基本介紹
- 中文名：張文華
- 畢業院校：華中科技大學
- 學位/學歷：博士
- 職務：助理研究員
人物簡介,人物經歷,研究方向,科研題目,專利信息,發表文章,
人物簡介
張文華，博士，南昌大學生命科學研究院恐懼與焦慮障礙研究室助理研究員。
人物經歷
教育經歷
1、2007-2014：華中科技大學生物化學與分子生物學專業博士學位
2、2003-2007：西南大學生命科學學院生物科學專業學士學位
工作經歷
2014至今南昌大學生命科學研究院，助理研究員
研究方向
恐懼和焦慮症是最為常見的神經精神疾病；大腦杏仁核和海馬區作為與恐懼和焦慮症相關的兩個最為重要的腦區，其結構與功能異常是導致恐懼和焦慮發生的重要因素。主要利用神經示蹤劑、光遺傳學、膜片鉗技術以及動物行為學等手段，著重研究慢性應激介導的杏仁核及海馬神經元結構和功能變化，以期闡明恐懼和焦慮症中的神經環路機制。
科研題目
1、2017.1-2019.12:國家自然科學基金青年基金項目“Rap1在慢性應激致海馬神經元結構和突觸功能損傷中的作用與機制”
2、2017.7-2019.6：江西省自然科學基金青年基金項目“Rap1在慢性應激導致小鼠焦慮樣行為的作用及機制研究”
3、2016.1-2017.12：江西省自然基金面上項目“毒蕈鹼型乙醯膽鹼M2受體通過格線蛋白非依賴的內吞分子機制研究”
4、2016.1-2018.12：江西省教育廳基金一般項目“慢性應激激活海馬Rap1機制及功能研究”
專利信息
一種細胞模型及其構建方法和在篩選抗神經紊亂性疾病藥物中的套用
發表文章
1.Jingjing He*,Wenhua Zhang*, Shiling Liu, Yifang Chen, Chenxi Liao, Qianqing Shen, Ping Hu. β-adrenergic receptor promotes cell proliferation in human glioblastoma cells. Oncology Letters, Accepted (*共同第一作者) 2017
2.Wen-Hua Zhang,JinZhou,Han-Qing Pan, Xiao-Yang Wang, Wei-Zhu Liu, Jun-Yu Zhang, Xiao-Ping Ying, Bing-Xing Pan. δ subunit-containing GABAA receptor prevents overgeneralization of fear in adult mice. Learning Memory, 2017, 24:381-384
3.Chen Song*,Wen-Hua Zhang*,Xue-Hui Wang, Jun-Yu Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bing-Xing Pan. Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits. Molecular Brain, 2017
4.Zhi-Peng Liu, Qing-Hai He, Han-Qing Pan, Xiao-Bin Xu, Wen-Bing Chen, Ye He, Jin Zhou,Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Ying, Ren-Wen Han, Bao-Ming Li, Tian-Ming Gao1, Bing-Xing Pan. Delta Subunit-Containing Gamma-Aminobutyric Acid a Receptor Disinhibits Lateral Amygdala andFacilitates Fear Expression in Mice. Biological Psychiatry, 2017, 81(12):990-1002
5.Xiao-Bin Xu, Shi-Jun Fan, Ye He, Xin Ke, Chen Song, Yao Xiao,Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Yin, Nobumasa Kato, Bing-Xing Pan. Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure. Molecular Neurobiology, 2017, 54(6):4524-4536
6.Ping Hu*,Wenhua Zhang*, Hongbo Xin and Glenn Deng. Single Cell IsolationandAnalysis. Frontiers in Cell and Development Biology, 2016,4:116
7.Ping Hu, Jingjing He, Shiling Liu, Meng Wang, Bingxing Pan,Wenhua Zhang#.β2 adrenergic receptor activation promotes the proliferation of A549 lung cancer cells via ERK/CREB pathway. Oncology Reports, 2016, 36:1757-1763
8.Wenhua Zhang, Chanjuan Xu, Haijun Tu, Yunyun Wang, Qian Sun, Ping Hu, Yongjian Hu, Philippe Rondard, Jianfeng Liu. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Scientific Reports, 2015, 5:10468
9.Zongyong Zhang*,Wenhua Zhang*, Siluo Huang*, Qian Sun, Yunyun Wang, Yongjian HU, Ninghua Sun, Yilei Zhang, Zhihua Jiang, Li Su, Jianfeng Liu. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. Journal of Cell Science, 2015
10.Min Wan*,Wenhua Zhang*, Yangli Tian, Chanjuan Xu, Tao Xu, Jianfeng Liu, Rongying Zhang. Unraveling a molecular determinant for clathrin-independent internalization and subsequent degradation of M2 mAChR. Scientific Reports, 2015
11.Chanjuan Xu,Wenhua Zhang, Philippe Rondard, Jean Philippe Pin, Jianfeng Liu. Complex GABAB receptor complexes: how to generate multiple functionally distinctunits from a single receptor. Frontiers in Pharmacology. 2014
12.Ping Hu, Bin Li,Wenhua Zhang, Yijian Li, Guang Li, Xinnong Jiang, Joanna Wdzieczak-Bakala, and Jianmiao Liu. AcSDKP regulates cell proliferation through PI3KCA/Akt signaling pathway. PLoS ONE, 2013
13.Guillaume A. Baloucoune*, Lei Chun*,Wenhua Zhang*, Chanjuan Xu, Siluo Huang, Qian Sun, Yunyun Wang, Haijun Tu, and Jianfeng Liu. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS ONE, 2012
14.Chun Lei, Zhang Wenhua, Liu Jianfeng. Structure and ligand recognition of Class C GPCR. Acta Pharmacologica Sinica, 2012
15.Xin Lin, Xin Li, Ming Jiang, linhai Chen, Chanjuan Xu,Wenhua Zhang,Han zhao, Bing Sun, Xiaoli Xu, Fajun Nan, Jianfeng Liu. An activity-based probe reveals dynamic protein-protein interactions mediate IGF-1R transactivation by GABAB receptor in neurons. Biochemical Journal, 2012
16.Haijun Tu, Chanjuan Xu,Wenhua Zhang, Qiuyao Liu, Philippe Rondard, Jean-Philippe Pin, Jianfeng Liu. GABAB receptor activation protects neurons from apoptosis via IGF-I receptor transactivation. Journal of Neuroscience. 2010
17.張文華，孫倩，胡勇箭，劉劍峰. GABAB受體與跨膜受體交叉對話研究新進展.生物物理學報，2013;
18.張文華，王云云，丁明柳，劉劍峰. GABA受體與脆性X染色體綜合徵研究新進展.生物物理學報，2013;
19.蔣明,黃思羅,林昕,春雷,皮振鈞,孫兵,張文華,趙菡,劉劍峰. GABAB受體變構劑藥學研究進展.現代生物醫學進展, 2011;
