於曉強(山東大學教授)

於曉強，男，1963年6月出生於吉林長春市。教授，博士生導師。1985年7月畢業於吉林大學化學系高分子專業，獲學士學位。1988年畢業於清華大學化學工程系獲工學碩士學位，1988年至1996年在山東工業大學任講師。1996年入吉林大學化學學科攻讀博士學位，1999年7月獲博士學位後，入山東大學晶體材料國家重點實驗室材料科學與工程博士後流動站進行博士後研究，2001年7月出站後留校工作。02年香港科技大學訪問學者。吉林大學電子科學學院集成光電子國家重點實驗室兼職教授。

基本介紹

• 中文名：於曉強
• 出生地：吉林長春市 
• 出生日期：1963年6月
• 職業：山東大學教授、博士生導師

研究領域及取得成果介紹

2000年開始從事雙光子方面的工作，在雙光子聚合方面已經取得了較大的成績。目前的工作集中在雙光子生物螢光探針的設計、製備和生物套用研究。此領域是一項多學科密集交叉的國際前沿領域，正在力爭在該領域作出創造性的工作。經過十年的建設，實驗室擁有先進有機材料製備、螢光性能表征、雙光子性能測試、活性生物細胞與組織培育、生物螢光顯微成像等一流設備。特別是雙光子螢光測試系統、雙光子生物螢光顯微系統是我們根據生物螢光探針的實驗要求自行建設的，並得到了國際國內同行的認可，我們的實驗數據已經為浙江大學、中國科學院化學研究所、吉林大學、中國海洋大學、重慶大學等單位提供數據，並協助其發表論文。

美麗的植物螢光顯微照片

主要承擔的科研課題

(1) 雙光子光聚合反應的研究 國家自然科學基金委員會

(2) 聚合物型三維光子晶體的雷射微加工和微型光學器件研究 國家自然科學基金委員會/香港資助局聯合資助

(3) 生物學光學視窗的水溶性雙光子螢光材料研究及相關核酸探針的探索 國家自然科學基金委員會

(4) 光波段具有負折射特性的特殊周期介質結構的研究 科技部973基礎研究課題

(5)雙光子DNA探針的研製 濟南試豪生物公司自主專利資助課題

作者論文發表情況

第一通訊作者論文：

AcceptedManuscript:

Xuechen Li,Minggang Tian, Ge Zhang, Ruoyao Zhang, Ruiqing, Feng, Lifang Guo，Xiaoqiang Yu*, Ning Zhao*, Xiuquan He*. Aspatial-dependent fluorescent probe for detecting different situations ofmitochondrial membrane potential conveniently and efficiently. Anal. Chem. 2017.2.14,DOI: 10.1021/acs.analchem.6b03842.

1. Minggang Tian,Yong Liu, Yuming Sun, Ruoyao Zhang, Ruiqing Feng, Ge Zhang, Lifang Guo, XuechenLi,Xiaoqiang Yu*, Jing Zhi Sun*,Xiuquan He*. A single fluorescent probe enables clearly discriminating andsimultaneously imaging liquid-ordered and liquid-disordered microdomains inplasma membrane of living cells. Biomaterilas 2017, 12, 46~56.

2. Minggang Tian,Yuming Sun, Lifang Guo, Ruoyao Zhang, Ge Zhang, Ruiqing Feng, Xuechen Li,Huamiao Zhang, Ge Li，Xiaoqiang Yu*,XiuQuan He*. A small-structure two-photon platform equipped with weakelectrondonor: Development of permeable two-photon probes for lysosomesandmitochondria in living cells. Sensors and Actuators B 2017, 243, 955~962.

3. Lifang Guo,Ruoyao Zhang, Yuming Sun, Minggang Tian, Ge Zhang, Ruiqing Feng, Xuechen Li,Huamiao Zhang, Li He,Xiaoqiang Yu*,Xiuquan He*. Styrylpyridine salts-based red emissive two-photon turn-on probefor imaging the plasma membrane in living cells and tissues. Analyst 2016,141(11), 3228~3232.

4. Ge Zhang,Yuming Sun, Xiuquan He, Weijia Zhang, Minggang Tian, Ruiqing Feng, RuoyaoZhang, Xuechen Li, Lifang Guo,XiaoqiangYu*, Shangli Zhang*. Red-Emitting Mitochondrial Probe with UltrahighSignal-to-Noise Ratio Enables High-Fidelity Fluorescent Images in Two-PhotonMicroscopy. Analytical Chemistry 2015, 87(24), 12088~12095.

