基本介紹
- 中文名：張義兵
- 國籍：中國
- 出生地：湖北仙桃
- 出生日期：1969年6月
- 職業：科研工作者
- 職稱：研究員
- 學歷：博士研究生
人物經歷,研究方向,研究項目及成果,代表論著,
人物經歷
1991年畢業於湖北大學生物系；1996年獲中國科學院水生生物研究所碩士學位；2003年獲中國科雅祖海學院研究生院理學博士學位，同年獲中國科學院院長特別獎。2007年12月至2008年11月在美國德州大學MD Anderson Cancer Center免疫學系做訪問研究。1996年進入中國科學院欠立愉水生生物研究所工作，歷任助理研究員，副研究員，研究員。
研究方向
（1）魚類抗病毒免疫反應的分子機制研究，尤其是魚類煮船套背干擾素系統基因的作用機理和信號通路研究；（2）魚類抗病毒免疫反應的啟動及分子調控；脊椎動物免疫系統的分子進化以及免疫反應調控機制的進化研究。（3）魚類乾謎蘭阿擾素及相漿汗櫃關抗病毒因子的套用研究。
研究項目及成果
主持包括國家自然科學基金面上項目、國家“863”課題、國家“973”項目子課題、中科院院長獎獲放淚得者科研啟動專項陵汽肯凳、武漢市科技晨光計畫、淡水生態與生物技術國家重點實驗室課題等多項研究。已在Journal of Immunology, Journal of Virology, Molecular Immunology, Gene, Immunogenetics, Developmental and Comparative Immunology, Fish & Shellfish Immunology, Disease of Aquatic Organisms, Biochemical and Biophysical Research Communication,《科學通報》等國內外核心刊物上發表研究論文50多篇。
代表論著
1. Zhang YB, Gui JF. 2012. Molecular regulation of interferon antiviral response in fish. Developmental and Comparative Immunology 38:193-202 (review paper)
2. Shi J, Zhang YB, Liu TK, Sun F, Gui JF. 2012. Subcellular localization and functional characterization of a fish IRF9 from crucian carp Carassius auratus. Fish & Shellfish Immunology 33(2):258-66.
3. Li S, Sun F, Zhang YB, Gui JF, Zhang QY. 2012. Identification of DreI as an Antiviral Factor Regulated by RLR Signaling Pathway. PLoS ONE 7(3): e32427.
4. Wang XH, Zhang YB, Yang XO, Nurieva RI, Chang, SH, Ojeda SS, Kang HS, Schluns, KS, Gui JF, Jetten AM, and Dong C. 2012. Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity. 36(1): 23-31.
5. Liu TK, Zhang YB, Liu Y, Sun F, Gui JF. 2011. Cooperative roles of fish protein kinase containing Z-DNA binding domains and double-stranded RNA-dependent protein kinase in interferon-mediated antiviral response. Journal of Virology. 85(23):12769-80.
6. Sun F, Zhang YB, Liu TK, Shi J, Wang B, Gui JF. 2011. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. Journal of Immunology. 187(5):2531-9.
7. Sun F, Zhang YB, Liu TK, Gan L, Yu FF, Liu Y, Gui JF. 2010. Characterization of fish IRF3 as an IFN-inducible protein reveals evolving regulation of IFN response in vertebrates. Journal of Immunology. 185:7573-7582.
8. Yu FF, Zhang YB, Liu TK, Liu Y, Sun F, Jiang J, Gui JF. 2010. Fish virus-induced interferon exerts antiviral function through Stat1 pathway. Molecular Immunology. 47(14):2330-2341.
9. Jiang J, Zhang YB, Li S, Yu FF, Sun F, Gui JF. 2009. Expression regulation and functional characterization of a novel interferon inducible gene Gig2 and its promoter. Molecular Immunology. 46(15):3131-40.
10. Zhu R, Zhang YB, Zhang QY, Gui JF. 2009. Subcellular localization and inductive expression of the dsRNA-dependent protein kinase PKR from Japanese flounder, Paralichthys olivaceus. Progress on Natural Science. 19(10):1227-1234.
