徐宏喜教授，現為上海中醫藥大學首席教授、博士生導師、上海中醫藥大學中藥學院院長。1994年獲得日本富山醫科藥科大學國立和漢藥研究所藥學博士學位。並於新加坡國立大學化學系及加拿大Dalhousie大學微生物學系進行博士後研究工作。曾先後受聘於香港中文大學中藥研究中心科學主任、香港和記黃埔(中國)有限公司副總經理兼高級醫藥顧問，上海和黃藥業有限公司董事兼研究開發總監。2001至2010年,擔任香港賽馬會中藥研究院副總裁兼中藥研究室主任。徐教授至今已發表SCI論文270多篇，被SCI源期刊引用7100餘次，H指數為47。入選2014、2015及2016年中國高被引用學者榜。獲授權美國發眀專利6項，PCT專利1項，中國發明專利11項。培養博士後25人，博士研究生9人，主編專著3部。
基本介紹
- 中文名：徐宏喜
- 國籍：中國
- 民族：漢
- 職業：上海中醫藥大學首席教授
- 主要成就：發表SCI論文270多篇，擁有1項PCT專利和6項美國專利。
- 性別：男
人物介紹,研究方向和領域,抗病毒及抗耐藥菌中藥藥理機制研究,抗腫瘤中藥藥理作用機制研究,中藥研究論文,
人物介紹
徐教授的主要社會兼職包括：中華中醫藥學會中藥實驗藥理學分會主任委員、世界中醫藥協會聯合會中藥分析專業委員會副會長、世中聯中藥鑑定專業委員會副會長、全國中醫藥高等教育學會中藥教育研究會第三屆理事會副理事長、國家藥典會天然藥物專業委員會委員、國際現代化中醫藥學術會議聯席主席、上海市僑界知識分子聯誼會第八屆理事會常務理事、上海市藥學會中藥專業委員會主任委員、香港中藥藥理學會副會長、國際國內十餘種學術刊物的編委、現代化中醫藥國際協會創會董事等職。先後50餘次應邀前往美國、日本、新加坡、韓國、巴西、加拿大、奧地利、印度等國家以及台灣、香港、澳門等地做特邀學術報告或學術大會報告。
研究方向和領域
主要研究領域包括中藥活性成分及藥效評價研究，中藥新藥開發以及中藥質量控制分析方法研究等。重點進行病毒、腫瘤、耐藥菌及糖尿病等重大疾病的中藥防治與藥效評價研究，闡明中藥藥效物質基礎及作用機制，研發具有自主智慧財產權的創新藥物。
抗病毒及抗耐藥菌中藥藥理機制研究
從事中藥及其活性成分抗病毒及抗耐藥菌藥理作用機制研究。已建立抗病毒（HSV和EV71）篩選平台及基於MgrA靶標蛋白螢光探針的高通量篩選體系，致力於闡明中藥抗病毒和抗金黃色葡萄球菌耐藥菌活性物質基礎，揭示其藥效作用機制，發現活性強、毒性小、選擇性高的先導化合物。
抗腫瘤中藥藥理作用機制研究
從事中藥及其活性成分抗腫瘤藥理作用機制研究。已建立分子、細胞及動物水平的抗腫瘤藥物篩選及藥效評價模型，重點開展肝癌、前列腺癌及胰腺癌的體內外藥效篩選和藥效評價，致力於從中草藥和天然產物中尋找抗腫瘤先導化合物，闡明其誘導腫瘤細胞凋亡、調節自噬、抑制轉移及防止復發等藥效作用機制。近年來重點開展中國產藤黃屬植物中具有抗腫瘤活性的PPAPs類和xanthones類成分的鑑定及其作用機制研究。
中藥研究論文
1. G. Lin, J. Y. Wang, N. Li, M. Li, H. Gao, Y. Ji, F. Zhang, H. L. Wang, Y. Zhou, Y. Ye,H. X. Xu, J. Zheng,Hepatic sinusoidalobstruction syndrome associated with consumption of Gynura segetum,Journal of Hepatology, 54(4), 666-673 (2011).
