張夢暉

1990 年在中國藥科大學藥學院藥理專業獲藥學學士學位;1999年至2005年在比利時布魯塞爾自由大學學習,先後獲得藥學碩士、藥學博士學位。

基本介紹

個人簡歷,研究方向,發表論文,

個人簡歷

1990至1998 年在湖南省藥檢所工作,主要從事藥品監督、生物檢定及新藥藥效學、毒理學評價;1998至1999 年作為日中醫學獎學金研修生由衛生部公派至日本富山醫科藥科大學和漢藥研究所從事痴呆模型與抗痴呆中草藥研究;1999至2005 年在比利時布魯塞爾自由大學師從D.L.Massart 教授,專攻化學計量學,偏重於醫、藥學數據分析的方法學研究。2005 年底至今在上海交通大學生命科學技術學院主要從事系統生物學研究中計算生物學部分的工作,重點為數據分析及生物信息挖掘。
作為項目負責人承擔的課題:
1、國家科技部 863 專題“元基因組學和代謝組學的系統整合計算分析平台與代謝性疾病研究”(2008-2010)
2、國家自然基金面上項目“多組學綜合生物信息挖掘技術在新發糖尿病病例研究中的套用”(2009-2011)

研究方向

多變數數據分析, 生物信息學

發表論文

1、T. Wang, G. Cai, Y. Qiu, N. Fei, M. Zhang, X. Pang, W. Jia, S. Cai, L. Zhao, Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers , ISME J., doi:10.1038/ismej.2011.109
2、 T. Wang, X. Zhang, M. Zhang, L. Wang, L. Zhao L, Development of a fluorophore-ribosomal DNArestriction typing method for monitoring structural shifts of microbial communities, Arch Microbiol. ,193(5):341-50, 2011
3、H. Wei, L. Dong, T. Wang, M .Zhang, W.Hua, C. Zhang, X.Pang, M. Chen, M. Su, Y. Qiu, M. Zhou, S.Yang, Z. Chen, M. Rantalainen5, J. K. Nicholson, W. Jia, D. Wu , L. Zhao, Structural shifts of gutmicrobiota as surrogate endpoints for monitoring host health changes induced by carcinogen exposure, FEMS Microbiol Ecol 73 (2010) 577–586
4、C. Zhang ,M. Zhang ,S. Wang ,R. Han ,Y. Cao,W. Hua,Y. Mao,X. Zhang, X. Pang, C. Wei, G. Zhao, Y. Chen, L. Zhao,Interactions between gut microbiota, host genetics, and diet relevant to development of metabolic syndromes in mice, ISME Journal, 2010 Feb;4(2):232-41
5、華蔚穎 徐昭,張夢暉*,李旻 ,張晨虹, 趙立平,CVTree 在454 高通量測序分析菌群結構中的套用,中國微生態學雜誌 2010,22(4):312-316 (*通訊作者)
6、M. Zhang, M. Zhang*, C. Zhang, H. Du, G Wei, X.Pang, H. Zhou, B. Liu, L. Zhao, Pattern extraction of structural responses of gut microbiota to rotavirus infection via multivariate statistical analysis of clone library data, FEMS Microbiol Ecol., 70(2009):177-185(*corresponding author)
7、M. Li*,B. Wang*, M.H. Zhang*, M. Rantalainen*, S. Wang*, et al., Symbiotic gut microbes modulate human metabolic phenotypes, PNAS, 105 (2008) 2117-2122 (* first co-author)
8、E. Deconinck, M.H. Zhang, F. Petitet, E. Dubus, I. Ijjaali, D. Coomans and Y. Vander Heyden, Boosted regression trees, multivariate adaptive regression splines and their two-step combinations with multiple linear regression or partial least squares to predict blood–brain barrier passage: A case study, Anal. Chimi. Acta , 609 (2008) 13-23
9、E. Deconinck, M.H. Zhang, D. Coomans and Y. Vander Heyden, Evaluation of boosted regression trees (BRT) and two-step BRT procedures to model and predict blood-brain barrier passage,Journal of Chemometrics,21(2007)280-291
10、E. Deconinck, M.H. Zhang, D. Coomans and Y. Vander Heyden, Classification tree models for the prediction of blood-brain barrier passage of drugs, J. Chem. Inf. Model., 46(2006) 1410-1419
11、M.H. Zhang, Q.S. Xu, D.L. Massart, Boosting PLS, Anal. Chem., 77(2005) 1423-1431
12、M.H. Zhang, Q.S. Xu, D.L. Massart, Application of boosting to classification problems in chemometrics, Anal. Chimi. Acta, 544(2005) 167-176
13、M.H. Zhang, Q.S. Xu, D.L. Massart, Averaged and weighted average Partial Least Squares, Anal. Chimi. Acta, 504 (2004) 279-289
14、M.H. Zhang, Q.S. Xu, D.L. Massart, Robust Principal Components Regression based on Principal Sensitivity Vectors, Chemo. Intell. Lab. Sys., 67 (2003) 175-185
15、M.H. Zhang, J. Luypaert, J.A. Fernandez Pierna, Q.S. Xu, D.L. Massart, Determination of total antioxidant capacity in green tea by near-infrared spectroscopy and multivariate calibration, Talanta, 62 (2004) 25-35
16、J. Luypaert, M.H. Zhang, D.L. Massart, A feasibility study for the use of near infrared spectroscopy (NIR) in the qualitative and quantitative analysis of plants with antioxidant capacity, Anal. Chimi. Acta, 478 (2003) 303-312。

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