安法梁，男，博士，華東理工大學生物工程學院碩士生導師。
基本介紹
- 中文名：安法梁
- 畢業院校：中國藥科大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：海洋真菌來源活性複雜天然產物研究
- 任職院校：華東理工大學
個人經歷,研究方向,學術成果,
個人經歷
教育經歷
2011.09-2016.06中國藥科大學藥物化學理學博士導師:孔令義教授
2007.09-2011.06中國藥科大學中藥學理學學士
工作經歷
2019.01-至今華東理工大學生物工程學院特聘副研究員
2016.07-2018.12華東理工大學生物工程學院師資博士後
研究方向
1.海洋真菌來源活性複雜天然產物研究
基於真菌基因組的生物信息學和波譜學分析為導向的具有新穎結構的活性天然產物快速發現、鑑定和活性篩選。
2.海洋微生物來源活性分子發酵過程最佳化與放大
通過對菌絲形態、前體代謝調控、生物合成途徑、發酵過程參數最佳化與控制，提高微生物藥用活性分子產量，滿足藥物開發需求。
3.中藥或藥用植物來源化妝品添加劑的篩選和機制研究
通過對傳統藥用植物功能分子的活性篩選、生物轉化和作用機制研究，提高植物提取物功效，闡明植物提取物活性物質基礎和作用機理，開發新型天然化妝品添加劑。
學術成果
1.國家自然科學基金青年基金(81703388, 2018.01-2020.12,主持)
2.國家自然科學基金面上項目(41876189, 2019.01-2022.12,主持)
3.國家重點研發計畫課題(2018YFC1706206, 2018.12-2020.12,主持)
4.國家重點研發計畫子課題(2018YFC1706201, 2021.01-2024.12,主持)
5.中國博士後基金特別資助(2018T110359, 2018.07-2020.06,主持)
6.中國博士後基金面上項目(2016M601532, 2016.11-2018.10,主持)
7.上海市青年英才“揚帆計畫”(17YF14033700, 2017.05-2020.04,主持)
8.中央高校基本科研業務費研究基金(222201714023, 2017.03-2018.02,主持)
代表性論文
1.An,Fa-Liang; Wang, Xiao-Bing; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Bioactive A-ring rearranged limonoids from the root barks ofWalsura robusta.Acta Pharmaceutica SinicaB2019,
2.Ding, Yi,An, Fa-Liang, Zhu, Xiao-Jing, Yu,Hai-Yuan, Hao, Li-Ling* and Lu, Yan-Hua*, Curdepsidones B–G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived FungusCurvulariasp. IFB-Z10.Marine Drugs2019,
3.An, Fa-Liang; Yin, Yong; Luo, Jun; Kong, Ling-Yi*, Highly oxygenous trichilin-type limonoids from Trichilia sinensis.Chinese Journal of Natural Medicines2019,
4.An, Fa-Liang; Liu, Wei-He; Zhang, Yi; Tao, Jun; Lu, Yan-Hua*, Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10.Phytochemistry Letters2019,
5.Wei, Xing-Chen; Liu, Chang-Qing; Zhang, Ri-Yu; Zheng, Gao-Fan;An, Fa-Liang*; Lu, Yan-Hua*, Improvement of Curvulamine Production by Precursors Co-addition Strategy in Liquid Culture of Marine-Derived Fungus Curvularia sp. IFB-Z10.Applied Biochemistry and Biotechnology2019,
6.Ji, Xiang; Wei, Xing; Qian, Jie; Mo, Xue-Jun; Kai, Guo-Yin;An, Fa-Liang*;Lu, Yan-Hua*, 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells.Food and Chemical Toxicology2019
7.An, Fa-Liang; Sun, Dong-Mei; Wang, Xiao-Bing; Yang, Lei; Yin, Yong; Luo, Jun*; Kong, Ling-Yi*, Trichiconlides C-F, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits ofTrichilia connaroides.Fitoterapia2018
8.An, Fa-Liang; Sun, Dong-Mei; Wang, Rui-Zhi; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Trijugin- and mexicanolide-type limonoids from the fruits ofHeynea trijugathat reverse multidrug resistance in MCF-7/DOX cells.Phytochemistry2018
9.An, Fa-Liang; Liu, Wei-He; Wei, Xing-Chen; Pan, Zheng-Hua; Lu, Yan-Hua*, Curdepsidone A, a Depsidone from the Marine-Derived Endophytic FungusCurvulariasp. IFB-Z10.Natural Product Communications2018
10.Liu, Wei-He; Ding, Yi; Ji, Xiang.;An, Fa-Liang*; Lu, Yan-Hua*, Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp.The Journal of Antibiotics (Tokyo)2018,
11.An, Fa-Liang; Sun, Dong-Mei; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Yin, Yong; Kong, Ling-Yi*; Luo, Jun*, Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks ofWalsura robusta.Organic Letters2017,
12.Yu, Wan-Guo; Pan, Zheng-Hua; Zhu, Yi-Xiang;An, Fa-Liang*;Lu, Yan-Hua*, Fumigaclavine C exhibits anti-inflammatory effects by suppressing high mobility group box protein 1 relocation and release.European Journal of Pharmacology2017,
13.Tang, Liu; Wei, Xing-Chen;An, Fa-Liang*; Lu, Yan-Hua*, Preparative separation of TL1-1 fromDaldinia eschscholziiextract by macroporous resin and evaluation of its antimicrobial activities.Journal of Chromatography B2017,
14.An, Fa-Liang; Wang, Xiao-Bing; Wang, Hui; Li, Zhong-Rui; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Cytotoxic Rocaglate Derivatives from Leaves ofAglaia perviridis.Scientific Reports2016,6, 20045.
