人物經歷
2004年9月—2007年7月, 西北農林科技大學動物科全連笑技學院
發育生物學專業,獲理學碩士學位;
2015年9月—2016年9月, 加拿大英屬哥倫比亞大學醫學院醫學遺傳系催拒擔表觀遺傳學專業訪問學者。
研究方向
體細胞重編程與生殖幹細胞命運維持機制研究
開設課程
主要講授本科《魚類生理學》、《動物生理學》和《套多動物生物技術進展》等課程;參與講授研究生《幹細胞與組織工程》、《動物克隆與轉基因》以及《
動物基因工程》等課程。
科研項目
2. 小鼠精原幹細胞命運決定因子的篩選駝槓姜頸及驗證,陝西省專項配套經費,2014.1-2017.1
3. 豬胎肝細胞重編程為iPS 細胞的研究,博士科研啟動基金,2012.1-2014.1
4. miRNA調控豬體細胞重編程的研究,中央高校基本科研業務費,2015.1-2017.12
5. 阻礙豬體細胞重編程的關鍵microRNAs篩選及功能鑑定,陝西省自然科學基礎研究青年人才項目,2016.1-2017.12
論著論文
發表學術論文如下:
1.Zhang, S., Guo, Y., Cui, Y., Liu, Y., Yu, T., and Wang, H. (2015). Generation of intermediate porcine iPS cells under culture condition favorable for mesenchymal-to-epithelial transition. Stem cell reviews and reports 11(1):24-38.
2.Gao, Y., Guo, Y.J., Duan, A.Q., Cheng, D.,Zhang, S., and Wang, H.Y. (2014). Optimization of culture conditions for maintaining porcine induced pluripotent stem cells. DNA Cell Biology 33 , 1-11.
3.Xu, R.,Zhang, S., and Lei, A. (2014). Chromatin changes in reprogramming of mammalian somatic cells. Rejuvenation research 17 , 3-10.
4.Zhang, S., and Teng, Y. (2013). Powering mammalian genetic screens with mouse haploid embryonic stem cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 741—742 , 44-50.
5.Li, W., Wang, X., Fan, W., Zhao, P., Chan, Y.C., Chen, S.,Zhang, S., Guo, X., Zhang, Y., Li, Y. , et al. (2012). Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Human molecular genetics 21 , 32-45.
6. Zhang, S., Chen, S., Li, W., Guo, X., Zhao, P., Xu, J., Chen, Y., Pan, Q., Liu, X., Zychlinski, D. , et al. (2011). Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Human molecular genetics 20 , 3176-3187.
7.Esteban, M.A., Wang, T., Qin, B., Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S. , Chen, K., Li, Y., Liu, X., Xu, J.,Zhang, S., et al. (2010). Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6 , 71-79.
4.Zhang, S., and Teng, Y. (2013). Powering mammalian genetic screens with mouse haploid embryonic stem cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 741—742 , 44-50.
5.Li, W., Wang, X., Fan, W., Zhao, P., Chan, Y.C., Chen, S.,Zhang, S., Guo, X., Zhang, Y., Li, Y. , et al. (2012). Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Human molecular genetics 21 , 32-45.
6. Zhang, S., Chen, S., Li, W., Guo, X., Zhao, P., Xu, J., Chen, Y., Pan, Q., Liu, X., Zychlinski, D. , et al. (2011). Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin. Human molecular genetics 20 , 3176-3187.
7.Esteban, M.A., Wang, T., Qin, B., Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S. , Chen, K., Li, Y., Liu, X., Xu, J.,Zhang, S., et al. (2010). Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6 , 71-79.