孫欽秒，女，博士，研究員，博士生導師；中國科學院動物研究所免疫和信號傳導研究組組長。
基本介紹
- 中文名：孫欽秒
- 國籍：中國
- 出生地：中國
- 職業：博士，研究員，博士生導師
- 畢業院校：山東農業大學
- 性別：女
個人簡介,研究領域,科研項目,代表論著,
個人簡介
孫欽秒，2007 - 至今 研究員，博士生導師，生物膜與膜生物工程國家重點實驗室，中國科學院動物所“百人計畫”引進國外傑出人才。
2006 - 2007 Instructor，UT Southwestern Medical Center at Dallas.
2001 - 2005 Postdoc researcher，UT Southwestern Medical Center at Dallas.
2000,2 - 2000,11 Postdoc researcher，Chandler Medical Center University of Kentucky
1996 - 1999 博士，中國科學院植物研究所
1993 - 1996 碩士，山東農業大學
1989 - 1993 學士，山東農業大學
研究領域
以小鼠和果蠅等模式動物作為研究系統，利用分子生物學、細胞生物學、遺傳學和生物化學等技術進行探討：1）免疫反應的信號傳導機制；2）幹細胞命運調控的分子機制
科研項目
1. 科技部資助項目 (973項目和轉基因重大專項)
（1）原始生殖細胞特化和定向遷移
（2）免疫細胞亞群定向發育分化的調控機制
（3）以果蠅、小鼠為模式研究生殖幹細胞命運決定的分子機理
（4）抗藍耳病病毒抗病相關基因的篩選和功能鑑定基因
2. 國家自然科學基金委資助項目
（1）MAVS和MyD88在抗病毒的天然免疫反應中的作用
（2）FMR1在小鼠卵巢早期發育中的機制研究
（3）線粒體電子傳遞鏈組分COX5B與自噬途徑協同調控MAVS介導的抗病毒天然免疫反應的分子機制
（4）E3泛素連線酶調控Toll信號介導的天然免疫反應分子機制的研究
3. 中國科學院“百人計畫
代表論著
Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L1, Wang H, Chen D, Sun Q*. Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD
Sun X, Sun L, Zhao Y, Li Y, Lin W, Chen D, Sun Q*. MAVS maintains mitochondrial homeostasis via autophagy
Jin W, Wang L, Zhu F, Tan W, Lin W, Chen D, Sun Q*, Xia Z*.Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming
Sun Q*, Huang S, Wang X, Zhu Y, Chen Z, Chen D*.N6-methyladenine functions as a potential epigenetic mark in eukaryotes. Bioessays
Li Z, Liu G, Sun L, Teng Y, Guo X, Jia J, Sha J, Yang X, Chen D, Sun Q*. PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation
Ji S, Sun M, Zheng X, Li L, Sun L, Chen D* and Sun Q*. Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signaling by controlling MyD88 turnover in Drosophila
Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Sun Q*, Jin P* and Chen D*. Coordination of engineered factors with TET 1/2 promotes the early stage epigenetic modification during somatic cell reprogramming
Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover
Zhao Y, Sun X, Nie X, Sun L, Tang TS, Chen D, Sun Q*. COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production
Dong X, Feng H, Sun Q , Li H, Wu TT, Sun R, Tibbetts SA, Chen ZJ, Feng P*. Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication
Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A, Chen D*. The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell
Chen, Dongsheng; Wang, Qi; Huang, Haidong; Xia, Laixin; Jiang, Xiaoyong; Kan, Lijuan; Sun Q; Chen, Dahua*. Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila
Bhoj VG, Sun Q, Bhoj EJ, Somers C, Chen X, Torres JP, Mejias A, Gomez AM, Jafri H, Ramilo O, Chen ZJ*. MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A
Chiu YH, Sun Q, Chen ZJ*. E1-L2 activates both ubiquitin and FAT10
Sun Q, Matta H, Lu G, Chaudhary PM. Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation.Oncogene
Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J, Chen ZJ*. The specific and essential role of MAVS in antiviral innate immune responses
Sun Q, Matta H, Chaudhary PM*. Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat
Sun Q, Zachariah S, Chaudhary PM*. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem
Matta H, Sun Q, Moses G, Chaudhary PM*. Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation
Sun Q, Matta H, Chaudhary PM*. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation
