基本介紹
- 中文名：巢傑
- 職業：教師
- 專業方向：肺部炎症及肺纖維化的機制研究
- 任職院校：東南大學醫學院
研究方向,榮譽獎項,學術成果,
研究方向
肺部炎症及肺纖維化的機制研究
榮譽獎項
- ∎Nature出版集團旗下期刊ScientificReports編委會成員(Editorial Board Member)∎2015年度江蘇省“六大人才高峰”高層次人才
- ∎美國毒理學會（Society of Toxicology，SOT）會員
- ∎美國生理學會（American Physiological Society，APS）會員
- ∎Pre-doctoral Fellowship from the American HeartAssociation, Midwest Affiliate entitled “Mechanisms of microvascular inflammation induced by alveolar hypoxia” from July 2008 to June 2010（美國優秀博士生獎學金，美國心臟協會）
- ∎First place of oral presentation in Cardiovascular Biology research topics of KUMC Student Research Forum 2009（美國堪薩斯大學學生論壇心血管分論壇演講一等獎）
學術成果
2020
1.HuangJ, HuangJ, NingX, LuoW, ChenM, WangZ, ZhangW, ZhangZ#,Chao J#.CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis.J Mater Chem B.2020,8 (8), 1713-1727.(SCI, IF:5.047, Q1)PubMedPDF
2.Huang J, Huang, J, Bao H, Ning X, Yu C, Chen Z,Chao J#,Zhang Z#. CT/MR dual-Modal Imaging tracking of mesenchymal stem cells labeled with Au/GdNC@SiO2 nanotracer in pulmonary fibrosis.ACS Applied Bio Materials.Accepted.PubMed PDF
3.ZhangW,Zhu T, Chen L, LuoW,Chao J#.MCP-1 mediates ischemia/reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR.Am J Physiol Heart Circ Physiol.2020,318(1):H59-H71.(SCI, IF:4.048, Q1)PubMedPDF
4.ChenL, Luo W, ZhangW, ChuH, WangJ, DaiX, ChengY, Zhu T#,ChaoJ#.circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress.RNA Biology.2020, 17(2):240-253.(SCI, IF:5.477, Q1)PubMedPDF
2019
1.Chu H, WangW, LuoW, ZhangW, ChengY, Huang J, WangJ, DaiX, Fang S,ChaoJ#. circHECTD1 mediates pulmonary fibroblast activation via HECTD1.Ther Adv Chronic Dis.2019, Vol. 10: 1-18.(SCI, IF:4.455,Q1)PubMedPDF
2.JiangR,LiaoY, YangF, ChengY, Dai X,Chao J#.SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO2.Exp Cell Res.2019, 383(1):111492.(SCI, IF:3.329, Q2)PubMedPDF
3.ChengY, LuoW, LiZ, Cao M, ZhuZ, HanC, DaiX, ZhangW, WangJ, YaoH,Chao J#.CircRNA-012091/PPP1R13B-mediated lung fibrotic response in silicosis via ER stress andaautophagy.Am J Resp Cell MolBiol.2019, 61(3):380-391.(SCI, IF:4.340, Q1)PubMedPDF
4.JiangR, ZhouZ, LiaoY, YangF, ChengY, HuangJ, WangJ, ChenH, ZhuT,Chao J#.The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial tomesenchymal transition.Toxicol Lett.2019; 307:26-40.(SCI, IF:3.499, Q2)PubMedPDF
5.Zhang Y, Huang R, Cheng M, Wang L,Chao J,Li J, Zheng P, Xie P, Zhang Z, Yao H. Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2.Microbiome.2019; 7(1):116.(SCI, IF:10.465, Q1)PubMedPDF
6.Cheng Y,Chao J,Chen C, Lv L, Han Y, Liu B#. The PKCβ-p66shc-NADPH oxidase pathway plays a crucial role in diabetic nephropathy.J Pharm Pharmacol. 2019, 71(3):338-347.(SCI, IF:2.390, Q2)PubMedPDF
7.Du L, Shen K, Bai Y,Chao J,Hu G, Zhang Y, Yao H.Involvement of NLRP3 inflammasome in methamphetamine-induced microglial activation through miR-143/PUMA axis.Toxicol Lett.2019; 301:53-63.(SCI, IF:3.499, Q2)PubMedPDF
8.Zhao L, Du L, Zhang Y,Chao J,Duan M, Yao H, Shen C, Zhang Y. Role of PUMA in the methamphetamine-induced migration of microglia.Metab Brain Dis.2019, 34(1):61-69.(SCI, IF:2.411, Q2)PubMedPDF
