Cao Pengxiu*, Aoki Yoshiro*, Badri Linda, Walker Natalie M., Manning Casey M., Lagstein Amir, Fearon Eric R., Lama Vibha N. (2017) Autocrine lysophosphatidic acidsignaling activates β-catenin and promotes lung allograft fibrosis. Journal of Clinical Investigation, 127(4):1517-1530. *Contribute equally.
2. Chen Shenghan, Cao Pengxiu, Dong Ningzheng, Peng Jianhao, Zhang Chunyi, Wang Hao, Zhou Tiantian, Yang Junhua, Zhang Yue, Martelli Elizabeth E., Prasad Sathyamangla V. Naga, Miller Rachel E., Malfait Anne-Marie, Zhou Yiqing, Wu Qingyu. (2015) PCSK6-mediated corin activation is essentialfor normal blood pressure. NatureMedicine, 21(9):1048-1053.
3. Cao Pengxiu*, Sun Wenyu*, Kramp Kristopher, Zheng Maohua, Salom David, Jastrzebska Beata, Jin Hui, Palczewski Krzysztof, Feng Zhaoyang. (2012) Light-sensitive coupling of rhodopsinand melanopsin to Gi/o and Gq signal transduction in Caenorhabditis elegans.FASEB J., 26(2):480-491. *Contribute equally.
4. Salom David*, Cao Pengxiu*, Sun Wenyu*, Kramp Kristopher, Jastrzebska Beata, Jin Hui, Feng Zhaoyang, Palczewski Krzysztof. (2012) Heterologous expression of functionalG-protein-coupled receptors in Caenorhabditis. FASEB J., 26(2):492-502. *Contribute equally.
5. Cao Pengxiu*, Yuan Yiyuan*, Pehek Elizabeth A., Moise Alex R., Huang Ying, Palczewski Krzysztof, Feng Zhaoyang. (2010) Alpha-synuclein disrupted dopaminehomeostasis leads to dopaminergic neuron degeneration in Caenorhabditiselegans. PLoS ONE, 5 (2), e9312. doi:10.1371/journal.pone.0009312. *Contributeequally.
6. Cao Pengxiu, Song Jian, Zhou Chunjiang, Weng Manli, Liu Jing, Wang Fuxin, Zhao Feng, Feng Dianqi, Wang Bin. (2009) Characterization of multiple coldinduced genes from Ammopiptanthus mongolicus and functional analyses of geneAmEBP1. Plant Molecular Biology, 69(5), 529-539.
7. Fei Y.B.*, Cao P.X.*, Gao S.Q., Wang B., Wei L.B.,Zhao J., Chen G.& Wang B.H. (2008) Purification and analysis of antifreezeproteins from a ligneous plant. Preparative Biochemistry and Biotechnology, 38(2), 172- 183. *Contribute equally.
8. Fei Y.B.*, Cao P.X.*, Gao S.Q., Wei L.B. &Wang B. (2005) Discovery of a homolog of siderophilin in a plant. Journal ofIntegrative Plant Biology, 47 (12), 1409-1411. *Contribute equally.
9. Chen Yuanyuan, Jastrzebska Beata, Cao Pengxiu, Zhang Jianye, Wang Benlian, Sun Wenyu, Yuan Yiyuan, Feng Zhaoyang, Palczewski Krzysztof. (2014) Inherent instability of the retinitispigmentosa P23H mutant opsin. The Journal of Biological Chemistry, 289(13):9288-9303.
10. Yuan Yiyuan, Hakimi Parvin, Kao Clara, Kao Allison, Liu Ruifu, Janocha Allison, Boyd-Tressler Andrea, Hang Xi, Alhoraibi Hanna, Slater Erin, Xia Kevin, Cao Pengxiu, Shue Quinn, Ching Tsui-Ting, Hsu Ao-Lin, Erzurum Serpil C., Dubyak George R., Berger Nathan A., Hanson RichardW., Feng Zhaoyang. (2016) Reciprocal Changes inPhosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are aDeterminant of Aging in Caenorhabditis elegans. The Journal of Biological Chemistry, 291(3):1307-1319.
11. Yuan Yiyuan, Cao Pengxiu, Smith Mark A., Kramp Kristopher, Huang Ying, Hisamoto Naoki, Matsumoto Kunihiro, Hatzoglou Maria, Jin Hui, Feng Zhaoyang. (2011) Dysregulated LRRK2/p38 signaling inresponse to endoplasmic reticulum stress leads todopaminergic neuron degeneration. PLoS ONE, 6 (8):e22354.
12. Salom David, Cao Pengxiu, Yuan Yiyuan, Miyagi Masaru, Feng Zhaoyang, Palczewski Krzysztof. (2015) Isotopic labeling of mammalian GPCRs heterologously expressed inCaenorhabditis elegans. Accepted in Anal Biochem., 2015,472:30-36.
13. Zheng Maohua, Cao Pengxiu, Yang Jiong, Xu X. Z. Shawn, Feng Zhaoyang. (2012) Calcium imaging of multiple neuronsin freely behaving C. elegans. Journal of Neuroscience Methods. 206 (1), 78–82.
14. Jastrzebska Beata, Salom David, Jin Hui, Cao Pengxiu, Sun Wenyu, Palczewski Krzysztof, Feng Zhaoyang. (2013) Expression of mammalian Gprotein-coupled receptors in Caenorhabditis elegans. Methods in Enzymology.520:239-256.
15. Zhou Chunjiang, Chen Cuixia, Cao Pengxiu, Wu Suowei, Sun Jianwei, Jin Demin, Wang Bin. (2007). Characterization and fine mapping of RppQ, aresistance gene to southern corn rust in maize. Molecular Genetics andGenomics, 278 (6), 723-728.
16. Song Jian, Liu Jing, Weng Manli, Huang Yanyan, Luo Lei, Cao Pengxiu, Sun Haiwei, Liu Jie, Zhao Jinhong, Feng Dianqi, Wang Bin. (2013) Cloning of Galactinol Synthase Gene fromAmmopiptanthus Mongolicus and its expression in transgenic Photinia serrulataplants. Gene. 15, 513(1):118-127.
17. Liang F., Kong F., ZhouC., Cao P., Ye C. & Wang B.(2005) Cloning and characterization of a non-TIR-NBS-LRR type diseaseresistance gene analogue from peach. DNA Sequence, 16 (2), 103-110.
18. BaiL., Ye C., Lu J., Yang D., Xue H., Pan Y., CaoP., Wang B., & Liu M. (2009) Ipt gene transformation in petunia by anAgrobacterium mediated method. Journal of Immunoassay and Immunochemistry, 30(2):224-31.
