方亮，男，吉林人，畢業於瀋陽藥學院，現為瀋陽藥科大學藥學院院長。
基本介紹
- 中文名：方亮
- 職業：教授/博士生導師/藥學院院長
- 畢業院校：瀋陽藥學院藥學系藥物製劑專業畢業
基本信息,學習/工作經歷,兼職情況,科研/獲獎情況,教學/指導研究生情況,發表論文/出版著作,
基本信息
姓名：方亮
性別：男
籍貫：吉林
職稱/職務：教授/博士生導師/藥學院院長
學習/工作經歷
1987年7月, 瀋陽藥學院藥學系藥物製劑專業畢業
1987年8月～1988年12月，吉林省醫藥工業研究所任助理工程師
1989年1月～1992年7月，吉林省延邊醫藥管理局工業科任科員
1992年8月～1994年2月，吉林省延邊中藥廠任副廠長，工程師
1994年3月～2000年3月，延邊大學藥學院藥劑學教研室任講師，副教授
1999年7月，在延邊大學藥學院獲得理學碩士學位
1999年4月～2000年3月，以日中笹川醫學研究者制度第22期生身份在日本城西大學藥學部留學
2003年3月，在日本城西大學藥學部獲得藥學博士學位
2003年4月～2004年3月，日本城西大學藥學部博士後
2004 年 4 月～現在，瀋陽藥科大學藥學院藥劑教研室任教授
1987年8月～1988年12月，吉林省醫藥工業研究所任助理工程師
1989年1月～1992年7月，吉林省延邊醫藥管理局工業科任科員
1992年8月～1994年2月，吉林省延邊中藥廠任副廠長，工程師
1994年3月～2000年3月，延邊大學藥學院藥劑學教研室任講師，副教授
1999年7月，在延邊大學藥學院獲得理學碩士學位
1999年4月～2000年3月，以日中笹川醫學研究者制度第22期生身份在日本城西大學藥學部留學
2003年3月，在日本城西大學藥學部獲得藥學博士學位
2003年4月～2004年3月，日本城西大學藥學部博士後
2004 年 4 月～現在，瀋陽藥科大學藥學院藥劑教研室任教授
兼職情況
世界中醫藥聯合會中藥藥劑專業委員會常務理事
Asian Journal of Pharmaceutical Sciences 編委
國家食品藥品監督管理局新藥審評專家
國家自然科學基金函審評議專家
教育部留學回國人員科研啟動基金評審專家
遼寧省委省政府決策諮詢委員會中青年專家
重慶市化學製藥工程技術中心技術委員會成員
瀋陽藥科大學學位評定委員會藥劑學分科委員會主席
《瀋陽藥科大學學報》常務編委
Asian Journal of Pharmaceutical Sciences 編委
國家食品藥品監督管理局新藥審評專家
國家自然科學基金函審評議專家
教育部留學回國人員科研啟動基金評審專家
遼寧省委省政府決策諮詢委員會中青年專家
重慶市化學製藥工程技術中心技術委員會成員
瀋陽藥科大學學位評定委員會藥劑學分科委員會主席
《瀋陽藥科大學學報》常務編委
科研/獲獎情況
近五年來，主持了國家自然科學基金項目“兩親經皮促透劑薄荷醇修飾物酯的結構最佳化及促透機制的研究”（批准號：81173007）和“l-香芹醇酯類衍生物經皮促透作用的可逆性及其機理研究”（批准號：30973654）兩項、高等學校博士學科點專項基金項目“l-香芹醇酯類衍生物經皮促透作用的可逆性及其機理研究”（批准號：20092134110002）一項、國家“十一五重大新藥創製”大平台子項目“左旋氨氯地平貼劑的開發”（新藥2009ZX09301—012）一項，國家“十一五重大新藥創製”遼寧省國家創新藥物孵化（本溪）基地建設子項目“阿扎司瓊貼劑的開發”（新藥2010ZX09401—304）一項，參與國家科技部“973”重大科學研究計畫項目“納米技術改善難溶性藥物功效的套用基礎研究”（2009CB903302）一項。在國際學術會議上，作大會報告6次，申請專利12項，授權專利2項，2011年被評為瀋陽藥科大學教學名師。
教學/指導研究生情況
講授本科生課程：藥劑學、生物藥劑學、藥物動力學
指導博士研究生16名（其中畢業7名）、碩士研究生30名（其中畢業 18名）
發表論文/出版著作
發表論文：在國內外學術期刊發表論文70多篇，其中SCI收載30多篇。
編寫著作：
《藥劑學學習指導書》（主編）中國醫藥科技出版社，2011年
《經皮給藥新劑型》（副主編）人民衛生出版社，2006年
《藥用高分子材料學》（副主編）中國醫藥科技出版社，2009年
《藥物製劑註解》（副主編）人民衛生出版社，2010年
《藥劑學》（第二版）（編者）中國醫藥科技出版社，2010年
《藥劑學》（第七版）（編者）人民衛生出版社，2011年