2.Y. Y. Li, Y. Lu, S. W. Wang, Z. J. Han, F. X. Zhu, Y. M. Ni, R. Liang, Y. Zhang, Q. B. Leng, G. Wei, G. C. Shi, R. H. Zhu, D. Li, H. K. Wang, S. G. Zheng, H. X. Xu, A.Tsun, B. Li, USP21 prevents the generation of T-helper-1-like Treg cells, Nature Communications, 7: 13559 (2016).
3. M.H.Feng, B.Q.Tang, N.Z.Wang,H. X. Xu, X.F.Jiang, Ligand Controlled Regiodivergent C1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids,Angewandte Chemie (International ed. in English), 54(49), 14960-4 (2015).
4.H. L. Zhao, Y. Sui, C. F. Qiao, K. Y. Yip, R. K. K. Leung, S. K. W. Tsui, H. M. Lee, H. K. T. Wong, X. Zhu, J. J. Siu, L. He, J. Guan, L. Z. Liu,H. X. Xu, P. C. Y. Tong, J. C. N. Chan, Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression,Diabetes, 61(4), 933-943 (2012).
5. Y. Z. Lao, G. Wan, Z. Y. Liu, X. Y. Wang, P. Ruan, W. Xu, D. Q. Xu, W. D. Xie, Y. Zhang,H. X. Xu, N. H. Xu, The naturalcompound oblongifolin C inhibits autophagic fluxand enhances antitumor efficacy of nutrient deprivation,Autophagy, 10(5): 1-14 (2014).
6. G. Wan, W. D. Xie, Z. Y. Liu, W. Xu, Y. Z. Lao, N. Huang, K. Cui, M. J. Liao, J. He, Y. Y. Jiang, Burton B Yang,H. X. Xu, N. H. Xu, Y. Zhang, Hypoxia-induced MIR155 is a potentautophagyinducer by targeting multiple players in the MTOR pathway,Autophagy, 10(1): 70-79 (2014).
7. M. H. Feng, B .Q. Tang, H. X. Xu, X. F. Jiang, Collective Synthesis of Phenanthridinone through C-H Activation Involving a Pd-Catalyzed Aryne Multicomponent Reaction, Organic Letters, 18(17):4352-5(2016).
8. Y. Liao, X. Liu, J. Yang, Y.Z. Lao, X.W.Yang, X.N.Li, J.J.Zhang, Z.J.Ding,H. X. Xuand G. Xu, Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile,Organic Letters, 17 (5), 1172–1175(2015).
9. Q. B. Han, T. F. Tso, S. Cheung, Tai, J. Z. Song, C. F. Qiao, H. D. Sun, andH. X. Xu, Maoecrystal Z, aCytotoxicDiterpenefrom Isodon eriocalyx with an Unique Skeleton,OrganicLetters, 8 (21), 4727-4730 (2006).
10. W. L. Ting Kan, C. Yin,H. X. Xu, G. Xu, K. K. W. To, C. H. Cho, J. A. Rudd, G. Lin, Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G0/G1 cell cycle arrest and apoptosis,International Journal of Cancer, 132(3): 707-716 (2013).
11. C. Feng, L. Y. Zhou, T. Yu, G. Xu, H. L. Tian, J. J. Xu,H. X. Xu, K. Q. Luo, A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation,International Journal of Cancer, 131(6): 1445-1454 (2012).
12. L.Zhang, J.L.Feng, S.Y.Kong, M.Wu, Z.C.Xia, B.J.Zhang, W.W.Fu, Y.Z.Lao, H.S.Tan,H. X. Xu.Nujiangexathone A, a novel compound from Garcinia nujiangensis,suppresses cervical cancer growth by targeting hnRNPK,Cancer letters, 380(2):447-456 (2016).
13. T. W. D. Chan, P. P. H. But, S. W. Cheng, I. M. Y. Kwok, F. W. Lau,H. X. Xu, Differentiation and authentication of Panax ginseng, Panax quinquefolius and ginseng products by using HPLC/MS,Analytical Chemistry, 72(6), 1281-1287 (2000).