9.Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L,Chao J,Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, Xie C, Zhang Z, Yao H.CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination.Mol Psychiatry.2018 Nov 9. doi: 10.1038/s41380-018-0285-0.(SCI, IF:11.973, Q1)PubMedPDF
2018
1.Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W#,Chao J#.circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.Cell Death Dis. 2018;9(3):396.(SCI, IF:5.959, Q1)PubMedPDF
2.Yang X*, Wang J*, Zhou Z*, Jiang R, Huang J, Chen L, Cao Z, Chu H, Han B, Cheng Y,Chao J#.Silica-induced initiation of circZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation.FASEB J.2018, 32(6):3264-3277.(SCI, IF:5.391, Q1)PubMedPDF
3.Zhou Z, Jiang R, Yang X, Guo H, Fang S, Zhang Y, Cheng Y, Wang J, Yao H,Chao J#.circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination.Theranostics.2018; 8:575-592.(SCI, IF:8.063, Q1)PubMedPDF
4.Chao J#,Lv Y, Chen J, Wang J, Yao H. SiO2-induced release of sVEGFRs from pulmonary macrophages.Respir Physiol Neurobiol.2018; 247:1-8.(SCI, IF:1.582, Q3)PubMedPDF
5.Xie X*, Zhu T*#, Chen L, Ding S, Chu H, Wang J, Yao H,Chao J#.MCPIP1-induced autophagy mediates ischemia/referfusion injury in endothlial cells via HMGB1 andCaSR.Sci Rep. 2018; 8(1):1735.(SCI, IF:4.011, Q1)PubMedPDF
6.Zhang Y, Shu G, Bai Y,Chao J,Chen X, Yao H. Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers.Metab Brain Dis.2018, 33(5):1585-1597.(SCI, IF:2.411, Q2)PubMedPDF
7.Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, Wu F, Leng S,Chao J,Zhang JH, Hu G, Yao H. Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.Autophagy. 2018;14:1164-1184.(SCI, IF:11.059, Q1)PubMedPDF
8.Han B,Chao J,Yao H. Circular RNA andits mechanisms in disease: From the bench to the clinic.Pharmacol Ther.2018, 187:31-44.(SCI, IF:9.396, Q1)PubMedPDF
9.Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F,Chao J,Liu P, Hu G, Zhang JH, Yao H.Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity.J Neurosci.2018; 38:32-50.(SCI, IF:6.074, Q1)PubMedPDF
10.Yang L, Han B, Zhang Y, Bai Y,Chao J,Hu G, Yao H. Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition.Autophagy.14(3):404-418.(SCI, IF:11.059, Q1)PubMedPDF 65.005
2017
1.CaoZ*, XiaoQ*, DaiX*, ZhouZ, JiangR, ChengY, YangX, Guo H, Wang J, Xi Z, Yao H,Chao J#.circHIPK2-mediated σ-1R promotes endoplasmic reticulum stress in human pulmonary fibroblasts exposed to silica.Cell Death Dis.2017;8:3212.(SCI, IF:5.638, Q1)PubMedPDF
2.Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H,ChaoJ#,Liao H#:BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis.Cell Death Dis.2017; 8:e2657.(SCI, IF:5.638, Q1)PubMedPDF
3. Chao J,Zhang Y, Du L, Zhou R, Wu X, Shen K, Yao H.Molecular mechanisms underlying the involvement of the sigma-1 receptor in methamphetamine-mediated microglial polarization.Sci Rep.2017; 7(1):11540.(SCI, IF:4.122, Q1)PubMedPDF