《中華醫學百科全書藥劑學分卷》（編者），正在編寫。
《經皮給藥新劑型》（副主編）人民衛生出版社，2006年
《藥用高分子材料學》（副主編）中國醫藥科技出版社，2009年
《藥物製劑註解》（副主編）人民衛生出版社，2010年
《藥劑學》（第二版）（編者）中國醫藥科技出版社，2010年
《藥劑學》（第七版）（編者）人民衛生出版社，2011年
《中華醫學百科全書藥劑學分卷》（編者），正在編寫。
近期發表的SCI收入論文：
1. HL, Xi, L Fang. The relationship between hydrogen-bonded ion-pair stability and transdermal penetration of lornoxicam with organic amines. Eur J Pharm Sci, accepted. (通訊作者)
2. NX, Zhao, DM Cun, W Li, L Sun, HL Xi, L Li, L Fang. In vitro percutaneous absorption enhancement of granisetron by chemical penetration enhancers. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2012.665924) (通訊作者)
3. N Zeng, QY Hu, ZY Liu, XL Gao, RK Hu, QX Song, GZGu, HM Xia, L Yao, ZQ Pang, XG Jiang, J Chen, L Fang. Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid
crystalline nanoparticles (LCNPs) for improved bioavailability. Int J Pharm, 2012, 424:58-56. (通訊作者)
4. J Liu, ZY Wang, C Liu, HL Xi, CM Li, Y Chen, L Sun, L Mu, L Fang. Silicone adhesive, a better matrix for tolterodine patches—a research based on in vitro/in vivo studies. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2011.637049) (通訊作者)
5. ZY Wen; ZQ Yan; K Hu; R He; ZQ Pang; LR Guo; Y Qian; XG Jiang; L Fang. Brain targeting and toxicity study of odorranalectin-conjugated nanoparticles following intranasal administration. Drug Delivery, 2011, 18 (3): 555-561. (通訊作者)
6.W Sun, W Tian, Y Zhang, J He, S Mao, L Fang. Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals. Nanoedicine, accepted. (通訊作者)
7. CM Li, C Liu, J Liu, L Fang. Correlation Between Rheological Properties, In Vitro Release, and Percutaneous Permeation of Tetrahydropalmatine. AAPS Pharm Sci Tech, 2011, 12 (3): 1002-1010. (通訊作者)
8. W Sun, SR Mao, Y Shi, LC Li, L Fang. Nanonization of itraconazole by high pressure homogenization: Stabilizer optimization and effect of particle size on oral absorption. J Pharm Sci, 2011, 100(8):3365-3373.