14. X. W. Yang,X. Deng,X. Liu, C. Y. Wu,X. N. Li,B. Wu, H. R. Luo, Y. Li,H. X. Xu, Q. S. Zhao, G. Xu, Hypercohin A, a new polycyclicpolyprenylatedacylphloroglucinols possessing an unusual bicyclo[5.3.1]hendecane core from Hypericum cohaerens,Chemical Communications, 48: 5998-6000 (2012).
15. Z.C.Xi, M.Yao, Y.Li, C.L.Xie, J. Holst, T. Liu, S.F.Cai, Y.Z.Lao, H.S.Tan,H. X. Xuand Q.H. Dong,Guttiferone Kimpedes cell cycle re-entry of quiescent prostate cancer cellsvia stabilization of FBXW7 and subsequent c-MYC degradation,Cell Death & Disease, 7(6):e2252(2016).
16. K.K. Shen, J.L.Xie, H. Wang, H.Zhang, M.Y.Yu, F.F. Lu, H.S. Tan,H. X. Xu, Cambogin induces caspase-independent apoptosis through the ROS/JNK pathway and epigenetic regulation in breast cancer cells,Molecular Cancer Therapeutics, 14(7):1738-1749. (2015).
17. K.K.Shen,F.F.Lu,J.L.Xie, M.F.Wu, B.Cai, Y.R.Liu, H.Zhang, H.S.Tan, Y.Y.Pan,H.X. Xu.Cambogin exerts anti-proliferative and pro-apoptotic effects onbreast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics,Oncotarget,doi: 10.18632/oncotarget.10585. [Epub ahead of print] (2016).
18. K.K.Shen, Z.C.Xi, J.L.Xie, H.Wang, C.L.Xie, C.S.Lee, P. Fahey, Q.H.Dong,H. X. Xu.Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1,Oncotarget, in press, (2016).
19. M.J.Wang, Q. Dong, H. Wang, Y.Q. He, Y.Chen, H.Zhang, R.Wu, X.C.Chen, B.P.Zhou, J.He, H.F.Kung, C.H.Huang, Y.Q.Wei, J.D.Huang,H. X. Xu, M.L.He, Oblongifolin M, an active compound isolated from a Chinese medical herb Garcinia oblongifolia, potently inhibits enterovirus 71 reproduction through downregulation of ERp57,Oncotarget, 7(8):8797-808. (2016).
20. Z.J.Ding, Y.Z.Lao, H.Zhang, W.W.Fu, L.L.Zhu, H.S.Tan,H. X. Xu, Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer,Oncotarget, 12;7(2):1826-37 (2015)
21. H.Zhang, D. Zheng，H.H. Li，H.Wang，H.S.Tan,H. X. Xu, Diagnostic filtering to screen polycyclic polyprenylated acylphloroglucinols from Garcinia oblongifolia by ultrahigh performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry,Analytica Chimica Acta,912:85-96. (2015).
22. Y. Zhou, N. Li, F. F. K. Choi, C. F. Qiao, J. Z. Song, S. L. Li, X. Liu, Z. W. Cai, P. P. Fu, G. Lin,H. X. Xu, A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry,AnalyticaChimicaActa, 681(1-2), 33-40 (2010).
23. Y. Zhou, Stephanie Lee, Franky F. K. Choi, G. Xu, X. Liu, J. Z. Song, S. L. Li, C. F. Qiao,H. X. Xu, Qualitative and quantitative analysis of polycyclic polyprenylated acylphloroglucinols from Garcinia species using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry,Analytica Chimica Acta, 678(1), 96-107 (2010).
24. Y. Zhou, X. Liu, J. Yang, Q. B. Han, J. Z. Song, S. L. Li, L. S. Ding,H. X. Xu, AnalysisofcagedxanthonesfromtheresinofGarciniahanburyiusingultraperformanceliquidchromatography/electrosprayionizationquadrupoletime-of-flighttandemmassspectrometry,Analytica Chimica Acta, 629, 104-118 (2008).
25.H.He,L.S.Ding,H. X. Xu,X.X.Lei,H.P.Xiao,Y.Zhou,GymnothelignansA-O:ConformationandAbsoluteConfigurationAnalysesofLignansBearingTetrahydrofuranfromGymnothecachinensis,JournalofOrganicChemistry, 77(19): 8435-8443 (2012).
