張曉東(武漢大學生命科學學院教授)

張曉東：武漢大學生命科學學院教授。學科專業： 細胞生物學研究方向： 腫瘤分子生物學。

基本介紹

• 中文名：張曉東
• 專業方向：細胞生物學研究方向： 腫瘤分子生物學
• 職務：武漢大學生命科學學院教授
• 性別：男

主要教育和工作經歷：
1991-1995 武漢大學生命科學學院學士
1995-1998 武漢大學生命科學學院碩士
1998-2000 中國醫學科學院基礎醫學研究所博士
2004-2005 Georgetown University 博士後
2000-2004 中國醫學科學院基礎醫學研究所助理研究員，副研究員
2005-2008 Case Western Reserve University 研究助理
2008-至今武漢大學生命科學學院教授
主要任職、獲獎及榮譽：
生命科學學院儀器設備共享中心主任
2011年獲教育部“新世紀優秀人才計畫”
中華預防醫學會科學技術獎評審委員會委員
湖北省腸病中心學術委員會委員
湖北省實驗動物專家委員會委員。

目前主要研究領域和興趣：
本實驗室以體細胞、斑馬魚、小鼠和大鼠基因敲除/敲入技術為主要研究方法，從分子水平探討腫瘤的發病機理, 研究相關基因作用途徑和尋找理想的分子靶標，為腫瘤的早期診斷、治療和預後提供理論依據。
主持課題項目：
1. 項目首席科學家：國家科技支撐計畫（2014BAI02B00），2014.07-2017.06
2. 課題組長：國家重大科學研究計畫（2011CB944404），2011.01-2015.12
3. 項目負責人：國家自然科學基金面上項目（30971499），2010.01-2012.12
4. 項目負責人：國家自然科學基金面上項目（81270306），2013.01-2016.12
5. 項目負責人：國家自然科學基金面上項目（81470375），2015.01-2018.12
6. 課題骨幹：國家科技支撐計畫（2012BAI39B03），2012.01-2014.12
教學情況：
分子生物學，本科生課程，3學分
實驗室研究技術訓練，研究生課程，2學分
細胞生物學研究前沿，研究生課程，2學分

代表論文和著作
[1]X.F. Zhang, K.K. Li, L. Gao, S.Z. Li, K. Chen, J.B. Zhang, D. Wang, R.F. Tu, J.X. Zhang, K.X. Tao, G. Wang, X.D. Zhang, miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPbeta, Oncotarget, 6 (2015) 4144-4158.

[2] Z.Y. Zhang, S.Z. Li, H.H. Zhang, Q.R. Wu, J. Gong, T. Liang, L. Gao, N.N. Xing, W.B. Liu, R.L. Du, X.D. Zhang, Stabilization of ATF5 by TAK1-NLK Critically Regulates the IL-1beta-stimulated C/EBP Signaling Pathway, Mol Cell Biol, (2014).

[3] X.F. Zhang, R. Zhang, L. Huang, P.X. Wang, Y. Zhang, D.S. Jiang, L.H. Zhu, S. Tian, X.D. Zhang, H. Li, TRAF1 is a key mediator for hepatic ischemia/reperfusion injury, Cell death & disease, 5 (2014) e1467.

[4] H.H. Zhang, S.Z. Li, Z.Y. Zhang, X.M. Hu, P.N. Hou, L. Gao, R.L. Du, X.D. Zhang, Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage, Cell death and differentiation, 21 (2014) 1656-1663.

[5] L. Yan, W. Liu, H. Zhang, C. Liu, Y. Shang, Y. Ye, X. Zhang, W. Li, Ube2g2-gp78-mediated HERP polyubiquitylation is involved in ER stress recovery, Journal of cell science, 127 (2014) 1417-1427.

[6] S.Z. Li, H.H. Zhang, J.B. Liang, Y. Song, B.X. Jin, N.N. Xing, G.C. Fan, R.L. Du, X.D. Zhang, Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKbeta, Biochimica et biophysica acta, (2014).