4.Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H,Chao J,Yao H. Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress andOxidative Damage.Front Cell Neurosci.2017; 11:377.(SCI, IF:4.3,Q2)PubMedPDF
5.Zhu X, Dong J, Han B, Huang R, Zhang A, Xia Z, Chang H,Chao J,Yao H.Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling-Induced Cognitive Impairment and Depressive-Like Behavior.Front Behav Neurosci.2017; 11:203.(SCI, IF:3.138, Q2)PubMedPDF
6.Zhang X, Wu F, Jiao Y, Tang T, Yang L, Lu C, Zhang Y, Zhang Y, Bai Y,Chao J,Teng G, Yao H.An Increase of Sigma-1 Receptor in the Penumbra Neuron after Acute Ischemic Stroke.J Stroke Cerebrovasc Dis.2017 26:1981-1987(SCI, IF:1.598, Q4)PubMedPDF
7.Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G,Chao J, Hu G, Yao H.Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy andER stress by targeting MIR124-2HG.Autophagy.2017,13(10):1722-1741.(SCI, IF:11.1,Q1)PubMedPDF
8.Casillan AJ,Chao J, Wood JG, Gonzalez NC. Acclimatization of the systemic microcirculation to alveolar hypoxia is mediated by iNOS-dependent increased nitric oxide availability.J Appl Physiol.2017,123(4):974-982.(SCI, IF:3.256, Q2)PubMedPDF
9.Zhang Y, Zhang Y, Bai Y,Chao J,Hu G, Chen X, Yao H.Involvement of PUMA in pericyte migration induced by methamphetamine.Exp Cell Res.2017;356:28-39.(SCI, IF:3.309, Q2)PubMedPDF
10.Zhu X, Dong J, Xia Z, Zhang A,Chao J,Yao H.Repeated restraint stress increases seizure susceptibility by activation of hippocampal endoplasmic reticulum stress.Neurochem Int.2017;110:25-37.(SCI, IF:3.603, Q2)PubMedPDF
11.Cheng Y,Chao J,Dai D, Dai Y, Zhu D, Liu B.AQP4-knockout aggravation of isoprenaline-induced myocardial injury is mediated by p66Shc and endoplasmic reticulum stress.Clin Exp Pharmacol Physiol.2017; 44:1106-1115.(SCI, IF:2.092, Q3)PubMedPDF47.794
2016
1.Liu H, Fang S, Wang W, Cheng Y, Zhang Y, Liao H, Yao H#,ChaoJ#.Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.Part Fibre Toxicol.2016;13: 55.(SCI, IF:8.577,Q1)PubMedPDF
2. Chao J*#,Wang X*, Zhang Y*, Zhu T, Zhang W, Zhou Z, Yang J, Han B, Cheng Y, Tu X, Yao H#.Role of MCPIP1 in the endothelial-mesenchymaltransition induced by silica.Cell Physiol Biochem.2016; 40:309-325.(SCI, IF:5.104, Q1)PubMedPDF
3.Zhang W, Zhang M, Wang Z, Cheng Y, Liu H, Zhou Z, Han B, Chen B, Yao H#,Chao J#.Neogambogic Acid Prevents Silica-induced Fibrosis via Inhibition of High-mobility group box1 and MCP-1-induced protein 1.Toxicol Appl Pharmacol.2016; 309:129-140.(SCI, IF:3.791, Q1)PubMedPDF
4.Zhu T, Yao Q, Wang W, Yao H,Chao J#.iNOS induced vascular endothelial cell migration andapoptosis via autophagy in ischemia/reperfusion injury.Cell Physiol Biochem.2016; 38: 1575-1588.(SCI, IF:5.104,Q1)PubMedPDF
5.Wang X, Zhang Y, Zhang W, Liu H, Zhou Z, Dai X, Cheng Y, Fang S, Zhang Y, Yao H,Chao J#:MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation afterin vitroexposure tosilica.Toxicol Sci.151(1):126-38.(SCI, IF:4.081, Q1)PubMedPDF
6.Liu H, Dai X, Cheng Y, Fang S,Zhang Y, Wang X, Zhang W, Liao H, Yao H,Chao J#: MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts.Am J Physiol-Lung C.2016;310(2):L121-L132.(SCI, IF:4.281, Q1)PubMedPDF