26. H. Y. Qin, J. C. Y. Wu, X. D. Tong, J. J. Y. Sung,H. X. Xu, Z. X. Bian, Systematic review of animal models of post-infectious/post-inflammatory irritable bowel syndrome.Journal of Gastroenterology, 46(2), 164-174 (2011).
27. Z. X. Bian, Z. Li, Z. X. Huang, M. Zhang, H. L. Chen,H. X. Xu, J. J. Y. Sung, Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients,Journal of Gastroenterology, 44(7), 666-674 (2009).
28. Y.Lu, S.F.Cai, J.Nie, Y.Y. Li, G.C.Shi, J.M.Hao, W.W.Fu, H.S.Tan, S.L.Chen, B. Li,H. X. Xu,The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma,Biochemical Pharmacology, 100:61-72(2015).
29. H. S. Tan, D. D. Hu, J. Z. Song, Y. Xu, S. F. Cai, Q. L. Chen, Q. W. Meng, S. L. Li, S. L. Chen, Q. Mao,H. X. Xu, Distinguishing Radix Angelica sinensis from different regions by HS-SFME/GC-MS,Food chemistry,186:200-206 (2015)
30. B. Xia, Y. Zhou, H. S. Tan, L. S. Ding,H. X. Xu, Advanced ultra-performance liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometric methods for simultaneous screening and quantification of triterpenoids in Poria cocos,Food Chemistry, 152: 237-244 (2014).
31. X. J. Zhang, Z. Li, W. M. Leung, L. Liu,H. X. Xu, Z. X. Bian, The Analgesic Effect of Paeoniflorin on Neonatal Maternal Separation-Induced Visceral Hyperalgesia in Rats,Journal of Pain, 9 (6), 497-505 (2008).
32. X. H. Pang, J. Y. Song, Y. J. Zhu,H. X. Xu, L. F. Huang, S. L. Chen, Applying plant DNA barcodes for Rosaceae species identification,Cladistics, 27(2), 165-170 (2011).
33. Y. W. Zhang, P. P. H. But, V. E. C. Ooi,H. X. Xu, G. D. Delaney, S. H. S. Lee, S. F. Lee, Chemical properties, mode of action, and in vivo anti-herpes activities of a lignin–carbohydrate complex from Prunella vulgaris,Antiviral Research,75 (3), 242-249 (2007).
34.H. X. Xu, S. H. S. Lee, S. F. Lee, R. L. White, J. Blay, Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris,Antiviral Research, 44(1), 43-54 (1999).
35. Kurokawa, H. Ochiai, K. Nagasaka,H. X. Xu, S. Kadota, T. Namba, and K. Shiraki, Antiviral traditional medicines against herpes simplex virus, poliovirus, and measles virus in vitro and their therapeutic efficacies for HSV infection in mice,Antiviral Research, 22, 175-188 (1993).
36. X.Y. Wang, Y. Z. Lao, N.H. Xu, Z.C. Xu, M. Wu, H. Wang, X. Li, H.S. Tan, M.H. Sun,H. X. Xu, Oblongifolin C inhibits metastesis by up-regulating keratin 18 and tubulins,Scientific Reports, 5:10293-10305. (2015).
37. L. T. Yi, Y.C. Li, Y. Pan, J. M. Li, Q. Xu, S. F. Mo, C. F. Mo, F. X. Xu,H. X. Xu, X. B. Lu, L. D. Kong, H. F. Kung, Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice,Progress in Neuro-Psychopharmacology & Biological Psychiatry, 15; 32(2), 510-519 (2008).
38. Q. B. Han, T. Yu, F. Lai, Y. Zhou, C. Feng, W. N. Wang, X. H. Fu, C. B. S. Lau, K. Q. Luo,H. X. Xu, H. D. Sun, K. P. Fung, P. C. Leung, Quick identification of apoptosis inducer from Isodon eriocalyx by a drug discovery platform composed of analytical high-speed counter-current chromatography and the fluorescence-based caspase-3 biosensor detection,Talanta, 82(4), 1521-1527 (2010).
