於舒洋

於舒洋，男，畢業於中國農業大學，博士，中國農業大學教授、博士生導師。

基本介紹

• 中文名：於舒洋
• 學位/學歷：博士
• 職業：教師
• 專業方向：重要的轉錄因子GABP家族
• 任職院校：中國農業大學

個人經歷

2005年6月畢業於中國農業大學生物學院獲得理學博士學位。先後在瑞典KarolinskaInstitute，美國Vanderbilt University和University of Iowa從事博士後研究工作。

2014年4月-：中國農業大學生物學院教授

2010年5月-2014年3月：Assistant Research Scientist，University of Iowa,

Carver College of Medicine.USA

2007年12月-2010年5月：博士後, University of Iowa, Carver College of Medicine.

2007年4月-2007年12月：博士後，Department of Reproductive Biology，

Vanderbilt University. USA

2005年3月-2007年3月：博士後，Department of Laboratory Medicine，

Karolinska Institute. Sweden

2000年9月-2005年3月：中國農業大學生物學院直博士生

1996年9月-2000年6月：中國農業大學生物學院本科生

研究方向

主要科研方向為重要的轉錄因子GABP家族和Wnt信號通路相關受體以及下游轉錄因子TCF/LEF在HSC以及成熟血細胞發育與分化過程中的功能和分子機制。

利用多種基因修飾小鼠模型分析重要的功能基因和信號通路對HSC自我更新和分化發育的分子機制

轉錄因子、MicroRNA和RNA結合蛋白在T細胞、B細胞、NK細胞、單核、巨噬細胞等免疫細胞亞群分化發育過程中的功能和調控機理

GABP和TCF/LEF互作蛋白及複合物在HSC及免疫細胞發育分化中的功能

1、圍繞著HSC和血液系統中具有重要功能的成熟細胞亞群的分化發育：

利用多種基因修飾小鼠模型分析重要的功能基因和信號通路對HSC自我更新和分化發育的分子機制；

轉錄因子及RNA結合蛋白在T細胞、B細胞、NK細胞等淋巴細胞中的功能和調控機理；

GABP和TCF/LEF轉錄因子的互作蛋白和複合物在HSC及成熟血細胞發育分化中的調控機制；

2、利用人源化小鼠模型研究幹細胞移植後免疫原性及免疫應答機制。

學術成果

發表SCI論文28篇，第一作者(含並列第一)、通訊作者文章15篇，包括Nature Immunology (2014)、Cell Stem Cell (2012)、Immunity (2010, 2012)、Blood (2011, 2013)、JI (2010)、JBC (2010, 2016)和JV (2006)等雜誌。其中2篇文章被F1000推薦，3篇文章被權威雜誌作為前沿和亮點推薦並同期發表評述文章。

