張緒穆，1961年10月出生，南方科技大學化學系系主任、武漢大學長江學者講座教授、綠色催化研究所所長、賓州州立大學教授、羅格斯-新澤西州立大學終身教授，博士生導師。職稱職務：南方科技大學化學系系主任、武漢大學長江學者講座教授、綠色催化研究所所長、賓州州立大學教授、羅格斯-新澤西州立大學終身教授，博士生導師。
基本介紹
人物經歷,研究方向,主要貢獻,獲獎記錄,
人物經歷
1982年畢業於武漢大學化學系，獲學士學位，1992年畢業於史丹福大學(Stanford)化學系，獲博士學位。1992年至1994年在史丹福大學(Stanford University)化學系做博士後研究。1994年至1999年於賓州州立大學（Penn State University）任助理教授，1999年至2003年於賓州州立大學（Penn State University）任副教授，2003年9月至今於賓州州立大學（Penn State University）任教授。已發表文章90多篇，專利及專利申請42件，曾多次被邀請在國際會議上做報告 （正式受邀演講: 210 次，其他受邀演講: 75 次）。並且是美國凱瑞生化有限公司(Chiral Quest Inc)的創始人和首席技術總監。
2015年，就任南方科技大學化學系系主任。
研究方向
研究方向：有機化學、金屬有機化學、生物無機化學。
主要貢獻
近期代表性研究論文：
1.Catalytic Enantioselective Desymmetrization of Meso Cyclic Anhydrides via Iridium-Catalyzed Hydrogenation. Liu, T. L.; Li, W.; Geng, H. L.; Wang, C. J.; Zhang, X. M. Organic Letters. 2013, 15, 1740.
2.Rhodium-Catalyzed Asymmetric Hydroformylation of 1,1-Disubstituted Allylphthalimides: A Catalytic Route to β3-Amino Acids. Zheng, X.; Cao, B. N.; Liu, T. L.; Zhang, X. M. Advanced Synthesis & Catalysis. 2013, 355, 679.
3.Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via Rhodium-Catalyzed Hydroaminomethylation. Li, S. K.; Huang, K. X.; Zhang, J. W.; Wu, W. J.; Zhang, X. M. Organic Letters. 2013, 15, 1036.
4.A Novel Triphosphoramidite Ligand for Highly Regioselective Linear Hydroformylation of Terminal and Internal Olefins Chen, C. Y.; Qiao, Y.; Geng, H. L.; Zhang, X. M. Organic Letters. 2013, 15, 1048.
5.Rhodium-Catalyzed Enantioselective Hydrogenation of Oxime Acetates.Huang, K. X.; Li, S. K.; Chang, M. X.; Zhang, X. M. Organic Letters. 2013, 15, 484.
6.Highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes. Li, Shengkun; Huang, Kexuan; Cao, Bonan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu. Angew. Chem. Int. Edit. 2012, 51, 10679. DOI: 10.1002/anie.201202715
7.New tetraphosphorus ligands for highly linear selective hydroformylation of allyl and vinyl derivatives. Cai, Chaoxian; Yu, Shichao; Cao, Bonan; Zhang, Xumu. Chem. Eur. J. 2012, 18, DOI: 10.1002/chem.201201396.
8.Access to both enantiomers of α-chloro-β-keto esters with a single chiral ligand: highly efficient enantioselective chlorination of cyclic β-keto esters catalyzed by chiral copper(II) and zinc(II) complexes of a spiro-2,2'-bischroman-based bisoxazoline ligand. Li, Jie; Pan, Wei; Wang, Zheng; Zhang, Xumu; Ding, Kuiling. Adv. Synth. Catal. 2012, 354, 1980.
9.Highly enantioselective hydrogenation of β-ketoenamides with the Rh-ZhangPhos catalyst. Huang, Kexuan; Zhang, Xiaowei; Geng, Huiling; Li, Sheng-kun; Zhang, Xumu. ACS Catalysis 2012, 2, 1343.
10.Highly regioselective isomerization-hydroaminomethylation of internal olefins catalyzed by Rh complex with Tetrabi-type phosphorus ligands. Liu, Guodu; Huang, Kexuan; Cao, Bonan; Chang, Mingxin; Li, Shengkun; Yu, Shichao; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Org. Lett. 2012, 14, 102.
11.Highly regioselective hydroaminomethylation of terminal olefins to linear amines using Rh complexes with a Tetrabi phosphorus ligand. Liu, Guodu; Huang, Kexuan; Cai, Chaoxian; Cao, Bonan; Chang, Mingxin; Wu, Wenjun; Zhang, Xumu. Chem. Eur. J. 2011, 17, 14559.
