徐書華

徐書華，萬人計畫/研究員。

研究方向：

群體基因組學是連線人類進化歷史和藥物遺傳學以及基因治療的橋樑。我們通過在群體水平進行大規模基因組學研究，了解遺傳變異在群體內以及群體間的分布模式，以及弄清影響其分布模式的各種因素，並試圖闡明遺傳變異在群體和基因組水平的動態演化機制。同時，通過對基因組範圍大量遺傳變異的研究，揭示其一般性質；尋找到那些偏離基因組一般性質的遺傳變異，建立起遺傳變異與環境及致病因素的關聯；並最終闡明遺傳變異與表型變異以及與內外環境相互作用的關係和機制。

職稱：

研究員

獲獎及榮譽：

[1]上海市科技啟明星（2011）; [2]教育部科學研究優秀成果獎（自然科學獎）（一等）（第二完成人）（2011）; [3]全國優秀博士論文（2011）; [4]入選中國科學院青年創新促進會（2011）; [5]復旦大學優秀博士論文（2010.1）; [6]上海市優秀博士論文（2009.12）; [7]中國科學院盧嘉錫青年人才獎（2009-2014）; [8]賽諾菲-安萬特（法國）－上海生科院優秀青年人才獎（2009); [9]明治乳業（日本）生命科學獎（2009）

