基本介紹
- 中文名：廖魯劍
- 學位/學歷：博士
- 職業：教師
- 專業方向：研究細胞器質量控制在神經退行性疾病發生中的作用。
- 職務：博士生導師
- 任職院校：華東師範大學
- 職稱：教授
個人經歷,研究方向,學術成果,
個人經歷
2002年12月在美國Bowling Green州立大學獲得計算機科學碩士和生物科學/神經生物學博士學位，在美國Emory大學及加州Scripps研究所John Yates實驗室從事博士後研究，後以Staff Scientist任職於Scripps 研究所。2012年5月回國任中科院上海生物化學與細胞生物學研究所/國家蛋白質科學研究中心研究員，獲中科院上海生科院特殊人才計畫支持。2013年8月擔任華東師範大學生命醫學研究所生物醫學教授、博士生導師，建立功能蛋白質組學實驗室。
研究方向
主要研究方向為利用蛋白質組學方法結合分子、細胞、動物等手段研究細胞器質量控制在神經退行性疾病發生中的作用。
學術成果
在確定神經退行性疾病主要病變的蛋白組成和定量蛋白質組學新方法探索做出開拓性的工作，成果發表於JBC，J Proteome Res, PNAS，Nat Methods。在SCI影響因子＞5的各類專業期刊上發表第一或共同第一作者研究論文10篇，應邀綜述1篇。利用高精度定量質譜的合作研究發現重要疾病模型的蛋白質差異表達和蛋白修飾，成果發表於Immunity，Cell，PNAS，Science，Nat Immunology，EMBO J，Nat Cell Biol等雜誌。
代表性論文(# 共同第一作者，* 通訊作者)
Gao Y, Liu X, Tang B, Li C, Kou Z, Li L, Liu W, Wu Y, Kou X, Li J, Zhao Y, Yin J, Wang H, Chen S, Liao L*, Gao S*. Protein Expression Landscape of Mouse Embryos during Pre-implantation Development. Cell Rep. 2017 Dec 26;21(13):3957-3969. PMID: 29281840
Wan H, Tang B*, Liao X, Zeng Q, Zhang Z, Liao L*. Analysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death. Cell Death & Diff. 2017 Dec 12. PMID:29234155
Tan GH, Liu YY, Wang L, et al., Liao LJ, Wu ZY, Xiong ZQ. PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell Res. 2017, doi: 10.1038/cr.2017.128. PMID: 29056747
Wang T, Yu Q, Li J, Hu B, Zhao Q, Ma C, Huang W, Zhuo L, Fang H, Liao L, Eugene Chin Y, Jiang Y. O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency. Nat Cell Biol. 2017, 19(7):833-843. PMID:28628081
Wei W, Mao A, Tang B, Zeng Q, Gao S, Liu X, Lu L, Li W, Du JX, Li J, Wong J*, Liao L*. Large-Scale Identification of Protein Crotonylation Reveals Its Role in Multiple Cellular Functions. J Proteome Res. 2017, 16(4):1743-1752.PMID:28234478
Xu DQ, Wang Z, Wang CY, et al., Liao LJ, Chen Y. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J. 2016, 35(5):496-514. PMID:26834238
Park Y, Jin HS, Lopez J, Lee J, Liao L, Elly C, Liu YC. SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Nat Immunol. 2016 Mar;17(3):286-96. PMID:26829767
Tang B, Wang T, Wan H, Han L, Qin X, Zhang Y, Wang J, Yu C, Berton F, Francesconi W, Yates JR, Vanderklish PW, Liao L*. Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome. Proc Natl Acad Sci U S A. 2015, 112(34):E4697-706. PMID:26307763
Qin X, Zheng C, Yates JR 3rd, Liao L*. Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins. Mol BioSyst. 2014, 10(7):1719-29. PMID:24626860
Li K, Zhou T, Liao L, Yang Z, Wong C, Henn F, Malinow R, Yates JR, Hu H. βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression. Science 2013;341:1016-1020.
Jin HS, Liao L, Park Y, Liu YC. Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling. Proc Natl Acad Sci U S A. 2013;110(2):624-9.
Sando R 3rd, Gounko N, Pieraut S, Liao L, Yates JR 3rd, and Maximov A. HDAC4 Governs Transcriptional Programs Essential for Synaptic Development and Function. Cell. 2012; 151(4):821-34.
Liao L, Sando RC, Farnum JB, Vanderklish PW, Maximov A, and Yates JR 3rd. 15N labeled brain enable quantification of proteome and phosphoproteome in neurons. J Proteome Res. 2012; 11(2):1341-53
Hart JR, Liao L, Yates JR 3rd, Vogt PK. An essential role of signal transducer and activator of transcription 3 in phosphatidylinositol 3-kinase-induced oncogenic transformation. Proc Natl Acad Sci USA. 2011; 108(32):13247-52
Hart JR*, Liao L*, Ueno L, Yates JR 3rd, Vogt PK. Protein expression profiles of C3H 10T1/2 murine fibroblasts and of isogenic cells transformed by the H1047R mutant of phosphoinositide 3-kinase (PI3K). Cell Cycle. 2011; 10(6):971-6
Huang H#, Jeon M#, Liao L#, Yang C, Elly C, Yates JR, and Liu YC. K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling. Immunity. 2010; 33(1):60-70
Liao L#, McClatchy DB#, Yates JR. Primer: shotgun proteomics in neuroscience. (Review) Neuron. 2009; 63(1):12-26
Park SK#, Liao L#, Kim JY, and Yates JR. A computational approach to correct arginine-to-proline conversion in quantitative proteomics. Nature Methods. 2009; 6(3):184-185
Liao L, Park SK, Xu T, Vanderklish PW, and Yates JR. Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice. Proc Natl Acad Sci USA. 2008; 105(40):15281-6
Liao L#, McClatchy DB#, Park SK, Xu T, Lu B and Yates JR. Quantitative analysis of brain nuclear phosphoproteins identifies developmentally regulated phosphorylation events. J Proteome Res. 2008; 7(11):4743-55
Xia Q#, Liao L#, Cheng D, Duong D, Gearing M, Lah JJ, Levey AI, and Peng J. Identification of novel kinases and ubiquitin ligases associated with Lewy bodies by comparative proteomics. Frontiers in Bioscience. 2008; 13:3850-6
Liao L, Cheng D, Wang J, Duong DM, Losik TG, Gearing M, Rees HD, Lah JJ, Levey AI, Peng J. Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection. J Biol Chem. 2004; 279(35):37061-8