12.Ruthenium-catalyzed asymmetric hydrogenation of β-keto enamines: an efficient approach to chiral γ-amino alcohols. Geng, Huiling; Zhang, Xiaowei; Chang, Mingxin; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 3039.
13.Highly regioselective isomerization-hydroformylation of internal olefins catalyzed by Rhodium/tetraphosphine complexes. Cai, Chaoxian; Yu, Shichao; Liu, Guodu; Zhang, Xiaowei; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 2665.
14.A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an Iridium catalyst. Chang, Mingxin; Li, Wei; Zhang, Xumu. Angew. Chem. Int. Edit. 2011, 50, 10679.
15.Spiro-2,2'-bichroman-based bisoxazoline (SPANbox) ligands for Zn(II)-catalyzed enantioselective hydroxylation of β-keto esters and 1,3-diester. Li, Jie; Chen, Gang; Wang, Zheng; Zhang, Ruzhou; Zhang, Xumu; Ding, Kuiling. Chem. Sci. 2011, 2, 1141.
16.New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation. Sun, Tian; Hou, Guohua; Ma, Miaofeng; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 253.
17.Enantioselective synthesis of optically pure β-amino ketones and γ -aryl amines by Rh-catalyzed asymmetric hydrogenation. Geng, Huiling; Huang, Kexuan; Sun, Tian; Li, Wei; Zhang, Xiaowei; Zhou, Le; Wu, Wenjun; Zhang, Xumu. J. Org. Chem. 2011, 76, 332.
18.Synthesis of enamides via Cu(I)-catalyzed reductive acylation of ketoximes with NaHSO3. Guan, Zheng-Hui; Zhang, Zhi-Yuan; Ren, Zhi-Hui; Wang, Yao-Yu; Zhang, Xumu. J. Org. Chem. 2011, 76, 339.
2.Rhodium-Catalyzed Asymmetric Hydroformylation of 1,1-Disubstituted Allylphthalimides: A Catalytic Route to β3-Amino Acids. Zheng, X.; Cao, B. N.; Liu, T. L.; Zhang, X. M. Advanced Synthesis & Catalysis. 2013, 355, 679.
3.Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via Rhodium-Catalyzed Hydroaminomethylation. Li, S. K.; Huang, K. X.; Zhang, J. W.; Wu, W. J.; Zhang, X. M. Organic Letters. 2013, 15, 1036.
4.A Novel Triphosphoramidite Ligand for Highly Regioselective Linear Hydroformylation of Terminal and Internal Olefins Chen, C. Y.; Qiao, Y.; Geng, H. L.; Zhang, X. M. Organic Letters. 2013, 15, 1048.
5.Rhodium-Catalyzed Enantioselective Hydrogenation of Oxime Acetates.Huang, K. X.; Li, S. K.; Chang, M. X.; Zhang, X. M. Organic Letters. 2013, 15, 484.
6.Highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes. Li, Shengkun; Huang, Kexuan; Cao, Bonan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu. Angew. Chem. Int. Edit. 2012, 51, 10679. DOI: 10.1002/anie.201202715
7.New tetraphosphorus ligands for highly linear selective hydroformylation of allyl and vinyl derivatives. Cai, Chaoxian; Yu, Shichao; Cao, Bonan; Zhang, Xumu. Chem. Eur. J. 2012, 18, DOI: 10.1002/chem.201201396.
8.Access to both enantiomers of α-chloro-β-keto esters with a single chiral ligand: highly efficient enantioselective chlorination of cyclic β-keto esters catalyzed by chiral copper(II) and zinc(II) complexes of a spiro-2,2'-bischroman-based bisoxazoline ligand. Li, Jie; Pan, Wei; Wang, Zheng; Zhang, Xumu; Ding, Kuiling. Adv. Synth. Catal. 2012, 354, 1980.
9.Highly enantioselective hydrogenation of β-ketoenamides with the Rh-ZhangPhos catalyst. Huang, Kexuan; Zhang, Xiaowei; Geng, Huiling; Li, Sheng-kun; Zhang, Xumu. ACS Catalysis 2012, 2, 1343.
10.Highly regioselective isomerization-hydroaminomethylation of internal olefins catalyzed by Rh complex with Tetrabi-type phosphorus ligands. Liu, Guodu; Huang, Kexuan; Cao, Bonan; Chang, Mingxin; Li, Shengkun; Yu, Shichao; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Org. Lett. 2012, 14, 102.
11.Highly regioselective hydroaminomethylation of terminal olefins to linear amines using Rh complexes with a Tetrabi phosphorus ligand. Liu, Guodu; Huang, Kexuan; Cai, Chaoxian; Cao, Bonan; Chang, Mingxin; Wu, Wenjun; Zhang, Xumu. Chem. Eur. J. 2011, 17, 14559.
