尹大志，男，博士，現任華東師範大學心理與認知科學學院紫江青年研究員。
基本介紹
- 中文名：尹大志
- 國籍：中國
- 民族：漢族
- 學位/學歷：博士
- 職業：教師
- 專業方向：功能磁共振成像技術在腦認知和腦疾病中的套用研究
- 任職院校：華東師範大學心理與認知科學學院
個人經歷,研究方向,學術成果,榮譽獎項,
個人經歷
2014年6月畢業於華東師範大學物理繫上海市磁共振重點實驗室，獲得理學博士學位。
博士期間（2012年9月至2014年5月），在美國哥倫比亞大學精神病學系進行博士生聯合培養（國家留學基金委公派）。
2014年8月至2019年9月，在中國科學院神經科學研究所腦影像中心依次擔任助理研究員、副研究員。
2017年入選“中國科學院青年創新促進會”。
研究方向
1. 科學問題：自發（內在）腦活動組織規律，認知/行為靈活性的神經基礎，腦可塑性，重大神經精神疾病的診療機制。
2. 研究方法：多模態磁共振成像技術，神經調控與干預，複雜網路，動態腦網路，圖論，複雜性。
學術成果
相關研究成果已發表在Biological Psychiatry、Journal of Neuroscience、JCEM、Human Brain Mapping等國際主流學術期刊上。
主持/參與科研項目情況：
1. 國家自然科學基金青年項目，“靜息態功能連線模式的動態重配及其套用研究”，20萬元（主持）
2. 中國科學院青年創新促進會資助基金，80萬元（20萬/年）（主持）
3. 中國科學院上海生命科學研究院優秀青年人才領域前沿項目, “一種聯合多模態磁共振成像方法預測腦中風患者手功能轉歸”，15萬元（主持）
4. 科技部重點研發計畫，“甲基苯丙胺依賴診斷與復發預警客觀指標和干預新技術體系的研發”，785萬元（骨幹成員）
已發表學術論文（#第一作者，*通訊作者）：
1.Yin D, Chen X, Zeljic K, Zhan Y, Shen X, Yan G, and Wang Z. A Graph Representation of Functional Diversity of Brain Regions.Brain and Behavior.
2. Fang F, Lai M, Huang J, Kang M, Ma M, Li K, Lian J, Wang Z,Yin D*,Wang Y*. Compensatory Hippocampal Connectivity in Young Adults with Early-Stage Type 2 Diabetes.The Journal of Clinical Endocrinology & Metabolism.
3.Yin D, Zhang Z, Wang Z, Zeljic K, Lv Q, Cai D, Wang Y, Wang Z. Brain Map of Intrinsic Functional Flexibility in Anesthetized Monkeys and Awake Humans.Frontiers in Neuroscience.
4. Li HF, Yang L,Yin D, Chen WJ, Liu GL, Ni W, Wang N, Yu W, Wu ZY, Wang Z. Associations between neuroanatomical abnormality and motor symptoms in paroxysmal kinesigenic dyskinesia.Parkinsonism & Related Disorders.
5.Yin D,Zhang C, Lv Q, Chen X, Zeljic K, Gong H, Zhan S, Jin H, Wang Z, Sun B. Dissociable Frontostriatal Connectivity: Mechanism and Predictor of the Clinical Efficacy of Capsulotomy in Obsessive-Compulsive Disorder.Biological Psychiatry. 2018; 84:926-936. Commentary by Hoexter MQ, Are we ready for individualized target planning of ablative procedures in intractable obsessive-compulsive disorder? Biological Psychiatry,
6. Zhao Z, Wu J, Fan M,Yin D, Tang C, Gong J, Xu G, Gao X, Yu Q, Yang H, Sun L, Jia J. Altered intra- and inter-network functional coupling of resting-state networks associated with motor dysfunction in stroke.Human Brain Mapping.
7. Zhao Z, Tang C,Yin D, Wu J, Gong J, Sun L, Jia J, Xu D, Fan M. Frequency-specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function.Human Brain Mapping.