15.An, Fa-Liang; Luo, Jun; Wang, Xiao-Bing; Yang, Ming-Hua; Kong, Ling-Yi*, Trichiconlides A and B: two novel limonoids from the fruits ofTrichilia connaroides.Organic & Biomolecular Chemistry2016,
16.An, Fa-Liang; Luo, Jun; Li, Rui-Jun; Luo, Jian-Guang; Wang, Xiao-Bing; Yang, Ming-Hua; Yang, Lei; Yao, He-Quan; Sun, Hong-Bin; Chen, Yi-Jun; Kong, Ling-Yi*, Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids fromTrichilia connaroides.Organic Letters2016,
17.An, Fa-Liang; Wang, Jun-Song; Wang, Hui; Wang, Xiao-Bing; Yang, Ming-Hua; Guo, Qing-Long; Dai, Yue; Luo, Jun; Kong, Ling-Yi*, Cytotoxic flavonol-diamide [3+2] adducts from the leaves ofAglaia odorata.Tetrahedron2015,
18.Wei, Xingchen; Liu, Changqing;An, Fa-Liang; Lu, Yan-Hua*, Induced effect of Ca2+ on curvulamine synthesis by marine-derived fungus Curvularia sp. IFB-Z10 under submerged fermentation.Process Biochemistry2019,
19. Liu, Changqing; Wei, Xing-Chen;An, Fa-Liang; Lu, Yan-Hua*, Ammonium Acetate Supplement Strategy for Enhancement of Chaetominine Production in Liquid Culture of Marine-Derived Aspergillus fumigatus CY018.Journal of Microbiology and Biotechnology2019
20.Wei, Xing(#); Mo, Xue-Jun(#);An, Fa-Liang; Ji, Xiang.; Lu, Yan-Hua*, 2',4'-Dihydroxy-6'- methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells.Food and Chemical Toxicology2018,
21.Tao, Jun;An, Fa-Liang; Pan, Zheng-Hua; Lu, Yan-Hua*, Stimulatory Effects of Sugarcane Molasses on Fumigaclavine C Biosynthesis byAspergillus fumigatusCY018 via Biofilm Enhancement.Journal of Microbiology and Biotechnology2018,
22.Sun, Dong-Mei; An, Fa-Liang; Wei, Shan-Shan; Zhang, Yan-Qiu; Wang, Xiao-Bing; Luo, Jun*; Kong, Ling-Yi*, Cipadessains A–K, eleven limonoids from the fruits ofCipadessa cinerascens.RSC Advances2018,
23.Lu, Yan-Hua*; Pan, Zheng-Hua; Tao, Jun;An, Fa-Liang, Induced effect of Ca(2+) on dalesconols A and B biosynthesis in the culture of Daldinia eschscholzii via calcium/calmodulin signaling.Journal of Bioscience and Bioengineering2018,
24.Liu, Chang-Qing; Pan, Zheng-Hua;An, Fa-Liang; Lu, Yan-Hua*, Co-addition Strategy for Enhancement of Chaetominine from Submerged Fermentation of Aspergillus fumigatus CY018.Applied Biochemistry and Biotechnology2018,
25.Zhang, Yao;An, Fa-Liang; Huang, Shan-Shan; Yang, Lei; Gu, Yu-Cheng; Luo, Jun; Kong, Ling-Yi*, Diverse tritepenoids from the fruits of Walsura robusta and their reversal of multidrug resistance phenotype in human breast cancer cells.Phytochemistry2017,
26.Tian, Xiao-Meng; Li, Hui;An, Fa-Liang; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Kong, Ling-Yi*; Luo, Jun*, New Structurally Diverse Limonoids from the Seeds ofKhaya senegalensis.Planta Medica2017,
27.Guo, Miao-Miao;An, Fa-Liang; Yu, Hai-Yuan; Wei, Xing; Hong, Min-Hua; Lu*, Yan-Hua*, Comparative effects of schisandrin A, B, and C on Propionibacterium acnesinduced, NLRP3 inflammasome activation-mediated IL-1β secretion and pyroptosis.Biomedicine & Pharmacotherapy2017,
28.Guo, Miao-Miao;An, Fa-Liang; Wei, Xing; Hong, Min-Hua*; Lu, Yan-Hua*, Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation.Inflammation2017
29.Zhang, Wen Yan;An, Fa-Liang; Zhou, Miao Miao; Chen, Meng Han; Jian, Kai Li; Quasie, Olga; Yang, Ming Hua; Luo, Jun*; Kong, Ling Yi*, Limonoids with diverse frameworks from the stem bark of Entandrophragma angolense and their bioactivities.RSC Advances2016
30.Zhang, Chao; Yang, Lei; Geng, Ya-Di ;An, Fa-Liang; Xia, Yuan-Zheng ; Guo, Chao ; Luo, Jian-Guang ; Zhang, Lu-Yong ; Guo, Qing-Long ; Kong, Ling-Yi*, Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells.Oncotarget2016
31.Li, Jun He; Li, Yi; An, Fa-Liang; Zhou, Miao-Miao; Luo, Jie; Jian, Kai-Li; Luo, Jun*; Kong, Ling-Yi*, Limonoids with modified furan rings from root barks ofToona sinensis.Tetrahedron2016,.
