張傳溪

張傳溪，浙江大學教授、博士生導師，男，1960年1月出生。博士學位論文於2000年被評為全國優秀博士學位論文。兼任該校生命科學院和生物化學與分子生物學博士生導師。

基本介紹

• 中文名：張傳溪
• 國籍：中國
• 出生日期：1960年1月
• 職業：教授、博士生導師
• 畢業院校：浙江農業大學
• 主要成就：浙江省優秀教師
• 代表作品： 昆蟲桿狀病毒ph、pk基因分析和人EPO基因在桿狀病毒-昆蟲系統中的表達
• 性別：男
• 職稱：教授

人物經歷

1982年畢業於浙江農業大學植保系。

1985年在同校獲昆蟲學專業碩士學位，並留校任教。

1994-1997年在中國科學院生物化學研究所在職從事博士學位論文工作，獲理學博士學位。

1998年晉升浙江大學教授。

2001-2003年任日本學術振興會和愛媛大學CMES特別研究員。

研究方向

本實驗室主要從事昆蟲分子生物學和動物病毒分子生物學與基因工程的研究。本分子生物學實驗室研究的目標是闡明昆蟲和病毒重要基因的特性和功能及其利用。目前正在進行的主要研究項目和方向包括：

1．家蠶重要經濟性狀功能基因研究。國家“863”計畫。

2．昆蟲乙醯膽鹼酯酶基因及表達產物在藥效活性評價中套用。 國家重點基礎研究發展計畫（973計畫）子項目。

3．BmNPV ODV囊膜蛋白在家蠶中腸細胞上受體基因的研究。國家自然科學基金。

4．家蠶2種類型乙醯膽鹼酯酶基因的特性與生物學功能比較。國家自然科學基金。

5．以桿狀病毒為載體，以昆蟲細胞和家蠶為生物反應器，表達生產人與經濟動物藥用多肽和科學研究用蛋白；氫菌基因工程（中意國際合作項目、國內合作項目、浙江省科技廳項目；“863”探索）。

主要貢獻

先後在《Virology》、《BMC Genomics》等國內外學術刊物上發表論文100餘篇（其中SCI收錄34篇），書著有《昆蟲桿狀病毒ph、pk基因分析和人EPO基因在桿狀病毒-昆蟲系統中的表達》（高等教育出版社）等2本，參編4本。已申請國家發明專利9項，已授權4項。

入選浙江省“151人才工程”。曾被授予浙江省優秀教師稱號。美國國家自然科學基金會（NSF）評審專家、《微生物學報》和《中國病毒學》編委。

主要論文

(*corresponding author)

Ya-Ming Shao, Ke dong, Chuan-Xi Zhang★, 2007. The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx mori. BMC Genomics, 8:324

Xiu-Cui Ma, Jin-Yan Shang, Zhang-Nv Yang,Yan-Yuan Bao, Qiang Xiao and ?Chuan-Xi Zhang★. 2007. Genome sequence and organization of a nucleopolyhedrovirus that infects the tea looper caterpillar, Ectropis oblique. Virology , 360: 235–246

Jun-Qing Ge, Zhang-Nv Yang, Xu-Dong Tang, Hai-Jun Xu, Jian Hong, Jian-Guo Chen and Chuan-Xi Zhang★, 2007. Characterization of a nucleopolyhedrovirus with a deletion of the baculovirus core gene Bm67. Journal of GeneralVirology (accepted)

Dun Wang and Chuan-Xi Zhang★. 2007. Helicoverpa armigera nucleopolyhedrovirus orf80 encodes a late, nonstructural protein. JBMB, 40 (1) 65-71 (SCI)

Dun Wang, Shao-wei Zhai, Chuan-xi Zhang,Qiang Zhang, Hui Chen. 2007 Nutrition value of the Chinese grasshopper Acrida cinerea (Thunberg) for broilers. Animal feed science and technology, 135 (1-2): 66-74. (SCI)

Hai-Jun Xu , Jian-Guo Lin, Chuan-Xi Zhang★ , Suzuki Satoru . 2007. Expression and immunogenic comparison of VP2 and VP3 from Marine Birnavirus (MABV) . Journal of Fish Diseases . (accepted).

