張幼怡

張幼怡，研究員，博士生導師。北京大學第三醫院血管醫學研究所副所長，衛生部心血管分子生物學與調節肽重點實驗室副主任，分子心血管教育部重點實驗室副主任，北京大學心血管研究所所長， 北京大學前沿交叉科學研究院生物醫學跨學科中心副主任。

基本介紹

• 中文名：張幼怡
• 國籍：中華人民共和國
• 民族：漢族
• 職業：研究員，博士生導師
• 畢業院校：北京醫科大學

教育背景

1992年在新疆醫科大學獲醫學博士學位，1994年在北京醫科大學第三醫院血管醫學研究所博士後出站。曾在日本大學研修和美國Emory大學作博士後。

社會兼職

現兼任國際病理生理學會副理事長、中國病理生理學會秘書長、中國病理生理學會心血管專業委員會主任委員，中國病理生理學會受體專業委員會副主任委員，中國藥理學會心血管藥理專業委員會委員。《中國科學：生命科學》和《Clinical and Experimental Pharmacology and Physiology》常務編委， 《J Pathophysiology》、《中國藥理與毒理》、《生理學報》、《中國病理生理學雜誌》、《中國藥學雜誌》《中華醫學雜誌英文版》等編委。

研究方向

1. 多種亞型腎上腺素受體在心血管共存的生理與病理意義；

2. 心血管重塑的網路調控及早期防治的基礎研究；

3. 腎上腺素受體單個分子在活細胞中的動態行為；

4. 心力衰竭的分子機制與轉化醫學。

主要成就

多年來一直從事腎上腺素受體與心血管疾病發病機制的研究， 特別是腎上腺素受體在心血管系統的分布，信號轉導，生理功能及在病理狀態下的改變和受體之間的互動作用的研究。作為項目主持者先後承擔10 餘項各級科學基金課題，包括：國家科技部重點基礎研究發展規劃項目“973”課題2 項(已結題)；國家自然科學基金8項，北京市自然科學基金1 項等。共發表學術論文180篇，其中SCI96篇（第一和責任作者58篇）近三年發表論文38篇，SCI 收錄35篇（責任作者23篇）。2001 年獲國家教委中國高校自然科學一等獎（第2 完成人）。參與編寫《動態心電圖》、《分子核醫學》、《受體信號轉導系統與疾病》和《生命科學中的單分子行為及細胞內實時檢測》等著作。

發表的部分學術論文

1. XF Zhao, XH Zheng, YM Wei, LJ Bian, SX Wang, JB Zheng, YY Zhang*, ZJ Li, WJ Zang*. Corrigendumto “Thermodynamic study of the interaction between terbutaline and salbutamolwith an immobilized b2-adrenoceptor by high-performance liquid chromatography”. JOURNAL OF CHROMATOGRAPHY, 2009, 877:911-918

2. JY Qi, M Xu, ZZ Lv, YY Zhang*.Differential expression of 14-3-3 eduringd physiological, pathological cardisc hypertrophy and chronicheart failure in mice. GENE THERAPY AND MOLECULAR BIOLOGY, 2009, 13: 71-81

3. GM Shi, QH Cui, YY Zhang*.microRNA Set: A Novel Wayto Uncover the Potential Black box of chronic Heart Failure in MicroRNAMicroarray Analysis. JOURNAL OF COMPUTER SCIENCE & SYSTEMS BIOLOGY, 2009, 2(4):240-246

4. W Wang, M Xu, YY Zhang, B He.Fenoterol, a beta2-adrenoceptor agonist, inhibits LPS-induced membrane-boundCD14, TLR4/CD14 complex, and inflammatory cytokines production throughbeta-arrestin-2 in THP-1cell line. ACTA PHARMACOL SIN, 2009, 11, 30(11): 1522-8

5. Y Xia, KZ Gong, M Xu, YY Zhang,JH Guo, Y Song, P Zhang. Regulation of gap-junction protein connexin 43 by beta-adrenergicreceptor stimulation in rat cardiomyocytes. ACTA PHARMACOL SIN, 2009, Jul,30(7): 928-34

6. D Ai, W Pang, N Li, M Xu, PD. Jones, J Yang,YY Zhang, N Chiamvimonvate, Y. J. Shyyf, BD. Hammock, Y Zhu. Solubleepoxide hydrolase plays an essential role in angiotensin II-induced cardiachypertrophy. PNAS, 2009, 106(2): 564–569

7. ZJ Li, N Liu, LS zhang, KZ Gong, YB Cai, W Gao, ZQ Liu, SY Liu, QD Han, YY Zhang*. Proteomic profiling revealscomprehensive insights into adrenergic receptor-mediated hypertrophy inneonatal rat cardiomyocytes. PROTEOMICS CLIN APPL, 2009, 3: 1407-1421

8. JY Huang, L Qin, XL Peng, CY Xiong ,YYZhang, J Fang .Cellular traction force recovery: An optimal filteringapproach in two-dimensional fourier space. JOURNAL OF THEORETICAL BIOLOGY, 2009,7, 259: 811–819

9. JY Huang, XL Peng, L Qin, T Zhu, CY Xiong, YY Zhang, J Fang. Determination of Cellular Tractions on ElasticSubstrate Based on an Integral Boussinesq Solution. JOURNAL OF BIOMECHANICALENGINEERING, 2009, 6, 131: 061009-9

10. F Wei, Y Song, C Chen, ZZ Lv, YY Zhang*.Stimulation of adenosine A2B receptors induces interleukin-6 secretion incardiac fibroblasts via the PKC–p38 signalling pathway. BRITISH JOURNAL OFPHARMACLOLGY. 2010, 159:1598-1607