12.Ruthenium-catalyzed asymmetric hydrogenation of β-keto enamines: an efficient approach to chiral γ-amino alcohols. Geng, Huiling; Zhang, Xiaowei; Chang, Mingxin; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 3039.
13.Highly regioselective isomerization-hydroformylation of internal olefins catalyzed by Rhodium/tetraphosphine complexes. Cai, Chaoxian; Yu, Shichao; Liu, Guodu; Zhang, Xiaowei; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 2665.
14.A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an Iridium catalyst. Chang, Mingxin; Li, Wei; Zhang, Xumu. Angew. Chem. Int. Edit. 2011, 50, 10679.
15.Spiro-2,2'-bichroman-based bisoxazoline (SPANbox) ligands for Zn(II)-catalyzed enantioselective hydroxylation of β-keto esters and 1,3-diester. Li, Jie; Chen, Gang; Wang, Zheng; Zhang, Ruzhou; Zhang, Xumu; Ding, Kuiling. Chem. Sci. 2011, 2, 1141.
16.New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation. Sun, Tian; Hou, Guohua; Ma, Miaofeng; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 253.
17.Enantioselective synthesis of optically pure β-amino ketones and γ -aryl amines by Rh-catalyzed asymmetric hydrogenation. Geng, Huiling; Huang, Kexuan; Sun, Tian; Li, Wei; Zhang, Xiaowei; Zhou, Le; Wu, Wenjun; Zhang, Xumu. J. Org. Chem. 2011, 76, 332.
18.Synthesis of enamides via Cu(I)-catalyzed reductive acylation of ketoximes with NaHSO3. Guan, Zheng-Hui; Zhang, Zhi-Yuan; Ren, Zhi-Hui; Wang, Yao-Yu; Zhang, Xumu. J. Org. Chem. 2011, 76, 339.
發明專利：
“New Chiral Ferrocene Phosphines and Their Applications for Asymmetric Catalytic Reactions” X. Zhang, US patent 09/781,083, filed February 9, 2001 and PCT/US01/044.
2."3,3'-Substituted Chiral Biaryl Phosphines and Phosphintes for Asymmetric Catalytic Reactions ” X. Zhang, U. S. Patent, filed November 16, 2001 and PCT Application.
3."New Transition Metal Catalyzed Reactions” A. Lei, X. Zhang, U. S. Provisional Patent, filed March 30, 2001.
4. “New Chiral Phospholanes for Asymmetric Catalysis” X. Zhang, US Patent filed November 6, 2001.
5. “P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US provisional Patent, November 10, 2001.
6. “Asymmetric Reductive Amination of Ketones” X. Zhang, US Provisional Patent, filed October 25, 2002.
7.“P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US Patent, November 10, 2002.
8. “New Chiral Oxazoline Ligands for Asymmetric Catalysis” D. Liu, X. Zhang, US Provisional Patent, December 17, 2003.
9.“Asymmetric Hydrogenation of Alpla-amino Carbonyl Compounds” X. Zhang, US Provisional Patent, January 10, 2004
10.“Preparation of chiral cyclic amino acids and derivatives” X. Zhang, W. Tang, US Patent 2004242889.
11.“P-Chiral Phospholanes and Phosphocyclic Compounds and their use in Asymmetric Catalytic Reactionss” X. Zhang, W. Tang, US patent 2004229846.
12. “Catalytic Asymmetric Reductive Amination of Ketones Via Transition Metal Complex Catalyst with Chiral Phosphine Ligands” X. Zhang, PCT, 2004, WO 2004058982.
13. “Preparation of Chiral Phosphorus Cyclic Compounds for Transition Metal-Catalyzed Asymmetric Reactions” X. Zhang, US patent, 2004, 2004072680.
14. “A preparation of aminoalcohols via asymmetric hydrogenation of beta-aminocarbonyl compounds” Zhang,
15.Xumu. US 2005159604 A1 20050721 Patent written in English. Application: US 2005-36157 20050114.
16.“New oxazoline ligands for asymmetric catalysis” Zhang, Xumu; Liu, Duan. U.S. Pat. Appl. Publ. (2005), 2005137403 A1 20050623.
17. “Chelating Tetraphosphorus Ligands with 1,1’-biphenyl backbone for transition Metal-catalyzed hydroformylation of Alkenes and Related Reactions” X. Zhang; Y. Yan, PCT Int. Appl. (2007) 2007078859. A2 20070712.
18.新型三齒膦配體及其線上性氫甲醯化及類似反應中的套用（P）. 張緒穆，陳才友. 中國發明專利，CN102875599. 2013-01-16.
2."3,3'-Substituted Chiral Biaryl Phosphines and Phosphintes for Asymmetric Catalytic Reactions ” X. Zhang, U. S. Patent, filed November 16, 2001 and PCT Application.