代表論著：

[1]Xiong Yang, Shuhua Xu*, The HUGO Pan-Asian SNP Consortium. 2011. Identification of Close Relatives in the HUGO Pan-Asian SNP Database. PLoS One 6 (12): e29502 (10.1371/journal.pone.0029502).; [2]Wenfei Jin, Shuhua Xu*, Haifeng Wang, Yongguo Li, Yiping Shen, Bailin Wu, Li Jin*. 2011. Genome-Wide Detection of Natural Selection in African Americans Pre-and Post-Admixture. Genome Research (doi:10.1101/gr.124784.111).; [3]Wenfei Jin, Pengfei Qin, Haiyi Lou, Li Jin*, Shuhua Xu*. 2011. A Systematic Characterization of Genes Underlying both Complex and Mendelian Diseases. Hum.Mol.Genet. (doi:10.1093/hmg/DDR599).; [4]Haiyi Lou, Shilin Li, Yajun Yang, Longli Kang, Xin Zhang, Wenfei Jin, Bailin Wu , Li Jin*, Shuhua Xu*. 2011. A Map of Copy Number Variations in Chinese Populations. PLoS One 6 (11): e27341.; [5]Shuhua Xu*, Li Jin. 2011. Chromosome-Wide Haplotype Sharing: A Measure Integrating Recombination Information to Reconstruct the Phylogeny of Human Populations. Ann.Hum.Genet. 75 (6): 694-706.; [6]Shuhua Xu*, Shilin Li, Yajun Yang, Jingze Tan, Haiyi Lou, Wenfei Jin, Ling Yang, Xuedong Pan, Jiucun Wang, Yiping Shen, Bailin Wu, Hongyan Wang, Li Jin*. 2011. A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans. Mol.Biol.Evol. 28: 1003-1011.; [7]Pankaj Jha, Swapnil Sinha, Kanika Kanchan, Tabish Qidwai, Ankita Narang, Prashant Kumar Singh, Sudhanshu S. Pati, Sanjib Mohanty, Saroj K. Mishra, Surya K. Sharma, Shally Awasthi, Vimala Venkatesh, Sanjeev Jain, Analabha Basu, Shuhua Xu, Indian Genome Variation Consortium, Mitali Mukerji, Saman Habib. 2011. Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria. Infection, Genetics and Evolution 12: 142-148 (10.1016/j.meegid.2011.11.001).; [8]Xiaoyun Cai, Zhendong Qin, Bo Wen, Shuhua Xu, Yi Wang, Yan Lu, Lanhai Wei, Chuanchao Wang, Shilin Li, Xingqiu Huang, Li Jin, Hui Li*, the Genographic Consortium. 2011. Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes. PLoS One 6 (8): e24282.; [9]Chumpol Ngamphiw, Anunchai Assawamakin, Shuhua Xu, Philip J. Shaw, Jin Ok Yang, Ho Ghang, Jong Bhak, Edison Liu, Sissades Tongsima*, The HUGO Pan-Asian SNP Consortium. 2011. PanSNPdb: The Pan-Asian SNP Genotyping Database. PLoS One 6 (6): e21451.; [10]Wan Isa Hatin, Ab Rajab Nur-Shafawati, Mohd-Khairi Zahri, Shuhua Xu, Li Jin, Soon-Guan Tan, Mohammed Rizman-Idid, Bin Alwi Zilfalil, The HUGO Pan-Asian SNP Consortium. 2011. Population Genetic Structure of Peninsular Malaysia Malay Sub-Ethnic Groups. PLoS One 6(4): e18312.; [11]Frederick Delfin, Jazelyn M Salvador, Gayvelline C Calacal, Henry B Perdigon, Kristina A Tabbada, Lilian P Villamor, Saturnina C Halos, Ellen Gunnarsdo´ ttir, Sean Myles, David A Hughes, Shuhua Xu, Li Jin, Oscar Lao, Manfred Kayser, Matthew E Hurles, Mark Stoneking and Maria Corazon A De Ungria*. 2011. The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups. Eur.J.Hum.Genet. 19: 224-230.; [12]Shuhua Xu*, Sanchit Guputa and Li Jin*. 2010. PEAS V1.0: A Package for Elementary Analysis of SNP Data. Mol.Ecol.Res. 10:1085-1088.; [13]Shuhua Xu, Daoroong Kangwanpong, Mark Seielstad, Metawee Srikummool, Jatupol Kampuansai, Li Jin*. The HUGO Pan-Asian SNP Consortium. 2010. Genetic Evidence Supports Linguistic Affinity of Mlabri — a Hunter-Gatherer Group in Thailand. BMC Genet. 11:18.; [14]The HUGO Pan-Asian SNP Consortium (Co-corresponding author). 2009. Mapping Genetic Diversity in Asia. Science 326: 1541-1545.; [15]Shuhua Xu, Xianyong Yin, Shilin Li, Wenfei Jin, Haiyi Lou, Ling Yang, Xiaohong Gong, Hongyan Wang, Yiping shen, Xuedong Pan, Yungang He, Yajun Yang, Yi Wang, Wenqing Fu, Yu An, Jiucun Wang, Jingze Tan, Ji Qian, Xiaoli Chen, Xin Zhang, Yangfei Sun, Xuejun Zhang, Bailin Wu, Li Jin. 2009. Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies. Am.J.Hum.Genet. 85:762-774.; [16]Shuhua Xu and Li Jin, 2009. Response to Li et al., Am.J.Hum.Genet. 85:937-939.; [17]Shuhua Xu, Wenfei Jin, Li Jin. 2009. Haplotype Sharing Analysis Showing Uyghurs Are Unlikely Genetic Donors. Mol.Biol.Evol. 26:2197-2206.; [18]Shuhua Xu, Li Jin. 2009. Computational Biology—Review and Prospects. Science (KEXUE). 61(4):34-37.; [19]Yungang He, Shuhua Xu, Chuan Jia, Li Jin. 2009. A design of multi-source samples as a shared control for association studies in genetically stratified populations. Cell Research 19:913-915.; [20]Shuhua Xu, Li Jin. 2008. A Genome-wide Analysis of Admixture in Uyghurs and a High-Density Admixture Map for Disease-Gene Discovery. Am.J.Hum.Genet. 83:322-336.; [21]Shuhua Xu, Wei Huang, Ji Qian, Li Jin. 2008. Analysis of Genomic Admixture in Uyghur and Its Implication in Mapping Strategy. Am.J.Hum.Genet. 82:883-894.; [22]Fuzhong Xue, Yi Wang, Shuhua Xu, Feng Zhang, Bo Wen, Xuesen Wu, Ming Lu, Ranjan Deka, Ji Qian, and Li Jin. 2008. A spatial analysis of genetic structure of human populations in China reveals distinct difference between maternal and paternal lineages. Eur.J.Hum.Genet. 16:705-717; [23]Shuhua Xu, Wei Huang, Haifeng Wang, Yungang He, Ying Wang, Yi Wang, Ji Qian, Momiao Xiong, Li Jin. 2007. Dissecting Linkage Disequilibrium in African American Genomes: Roles of Markers and Individuals. Mol.Biol.Evol. 24:2049-2058.