暢君雷:研究領域,教育背景,工作經歷,教授課程,專利與獎勵,發表文章,

1982年12月出生於河南新鄉，2007年畢業於清華大學，獲本科和碩士學位，現任中國科學院深圳先進技術研究院研究員，研究方向為腦血管和血腦屏障發育、腦血管病的發生髮展機制和診療新方法研發。

基本介紹

中文名：暢君雷
國籍：中國
民族：漢
出生地：河南新鄉
出生日期：1982年12月
職業：研究員
畢業院校：香港大學

研究領域,教育背景,工作經歷,教授課程,專利與獎勵,發表文章,

研究領域

腦血管發育與血腦屏障功能的分子調節機制；

腦血管病發生髮展的機制與治療藥物研發；

Wnt信號通路的調節與生物學功能。

教育背景

2008-09--2012-02美國哈佛醫學院麻省總醫院聯合培養博士生

2007-09--2012-11香港大學李嘉誠醫學院博士
2005-09--2007-07清華大學醫學院碩士
2001-09--2005-07清華大學生物科學與技術系本科

工作經歷

2017-01~2018-11, 中國科學院深圳先進技術研究院，生物醫藥與技術研究所，研究員。

2012-02~2016-12, 美國史丹福大學醫學院,博士後. 導師：Calvin J. Kuo。

教授課程

神經生物學基礎

專利與獎勵

（1）美國心臟學會博士後獎學金,一等獎,專項,2015
（2）香港大學研究生特別獎學金,特等獎,研究所（學校）,2007
（3）光華獎學金,二等獎,研究所（學校）,2006

發表文章

15. Ma YZ, Li L, Kong LL, Zhu ZM, Zhang W, Song JK,Chang JL* and Du GH*. Pinocembrin protects blood–brain barrier function and expands the therapeutic time window for tissue-type plasminogen activator treatment in a rat thromboembolic stroke model.BioMed Research International, In press (2018). (*corresponding author). (IF 2.476)

14. Yan KS, Janda CY,Chang JL, Zheng GX, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC and Kuo CJ. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.Nature, May; 545(7653): 238-242 (2017).

13. Janda CY#, Dang LT#, You CJ,Chang JL, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li XN, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ and Garcia KC. Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signaling. Nature, May; 545(7653): 234-237 (2017). (#co-first author)

12.Chang JL#, Mancuso MR#, Maier C, Liang XB, Kanako Y, Yang L, Kwong JK, Wang J, Rao V, Vallon M, Kosinski C, Zhang HJ, Mah A, Xu LJ, Li L, Gholamin S, Reyes T, Li R, Kuhnert F, Han XY, Yuan JJ, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier S, Shortliffe LD, Wu XW, Snyder M, Chang HY, Giffard R, Chan P, Andreasson KI and Kuo CJ. Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.Nature Medicine, Apr; 23(4): 450-460 (2017). Article. (#co-first author) ***Recommended by the Faculty of 1000.

11. Furman D,Chang JL, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Dechanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nature Medicine, Jan; 23(2): 174-184 (2017). Article.

10. Lange C, Garcia MT, Decimo I, Bifari F, Quaegebeur A, Boon R, Zhao H, Boeckx B,Chang JL, Wu C, Le Noble F, Lambrechts D, Dewerchin M, Kuo CJ, Huttner WB and Carmeliet P. Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO Journal, Feb; 35(9): 924-941 (2016). ***Cover article.

9. Tsai HH, Niu JQ, Munji R, Davalos D,Chang JL, Zhang HJ, Tien AC, Kuo CJ, Chan JR, Daneman R and Fancy SP. Oligodendrocyte precursors migrate along vasculature in the developing nervous system. Science, Jan; 351(6271): 379-84 (2016).

8. Diao S, Blackburn JL, Hong GS, Antaris AL,Chang JL, Wu JZ, Zhang B, Cheng K, Kuo CJ and Dai HJ. Fluorescence imaging in vivo at wavelengths beyond 1500 nm. Angew Chem Int Ed Engl.Oct 13; 54(49): 14758-14762 (2015).

7. Hong GS#, Diao S#,Chang JL#, Antaris AL, Chen CX, Zhang B, Zhao S, Atochin DN, Huang PL, Andreasson KI, Kuo CJ and Dai HJ. Through skull fluorescence imaging of the brain in a new near-infrared window. Nature Photonics. Sep; 8(9): 723-730 (2014). (#co-first author).

6. Vallon M#,Chang JL#, Zhang HJ and Kuo CJ. Developmental and pathological angiogenesis in the central nervous system.Cellular and Molecular Life Sciences. Apr; 71:3489-3506 (2014). (#co-first author). ***Cover article.

5.Chang JL, Atochin DN, Li Q, Lam KSL, Xu AM and Huang PL. Bone marrow-derived circulating endothelial progenitor cells contribute to eNOS-regulated endothelial repair and vasodilation after arterial injury in vivo.Journal of Cardiology and Vascular Medicine, Aug; 1: 1-8 (2013).

4.Chang JL, Li YM, Huang Y, Lam KSL, Hoo RLC, Wong WT, Cheng KKY, Wang YQ, Vanhoutte PM and Xu AM. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway.Diabetes, Nov; 59(11): 2949-59 (2010).

3. Atochin DN, Yuzawa I, Li Q, Rauwerdink KM, Malhotra R,Chang JL, Broukaert P, Ayata C, Moskowitz MA, Bloch KD, Huang PL and Buys ES. Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury. Stroke. Aug; 41(8): 1815-9 (2010).

2. Du J,Chang JL, Guo SX, Zhang Q, and Wang Z. ApoE 4 reduces the expression of A-beta degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons.Neuroscience Letters. Oct; 23; 464(2):140-145 (2009).

1. Hu QL,Chang JL, Tao LT, Yan GL, Xie MC and Wang Z. Endoplasmic Reticulum mediated necrosis-like apoptosis of HeLa cells induced by Ca2+ oscillation.Journal of Biochemistry and Molecular Biology, Nov; 38(6): 709-716 (2005).

暢君雷