9.ZY Wen; ZQ Yan; K Hu; ZQ Pang; XF Cheng; LR Guo; QZ Zhang; R Lai; XG Jiang; L Fang. Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on parkinson‘s disease following intranasal administration. J Control Release, 2011, (15)：131-138. (通訊作者)
10. W Li, YG Yang, YS Tian, XL Xu, YChen, L Mu, YQ Zhang, L Fang. Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. Int J Pharm, 2011, 408:157-162. (通訊作者)
11.LG Zhao, L Fang, YN Xu, N Zheng, ZG He. Effect of (E)-2-isopropyl-5- methylcyclohexyl octadec-9-enoate on transdermal delivery of aconitum alkaloids. Drug Deve Ind Pharm, 2011;37(3):290-299. (通訊作者)
12.L Li, L Fang, XL Xu, Y Liu, YH Sun, ZG He. The Transdermal Patches for Site-Specific Delivery of Letrozole: A New Option for Breast Cancer Therapy. AAPS Pharm Sci Tech, 2010, 11(3):1054-7. (通訊作者)
13.X Ma, L Fang, JP Guo, NX Zhao, ZG He. Effect of counter-ions and penetration enhancers on the skin permeation of flurbiprofen. J Pharm Sci, 2010, 99(4):1826-1837. (通訊作者)
14.HL Xi, YG Yang, DM Zhao, L Fang, L Sun, LW Mu, J Liu, NX Zhao, YY Zhao, N Zheng, ZG He. Transdermal patches for site-specific delivery of anastrozole: In vitro and local tissue disposition evaluation. Int J Pharm, 2010, 391:73–78. (通訊作者)
1. HL, Xi, L Fang. The relationship between hydrogen-bonded ion-pair stability and transdermal penetration of lornoxicam with organic amines. Eur J Pharm Sci, accepted. (通訊作者)
2. NX, Zhao, DM Cun, W Li, L Sun, HL Xi, L Li, L Fang. In vitro percutaneous absorption enhancement of granisetron by chemical penetration enhancers. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2012.665924) (通訊作者)
3. N Zeng, QY Hu, ZY Liu, XL Gao, RK Hu, QX Song, GZGu, HM Xia, L Yao, ZQ Pang, XG Jiang, J Chen, L Fang. Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid
crystalline nanoparticles (LCNPs) for improved bioavailability. Int J Pharm, 2012, 424:58-56. (通訊作者)
4. J Liu, ZY Wang, C Liu, HL Xi, CM Li, Y Chen, L Sun, L Mu, L Fang. Silicone adhesive, a better matrix for tolterodine patches—a research based on in vitro/in vivo studies. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2011.637049) (通訊作者)
5. ZY Wen; ZQ Yan; K Hu; R He; ZQ Pang; LR Guo; Y Qian; XG Jiang; L Fang. Brain targeting and toxicity study of odorranalectin-conjugated nanoparticles following intranasal administration. Drug Delivery, 2011, 18 (3): 555-561. (通訊作者)
6.W Sun, W Tian, Y Zhang, J He, S Mao, L Fang. Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals. Nanoedicine, accepted. (通訊作者)
7. CM Li, C Liu, J Liu, L Fang. Correlation Between Rheological Properties, In Vitro Release, and Percutaneous Permeation of Tetrahydropalmatine. AAPS Pharm Sci Tech, 2011, 12 (3): 1002-1010. (通訊作者)
8. W Sun, SR Mao, Y Shi, LC Li, L Fang. Nanonization of itraconazole by high pressure homogenization: Stabilizer optimization and effect of particle size on oral absorption. J Pharm Sci, 2011, 100(8):3365-3373.
9.ZY Wen; ZQ Yan; K Hu; ZQ Pang; XF Cheng; LR Guo; QZ Zhang; R Lai; XG Jiang; L Fang. Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on parkinson‘s disease following intranasal administration. J Control Release, 2011, (15)：131-138. (通訊作者)
10. W Li, YG Yang, YS Tian, XL Xu, YChen, L Mu, YQ Zhang, L Fang. Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. Int J Pharm, 2011, 408:157-162. (通訊作者)
11.LG Zhao, L Fang, YN Xu, N Zheng, ZG He. Effect of (E)-2-isopropyl-5- methylcyclohexyl octadec-9-enoate on transdermal delivery of aconitum alkaloids. Drug Deve Ind Pharm, 2011;37(3):290-299. (通訊作者)
12.L Li, L Fang, XL Xu, Y Liu, YH Sun, ZG He. The Transdermal Patches for Site-Specific Delivery of Letrozole: A New Option for Breast Cancer Therapy. AAPS Pharm Sci Tech, 2010, 11(3):1054-7. (通訊作者)
13.X Ma, L Fang, JP Guo, NX Zhao, ZG He. Effect of counter-ions and penetration enhancers on the skin permeation of flurbiprofen. J Pharm Sci, 2010, 99(4):1826-1837. (通訊作者)
14.HL Xi, YG Yang, DM Zhao, L Fang, L Sun, LW Mu, J Liu, NX Zhao, YY Zhao, N Zheng, ZG He. Transdermal patches for site-specific delivery of anastrozole: In vitro and local tissue disposition evaluation. Int J Pharm, 2010, 391:73–78. (通訊作者)
15.L Li, L Fang, XL Xu, Y Liu, YH Sun, ZG He. Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole. Biopharmaceutics & Drug Disposition, 2010, 31: 138-149. (通訊作者)
16. Y Liu, SD Yoo, L Fang, X Jin, L Li, TF Li. . Ion-pair LC-UV method for the determination of boanmycin in moude plasma and its application to a pharmacokinetic atudy. Chromatographia, 2010, 72:357-359.