11. Lan J, Lei MG, Zhang YB, Wang JH, Feng XT, Xu DQ, Gui JF, Xiong YZ. 2009. Characterization of the porcine differentially expressed PDK4 gene and association with meat quality. Molecular Biology Reports. 152(2)：161-170.
12. Zhong XP, Wang D, Zhang YB, Gui JF. 2009. Identification and characterization of hypoxia-induced genes in Carassius auratus blastulae embryonic cells using suppression subtractive hybridization. Comp Biochem Physiol B Biochem Mol Biol. 152(2):161-70.
13. Zhao JG, Zhou L, Jin JY, Zhao Z, Lan J, Zhang YB, Zhang QY, Gui JF. 2009. Antimicrobial activity-specific to Gram-negative bacteria and immune modulation-mediated NF-kappaB and Sp1 of a medaka beta-defensin. Dev Comp Immunol. 33(4):624-37
14. Zhang FT, Zhang YB, Chen YD, Zhu R, Dong CW, Li YY, Zhang QY, Gui JF. 2008. Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide. Fish Shellfish Immunol. 25(5):542-9.
15. Zhu R, Zhang YB, Zhang QY, Gui JF. 2008. Functional domains and the antiviral effect of the dsRNA-dependent protein kinase PKR from Paralichthys olivaceus. Journal of Virology, 82(14):6889-901.
16. Shi Y, Zhang YB, Zhao Z, Jiang J, Zhang QY, Gui JF. 2008. Molecular characterization and subcellular localization of Carassius auratus interferon regulatory factor-1. Dev Comp Immunol. 32(2):134-46.
17. Zhang YB, Wang YL, Gui JF. 2007. Identification and characterization of two homologs of interferon stimulated gene ISG15 in crucian carp. Fish Shellfish Immunol. 23(1), 52-61.
18. Dong CW, Zhang YB, Lu AJ, Zhu R, Zhang FT, Zhang QY, Gui JF. 2007. Molecular characterization and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Fish Shellfish Immunol. 22(4):380-93.
19. Zhang YB, Jiang J, Chen YD, Zhu R, Shi Y, Zhang QY, Gui JF. 2007.The innate immune response to grass carp hemorrhage virus (GCHV) in cultured Carassius auturas blastula (CAB) cells. Developmental and Comparative Immunology. 31(3), 232-243.
20. Zhang YB, Gui JF. 2006. Identification of interferon system genes from a cultured fish cell line in response to virus infection. In Barbara A. Veskler edited, Focus on Immunology Research. Nova Science Publishers, Inc. N.Y. USA, 2006, pp77-120.
21. Zhu R, Zhang YB, Chen YD, Dong CW, Zhang FT, Zhang QY, Gui JF. 2006. Molecular characterization and stress-induced expression of a cDNA encoding Paralichthys olivaceus heme-regulated initiation factor 2α kinase. Developmental and Comparative Immunology. 30:1047-1059.
22. Dong CW, Zhang YB, Zhang QY, Gui JF. 2006, Differential expression of three Paralichthys olivaceus Hsp40 genes in responses to virus infection and heat shock. Fish & Shellfish Immunology. 21:146-158.
23. Chen YD, Zhang YB, Zhu R, Zhang FT, Jiang J, Shi Y, Zhang QY, Chen SL, Gui JF. 2005. Inductive expression and characterization analysis of Paralichthys olivaceus pigment epithelium-derived factor in a virally infected cell line. Biochemical and Biophysical Research Communication. 335:799-809.
24. Zhang YB, Li Q, Gui JF. 2004. Differential expression of two Carassius auratus Mx genes in cultured CAB cells induced by grass carp hemorrhage virus and interferon. Immunogenetics. 56:68-75.
25. Zhang YB, Gui JF. 2004. Molecular characterization and IFN signal pathway analysis of Carassius auratus CaSTAT1 identified from the cultured cells in response to virus infection. Developmental and Comparative Immunology. 28:211-227.
26. Zhang YB, Gui JF. 2004. Identification and expression analysis of two IFN-inducible genes in crucian carp (Carassius auratus L.). Gene. 325:43-51.