Jin-Yan Shang ,? Ya-Ming? Shao , Chuan-Xi Zhang★, GanYuan and Zhen-Hua Tang. 2007. Expression of two types of acetylcholinesterase gene from the silkworm, Bombyx mori, in insect cells. Insect Science, DOI 10.1111/j.1744-7917.2007.00177.x.

Wan-Fu Yue, Min-Li Yao, Jian-Mei Liu, Guang-Li Li, Xing-Hua Li, Xiao-Feng Wu, Wen Deng, Hong-Xiang Sun, Ji-Yong Zhou, Chuan-Xi Zhang, Yun-Gen Miao. Manganese superoxide dismutase expressed in silkworm larvae, Bombyx mori L enhances the NK activity and splenocyte proliferation against Sarcoma 180 tumor cells in vivo. Mol Biol Rep, DOI 10.1007/s11033-007

Xiu-Cui Ma, Hai-Jun Xu, Mei-Jun Tang, Qiang Xiao, Jian Hong, and Chuan-Xi Zhang★. 2006. Morphological, phylogenetic and biological characteristics of Ectropis obliqua single-nucleocapsid nucleopolyhedrovirus. Journal of Microbiology, 44(1): 77-82(SCI)

Hai-Jun Xu, Yan-He Liu, Zhang-Nv Yang, Chuan-Xi Zhang★. 2006.Characterization of ORF39 from Helicoverpa armigera single-nucleocapsid Nucleopolyhedrovirus, the gene containing RNA recognition motif. Journal of Biochemistry and Molecular Biology, 39(3): 39(3):263-269 (SCI)

Dun Wang and Chuan-Xi Zhang★. 2006. HearSNPV orf83 encodes a late, nonstructural protein with an active chitin binding domain. Virus Research. 117 (2006) 237–243. (SCI)

．Hai-jun Xu, Zhang-Nv Yang, Fang Wang, Chuan-Xi Zhang★.2006. Bombyx mori nucleopolyhedrovirus ORF79 encodes a structural protein of ODV envelope with a molecular weight of 28kDa. Archives of Virology,151(4):681-695 . (SCI)

Shi-Heng An, Li-Ping Xing, Wan-Jun Shi and Chuan-Xi Zhang★. 2006. Characterization of a lepidopteran nucleopolyhedrovirus (NPV) core gene, ORF17 from Autographa californica MNPV (AcMNPV). Acta Virologica, 50 (1):17-23. (SCI).

Shi-Heng An, Jin-Yan Shang, Yan-He Liu,V Shyam Kumar, Zhong-Jian Guo, Dun Wang, Zhang-Nv Yang and Chuan-Xi Zhang★.2006. Characterization of a unique gene ORF135 from Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus. Virus Genes, 2006, 32:21-26. (SCI)

Wang F., Yang LR, Tang XD, Mo JC, W-J Yang, Chuan-Xi Zhang★.2006. Characterization of the translational and transcriptional start site of BmNPV lef-7 gene. Virus Genes, 33:351–357 (SCI).

Li-Rong YANG, Dun WANG, Li-Qing DUAN, Chuan-Xi ZHANG★.2006. Polyhedrin gene sequence and phylogenetic analysis of a nucleopolyhedrovirus isolated from Orgyia ericae Germar. DNA Sequence, 17 (3): 215-222 (SCI)

Wan-jun SHI, Jia-An CHENG, Chuan-Xi ZHANG★ 2006.Expression of the melittin gene of Apis cerana cerana in insect cells. European Journal of Entomology,103: 867–870 (SCI)

Zhong-Jian Guo, Jun-Qing Ge, Dun Wang, Ya-Ming Shao, Qi-Yi Tang, Chuan-Xi Zhang★. 2006. Biological comparison of two strains of Helicoverpa armigera single-nucleocapsid nucleopolyhedrovirus. Biocontrol, 51:809–820. (SCI).