[7] S.-Z. Li, Y. Song, H.-H. Zhang, B.-X. Jin, Y. Liu, W.-B. Liu, X.-D. Zhang, R.-L. Du, UbcH10 overexpression increases carcinogenesis and blocks ALLN susceptibility in colorectal cancer, Sci. Rep., 4 (2014).

[8] X.A. Wang, R. Zhang, Z.G. She, X.F. Zhang, D.S. Jiang, T. Wang, L. Gao, W. Deng, S.M. Zhang, L.H. Zhu, S. Guo, K. Chen, X.D. Zhang, D.P. Liu, H. Li, Interferon regulatory factor 3 constrains IKKbeta/NF-kappaB signaling to alleviate hepatic steatosis and insulin resistance, Hepatology, (2013).

[9] L. Wang, Y. Lu, X. Zhang, Y. Zhang, D. Jiang, X. Dong, S. Deng, L. Yang, Y. Guan, L. Zhu, Y. Zhou, X. Zhang, H. Li, Mindin is a critical mediator of ischemic brain injury in an experimental stroke model, Experimental neurology, 247 (2013) 506-516.

[10] S.Z. Li, H.H. Zhang, J.N. Zhang, Z.Y. Zhang, X.F. Zhang, X.D. Zhang, R.L. Du, ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis, Biochemical and biophysical research communications, 437 (2013) 325-330.

[11] D.S. Jiang, X.F. Zhang, L. Gao, J. Zong, H. Zhou, Y. Liu, Y. Zhang, Z.Y. Bian, L.H. Zhu, G.C. Fan, X.D. Zhang, H. Li, Signal Regulatory Protein-alpha Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling, Hypertension, (2013).

[12] Z. Huang, S. Li, W. Song, X. Li, Q. Li, Z. Zhang, Y. Han, X. Zhang, S. Miao, R. Du, L. Wang, Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/Beta-catenin pathway by down-regulating Dickkopf-1 (DKK1), PloS one, 8 (2013) e70077.

[13] K. Chen, L. Gao, Y. Liu, Y. Zhang, D.-S. Jiang, X. Wei, X. Zhu, R. Zhang, Y. Chen, Q. Yang, N. Kioka, X.-D. Zhang, H. Li, Vinexin-β protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway, Basic research in cardiology, 108 (2013) 1-14.

[14] Y. Liu, S. Li, H. Zhang, Z. Wan,X. Zhang, R. Du, A one-step cloning method for the construction of somatic cell gene targeting vectors: application to production of human knockout cell lines, BMC biotechnology, 12 (2012) 71.

[15] P. Zhang, Y. Zhao, X. Zhu, D. Sedwick, X. Zhang, Z. Wang, Cross-talk between phospho-STAT3 and PLCgamma1 plays a critical role in colorectal tumorigenesis, Molecular cancer research : MCR, 9 (2011) 1418-1428.

[16] R. Du, S. Li, X. Zhang, A modified plasmid vector pCMV-3Tag-LIC for rapid, reliable, ligation-independent cloning of polymerase chain reaction products, Analytical biochemistry, 408 (2011) 357-359.

[17] P. Wang, F. Zou,X. Zhang, H. Li, A. Dulak, R.J. Tomko, Jr., J.S. Lazo, Z. Wang, L. Zhang, J. Yu, microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells, Cancer research, 69 (2009) 8157-8165.

[18] X. Zhang, C. Guo, Y. Chen, H.P. Shulha, M.P. Schnetz, T. LaFramboise, C.F. Bartels, S. Markowitz, Z. Weng, P.C. Scacheri, Z. Wang, Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies, Nature methods, 5 (2008) 163-165.

[19] C. Guo, X. Zhang, S.P. Fink, P. Platzer, K. Wilson, J.K. Willson, Z. Wang, S.D. Markowitz, Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase, Cancer research, 68 (2008) 6118-6126.

[20] X. Zhang, A. Guo, J. Yu, A. Possemato, Y. Chen, W. Zheng, R.D. Polakiewicz, K.W. Kinzler, B. Vogelstein, V.E. Velculescu, Z.J. Wang, Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T, Proceedings of the National Academy of Sciences of the United States of America, 104 (2007) 4060-4064.