3."New Transition Metal Catalyzed Reactions” A. Lei, X. Zhang, U. S. Provisional Patent, filed March 30, 2001.
4. “New Chiral Phospholanes for Asymmetric Catalysis” X. Zhang, US Patent filed November 6, 2001.
5. “P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US provisional Patent, November 10, 2001.
6. “Asymmetric Reductive Amination of Ketones” X. Zhang, US Provisional Patent, filed October 25, 2002.
7.“P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US Patent, November 10, 2002.
8. “New Chiral Oxazoline Ligands for Asymmetric Catalysis” D. Liu, X. Zhang, US Provisional Patent, December 17, 2003.
9.“Asymmetric Hydrogenation of Alpla-amino Carbonyl Compounds” X. Zhang, US Provisional Patent, January 10, 2004
10.“Preparation of chiral cyclic amino acids and derivatives” X. Zhang, W. Tang, US Patent 2004242889.
11.“P-Chiral Phospholanes and Phosphocyclic Compounds and their use in Asymmetric Catalytic Reactionss” X. Zhang, W. Tang, US patent 2004229846.
12. “Catalytic Asymmetric Reductive Amination of Ketones Via Transition Metal Complex Catalyst with Chiral Phosphine Ligands” X. Zhang, PCT, 2004, WO 2004058982.
13. “Preparation of Chiral Phosphorus Cyclic Compounds for Transition Metal-Catalyzed Asymmetric Reactions” X. Zhang, US patent, 2004, 2004072680.
14. “A preparation of aminoalcohols via asymmetric hydrogenation of beta-aminocarbonyl compounds” Zhang,
15.Xumu. US 2005159604 A1 20050721 Patent written in English. Application: US 2005-36157 20050114.
16.“New oxazoline ligands for asymmetric catalysis” Zhang, Xumu; Liu, Duan. U.S. Pat. Appl. Publ. (2005), 2005137403 A1 20050623.
17. “Chelating Tetraphosphorus Ligands with 1,1’-biphenyl backbone for transition Metal-catalyzed hydroformylation of Alkenes and Related Reactions” X. Zhang; Y. Yan, PCT Int. Appl. (2007) 2007078859. A2 20070712.
18.新型三齒膦配體及其線上性氫甲醯化及類似反應中的套用（P）. 張緒穆，陳才友. 中國發明專利，CN102875599. 2013-01-16.
獲獎記錄
Franklin Veatch Graduate Fellowship, 1991, Stanford University
The Camille and Henry Dreyfus Foundation New Faculty Award, 1994
DuPont Young Faculty Award, 1996
Office of Naval Research Young Investigator Award, 1996
The Camille and Henry Dreyfus Foundation Teacher-Scholar Award, 1998
The John Simon Guggenheim Foundation Fellow, 2000
The Outstanding Oversea Chinese Young Scientist B, Chinese Academy of Sciences, 2000
The Penn State Faculty Scholar Medal, 2001
The Young Innovation Award of ChiTec (Chinese High Tech) in Chemistry, 2001
The American Chemical Society Arthur C. Cope Scholar Award, 2002
The Camille and Henry Dreyfus Foundation New Faculty Award, 1994
DuPont Young Faculty Award, 1996
Office of Naval Research Young Investigator Award, 1996
The Camille and Henry Dreyfus Foundation Teacher-Scholar Award, 1998
The John Simon Guggenheim Foundation Fellow, 2000
The Outstanding Oversea Chinese Young Scientist B, Chinese Academy of Sciences, 2000
The Penn State Faculty Scholar Medal, 2001
The Young Innovation Award of ChiTec (Chinese High Tech) in Chemistry, 2001
The American Chemical Society Arthur C. Cope Scholar Award, 2002
The SDCA (San Diego Chinese Association) Achievement Award, 2002
Guest Professor of Shanghai Institute of Organic Chemistry
Guest Professor of Dalian Institute of Chemical Physics
Guest Professor of Wuhan University
2008年， 蘇州工業園區第二屆科技領軍人才
2008年， “江蘇省高層次創新創業人才引進計畫”引進人才；
2009年， 姑蘇創新創業領軍人才；
2011年, 獲2010年度“中國經濟十大創新人物”。
Guest Professor of Shanghai Institute of Organic Chemistry
Guest Professor of Dalian Institute of Chemical Physics
Guest Professor of Wuhan University
2008年， 蘇州工業園區第二屆科技領軍人才
2008年， “江蘇省高層次創新創業人才引進計畫”引進人才；
2009年， 姑蘇創新創業領軍人才；
2011年, 獲2010年度“中國經濟十大創新人物”。
