戴維·克倫納曼（David Klenerman），發明Solexa-Illumina 新一代 DNA 測序（NGS）技術，現為劍橋大學教授。
基本介紹
- 中文名：戴維·克倫納曼
- 外文名：David Klenerman
代表論文
2014
Horrocks MH, Palayret M, Klenerman D, Lee SF (2014), “The changing point-spread function: single-molecule-based super-resolution imaging.” Histochem Cell Biol Details
2013
Clarke RW, Drews A, Browne H, Klenerman D (2013), “A single gD glycoprotein can mediate infection by Herpes simplex virus.” J Am Chem Soc 135(30):11175-80 Details
Clarke RW, Zhukov A, Richards O, Johnson N, Ostanin V, Klenerman D (2013), “Pipette-surface interaction: current enhancement and intrinsic force.” J Am Chem Soc 135(1):322-9 Details
Horrocks MH, Rajah L, Jönsson P, Kjaergaard M, Vendruscolo M, Knowles TP, Klenerman D (2013), “Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.” Anal Chem 85(14):6855-9 Details
Klenerman D, Shevchuk A, Novak P, Korchev YE, Davis SJ (2013), “Imaging the cell surface and its organization down to the level of single molecules.” Philos Trans R Soc Lond B Biol Sci 368(1611):20120027 Details
Narayan P, Ganzinger KA, McColl J, Weimann L, Meehan S, Qamar S, Carver JA, Wilson MR, St George-Hyslop P, Dobson CM, Klenerman D (2013), “Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells.” J Am Chem Soc 135(4):1491-8 Details
Shim JU, Ranasinghe RT, Smith CA, Ibrahim SM, Hollfelder F, Huck WT, Klenerman D, Abell C (2013), “Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays.” ACS Nano 7(7):5955-64 Details
Stephenson JD, Li H, Kenyon JC, Symmons M, Klenerman D, Lever AM (2013), “Three-dimensional RNA structure of the major HIV-1 packaging signal region.” Structure 21(6):951-62 Details
Weimann L, Ganzinger KA, McColl J, Irvine KL, Davis SJ, Gay NJ, Bryant CE, Klenerman D (2013), “A quantitative comparison of single-dye tracking analysis tools using Monte Carlo simulations.” PLoS One 8(5):e64287 Details
2012
Cremades N, Cohen SI, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TP, Dobson CM, Klenerman D (2012), “Direct observation of the interconversion of normal and toxic forms of α-synuclein.” Cell 149(5):1048-59 Details
Horrocks MH, Li H, Shim JU, Ranasinghe RT, Clarke RW, Huck WT, Abell C, Klenerman D (2012), “Single molecule fluorescence under conditions of fast flow.” Anal Chem 84(1):179-85 Details
Jönsson P, McColl J, Clarke RW, Ostanin VP, Jönsson B, Klenerman D (2012), “Hydrodynamic trapping of molecules in lipid bilayers.” Proc Natl Acad Sci U S A 109(26):10328-33 Details
Lando D, Endesfelder U, Berger H, Subramanian L, Dunne PD, McColl J, Klenerman D, Carr AM, Sauer M, Allshire RC, Heilemann M, Laue ED (2012), “Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast.” Open Biol 2(7):120078 Details
Narayan P, Meehan S, Carver JA, Wilson MR, Dobson CM, Klenerman D (2012), “Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones.” Biochemistry 51(46):9270-6 Details
Ye Y, Blaser G, Horrocks MH, Ruedas-Rama MJ, Ibrahim S, Zhukov AA, Orte A, Klenerman D, Jackson SE, Komander D (2012), “Ubiquitin chain conformation regulates recognition and activity of interacting proteins.” Nature 492(7428):266-70 Details
Zhukov A, Richards O, Ostanin V, Korchev Y, Klenerman D (2012), “A hybrid scanning mode for fast scanning ion conductance microscopy (SICM) imaging.” Ultramicroscopy 121:1-7 Details
2011
Klenerman D, Korchev YE, Davis SJ (2011), “Imaging and characterisation of the surface of live cells.” Curr Opin Chem Biol 15(5):696-703 Details
Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, Meehan S, Wilson MR, Dobson CM, Klenerman D (2011), “The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.” Nat Struct Mol Biol 19(1):79-83 Details
2010
Bruckbauer A, Dunne PD, James P, Howes E, Zhou D, Jones R, Klenerman D (2010), “Selective diffusion barriers separate membrane compartments.” Biophys J 99(1):L1-3 Details
Jones R, Howes E, Dunne PD, James P, Bruckbauer A, Klenerman D (2010), “Tracking diffusion of GM1 gangliosides and zona pellucida binding molecules in sperm plasma membranes following cholesterol efflux.” Dev Biol 339(2):398-406 Details
Yeoman JA, Orte A, Ashbridge B, Klenerman D, Balasubramanian S (2010), “RNA conformation in catalytically active human telomerase.” J Am Chem Soc 132(9):2852-3 Details
2009
Ashbridge B, Orte A, Yeoman JA, Kirwan M, Vulliamy T, Dokal I, Klenerman D, Balasubramanian S (2009), “Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.” Biochemistry 48(46):10858-65 Details
Chiou A, Hägglöf P, Orte A, Chen AY, Dunne PD, Belorgey D, Karlsson-Li S, Lomas DA, Klenerman D (2009), “Probing neuroserpin polymerization and interaction with amyloid-beta peptides using single molecule fluorescence.” Biophys J 97(8):2306-15 Details
Shivji MK, Mukund SR, Rajendra E, Chen S, Short JM, Savill J, Klenerman D, Venkitaraman AR (2009), “The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.” Proc Natl Acad Sci U S A 106(32):13254-9 Details
2008
Alves D, Li H, Codrington R, Orte A, Ren X, Klenerman D, Balasubramanian S (2008), “Single-molecule analysis of human telomerase monomer.” Nat Chem Biol 4(5):287-9 Details
Bentley DR, Balasubramanian S, Swerdlow HP, Smith GP, Milton J, Brown CG, Hall KP, Evers DJ, Barnes CL, Bignell HR, Boutell JM, Bryant J, Carter RJ, Keira Cheetham R, Cox AJ, Ellis DJ, Flatbush MR, Gormley NA, Humphray SJ, Irving LJ, Karbelashvili MS, Kirk SM, Li H, Liu X, Maisinger KS, Murray LJ, Obradovic B, Ost T, Parkinson ML, Pratt MR, Rasolonjatovo IM, Reed MT, Rigatti R, Rodighiero C, Ross MT, Sabot A, Sankar SV, Scally A, Schroth GP, Smith ME, Smith VP, Spiridou A, Torrance PE, Tzonev SS, Vermaas EH, Walter K, Wu X, Zhang L, Alam MD, Anastasi C, Aniebo IC, Bailey DM, Bancarz IR, Banerjee S, Barbour SG, Baybayan PA, Benoit VA, Benson KF, Bevis C, Black PJ, Boodhun A, Brennan JS, Bridgham JA, Brown RC, Brown AA, Buermann DH, Bundu AA, Burrows JC, Carter NP, Castillo N, Chiara E Catenazzi M, Chang S, Neil Cooley R, Crake NR, Dada OO, Diakoumakos KD, Dominguez-Fernandez B, Earnshaw DJ, Egbujor UC, Elmore DW, Etchin SS, Ewan MR, Fedurco M, Fraser LJ, Fuentes Fajardo KV, Scott Furey W, George D, Gietzen KJ (2008), “Accurate whole human genome sequencing using reversible terminator chemistry.” Nature 456(7218):53-9 Details
Orte A, Birkett NR, Clarke RW, Devlin GL, Dobson CM, Klenerman D (2008), “Direct characterization of amyloidogenic oligomers by single-molecule fluorescence.” Proc Natl Acad Sci U S A 105(38):14424-9 Details
Orte A, Clarke RW, Klenerman D (2008), “Fluorescence coincidence spectroscopy for single-molecule fluorescence resonance energy-transfer measurements.” Anal Chem 80(22):8389-97 Details
Orte A, Craggs TD, White SS, Jackson SE, Klenerman D (2008), “Evidence of an intermediate and parallel pathways in protein unfolding from single-molecule fluorescence.” J Am Chem Soc 130(25):7898-907 Details
Piper JD, Li C, Lo CJ, Berry R, Korchev Y, Ying L, Klenerman D (2008), “Characterization and application of controllable local chemical changes produced by reagent delivery from a nanopipet.” J Am Chem Soc 130(31):10386-93 Details