11. JY Qi, M Xu, ZZ Lv, YY Zhang*.14-3-3 inhibits IGF-I induced proliferation of cardiacfibroblasts via PI3K-dependent NFAT pathway. CLIN EXP PHARMACOL PHYSIOL, 2010,37: 296-302

12 He K,Luo W,Zhang Y,Liu F,Liu D,Xu L,Qin L,Xiong C,Lu Z,Fang X,Zhang Y*.Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes.ACS Nano, 2010, 4 (6): 3015–3022

13. Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M, Shen Q, Zhu Y, Zhang Y*. Metformin attenuatescardiac fibrosis by inhibiting the TGFb1-smad3signalling pathway. Cardiovasc Res , 2010: 87, 504–513

14 Jiang SY, Xu M, Ma XW, Xiao H, ZhangYY. Distinct AMPK phosphorylationsite characterizes cardiac hypertrophy induced by L-thyroxine andangiotensinII. Clin ExpPharmacol Physiol, 2010:37;919–925

15 Xiao H, Zhang YY, Du XJ, Lu ZZ. Developmental changes in the geometry, functionand responsiveness of the mouse heart to β-adrenergic stimulation as determinedby high-resolution echocardiography. Clin Exp Pharmacol Physiol.2010;37:826-832

16. Liu X, Gai Y, Liu F, Gao W, Zhang Y, Xu M, Li Z. Trimetazidineinhibits pressure overload-induced cardiac fibrosis through NADPHoxidase-ROS-CTGF pathway. Cardiovasc Res. 2010;88:150-158

17. Zhao X, Nan Y, Xiao C, Zheng J, ZhengX*, Wei Y, Zhang Y*. Screening thebioactive compounds in aqueous extract of Coptidis rhizoma which specificallybind to rabbit lung tissues beta2-adrenoceptor using an affinitychromatographic selection method.J Chromatogr B Analyt Technol Biomed Life Sci.2010 Jul 15;878(22):2029-34

18. He K, Fu Y, Zhang W, Yuan J, Li Z, Lv Z, Zhang Y*, Fang X. Single-molecule imaging revealed enhanceddimerization of transforming growth factor β type Ⅱreceptors in hypertrophiccardiomyocytes. Biochem Biophys Res Commun. 2011;407(2):313-7

19. Ma X, Song Y, Chen C, Fu Y, Shen Q, Li Z,Zhang Y.* Distinct actions of intermittent and sustained b-adrenoceptor stimulation on cardiac remodeling. Sci China Life Sci. 2011;54(6):493-501

20. Shi X,Qin L,Zhang X,He K,Xiong C,Fang J,Fang X,Zhang Y*.Elasticity of cardiac cells on the polymer substrates with different stiffness:an atomic force microscopy study. Phys Chem Chem Phys.2011;13(16):7540-5

21. Fu YN,Xiao H,Ma XW,Jiang SY,Xu M,Zhang YY*. Metformin attenuates pressureoverload-induced cardiac hypertrophy via AMPK activation. Acta Pharmacol Sin. 2011;32(7):879-87

22. Liu F, He K, Yang X, Xu N, Liang Z, Xu M, Zhao XS, Han QD, zhang YY*. 1A-Adrenergic receptor induces activation ofextracellular signal-regulated kinase 1/2 through endocytic pathway. PLoS ONE 2011;6(6): e21520

23. He K, Shi X, Zhang X, Ma X, Liu F, Xu M, LvZ, Fang X, Zhang Y*. Long-distance intercellular connectivity between cardiomyocytes andcardiofibroblasts mediated by membrane nanotubes. Cardiovasc Res. 2011; 92, 39–47

24. Li Z, Liu N, Han Q, Zhang Y*. A proteome reference map andregulation network of the neonatal rat cardiomyocyte. Acta Pharmacologica Sinica，2011; 32(9):1116-27

25. Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lü Z, Li Z, Zhang Y*. Transactivated EGFR mediatesα1-AR-induced STAT3 activation and cardiac hypertrophy. Am J PhysiolHeart Circ Physiol. 2011;301(5):H1941-51

26. Xu Q,Dalic A,Fang L,Kiriazis H,Ritchie RH,Sim K,Gao XM,Drummond G,Sarwar M,Zhang YY,Dart AM,Du XJ.Myocardial oxidative stress contributes to transgenic β-adrenoceptoractivation-induced cardiomyopathy and heart failure. Br J Pharmacol. 2011Mar;162(5):1012-28

27. Wang J,Song Y,Zhang Y,Xiao H,Sun Q,Hou N,Guo S,Wang Y,Fan K,Zhan D,Zha L,Cao Y,Li Z,Cheng X,Zhang Y*,Yang X.Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy anddysfunction in mice. Cell Research, 2011 Aug 16. doi: 10.1038/cr.2011.132

28. Chen C, Du J, Feng W, Song Y, Lu Z, Xu M, LiZ, Zhang Y*. b-adrenergic receptors stimulate interleukin-6 production throughEpac-dependent activation of PKCd/p38 MAPKsignaling in neonatal mouse cardiac fibroblasts. Br J Pharmacol, 2011 Nov 21.doi: 10.1111/j.1476-5381.2011.01785.x.

29. Yongnan Fu, Han Xiao, YouyiZhang*. β-adrenoceptor signaling pathways mediate cardiac pathologicalremodeling. FRONTIERS IN BIOSCIENCE. 2012 Jan 1;4:1625-37