8. Zou Y, Zhao Z,Yin D, Fan M, Small M, Liu Z, Hilgetag CC, Kurths J. Brain anomaly networks uncover heterogeneous functional reorganization patterns after stroke.Neuroimage Clinical.
9. Peng W, Mao L,Yin D, Sun W, Wang H, Zhang Q, Wang J, Chen C, Zeng M, Ding J, Wang X. Functional network changes in the hippocampus contribute to depressive symptoms in epilepsy.Seizure.
10. Fang F, Zhan Y, Zhuo Y,Yin D, Li K, Wang Y. Brain atrophy in middle-aged subjects with Type 2 diabetes mellitus, with and without microvascular complications.Journal of Diabetes.
11. Song Y, Li W, Meng S, Zhou W, Su B, Tang L, Zhao Y, Wu X,Yin D, Fan M, Zhou C. Dual integrin alphavbeta 3 and NRP-1-Targeting Paramagnetic Liposome for Tumor Early Detection in Magnetic Resonance Imaging.Nanoscale Research Letters.
12.Yin D, Liu W, Zeljic K, Lv Q, Wang Z, You M, Men W, Fan M, Cheng W, Wang Z. Failure in Cognitive Suppression of Negative Affect in Adolescents with Generalized Anxiety Disorder.Scientific Reports.
13. Wen Z, Cheng ,Yin D, Sun S, Wang Z, Yu S, Zhang Y, Qiu Z, Du Y. Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing.Neuroscience Bulletin.
14.Yin D, Liu W, Zeljic K, Wang Z, Lv Q, Fan M, Cheng W, Wang Z. Dissociable Changes of Frontal and Parietal Cortices in Inherent Functional Flexibility across the Human Life Span.Journal of Neuroscience.
15. Zheng X, Sun L,Yin D, Jia J, Zhao Z, Jiang Y, Wang X, Wu J, Gong J, Fan M. The plasticity of intrinsic functional connectivity patterns associated with rehabilitation intervention in chronic stroke patients.Neuroradiology.
16. Zhao Z, Wang X, Fan M,Yin D, Sun L, Jia J, Tang C, Zheng X, Jiang Y, Wu J, Gong J. Altered Effective Connectivity of the Primary Motor Cortex in Stroke: A Resting-State fMRI Study with Granger Causality Analysis.PLoS One.
17. Yan C, Su L, Wang Y, Xu T,Yin D, Fan M, Deng C, Hu Y, Wang Z, Cheung E, Lim K, Chan R. Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex.Scientific Reports.
18. Yan C, Wang Y, Su L, Xu T,Yin D, Fan M, Deng C, Wang Z, Lui S, Cheung E, Chan R. Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy.Psychiatry Research: Neuroimaging.
19. Liu W,Yin D, Cheng W, Fan M, You M, Men W, Zang L, Shi D, Zhang F. Abnormal Functional Connectivity of the Amygdala-Based Network in Resting-State fMRI in Adolescents with Generalized Anxiety Disorder.Medical Science Monitor.
20. Jiang Y,Yin D, Xu D, Men W, Cao R, Li B, Fan M. Investigating microbleeding in cerebral ischemia rats using susceptibility-weighted imaging.Magnetic Resonance Imaging.
21. Wang Y, Yan C,Yin D, Fan M, Cheung E, Pantelis C, Chan RC. Neurobiological changes of schizotypy: evidence from both volume-based morphometric analysis and resting-state functional connectivity.Schizophrenia Bulletin.
22.Yin D, Song F, Xu D, Sun L, Men W, Zang L, Yan X, Fan M. Altered topological properties of the cortical motor-related network in patients with subcortical stroke revealed by graph theoretical analysis.Human Brain Mapping.
23. He X, Liu W, Li X, Li Q, Liu F, Rauh VA,Yin D, Bansal R, Duan Y, Kangarlu A, Peterson BS, Xu D. Automated assessment of the quality of diffusion tensor imaging data using color cast of color-encoded fractional anisotropy images.Magnetic Resonance Imaging.