27. Zhang YB, Gui JF. Identification of two novel IFN-stimulated genes from cultured CAB cells induced by UV-inactivated grass carp hemorrhage virus. Disease of Aquatic Organisms,2004, 60:1-9.
28. Hu CY, Zhang YB, Huang GP, Zhang QY, Gui JF. 2004. Molecular cloning and characterization of a fish PKR homologue CaPKR from the cultured CAB cells induced by UV-inactivated virus. Fish & Shellfish Immunology. 17:353-366.
29. Zhang YB, Zhang QY, Xu DQ, Hu CY and Gui JF. 2003. Identification of antiviral-relevant genes in the cultured fish cells induced by UV-inactivated virus. Chinese Science Bulletin. 48(6):581-588.
30. Zhang YB, Hu CY, Zhang J, Huang GP, Wei LH, Zhang QY and Gui JF. 2003. Molecular cloning and characterization of crucian carp (Carassius auratus L.) interferon regulator factor 7. Fish & Shellfish Immunology. 15:453-466.
31. Wei WH, Zhang J, Zhang YB, Zhou L, Gui JF. Analysis of different clonal lines of gynogenetic silver crucian carp by flow cytometry. Cytometry, 2003, 2003, 56A(1): 46-52
5. Liu TK, Zhang YB, Liu Y, Sun F, Gui JF. 2011. Cooperative roles of fish protein kinase containing Z-DNA binding domains and double-stranded RNA-dependent protein kinase in interferon-mediated antiviral response. Journal of Virology. 85(23):12769-80.
6. Sun F, Zhang YB, Liu TK, Shi J, Wang B, Gui JF. 2011. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. Journal of Immunology. 187(5):2531-9.
7. Sun F, Zhang YB, Liu TK, Gan L, Yu FF, Liu Y, Gui JF. 2010. Characterization of fish IRF3 as an IFN-inducible protein reveals evolving regulation of IFN response in vertebrates. Journal of Immunology. 185:7573-7582.
8. Yu FF, Zhang YB, Liu TK, Liu Y, Sun F, Jiang J, Gui JF. 2010. Fish virus-induced interferon exerts antiviral function through Stat1 pathway. Molecular Immunology. 47(14):2330-2341.
9. Jiang J, Zhang YB, Li S, Yu FF, Sun F, Gui JF. 2009. Expression regulation and functional characterization of a novel interferon inducible gene Gig2 and its promoter. Molecular Immunology. 46(15):3131-40.
10. Zhu R, Zhang YB, Zhang QY, Gui JF. 2009. Subcellular localization and inductive expression of the dsRNA-dependent protein kinase PKR from Japanese flounder, Paralichthys olivaceus. Progress on Natural Science. 19(10):1227-1234.
11. Lan J, Lei MG, Zhang YB, Wang JH, Feng XT, Xu DQ, Gui JF, Xiong YZ. 2009. Characterization of the porcine differentially expressed PDK4 gene and association with meat quality. Molecular Biology Reports. 152(2)：161-170.
12. Zhong XP, Wang D, Zhang YB, Gui JF. 2009. Identification and characterization of hypoxia-induced genes in Carassius auratus blastulae embryonic cells using suppression subtractive hybridization. Comp Biochem Physiol B Biochem Mol Biol. 152(2):161-70.
13. Zhao JG, Zhou L, Jin JY, Zhao Z, Lan J, Zhang YB, Zhang QY, Gui JF. 2009. Antimicrobial activity-specific to Gram-negative bacteria and immune modulation-mediated NF-kappaB and Sp1 of a medaka beta-defensin. Dev Comp Immunol. 33(4):624-37
14. Zhang FT, Zhang YB, Chen YD, Zhu R, Dong CW, Li YY, Zhang QY, Gui JF. 2008. Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide. Fish Shellfish Immunol. 25(5):542-9.
15. Zhu R, Zhang YB, Zhang QY, Gui JF. 2008. Functional domains and the antiviral effect of the dsRNA-dependent protein kinase PKR from Paralichthys olivaceus. Journal of Virology, 82(14):6889-901.