Li-ming Tao, Ming-an Shi, Yuang Jiangzhong，Peijun Zhuang, Chuan-Xi Zhang and Zhen-HuaTang. 2006.Resistance pattern and point mutations of insensitive acetylcholinesterase in a propoxur-resistant strain of housefly (Musca domestica). Pesticide Biochemistry and Physhiology 86: 1–6. (SCI)

Shi-Heng An, Dun Wang,Yang Zhang-Nv, Zhong-Jian Guo, Hai-Jun Xu, Jianxin Sun and Chuan-Xi Zhang★.2005.Characterization of a late expression gene, Open reading frame 128 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus. Archives of Virology. 150(12): 2453–2466. (SCI)

Jiang-Hong Li, Chuan-Xi Zhang★ and Zhen-hua Tang. (2005) Expression of melittin gene in the venom gland of the Chinese honeybee, Apis cerana cerana. Apidologie 36(4): 533–541. (SCI).

Jiang-Hong Li, Chuan-Xi Zhang★, Zhen-Hua Tang and Jia-an Cheng 2005 Expression and regulation of phospholipase A2 in the Chinese honeybee, Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 60:1-12. (SCI).

Wang Dun, An Shi-Heng, Guo Zhong-Jian, Xu Hai-Jun and Zhang Chuan-Xi★. 2005.Characterization of Helicoverpa armigera nucleopolyhedrovirus orf33 that encodes a novel budded virion derived protein, BV-e31. Archives of Virology. 150（8）:1505- 1515. (SCI).

Zhong-Jian Guo, Shi-Heng An, Dun Wang, Yan-He Liu, Shyam Kumar and Chuan-Xi Zhang★ 2005. Characterization of Ha29, a specific gene for Helicoverpa armigera single-nucleocapsid nucleopolyhedrovirus. Journal of Biochemistry and Molecular Biology 38(3): 354-359. (SCI).

Jian-Guo Lin，Chuan-Xi Zhang★ and Satoru Suzuki.2005 An Anti-apoptosis Gene of the Bcl-2 Family from Marine Birnavirus Inhibiting Apoptosis of Insect Cells Infected with Baculovirus. Virus Genes, 31(2):185-193. (SCI).

Wang Fang, Zhang Chuan-Xi★, V Shyam Kumar and Wu Xiang-Fu 2005 Chitinase gene deletion from BmNPV influences cell lysis and host liquefaction. Archives of Virology，150（5）：981-990。(SCI)

Shi W.-J., Zhang C.-X., Cheng J.-A. 2005 Expression and activity identification of the melittin gene of Polistes hebraeus in insect expression system[abstract number: L3-032P]. FEBS Journal 272(s1): 516-516 (SCI)

Dun Wang, Shao Wei Zhai, Chuan Xi Zhang, Yao Yu Bai, Shi Heng An, Ying Nan Xu (2005) Evaluation on nutritional value of field cricket as poultry feedstuff. Asian-Australasian Journal of Animal Sciences. 18(5):667-670. (SCI).

Chuan-Xi Zhang★, Xiu-Cui Ma and Zhong-jian Guo.(2005) Comparison of the complete genome sequences between C1 and G4 isolates of the Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus. Virology: 333: 190-199. (SCI).

出版著作

張傳溪 2001 昆蟲桿狀病毒ph、pk基因分析和人EPO基因在桿狀病毒-昆蟲系統中的表達。高等教育出版社。287頁。ISBN 7-04-010282-X。Zhang Chuan-Xi. 2001. Analysis of Baculovirus polyhedrin gene and protein kinase gene, and expression of human erythropoietin gene in baculovirus-insect system. Higher Education Press. Pp.287.

2. 張傳溪、許文華（1990）資源昆蟲 上海科學技術出版社。168頁。Zhang Chuanxi and Xu WH. 1990. Insect Resources. Shanghai Science and Technology Press. pp168.