5. Ruiqing Feng,Yuming Sun, Minggang Tian, Ge Zhang, Ruoyao Zhang, Lifang Guo, Xuechen Li,Xiaoqiang Yu*, Ning Zhao*. Amembrane-permeable dye for living cells with large two-photon excitedfluorescence action cross-sections for bioimaging. Journal of MaterialsChemistry B 2015, 3(44), 8644~8649.

6. Guofen Song,Yuming Sun, Yong Liu, Xiankun Wang, Meiling Chen, Fang Miao, Weijia Zhang,Xiaoqiang Yu*, Jianling Jin*. Lowmolecular weight fluorescent probes with good photostability for imagingRNA-rich nucleolus and RNA in cytoplasm in living cells. Biomaterials 2014,35(7), 2103~2112.

7. Fang Miao,Weijia Zhang, Yuming Sun, Ruoyao Zhang, Yong Liu, Fuqiang Guo, Guofen Song,Minggang Tian,Xiaoqiang Yu*. Novelfluorescent probes for highly selective two-photon imaging of mitochondria inliving cells. Biosens. Bioelectron. 2014, 55(15), 423~429.

8. Minggang Tian,Fuqiang Guo, Yuming Sun, Weijia Zhang, Fang Miao, Yong Liu, Guofen Song, Cheuk-LamHo,Xiaoqiang Yu,* Jing Zhi Sun* andWai-Yeung Wong*. A fluorescent probe for intracellular cysteine overcoming theinterference by glutathione. Org. Biomol. Chem., 2014, 12(32), 6128~6133.

9. Yong Liu,Weijia Zhang, Yuming Sun, Guofen Song, Fang Miao, Fuqiang Guo, Minggang Tian,Xiaoqiang Yu*, Jing Zhi Sun*.Two-photon fluorescence imaging of RNA in nucleoli and cytoplasm in livingcells based on low molecular weight probes. Dyes and Pigments, 2014, 103(6), 191~201.

10. Junjie Wang,Yuming Sun, Weijia Zhang, Yong Liu,XiaoqiangYu*, Ning Zhao* A two-photon ratiometric fluorescent probe enables spatialcoordinates determination of intracellular pH. Talanta, 2014, 129, 241~248.

11. Fang Miao,Guofen Song, Yuming Sun, Yong Liu, Fuqiang Guo, Weijia Zhang, Minggang Tian,Xiaoqiang Yu*. Fluorescent imaging ofacidic compartments in living cells with a high selective novel one-photonratiometric and two-photon acidic pH probe. Biosens. Bioelectron. 2013, 50(4) 42~49.

12. Fuqiang Guo,Minggang Tian, Fang Miao, Weijia Zhang, Guofen Song, Yong Liu,Xiaoqiang Yu*, Jing Zhi Sun*, Wai-YeungWong*. Lighting up cysteine and homocysteine in sequence based on the kineticdifference of the cyclization/addition reaction. Org. Biomol. Chem., 2013,11(44), 7721~7728.

18. ZHAO Ning,ZHANG YuanHong, LIU Xin,YU XiaoQiang*,GE MaoFa. Carbazoletricationic salt: a novel potential two-photon fluorescentDNA probe for nucleic imaging of cells Chin. Sci. Bull. 2010, 55(32),3661-3667.

19. ZHANGYuan-Hong, SUN Yu-Ming, LIU Xin, ZHAO Ning,YU Xiao-Qiang*, HUANG Bai-Biao*. Interaction Between DicationicCarbazole Derivatives and Nucleic Acidby Spectrum. CHEMICALJOURNAL OF CHINESEUNIVERSITIES 2010, 31(9), 1860-1863.

授權專利:

1.於曉強、孫渝明一種單、雙光子半胱氨酸螢光探針及其套用 ZL 2010 1 0558433.0

2.於曉強、馮瑞卿，孫渝明、苗芳一種單、雙光子酸性細胞器螢光探針及其套用ZL201310018340.2

3.於曉強、田明剛、孫渝明、苗芳一種單、雙光子線粒體螢光探針及其套用ZL 201310256318.1

4.於曉強、張革、孫渝明、宋國芬一種用於活細胞中RNA和核仁成像的吲哚吡啶鹽類螢光探針，ZL 201310216501.9

5.於曉強、張若瑤、孫渝明、張革、宋國芬一種用於活細胞中RNA和核仁成像的吡咯吡啶鹽類螢光探針，ZL 201310215970.9