39. Q. B. Han, Y. K. Yip, N. Y. Yang, L. Wong, C. F. Qiao, J. Z. Song, H. Yiu,H. X. Xu, Rapid analysis of pseudolaric acids in Cortex Pseudolaricis and related medicinal products by high performance liquid chromatography,Talanta, 73(4), 757-763 (2007).
40. X. Wang, Y. C. Chen, Q. B. Han, C. Y. Chan, H. Wang, Z. Liu, C. H. K. Cheng, D. T. Yew, M. C. M. Lin, M. L. He,H. X. Xu, J. J. Y. Sung, H. F. Kung, Proteomic identification of molecular targets of gambogic acid: Role of stathmin in hepatocellular carcinoma,Proteomics, 9(2), 242-253 (2009).
41. S. L. Li, H. Shen, L. Y. Zhu, J. Xu, X. B. Jia, H. M. Zhang ,H. X. Xu, G. Lin, H. Cai, B. C. Cai, S. L. Chen, Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry based chemical profiling approach to rapidly reveal chemical transformation of sulfur-fumigated medicinal herbs, a case study on white ginseng,Journal of Chromatography A, 1231: 31-45 (2012).
42. Y. Zhou, J. Z. Song, Franky F. K. Choi, H. F. Wu, C. F. Qiao, L. S. Ding, S. L. Gesang,H. X. Xu, An experimental design approach using response surface techniques to obtain optimal liquid chromatography and mass spectrometry conditions to determine the alkaloids in Meconopsi species,Journal of Chromatography A, 1216 (42), 7013-7023 (2009).
43. J. Z. Song, C. F. Qiao, S. L. Li, Y. Zhou, M. T. Hsieh,H. X. Xu, Rapid optimization of dual-mode gradient high performance liquid chromatographic separation ofRadix et RhizomaSalviae Miltiorrhizaeby Response Surface Methodology,Journal of Chromatography A, 1216 (42), 7007-7012 (2009).
44. Y. Zhou, G. Xu, F. F. K. Choi, L. S. Ding, Q. B. Han, J. Z. Song, C. F. Qiao, Q. S. Zhao,H. X. Xu, Qualitative and quantitative analysis of diterpenoids in Salvia species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry,Journal of Chromatography A, 1216 (24), 4847-4858 (2009).
45. C. Y. Li,H. X. Xu, Q. B. Han, T. S. Wu, Quality assessmentRadixCodonopsisby quantitative nuclear magnetic resonance,Journal of Chromatography A, 1216(11), 2124-2129 (2009).
46. Y. Zhou, Q. B. Han, J. Z. Song,H. X. Xu, Characterization of polyprenylated xanthones in Garcinia xipshuanbannaensis using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry,Journal of Chromatography A, 1206 (2), 131-139 (2008).
47. Q. B. Han, J. Z. Song, C. F. Qiao, L. Wong, andH. X. Xu, Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography,Journal of Chromatography A, 1127(1-2), 298-301 (2006).
48. S. B. Chen, H. P. Liu, R. T. Yian, D. J. Yang, S. L. Chen,H. X. Xu, A. S. C. Chan, and P. S. Xie, High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii.Journal of Chromatography A, 1121(1), 114-119 (2006).
49. Y. Xie, Z. H. Jiang, H. Zhou,H. X. Xu, and L. Liu, Simultaneous determination of six Aconitum alkaloids in proprietary Chinese medicines by high-performance liquid chromatography,Journal of Chromatography A, 1093 (1-2), 195-203 (2005).
50. J. Z. Song,H. X. Xu, S. J. Tian, and P. P. H. But, Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis,Journal of Chromatography A, 857, 303-311(1999).
51. M.S. Liu, L.Tao, S. L. Chow, R. Wu, H. Zhang, Y.F.Yang, D.J.Yang, Z.X.Bian, A.P.Lu, Q.B.Han,H. X. Xu, Folding fan mode counter-current chromatography offers fast blind screening for drug discovery. Case study: finding anti-enterovirus 71 agents from Anemarrhena asphodeloide.,Journal of Chromatography A, 1368：116-124 (2014).