參編

3. 張傳溪 2011 昆蟲與植物病毒傳播. 10000個科學難題（農業科學卷）科學出版社，145-148。 Insect and plant virus transmition. 10000 Selected Problems in Sciences (Agriculture Science), Science Press, 145-148

4. 張傳溪、田澤君 1998 五倍子蚜。中國昆蟲資源利用和產業化（楊冠煌主編），中國農業出版社，156-171。Zhang Chuanxi and Tian ZJ. 1998 Chinese gall aphids. In Chinese Insect Resources and Their Industrilization (Yang GH ed). Agricultural Press of China, 156-171.

4. 張傳溪（1996）第三章 其它工業原料資源昆蟲。資源昆蟲及其利用（胡萃主編），中國農業出版社，104-159頁。Zhang C.X.1996 Other industrial insects. In Insect Resource and Their Utilization (Hu ed). Agricultural Press of China, 104-159.

5. 楊冠煌、張傳溪，2001，第五章.昆蟲又是我們的朋友。在《21世紀學科發展叢書-昆蟲學》。山東科技出版社。ISBN 7- 80603-534-6，第五章(是楊冠煌合寫)185-240頁，約38168字。Yang Guan-Huang, Zhang Chuan-Xi. 2001. Chapter 5 Many insects are our friends. In science book series for the 21th Century—Entomology. Shandong Science and Technology Press. Page 185-240.

6. 張傳溪 2002。桿狀病毒的分子生物學和基因工程。昆蟲分子科學（程家安唐振華主編）。科學出版社。ISBN 7-03-009758-0。249-292頁。Zhang Chuanxi. 2002..Baculovirus molecular biology and engineering. In Insect Molecular Science (Chen & Tang eds). Shanghai Literature Press of Science and Technology. 249-292

7. 張傳溪 魯興萌 2002。轉基因昆蟲。昆蟲分子科學（程家安唐振華主編）。科學出版社ISBN 7-03-009758-0。347-362頁。Zhang Chuanxi and Lu XM. 2002.Transgenetic insects. In Insect Molecular Science (Chen & Tang eds). Shanghai Literature Press of Science and Technology

8. Zhang Chuanxi Xu Junliang (1994) Artificial diets for the silkworm. in Silkworm Physiology, Editorial Department, Bulletin of Sericulture, 211-232.9.

專利成果

1.張傳溪 郎國竣， 野蠶1型乙醯膽鹼酯酶活性蛋白的製備方法及其用途 申請日：2009.1.8. 授權公告日2011-4-6.。

2.張傳溪、徐海君、 楊章女、林建國 海洋雙RNA病毒MABV重組蛋白的製備方法與套用 申請日：2007.1.25授權公告日:⒛ 10年07月28日. 專利號：
證書號第651848號。
3.張傳溪、楊章女、孫建新 G-eGFP蛋白及其製備方法與套用。專利號：申請日： 2006.12.19. 授權公告日：2009-5-20。證書號：第499281號。
4.張素方，張傳溪，施婉君，程家安，沈立榮. 已授權發明專利名稱:大胡蜂鎮靜肽前體基因及其編碼的多肽和製備方法. 授權發明專利。授權日：2005-3-23國際專利主分類號C12N 15/11. 證書號：第200613號.。
5.施婉君，張傳溪，張素方，程家安，沈立榮.已授權發明專利名稱: 中華蜜蜂大胡蜂溶血肽前
體基因及其編碼的多肽和製備方法. 授權發明專利授權日：2005-12-28國際專利主分類號C12N 15/11. 證書號：第241698號。
6.施婉君，張傳溪，張素方，程家安，沈立榮.亞非馬蜂蜂毒溶血肽前體基因及其編碼的多肽和製備方法. 授權發明專利授權日：06-1-18證書號：第245642號。
7.張素方，張傳溪，施婉君，程家安，沈立榮.亞非馬蜂鎮靜肽前體基因及其編碼的多肽和製備方法. 授權發明專利授權日：06-1-18 證書號：第245641號。