基本情況
2009年6月於
武漢大學獲博士學位,2009年7月起在武漢大學化學與分子科學學院生物醫用高分子材料教育部重點實驗室工作。
主要研究方向與成果
研究方向:
學術成果
1.Sun YX,Zeng X, Meng QF, Zhang XZ, Cheng SX, Zhuo RX. The influence of RGD addition on the gene transfer characteristics of disulfide-containing polyethyleneimine/DNA complexes. Biomaterials 2008, 29, 4356-4365.
2.Sun YX,Xiao W, Cheng SX, Zhang XZ, Zhuo RX. Synthesis of (Dex-HMDI)-g-PEIs as effective and low cytotoxic nonviral gene vectors. J. Control. Release 2008, 128, 171-178.
3.Sun YX,Chen H, Cheng SX, Zhang XZ, Zhuo RX. A low-toxic and efficient gene vector: carboxymethyl dextran-graft-polyethylenimine. J. Biomed. Mater. Res. Part A 2008, 84A, 1102-1110.
4.Zeng X, Sun YX, Qu W, Zhang XZ, Zhuo RX. Biotinylated transferrin/avidin/biotinylated disul?de containing PEI bioconjugates mediated p53 gene delivery system for tumor targeted transfection. Biomaterials 2010,31, 4771-4780.
5.Wang YQ, Sun YX, Hong XL, Zhang XZ, Zhang GY. Poly(methyl methacrylate)-graft-oligoamines as low cytotoxic and efficient nonviral gene vectors. Mol. BioSyst.2010, 1, 256-263.
6.Zeng X, Sun YX, Zhang XZ, Zhuo RX. Biotinylated disulfide containing PEI/avidin bioconjugate shows specific enhanced transfection efficiency in HepG2 cells. Org. Biomol. Chem. 2009, 20, 4201-4210.
7.Lu B, Sun YX, Li YQ, Zhang XZ, Zhuo RX. N-Succinyl-chitosan grafted with low molecular weight polyethylenimine as serum-resistant gene vector. Mol. BioSyst. 2009, 6, 629-637.
8.Zeng X, Sun YX, Zhang XZ, Cheng SX, Zhuo RX. A potential targeting gene vector based on biotinylated polyethyleneimine/avidin bioconjugates. Pharm. Res. 2009,8,1931-1941.
9.Wu DQ, Sun YX, Xu XD, Cheng SX, Zhang XZ, Zhuo RX. Biodegradable and pH-sensitive hydrogels for cell encapsulation and controlled drug release. Biomacromolecules 2008, 9, 1155-1162.
10.Quan CY, SunYX, Cheng H, Cheng SX, Zhang XZ, Zhuo RX. Thermosensitive P(NIPAAm-co-PAAc-co-HEMA) nanogels conjugated with transferrin for tumor cell targeting delivery.Nanotechnology2008,19, 275102.
11.Song YB,Sun YX, Zhang XZ, Zhou JP, Zhang LN. Homogeneous quaternization of cellulose in NaOH/urea aqueous solutions as gene carriers. Biomacromolecules 2008, 9, 2259-2264.
12.Liu SL, Zhang LN, Sun YX, Lin Y, Zhang XZ, Nishiyama Y. Supramolecular structure and properties of high strength regenerated cellulose films. Macromol. Biosci. 2009, 9,29-35.
13.Cheng H, Zhu JL, Sun YX, Cheng SX, Zhang XZ, Zhuo RX. Novel thermoresponsive nonviral gene vector: P(NIPAAm-co-NDAPM)-b-PEI with adjustable gene transfection efficiency. Bioconjugate Chem. 2008, 19, 1368-1374.
14.Quan CY, Wei H, Sun YX, Cheng SX, Shen K, Gu ZW, Zhang XZ, Zhuo RX. Polyethyleneimine modified biocompatible poly(N-isopropylacrylamide)-based nanogels for drug delivery. J Nanosci. Nanotechno. 2008, 8, 2377-2384.
15.Chen H, Li YY, Zeng X, Sun YX, Zhang XZ, Zhuo RX. Protamine sulfate/poly(L-aspartic acid) (PS/PASP) polyionic complexes (PICs) self-assembled via electrostatic attractions for co-delivery of drug and gene. Biomaterials 2009, 30, 1246-1253.
16.Yang QL, Lue A, Qi HS, Sun YX, Zhang XZ, Zhang LN. Properties and bioapplications of blended cellulose and corn protein films. Macromol. Biosci. 2009, 9, 849-856.