24. Guo W, Li D, Zhu J, Wei X, Men W,Yin D, Fan M, Xu Y. A magnetic nanoparticle stabilized gas containing emulsion for multimodal imaging and triggered drug release.Pharmaceutical Research.
25. Lin Z, Tao J, Gao Y,Yin D, Chen A, Chen L. Analysis of central mechanism of cognitive training on cognitive impairment after stroke: Resting-state functional magnetic resonance imaging study.Journal of International Medical Research.
26.Yin D, Yan X, Fan M, Hu Y, Men W, Sun L, Song F. Secondary degeneration detected by combining voxel-based morphometry and tract-based spatial statistics in subcortical strokes with different outcomes in hand function.American Journal of Neuroradiology.
27.Yin D, Luo Y, Song F, Xu D, Peterson BS, Sun L, Men W, Yan X, Fan M. Functional reorganization associated with outcome in hand function after stroke revealed by regional homogeneity.Neuroradiology.
28. Dai H,Yin D, Hu C, Morelli JN, Hu S, Yan X, Xu D. Whole-brain voxel-based analysis of diffusion tensor mri parameters in patients with primary open angle glaucoma and correlation with clinical glaucoma stage.Neuroradiology.
29. Sun L,Yin D, Zhu Y, Fan M, Zang L, Wu Y, Jia J, Bai Y, Zhu B, Hu Y. Cortical reorganization after motor imagery training in chronic stroke patients with severe motor impairment: A longitudinal fmri study.Neuroradiology.
30. Dai H, Morelli JN, Ai F,Yin D, Hu C, Xu D, Li Y. Resting-state functional mri: Functional connectivity analysis of the visual cortex in primary open-angle glaucoma patients.Human Brain Mapping.
31. Yan X, Zhou M, Ying L,Yin D, Fan M, Yang G, Zhou Y, Song F, Xu D. Evaluation of optimized b-value sampling schemas for diffusion kurtosis imaging with an application to stroke patient data.Computerized Medical Imaging and Graphics.
32. Men W, Falk D, Sun T, Chen W, Li J,Yin D, Zang L, Fan M. The corpus callosum of albert einstein's brain: Another clue to his high intelligence?
33.Yin D, Song F, Xu D, Peterson BS, Sun L, Men W, Yan X, Fan M. Patterns in cortical connectivity for determining outcomes in hand function after subcortical stroke.PLoS One.
34. Song F, Zhang F,Yin D, Hu Y, Fan M, Ni H, Nan X, Cui X, Zhou C, Huang C, Zhao Q, Ma L, Xu Y, Xia Q. Diffusion tensor imaging for predicting hand motor outcome in chronic stroke patients.Journal of International Medical Research.
35. 邵方方，尹大志，賈傑，趙智勇，王想敏，鄭曉慧，宋凡，范明霞，孫莉敏，皮質下腦卒中對運動想像有關腦區功能連線的影響，中國康復醫學雜誌。
36. 王想敏，趙智勇，尹大志，孫莉敏，鄭曉慧，賈傑，范明霞，腦卒中靜息態下腦活動異常的比率低頻振幅，磁共振成像。
37. 孫莉敏，吳毅，尹大志，范明霞，臧麗麗，胡永善，健康成人在手部主動、被動和想像握拳運動時腦區激活特點的功能性磁共振成像研究，中華物理醫學與康複雜志。
38. 孫莉敏，吳毅，尹大志，范明霞，臧麗麗，胡永善，朱秉，徐一鳴，運動想像訓練促進腦卒中患者上肢運動功能恢復的功能磁共振研究，中國康復醫學雜誌。
39. 范亮艷，范曉芳，羅位超，吳功航，嚴 序，尹大志，呂 岳，朱君明，徐冬溶，藝術設計中創造性思維的fMRI 研究：一項基於智慧型 CAD 的探索，心理學報。
40. 宋凡，尹大志，胡永善，范明霞，倪歡歡，崔曉，基於體素的形態學測量分析腦卒中後殘障手的機制。
榮譽獎項
2018年獲得“長三角神經科學青年科學家獎”和“賽諾菲-中國科學院上海生命科學研究院”優秀青年人才獎勵基金。