16. Shi Y, Zhang YB, Zhao Z, Jiang J, Zhang QY, Gui JF. 2008. Molecular characterization and subcellular localization of Carassius auratus interferon regulatory factor-1. Dev Comp Immunol. 32(2):134-46.
17. Zhang YB, Wang YL, Gui JF. 2007. Identification and characterization of two homologs of interferon stimulated gene ISG15 in crucian carp. Fish Shellfish Immunol. 23(1), 52-61.
18. Dong CW, Zhang YB, Lu AJ, Zhu R, Zhang FT, Zhang QY, Gui JF. 2007. Molecular characterization and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Fish Shellfish Immunol. 22(4):380-93.
19. Zhang YB, Jiang J, Chen YD, Zhu R, Shi Y, Zhang QY, Gui JF. 2007.The innate immune response to grass carp hemorrhage virus (GCHV) in cultured Carassius auturas blastula (CAB) cells. Developmental and Comparative Immunology. 31(3), 232-243.
20. Zhang YB, Gui JF. 2006. Identification of interferon system genes from a cultured fish cell line in response to virus infection. In Barbara A. Veskler edited, Focus on Immunology Research. Nova Science Publishers, Inc. N.Y. USA, 2006, pp77-120.
21. Zhu R, Zhang YB, Chen YD, Dong CW, Zhang FT, Zhang QY, Gui JF. 2006. Molecular characterization and stress-induced expression of a cDNA encoding Paralichthys olivaceus heme-regulated initiation factor 2α kinase. Developmental and Comparative Immunology. 30:1047-1059.
22. Dong CW, Zhang YB, Zhang QY, Gui JF. 2006, Differential expression of three Paralichthys olivaceus Hsp40 genes in responses to virus infection and heat shock. Fish & Shellfish Immunology. 21:146-158.
23. Chen YD, Zhang YB, Zhu R, Zhang FT, Jiang J, Shi Y, Zhang QY, Chen SL, Gui JF. 2005. Inductive expression and characterization analysis of Paralichthys olivaceus pigment epithelium-derived factor in a virally infected cell line. Biochemical and Biophysical Research Communication. 335:799-809.
24. Zhang YB, Li Q, Gui JF. 2004. Differential expression of two Carassius auratus Mx genes in cultured CAB cells induced by grass carp hemorrhage virus and interferon. Immunogenetics. 56:68-75.
25. Zhang YB, Gui JF. 2004. Molecular characterization and IFN signal pathway analysis of Carassius auratus CaSTAT1 identified from the cultured cells in response to virus infection. Developmental and Comparative Immunology. 28:211-227.
26. Zhang YB, Gui JF. 2004. Identification and expression analysis of two IFN-inducible genes in crucian carp (Carassius auratus L.). Gene. 325:43-51.
27. Zhang YB, Gui JF. Identification of two novel IFN-stimulated genes from cultured CAB cells induced by UV-inactivated grass carp hemorrhage virus. Disease of Aquatic Organisms,2004, 60:1-9.
28. Hu CY, Zhang YB, Huang GP, Zhang QY, Gui JF. 2004. Molecular cloning and characterization of a fish PKR homologue CaPKR from the cultured CAB cells induced by UV-inactivated virus. Fish & Shellfish Immunology. 17:353-366.
29. Zhang YB, Zhang QY, Xu DQ, Hu CY and Gui JF. 2003. Identification of antiviral-relevant genes in the cultured fish cells induced by UV-inactivated virus. Chinese Science Bulletin. 48(6):581-588.
30. Zhang YB, Hu CY, Zhang J, Huang GP, Wei LH, Zhang QY and Gui JF. 2003. Molecular cloning and characterization of crucian carp (Carassius auratus L.) interferon regulator factor 7. Fish & Shellfish Immunology. 15:453-466.
31. Wei WH, Zhang J, Zhang YB, Zhou L, Gui JF. Analysis of different clonal lines of gynogenetic silver crucian carp by flow cytometry. Cytometry, 2003, 2003, 56A(1): 46-52
