尹世金，男，1974年生，湖北襄陽人。生物信息學博士，主攻離子通道蛋白與其配體相互作用的研究。1998年至2001年於武漢大學醫學院攻讀並獲得神經生物學碩士學位；
基本介紹
- 中文名：尹世金
- 國籍：中國
- 出生日期：1974年生
- 性別：男
職務,學術成果,
職務
生物學博士，中南民族大學碩士生導師。2001年至今中南民族大學生物醫學工程研究所工作。2006年至2009年於武漢大學生命科學院攻讀並獲得生物學博士學位。近年來，主要從事疾病相關性離子通道蛋白結構與功能關係研究，採用電生理學、分子生物學、生物信息學等技術研究生物活性肽及小分子有機物對離子通道蛋白的調節作用。主持和參與了國家自然科學基金2項，省自然科學基金1項，以及校基金多項。
★學科專業：生物醫學工程（生物信息學）
★所授課程：有機化學、生物化學與分子生物學、電生理學
★研究興趣：離子通道蛋白結構與功能關係研究，離子通道蛋白與其配體相互作用的研究
★承擔項目：
1）BmαTX14多肽與通道β亞基協同調節鈉通道功能的機制研究（30900239） 國家自然科學基金 課題主持人
2）鉀通道KCNQ1孔區外庭的結構特徵與功能研究（30900265） 國家自然科學基金 第一參與人
3）血竭薄膜衣片的研究（BZZ03001）。湖北省自然科學基金項目，項目號：，2003.06，項目參與人
★學科專業：生物醫學工程（生物信息學）
★所授課程：有機化學、生物化學與分子生物學、電生理學
★研究興趣：離子通道蛋白結構與功能關係研究，離子通道蛋白與其配體相互作用的研究
★承擔項目：
1）BmαTX14多肽與通道β亞基協同調節鈉通道功能的機制研究（30900239） 國家自然科學基金 課題主持人
2）鉀通道KCNQ1孔區外庭的結構特徵與功能研究（30900265） 國家自然科學基金 第一參與人
3）血竭薄膜衣片的研究（BZZ03001）。湖北省自然科學基金項目，項目號：，2003.06，項目參與人
學術成果
(1) Yin S.J, Jiang L., Yi H., Han S., Yang D.W., Liu M.L., Liu H., Cao Z.J., Wu Y.L. & Li W.X. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels. J Proteome Res,2008, 7, 4890-4897.(SCI, IF 5.67)
(2) Shijin,Y; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L. Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides 2008，29（9）：1514-20. (SCI,IF 2.6)
(3) Wu, W.; Yin, S.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W. Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides 2007, 28, 2306-2312.（SCI, IF 2.6, 並列第一作者）
(4) Han, S.; Yi, H.; Yin, S. J.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X. Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem 2008, 283, 19058-19065.(SCI, IF 5.7, 並列第一作者)
(5) Liu, J., Ma, Y., Yin, S., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus.Peptides 2009, 30, 675-680.（SCI, IF 2.6）
(6) Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Yin, S.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W. A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. J Psychiatry Neurosci 2008, 33, 43-46.(SCI, IF 3.71)
(7) Xiao Z, Lu Z, Liu Z, Liu W, Li L, Yin S, Yu S, Dong H, Zhu F. Ethanol inhibits voltage-gated sodium channels in cultured superior cervical ganglion neurons，Neuroreport. 2008 Dec 3;19(18):1773-6.(SCI, IF 2.16)
(8)Yi, H.; Cao, Z.; Yin, S.; Dai, C.; Wu, Y.; Li, W. Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res 2007, 6, 611-620. (SCI, IF 5.67)
(9)Mao, X.; Cao, Z.; Yin, S.; Ma, Y.; Wu, Y.; Li, W. Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun 2007, 360, 728-734.(SCI,IF 2.9)
(10)Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.;Shijin, Y.; Yingliang, W.; Wenxin, L. Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides 2006, 27, 1235-1240. (SCI,IF 2.6）
(11)Zhijian, C.; Chao, D.; Shijin, Y.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L. Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. J Biochem Mol Toxicol 2006, 20, 1-6.(SCI)
(12)Wang, K.; Yin, S. J.; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X. Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. Biotechnol Lett 2006, 28, 1767-1772.(SCI)
(13)Liu, X.; Yin, S.; Chen, S.; Ma, Q. Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons.Conf Proc IEEE Eng Med Biol Soc 2005, 5, 4962-4965. (SCI)