7.Bai Y, Zhang Y, Hua J, Yang X, Zhang X, Duan M, Zhu X, Huang W,Chao J, Zhou R, Hu G, Yao H.Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse.Sci Rep.2015; 6:35642.(SCI, IF:4.259, Q1)PubMedPDF
8. Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W,Chao J,Nguyen LK, Hua J, Gan G, Hu G, Yao H.Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis andautophagy: Implications for methamphetamine-mediated neurotoxicity.Autophagy.2016,12(9):1538-59.(SCI, IF:8.593,Q1)PubMedPDF
9.Zhu X, Shen K, Bai Y, Zhang A, Xia Z,Chao J, Yao H.NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy.Free Radic Biol Med.2016; 94:230-242.(SCI, IF:5.606,Q1)PubMedPDF
10.Zhu X, Dong J, Shen K, Bai Y,Chao J, Yao H. Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.Brain Res Bull.2016. 121:138-47.(SCI, IF:3.033,Q3)PubMedPDF
11.Zhang Y, Huang R, Zhang Y, Yi H, Bai Y,Chao J,Yao H. IL-17 induces MIP-1α expression in primary mouse astrocytes via TRPC channel.Inflammopharmacology.2016, 24(1):33-42.(SCI, IF:2.59, Q3)PubMed 55.019
2015
1.Wang W, Liu H, Dai X, Fang S, Wang X, Zhang Y, Yao H, Zhang X#,Chao J#:p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis.Sci Rep.2015; 5:16900.(SCI, IF:5.228, Q1)PubMedPDF
2.Zhu T, Yao Q, Hu X, Chen C, Yao H,Chao J#: The role of MCPIP1 in ischemia/reperfusion injury-induced HUVEC migration and apoptosis.Cell Physiol Biochem.2015;37:577-591.(SCI, IF:4.652, Q1)PubMedPDF
3.Liu X, Fang S, Liu H, Wang X, Dai X, Yin Q, Yun T, Wang W, Zhang Y, Liao H, Zhang W, Yao H,Chao J#: Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis.Toxicol Appl Pharmacol.2015; 288:152-160.(SCI, IF:3.847, Q1)Global Medical DiscoveryPubMedPDF
4.Chao J,Dai X, Pena T, Doyle DA, Guenther TM, Carlson MA: MCPIP1 regulates fibroblast migration in 3-D collagen matrices downstream of MAP kinases and NF-kappa B.J Invest Dermatol.2015; 135:2944-54.(SCI, IF:6.915, Q1)PubMedPDF
5.Bai Y*, Zhu X*,Chao J*, Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H: Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGFR expression: Implications for stroke.PLoS One.2015;10:e0124362.(SCI, IF:3.057, Q1)PubMedPDF
6.Zhang Y, Lv X, Bai Y, Zhu X, Wu X,Chao J, Duan M, Buch S, Chen L, Yao H: Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulationof its own expression.J Neuroinflammation.2015;12:29.(SCI, IF:4.667, Q1)PubMedPDF
7.Zhang Y, Zhu T, Zhang X,Chao J,Hu G, Yao H: Role of high-mobility group box 1 inmethamphetamine-induced activation and migration of astrocytes.J Neuroinflammation.2015;12:156.(SCI, IF:4.667, Q2)PubMedPDF
8.Zhu X, Dong J, Shen K, Bai Y, Zhang Y, Lv X,Chao J,Yao H: NMDA receptor NR2b subunits contribute to ptz-kindling-induced hippocampal astrocytosis and oxidative stress.Brain Res Bull.2015;114:70-78.(SCI, IF:2.572, Q3)PubMedPDF 35.605
Before 2015
1.Yi H, Bai Y, Zhu X, Lin L, Zhao L, Wu X, Buch S, Wang L,Chao J#, Yao H#: IL-17a induces MIP-1alpha expression in primary astrocytes via Src/MAPK/PI3K/NF-kB pathways:Implications for multiple sclerosis.J Neuroimmune Pharmacol.2014;9:629-641.(SCI, IF:4.11, Q2)PubMedPDF