52. W. M. Fu, J. F. Zhang, H. Wang, Z.C. Xi, W.M. Wang, P. Zhuang, X. Zhu, S.C. Chen, T. M. Chan, K. S. Leung, G. Lu,H. X. Xu, H. F. Kung, Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma,Journal of Proteomics, 75(15): 4833-4843 (2012).
53. X. J. Zhang, F. F. K. Choi, Y. Zhou, F. P. Leung, S. Tan, S. H. Lin,H. X. Xu, W. Jia, J. J. Y. Sung, Z. W. Cai, Z. X. Bian, Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics: A pilot study,FEBS Journal, 279(13): 2322-2338 (2012).
54. X. Wang, Y. J. Lou, M. X. Wang, Y. W. Shi,H. X. Xu, L. D. Kong, Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice,Toxicology Letters, 209(1): 67-77 (2012).
55. W.M. Fu, L.P. Tang, X. Zhu, Y.F. Lu, Y.L. Zhang, W.Y. Lee, H. Wang, Y. Yu, W.C. Liang, C.H. Ko,H. X. Xu, H.F. Kung, J.F. Zhang. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells,Apoptosis, 20(1):75-82. (2015).
56. W. M. Fu, J. F. Zhang, H. Wang, H. S. Tan, W. M. Wang, S. C. Chen, X. Zhu, T. M. Chan, C. M. Tse, K. S. Leung, G. Lu,H. X. Xu, H. F. Kung, Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis,Apoptosis, 17(8): 842-851 (2012).
57. L. Z. Liu, S. C. K. Cheung, L. L. Lan, S. K. S. Ho,H. X. Xu, J. C. N. Chan, P. C. Y. Tong, Berberine modulates insulin signaling transduction in insulin-resistant cells,Molecular and Cellular Endocrinology, 317 (1-2), 148-153 (2010).
58. M.S. Liu, S.L.Chau, D.L. Ma, C.H. Leung, Z.X.Bian, A. P.Lu,H. X. Xu, Q.B. Han, Using two-phase solvent systems for sample pretreatment increases yield of counter-current chromatography: Anemarrhena asphodeloides saponins, a case study,Separation and Purification Technology, 138:138-143, (2014).
59. X.Li, Y.Z.Lao, H.Zhang, X.Y.Wang, H.S.Tan, Z.X.Lin,H. X. Xu,The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation,BMC Cancer,15:254-266, (2015).
60. Y.X.Tang, W.W.Fu, R.Wu, H.S.Tan,Z.W.Shen,H. X. Xu.Bioassay-Guided Isolation of Prenylated Xanthone Derivatives from the Leaves of Garcinia oligantha,Journal of Natural Products,79(7):1752-61 (2016).
61. H. Zhang, D. D. Zhang, Y. Z. Lao, W. W. Fu, S. Liang, Q. H. Yuan, L. Yang, andH. X. Xu,Cytotoxic and Anti-inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs ofGarcinia esculenta,Journal of Natural Products, 77:1700-1707(2014).
62. H. Zhang, L. Tao, W. W. Fu, S. Liang, Y. F. Yang, Q. H. Yuan, D. J. Yang, A. P. Lu,H. X. Xu,Prenylated benzoylphloroglucinols and xanthones from the leaves of Garcinia oblongifolia with antienteroviral activity,Journal of Natural Products, 77:1037-1046(2014).
63. C. Feng, S. X. Huang, X. M. Gao,H. X. Xu, Kathy Luo, Characterization of proapoptotic compounds from the bard of Garciniaoblongifolia,Journal of Natural Products. 77:1111-1116 (2014).
64. Z. X. Xia, D. D. Zhang, S. Liang, Y. Z. Lao, H. Zhang, H. S. Tan, S. L. Chen, X. H. Wang,H. X. Xu. Bioassay-Guided Isolation of Prenylated Xanthones and Polycyclic Acylphloroglucinols from the Leaves of Garcinia nujiangensis，Journal of Natural Products. 75(8): 1459-1464 (2012).