(14)Shi-jin Yin,Xiang-ming Liu. Dual modulation of interleukin-1 beta on tetrodotoxin-sensitive sodium currents in mice trigeminal ganglion cells. Cell bilolgy international, 2005, 29(10):S16. (SCI)
(15)Xiangming, L.; Su, C.; Shijin, Y.; Zhinan, M. Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons.Sci China C Life Sci 2004, 47, 340-348. (SCI)
(2) Shijin,Y; Hong, Y.; Yibao, M.; Zongyun, C.; Han, S.; Yingliang, W.; Zhijian, C.; Wenxin, L. Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch. Peptides 2008，29（9）：1514-20. (SCI,IF 2.6)
(3) Wu, W.; Yin, S.; Ma, Y.; Wu, Y. L.; Zhao, R.; Gan, G.; Ding, J.; Cao, Z.; Li, W. Molecular cloning and electrophysiological studies on the first K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides 2007, 28, 2306-2312.（SCI, IF 2.6, 並列第一作者）
(4) Han, S.; Yi, H.; Yin, S. J.; Chen, Z. Y.; Liu, H.; Cao, Z. J.; Wu, Y. L.; Li, W. X. Structural basis of a potent Peptide inhibitor designed for kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem 2008, 283, 19058-19065.(SCI, IF 5.7, 並列第一作者)
(5) Liu, J., Ma, Y., Yin, S., Zhao, R., Fan, S., Hu, Y., Wu, Y., Cao, Z., Li, W. Molecular cloning and functional identification of a new K(+) channel blocker, LmKTx10, from the scorpion Lychas mucronatus.Peptides 2009, 30, 675-680.（SCI, IF 2.6）
(6) Liu, Z.; Liu, W.; Xiao, Z.; Wang, G.; Yin, S.; Zhu, F.; Wang, H.; Cheng, J.; Wang, X.; He, X.; Li, W. A major single nucleotide polymorphism of the PDLIM5 gene associated with recurrent major depressive disorder. J Psychiatry Neurosci 2008, 33, 43-46.(SCI, IF 3.71)
(7) Xiao Z, Lu Z, Liu Z, Liu W, Li L, Yin S, Yu S, Dong H, Zhu F. Ethanol inhibits voltage-gated sodium channels in cultured superior cervical ganglion neurons，Neuroreport. 2008 Dec 3;19(18):1773-6.(SCI, IF 2.16)
(8)Yi, H.; Cao, Z.; Yin, S.; Dai, C.; Wu, Y.; Li, W. Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res 2007, 6, 611-620. (SCI, IF 5.67)
(9)Mao, X.; Cao, Z.; Yin, S.; Ma, Y.; Wu, Y.; Li, W. Cloning and characterization of BmK86, a novel K+ -channel blocker from scorpion venom. Biochem Biophys Res Commun 2007, 360, 728-734.(SCI,IF 2.9)
(10)Zhijian, C.; Yun, X.; Chao, D.; Shunyi, Z.;Shijin, Y.; Yingliang, W.; Wenxin, L. Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides 2006, 27, 1235-1240. (SCI,IF 2.6）
(11)Zhijian, C.; Chao, D.; Shijin, Y.; Yingliang, W.; Jiqun, S.; Yonggang, S.; Wenxin, L. Splicing of scorpion toxin gene BmKK2 in HEK 293T cells. J Biochem Mol Toxicol 2006, 20, 1-6.(SCI)
(12)Wang, K.; Yin, S. J.; Lu, M.; Yi, H.; Dai, C.; Xu, X. J.; Cao, Z. J.; Wu, Y. L.; Li, W. X. Functional analysis of the alpha-neurotoxin, BmalphaTX14, derived from the Chinese scorpion, Buthus martensii Karsch. Biotechnol Lett 2006, 28, 1767-1772.(SCI)
(13)Liu, X.; Yin, S.; Chen, S.; Ma, Q. Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons.Conf Proc IEEE Eng Med Biol Soc 2005, 5, 4962-4965. (SCI)
(14)Shi-jin Yin,Xiang-ming Liu. Dual modulation of interleukin-1 beta on tetrodotoxin-sensitive sodium currents in mice trigeminal ganglion cells. Cell bilolgy international, 2005, 29(10):S16. (SCI)
(15)Xiangming, L.; Su, C.; Shijin, Y.; Zhinan, M. Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons.Sci China C Life Sci 2004, 47, 340-348. (SCI)