17. YH Suna, L Fang, M Zhua, W Li , P Meng, L Li, ZG He. A drug-in-adhesive transdermal patch for S-amlodipine free base: In vitro and in vivo characterization. Int J Pharm, 2009, 382 : 165–171 (通訊作者)
18.Z Tan, JY Zhang, J Wu, L Fang, ZG He. The Enhancing Effect of Ionpairing on the Skin Permeation of Glipizide. AAPS Pharm Sci Tech, 2009, 10(3):967-976. (通訊作者)
19.Y Liu, SD Yoo, L Fang, X Jin, L Li, YJ Ren, CS Yao, TF Li. Determiniation of boanmycinin pharmaceiytical preparations by a simple and rapid ion-pair LC method. Chromatographia, 2009, 70:643-646.
20.LG Zhao, Y Li, L Fang, YN Xu, ZG He. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation. Int J Pharm, 2009, 374: 73–81. (通訊作者)
21.LG Zhao, Y Li, L Fang, YN Xu, ZG He. Effect of O-acylmenthol and salt formation on the skin permeation of diclofenac acid. Drug Dev Ind Pharm, 2009, 35: 814–826 (通訊作者)
22.ZY Wen, L Fang, ZG He. Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Delivery, 2009, 16: 214-223. (通訊作者)
23.JY Zhang, L Fang, Zhe Tan, Jian Wu, and Zhong-Gui He. Influence of ion-pairing and chemical enhancers on the transdermal delivery of meloxicam. Drug Dev Ind Pharm, 2009; 35: 663–670. (通訊作者)
24.CS Ren, L Fang, L Ling, Q Wang, S Liu, LG Zhao, ZG He. Design and in vivo evaluation of an indapamide transdermal patch. Int J Pharm, 2009, 370: 129-135. (通訊作者)
25.LG Zhao, L Fang, YN Xu, S Liu, ZG He, YY Zhao. Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers. Eur J Pharm Biopharm, 2008, 69:199–213. (通訊作者)
26.LG Zhao, L Fang, YN Xu, YY Zhao, ZG He. Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity. Int J Pharm, 2008, 352: 92–103. (通訊作者)
27.CS Ren, L Fang, T Li, ML Wang, LG Zhao, ZG He. Effect of permeation enhancers and organic acids on the skin permeation of indapamide. Int J Pharm, 2008, 350: 43–47. (通訊作者)
28.ML Wang, L Fang, CS Ren, T Li. Effect of ion-pairing and enhancers on scutellarin skin permeability. J Pharm Pharmacol, 2008, 60: 425–435. (通訊作者)
29. YX Jiang, L Fang, XC Niu, R Ma, ZG He. The effect of ion pairing on the skin permeation of amlodipine. Die pharmazie, 2008, 63(5): 356-360. (通訊作者)
30.R Ma, L Fang, XC Niu, YX Jiang, ZG He. Effect of ion-pairing on the permeation of glibenclamide through rat skin. J Drug Deliv Sci Tech, 2008, 18(4): 279-284. (通訊作者)
31.Y Morimoto, M Mutoh, H Ueda, L Fang, K Hirayama, M Atobe, D Kobayashi. Elucidation of the transport pathway enhanced by low-frequency sonophoresis using hydrodynamic pore theory and confocal microscopy in hairless rat skin. J Control Release, 2005, 103: 587–597.
32. L Fang, S Numajiri, D Kobayashi, H Ueda, K Nakayama, H Miyamae, Y Morimoto. Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines. J Pharm Sci, 2004, 93: 144–54.
33. L Fang, S Numajiri, D Kobayashi, Y Morimoto. The use of complexation with alkanolamines to facilitate skin permeation of mefenamic acid. Int J Pharm, 2003, 262: 13–22.
34. L Fang, Y Kobayashi, S Numajiri, D Kobayashi, Y Morimoto. The enhancing effect of a triethanolamine- ethanol-isoproply myristate mixed system on the skin permeation of acidic drugs. Biol Pharm Bull, 2002, 25: 1339–1344.