65. X. Liu, T. Yu, X. M. Gao, Y. Zhou, C. F. Qiao, Y. Peng, S. L. Chen, Kathy Q. Luo,H. X. Xu, Apoptosis effects of Polyprenylated Benzoylphloroglucinol Derivatives from the Twigs of Garcinia multiflora,Journal of Natural Product, 73(8),1355-1359 (2010).
66. G. Xu, W. L. T. Kan, Y. Zhou, J. Z. Song, Q. B. Han, C. F. Qiao, C. H. Cho, J. A. Rudd, G. Lin,H. X. Xu, Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa,Journal of Natural Product, 73(2), 104-108 (2010).
67. S. X. Huang, C. Feng, Y. Zhou, G. Xu, Q. B. Han, C. F. Qiao, D. C. Chang, K. Q. Luo,H. X. Xu, Bioassay-guided isolation of xanthones and polycyclic prenylated acylphloroglucinols from Garcinia oblongifolia,Journal of Natural Product, 72 (1), 130-135 (2009).
68. R. W. Jiang, J. R. Zhou, P. M. Hon, S. L. Li, Y. Zhou, L. L. I, W. C. Ye,H. X. Xu, P. C. Shaw, P. P. But, Lignans from Dysosma versipellis with Inhibitory Effects on Prostate Cancer Cell Lines,Journal of Natural Product, 70 (2), 283-286 (2007).
69. R. W. Jiang, P. M. Hon, Y. Zhou, Y. M. Chan, Y. T. Xu,H. X. Xu, H. Greger, P. C. Shaw, P. P. H. But, Alkaloids and Chemical Diversity ofStemona tuberose,Journal of Natural Product, 69(5), 749-754 (2006).
70. H. Dong, S. X. Chen, R. M. Kini,H. X. Xu, Effects of Tannins from Geum japonicum on the Catalytic Activity of Thrombin and Factor Xa of Blood Coagulation Cascade,Journal of Natural Product, 61(11), 1356-1360 (1998).
71. H. Dong, S. X. Chen,H. X. Xu, S, Kadota, and T. Namba, A new antiplatelet Diarylheptanoid from Alpinia blepharocalyx,Journal of Natural Product, 61 (1), 142-144 (1998).
72.H. X. Xu, F. Q. Zeng, M. Wan, K. Y. Sim, Anti-HIV triterpene acids from Geum japonicum,Journal of Natural Product, 59 (7), 643-645 (1996).
73. Q. B. Han,H. X. Xu, Caged Garcinia Xanthones: Development Since 1937,Current Medicinal Chemistry, 16 (28), 3775-3796 (2009). Review
74. D.D.Zhang, H.Zhang, Y.Z.Lao, R.Wu, J.W.Xu, F.Murad, K. Bian,H. X. Xu, Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage,Mediators of Inflammation, http://dx.doi.org/10.1155/2015/350564(2015).
75. W.W.Fu, M.Wu, L.L.Zhu, Y.Z. Lao, L.P.Wang, H.S.Tan, Q.H. Yuan,H. X. Xu. Prenylated benzoylphloroglucinols and biphenyl derivatives from the leaves of Garcinia multiflora Champ,RSC Advances, 5, 78259-78267 (2015).
76. Y.J.Wang, H.Zhang, Q.Z. Zhang, Y.J. Liang, L.Ma, H.S.Tan, Y.Z.Lao,H. X. Xuand Z.G.Li, Genetically encoded fluorescence screening probe for MgrA, a global regulator inStaphylococcus aureus,RSC Advances, 5, 87216-87220 (2015).
77. G.Y.He, S.X.Zhang, L.Xu, Y.L.Xia, P.Wang, S.Y.Li, L.L.Zhu,H. X. Xu, G.B.Ge and L.Yang, C-8 Mannich base derivatives of baicalein display improved glucuronidation stability: exploring the mechanism by experimentation and theoretical calculations,RSC Advances, DOI: 10.1039/C5RA20213B (2015).
78. S. D. Qi, S. L. Tian,H. X. Xu, J. J. Y. Sung, Z. X. Bian, Quantification of luminally released serotonin in rat proximal colon by capillary electrophoresis with laser-induced fluorescence detection,Analytical and Bioanalytical Chemistry, 393 (8), 2059-2066 (2009).