2.Chao J*,Yang L*, Yao H, Buch S: Platelet-derived growth factor-bb restores HIV Tat -mediated impairment of neurogenesis: Role of GSK-3beta/beta-catenin.J Neuroimmune Pharmacol.2014;9:259-268.(SCI, IF:4.11, Q2)PubMedPDF
3.Chao J,Pena T, Heimann DG, Hansen C, Doyle DA, Yanala UR, Guenther TM, Carlson MA: Expression of green fluorescent protein in human foreskin fibroblasts for use in 2D and 3D culture models.Wound Repair Regen.2014;22:134-140.(SCI, IF:2.768, Q1) Cover storyMDLinxGlobal Medical DiscoveryPubMedPDF
4.Chao J,Yang L, Buch S, Gao L: Angiotensin II increased neuronal stem cell proliferation: Role of AT2R.PLoS One.2013;8:e63488.(SCI, IF:3.534)PubMedPDF
5.Yang L*,Chao J*, Kook YH, Gao Y, Yao H, Buch SJ: Involvement of mir-9/MCPIP1 axis in PDGF-bb-mediated neurogenesis in neuronal progenitor cells.Cell Death Dis.2013;4:e960.(SCI, IF:5.177)PubMedPDF
6.Carlson MA, Smith LM, Cordes CM,Chao J,Eudy JD: Attachment-regulated signaling networks in the fibroblast-populated 3D collagen matrix.Sci Rep.2013;3:1880.(SCI, IF:5.078)PubMedPDF
7.Chao J,Gao J, Parbhu KJ, Gao L: Angiotensin type 2 receptors in the intermediolateral cell column of the spinal cord: Negative regulation of sympathetic nerve activity and blood pressure.Int J Cardiol.2013;168:4046-4055.(SCI, IF:6.175)PubMedPDF
8.Chao J,Viets Z, Donham P, Wood JG, Gonzalez NC: Dexamethasone blocks the systemic inflammation of alveolar hypoxia at several sites in the inflammatory cascade.Am J Physiol Heart Circ Physiol.2012;303:H168-177.(SCI, IF:3.629)PubMedPDF
9.Gao J,Chao J, Parbhu KJ, Yu L, Xiao L, Gao F, Gao L: Ontogeny of angiotensin type 2 and type1 receptor expression in mice.J Renin Angiotensin Aldosterone Syst.2012;13:341-352.(SCI, IF:2.286)PubMedPDF
10.Chao J,Blanco G, Wood JG, Gonzalez NC: Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia.Am J Physiol Heart Circ Physiol.2011;301:H2264-2270.(SCI, IF:3.708)PubMedPDF
11.Chao J,Wood JG, Gonzalez NC: Alveolar macrophages initiate the systemic microvascular inflammatory response to alveolar hypoxia.Respir Physiol Neurobiol.2011;178:439-448.(SCI, IF:2.242)PubMedPDF
12.Gao J, Zhang H, Le KD,Chao J, Gao L: Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats.Am J Hypertens.2011;24:724-730.(SCI, IF:3.181)PubMedPDF
13.Chao J,Donham P, van Rooijen N, Wood JG, Gonzalez NC: Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia.Am J Respir Cell Mol Biol.2011;45:53-61.(SCI, IF:5.125)PubMedPDF
14.Chao J,Wood JG, Gonzalez NC: Alveolar hypoxia, alveolar macrophages, and systemic inflammation.Respir Res.2009;10:54.(SCI, IF:3.36)PubMedPDF
15.Chao J,Wood JG, Blanco VG, Gonzalez NC: The systemic inflammation of alveolar hypoxia is initiated by alveolar macrophage-borne mediator(s).Am J Respir Cell Mol Biol.2009;41:573-582.(SCI, IF:5.125)PubMedPDF
16.Meng X,Chao J, Xiang Y: Identification from diversemammalian poxviruses of host-range regulatory genes functioning equivalently tovaccinia virus C7l.Virology.2008;372:372-383.(SCI, IF:3.351)PubMedPDF 51.971