16. Y Liu, SD Yoo, L Fang, X Jin, L Li, TF Li. . Ion-pair LC-UV method for the determination of boanmycin in moude plasma and its application to a pharmacokinetic atudy. Chromatographia, 2010, 72:357-359.
17. YH Suna, L Fang, M Zhua, W Li , P Meng, L Li, ZG He. A drug-in-adhesive transdermal patch for S-amlodipine free base: In vitro and in vivo characterization. Int J Pharm, 2009, 382 : 165–171 (通訊作者)
18.Z Tan, JY Zhang, J Wu, L Fang, ZG He. The Enhancing Effect of Ionpairing on the Skin Permeation of Glipizide. AAPS Pharm Sci Tech, 2009, 10(3):967-976. (通訊作者)
19.Y Liu, SD Yoo, L Fang, X Jin, L Li, YJ Ren, CS Yao, TF Li. Determiniation of boanmycinin pharmaceiytical preparations by a simple and rapid ion-pair LC method. Chromatographia, 2009, 70:643-646.
20.LG Zhao, Y Li, L Fang, YN Xu, ZG He. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation. Int J Pharm, 2009, 374: 73–81. (通訊作者)
21.LG Zhao, Y Li, L Fang, YN Xu, ZG He. Effect of O-acylmenthol and salt formation on the skin permeation of diclofenac acid. Drug Dev Ind Pharm, 2009, 35: 814–826 (通訊作者)
22.ZY Wen, L Fang, ZG He. Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Delivery, 2009, 16: 214-223. (通訊作者)
23.JY Zhang, L Fang, Zhe Tan, Jian Wu, and Zhong-Gui He. Influence of ion-pairing and chemical enhancers on the transdermal delivery of meloxicam. Drug Dev Ind Pharm, 2009; 35: 663–670. (通訊作者)
24.CS Ren, L Fang, L Ling, Q Wang, S Liu, LG Zhao, ZG He. Design and in vivo evaluation of an indapamide transdermal patch. Int J Pharm, 2009, 370: 129-135. (通訊作者)
25.LG Zhao, L Fang, YN Xu, S Liu, ZG He, YY Zhao. Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers. Eur J Pharm Biopharm, 2008, 69:199–213. (通訊作者)
26.LG Zhao, L Fang, YN Xu, YY Zhao, ZG He. Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity. Int J Pharm, 2008, 352: 92–103. (通訊作者)
27.CS Ren, L Fang, T Li, ML Wang, LG Zhao, ZG He. Effect of permeation enhancers and organic acids on the skin permeation of indapamide. Int J Pharm, 2008, 350: 43–47. (通訊作者)
28.ML Wang, L Fang, CS Ren, T Li. Effect of ion-pairing and enhancers on scutellarin skin permeability. J Pharm Pharmacol, 2008, 60: 425–435. (通訊作者)
29. YX Jiang, L Fang, XC Niu, R Ma, ZG He. The effect of ion pairing on the skin permeation of amlodipine. Die pharmazie, 2008, 63(5): 356-360. (通訊作者)
30.R Ma, L Fang, XC Niu, YX Jiang, ZG He. Effect of ion-pairing on the permeation of glibenclamide through rat skin. J Drug Deliv Sci Tech, 2008, 18(4): 279-284. (通訊作者)
31.Y Morimoto, M Mutoh, H Ueda, L Fang, K Hirayama, M Atobe, D Kobayashi. Elucidation of the transport pathway enhanced by low-frequency sonophoresis using hydrodynamic pore theory and confocal microscopy in hairless rat skin. J Control Release, 2005, 103: 587–597.
32. L Fang, S Numajiri, D Kobayashi, H Ueda, K Nakayama, H Miyamae, Y Morimoto. Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines. J Pharm Sci, 2004, 93: 144–54.
33. L Fang, S Numajiri, D Kobayashi, Y Morimoto. The use of complexation with alkanolamines to facilitate skin permeation of mefenamic acid. Int J Pharm, 2003, 262: 13–22.
34. L Fang, Y Kobayashi, S Numajiri, D Kobayashi, Y Morimoto. The enhancing effect of a triethanolamine- ethanol-isoproply myristate mixed system on the skin permeation of acidic drugs. Biol Pharm Bull, 2002, 25: 1339–1344.