論文

論文

論文題目	刊物名稱	收錄類別	發表年月	第一作者或全部作者	第一作者單位	排名
Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	FASEB J	SCI	2019 Jan	Liu Juanjuan	China Agricultural University	Corresponding (16/16)
Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.	FASEB J	SCI	2019 Feb	Cao Dengchao	China Agricultural University	Co-corresponding (20/21)
Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice.	Front Immunol	SCI	2018 Sep	Zhang Tianyi	China Agricultural University	Co-corresponding (14/16)
Long noncoding RNA Malat1 is not essential for T cell development and response to LCMV infection.	RNA biology	SCI	2018 Nov	Yao Yinpeng	China Agricultural University	Corresponding (13/13)
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes	Cell Res	SCI	2018 Aug	Juan Chen	Institute of Biophysics, Chinese Academy of Sciences	Co-author (16/18)
Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity	J Exp Med	SCI	2018 Aug	Xing Shaojun	University of Iowa	Co-author (11/15)
Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1	Cell Stem Cell	SCI	2017 Sep	Li Fenglin	University of Iowa	Co-author (4/10)
Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice.	Science Bulletin	SCI	2017 Nov	Cui Zhengzhi	China Agricultural University	Co-corresponding (10/10)
Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors	J Biol Chem	SCI	2016 May	Yu Shuyang	China Agricultural University	First and Co-corresponding (1/6)
Developing a triple transgenic cell line for high-efficiency porcine reproductive and respiratory syndrome virus infection	PLoS One	SCI	2016 May	Zhang Linlin	China Agricultural University	Co-corresponding (8/9)
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity	Nat Immunol	SCI	2016 Jun	Xing Shaojun	University of Iowa	Co-author (5/17)
Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds	J Immunol	SCI	2016 Jun	Han Binyue	China Agricultural University	Co-author (6/23)
CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections	Immunity	SCI	2016 Dec	He Bing	University of Iowa	Co-author (9/13)
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow	Nat Immunol	SCI	2015 Oct	Yang Qi	University of Iowa	Co-author (9/13)
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation	J Exp Med	SCI	2015 May	Tiffany Carr	The University of Chicago	Co-author (3/6)
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells	Nat Immunol	SCI	2014 Jul	Farrah C Steinke	University of Iowa	Co-first (2/10)
TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes	Blood	SCI	2013 May	Yu Shuyang	China Agricultural University	First and Co-corresponding (1/2)
The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy	Immunity	SCI	2012 Oct	Yu Shuyang	University of Iowa	First (1/13)
Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7Rα in T cells	Transgenic Res	SCI	2012 Feb	Yu Shuyang	University of Iowa	First (1/6)
Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells	Cell Stem Cell	SCI	2012 Aug	Yu Shuyang	University of Iowa	First (1/5)
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells	Blood	SCI	2011 Feb	Yu Shuyang	University of Iowa	First (1/7)
Constitutive activation of Wnt signaling favors generation of memory CD8 T cells	J Immunol	SCI	2010 Feb	Zhao Dongmei	University of Iowa	Co-first (2/8)
Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1.Immunity	Immunity	SCI	2010 Aug	Zhou Xinyuan	University of Iowa	Co-first (2/6)
Critical requirement of GABP{alpha} for normal T cell development	J Biol Chem	SCI	2010 Apr	Yu Shuyang	University of Iowa	First (1/4)
Construction of a high efficiency PCR products cloning T vector using pGEM-5zf (+)	Avicenna J Med Biotechnol	SCI	2009 Apr	Zhao Yaofeng	Karolinska University Hospital Huddinge	Co-author (3/6)
PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis	J Neuroimmunol	SCI	2008 Jul	Ann Kari Lefvert	Karolinska University Hospital Solna	Co-author (4/6)
Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice	Immunology	SCI	2007 Jul	Lu wei	China Agricultural University	Co-author (4/9)
Construct synthetic gene encoding artificial spider dragline silk protein and its expression in milk of transgenic mice	Anim Biotechnol	SCI	2007 Feb	Xu hongtao	China Agricultural University	Co-author (3/11)
Expression of insulin-like growth factors systems in cloned cattle dead within hours after birth	Mol Reprod Dev	SCI	2006 Nov	Li Shijie	China Agricultural University	Co-author (3/8)
Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis	Proc Natl Acad Sci U S A	SCI	2006 Aug	Zhao Yaofeng	China Agricultural University	Co-author (3/8)
Maternally derived recombinant human anti-hantavirus monoclonal antibodies are transferred to mouse offspring during lactation and neutralize virus in vitro	Journal of Virology	SCI	2006 Apr	Yu Shuyang	China Agricultural University	First (1/15)
Aberrant gene expression in organs of bovine clones that die within two days after birth	Biol Reprod	SCI	2005 Feb	Li Shijie	China Agricultural University	Co-author (5/8)
Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene	Sci China C Life Sci	SCI	2005 Aug	Yu Zhengquan	China Agricultural University	Co-author (10/11)
Effects of Fucosylated Milk of Goat and Mice on H. pylori Binding to Lewis b Antigen	World J Gastroenterol	SCI	2004 Jul	Xu hongtao	China Agricultural University	Co-author (6/13)
The Cloning of Human alpha-Lactalbumin Gene and High-Level Expression in Milk of Transgenic Mice	Progress in Biochemistry and Biophysics	SCI	2004 Jan	Yu Shuyang	China Agricultural University	First (1/7)

榮譽獎項

2013年以“拔尖人才”引進中國農業大學，任生物學院教授、博導。