文鐵橋，博士，上海大學教授，博士研究生導師。
基本介紹
- 中文名：文鐵橋
- 國籍：中國
- 民族：漢族
- 職業：上海大學教授
教育背景,研究方向,近期發表的代表性論文,
教育背景
先後於復旦大學、美國the University of Georgia完成博士後研究。現任上海大學生命科學學院教授、上海大學系統生物技術研究所教授，國際人類基因組組織成員、中國系統仿真學會生命系統建模專業委員會副主任、中國神經科學學會會員、美國遺傳學會會員、上海市生物化學與分子生物學學會常務理事、上海市微生物學會理事、上海市科技預見專家等。主要從事分子神經生物學研究。
研究方向
1、神經幹細胞分化調控機制及信號傳導途徑；2、神經退行性疾病（老年痴呆症、帕金森氏症）發病機制及治療的分子基礎；3、大腦、神經發育調控的系統生物學研究。承擔的科研項目有國家973計畫、國家自然科學基金、國際合作計畫、上海市重點基礎研究項目、上海市教委重點創新項目等。
近期發表的代表性論文
1. Liu X, Ren X, Deng X, Huo Y, Xie J, Huang H, Jiao Z, Wu M, Liu Y, Wen T*. A protein interaction network for the analysis of the neuronal differentiation of neural stem cells in response to titanium dioxide nanoparticles. Biomaterials. 2010 Apr;31(11):3063-3070.
2. Gu S, Huang H, Bi J, Yao Y, Wen T*. Combined treatment of neurotrophin-3 gene and neural stem cells is ameliorative to behavior recovery of Parkinson's disease rat model. Brain Res. 2009 Feb 27;1257:1-9.
3. Huang T, Cui W, He ZS, Hu L, Liu F, Wen T, Li Y, Cai Y. Functional association between influenza A (H1N1) virus and human. Biochem Biophys Res Commun. 2009, 390(4):1111-3.
4. Lu W, Wang J, Wen T*..Downregulation of Rho-GDI gamma promotes differentiation of neural stem cells.Mol Cell Biochem. 2008 Apr;311(1-2):233-40. Epub 2008 Feb 14.
5. Zang Y, Yu LF, Pang T, Fang LP, Feng X, Wen TQ, Nan FJ, Feng LY, Li J.AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase J Biol Chem. 2008, 283(10):6201-8.
6. Wang L, Wang J, Wu Y, Wu J, Pang S, Pan R, Wen T*. A Novel Function of dcf1 During the Differentiation of Neural Stem Cells In vitro.Cell Mol Neurobiol. 2008 28（6）887-894.
7. Yiqun Yu, Shuting Gu, Tieqiao Wen*.Combination of bFGF, heparin and laminin induce the generation of dopaminergic neurons from rat neural stem cells both in vitro and in vivo. J.Neurol.Sci. 2007，255：81-86
8. Luyi Zhang, Shuting Gu, Tieqiao Wen*. Combined treatment of neurotrophin-3 gene and neural stem cells is propitious to functional recovery after spinal cord injury Cell Transplantation. 2007，16(5): 475-481
9. Tieqiao Wen*, Kuiyi Bao, Hailong Li. Blocking BE301622 gene expression by RNAi initiates differentiation of neural stem cells. Cell biochemistry and function. 2007 Nov-Dec; 25(6): 775-779.)
10. Tieqiao Wen*, Hailong Li, Hongsheng Song, Fuxue Chen, Cuiping Zhao, Wei Lu, Kuiyi Bao, Ye Jin Down-regulation of specific gene expression by double-strand RNA induces neural stem cell differentiation in vitro. Mol Cell Biochem. 2005 Jul ;275:215-21
11. Tieqiao Wen, Clayton A Parrish, Dan Xu, Qi Wu, Ping Shen . Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity. Proc Natl Acad Sci U S A. 2005 Feb 8;102:2141-6
