孫琳琳，女，博士學歷，北京大學神經科學研究所特聘研究員，博士生導師。
基本介紹
學術經歷,研究方向,主要作品,
學術經歷
孫琳琳於2005年入讀北京大學基礎醫學八年制，2013年於北京大學神經科學研究所獲理學博士學位。曾先後於羅格斯大學，紐約大學，哥倫比亞大學作博士後研究，2021年歸國於北京大學基礎醫學院神經生物學系任教。長期從事藥物成癮記憶及認知障礙，神經病理痛的外周及中樞機制，以及孤獨症神經機制相關的工作，以第一作者/通訊作者在Advanced Science, Nature Communications等國內外高水平期刊發表研究論文多篇。
研究方向
1. 慢性神經病理痛發生髮展的外周及中樞機制。
2. 孤獨症的本體感覺異常及認知障礙的神經機制。
3. 藥物成癮記憶形成、消退和喚起過程中的神經元突觸可塑性及其分子機制。
主要作品
1. Li, Y. , Guo, X. , Sun, L. , Xiao, J. , Su, S. , Du, S. , Li, Z., Wu, S., Liu, W., Mo, K., Xia, S., Chang, Y., Denis, D., Tao, YX. (2020) N-methyladenosine demethylase FTO contributes to neuropathic pain by stabilizing G9a expression in primary sensory neurons. Advanced Science, 375(1799): 234. co-first author.
2. Chen, C. , Zhang, J. , Sun, L. , Y. Zhang, W. Gan, P. Tang, G. Yang. (2019) "Long-term imaging of dorsal root ganglia in awake behaving mice." Nature Communications 10(1):3087. co-first author.
3. Sun, L., Zhou, H., Cichon, J., Yang, G. (2019) Experience and sleep-dependent synaptic plasticity: from structure to activity. Philosophical Transactions B 375(1799): 20190234.
4. Sun, L. , Gu, X. , Z. Pan, X. Guo, J. Liu, F. E. Atianjoh, S. Wu, K. Mo, B. Xu, L. Liang, A. Bekker and Y. X. Tao. (2019) "Contribution of DNMT1 to neuropathic pain genesis partially through epigenetically repressing Kcna2 in primary afferent neurons." The Journal of Neuroscience 39(33): 6595– 6607. co-first author.
5. Sun, L., J. Y. Zhao, X. Gu, L. Liang, S. Wu, K. Mo, J. Feng, W. Guo, J. Zhang, A. Bekker, X. Zhao, E. J. Nestler and Y. X. Tao. (2017). "Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons." Pain 158(6): 1153-1165. co-first author.
6. Sun, L., B. M. Lutz and Y. X. Tao (2016). "The CRISPR/Cas9 system for gene editing and its potential application in pain research." Translational Perioperative and Pain Medicine 1(3): 22-33. (Review)
7. Sun, L., Hu, L. , Li, Y. and Cui, C. (2013). "Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal." Brain Structure and Function 219(5): 1755-1771. co-first author.
8. Li, Z., Gu, X. , Sun, L. , S. Wu, L. Liang, J. Cao, B. M. Lutz, A. Bekker, W. Zhang and Y. X. Tao. (2015). "Dorsal root ganglion myeloid zinc finger protein 1 contributes to neuropathic pain after peripheral nerve trauma." Pain 156(4): 711-721. co-first authors
9. Cichon, J., J. Magrane, E. Shtridler, C. Chen, Sun. L, G. Yang and W. B. Gan (2020). "Imaging neuronal activity in the central and peripheral nervous systems using new Thy1.2-GCaMP6 transgenic mouse lines."Journal of Neuroscience Methods 334: 108535.
10. Griffiths, K. K., A. Wang, L. Wang, M. Tracey, G. Kleiner, C. M. Quinzii, Sun. L, G. Yang, J. F. Perez-Zoghbi, P. Licznerski, M. Yang, E. A. Jonas and R. J. Levy (2020). "Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome." The FASEB Journal 10.1096/fj.202000283RR .
11. Ruan, C., Sun, L., Kroshilina, A., Beckers, L., De Jager, P., Bradshaw, E., Hasson, L., Yang, G., Elyaman, W. (2020) A Novel Tmem119-tdTomato Reporter Mouse Model for Studying Microglia in the Central Nervous System. Brain Behavior and Immunity 83(180)-191.
12. Mao, Q., S. Wu, X. Gu, S. Du, K. Mo, Sun, L., J. Cao, A. Bekker, L. Chen and Y. X. Tao. (2019). "DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain." International Journal of Cancer 145(8):2122-34.
13. Cichon, J., Sun, L. and Yang, G. (2018). Spared Nerve Injury Model of Neuropathic Pain in Mice. Bio-protocol 8(6): e2777.
14. Sun, X., Wang, N., Wang, X., Sun, L., Li, Y., Cui, C. (2019). AMPA Receptor in Ventromedial Prefrontal Cortex Plays Different Roles in the Recent and Remote Retrieval of Morphine-Associated Memory. Neurochemical Research 44(8):1939-1949.
15. Wang, N., F. Ge, C. Cui, Y. Li, X. Sun, L. Sun, X. Wang, S. Liu, H. Zhang, Y. Liu, M. Jia and M. Yang. (2018). "Role of Glutamatergic Projections from the Ventral CA1 to Infralimbic Cortex in Context-Induced Reinstatement of Heroin Seeking." Neuropsychopharmacology 43(6):1373-1384. doi: 10.1038/npp.2017.279 . Epub 2017 Nov 14.
16. Zhao, J. Y., L. Liang, X. Gu, Z. Li, S. Wu, L. Sun, F. E. Atianjoh, J. Feng, K. Mo, S. Jia, B. M. Lutz, A. Bekker, E. J. Nestler and Y. X. Tao. (2017). "DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons." Nature Communications 8: 14712.
17. Xu, J. T., L. Sun, B. M. Lutz, A. Bekker and Y. X. Tao. (2016) "Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain." Translational Perioperative and Pain Medicine 2(2): 27-34.
18. Li, Y. J., X. J. Ping, C. Qi, F. Shen, L. L. Sun, X. W. Sun, F. F. Ge, G. G. Xing and C. L. Cui. (2015). "Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation." Addiction Biology 22(2): 435-445.
19. Lv, X. F., L.L. Sun, C. L. Cui and J. S. Han. (2015). "NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required." International Journal of Neuropsychopharmacology 18(9): pyv030. Published online 2015 Apr 15. doi: 10.1093/ijnp/pyv030
20. Hu, L., N. N. Chu, L. L. Sun, R. Zhang, J. S. Han and C. L. Cui. (2009). "Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area." Addiction Biology 14(4): 431-437.
