孫建偉，男，博士，雲南大學生命科學中心研究員、博士生導師。
基本介紹
- 中文名：孫建偉
- 國籍：中國
- 畢業院校：中國科學院遺傳與發育生育學研究所
- 學位/學歷：博士
- 專業方向：線粒體功能調控與腫瘤發生
- 職務：雲南大學博士生導師
人物經歷,研究方向,研究論文,
人物經歷
2010年於中國科學院遺傳與發育生育學研究所獲博士學位。2011-2015年在美國佛羅里達MOFFITT癌症研究中心從事博士後研究。2015年進入華南農業大學工作。2018年調入雲南大學生命科學中心研究員。以通訊/第一作者身份在Journal of Cell Biology、Oncogene、Journal of Biological Chemistry等國際一流學術期刊發表多篇研究論文。
研究方向
1．腫瘤的發生與腫瘤抗藥性
2．線粒體功能的調控
3．抗腫瘤藥物的篩選
研究論文
1.Jian Wang, Junling Shen, Kaili Zhao, Jinmeng Hu, Jiuxing Dong and Jianwei Sun*.STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression. Cancer Biology & Medicine. 2019 (In press)
2. Fujian Lu#, Jianwei Sun#, Jinghang Li,Yuanzhao Hu, Peng Yu,Huifang He, Yan Zhao, Xianhua Wang, Shengyu Yang* and Heping Cheng*.Imaging STIM1-Orai1 Ca2+ Sparks in Invading Cancer Cells with Targeted Sensors. Journal of Cell Sciences. 2019(In press)(#共同第一作者)
3. Jiaxin Kang, Jian Wang, Zhuang Yao，Yuanzhao Hu, Shijie Ma，Qin Fan，Yan Sun* and Jianwei Sun*. Fascin inducemelanoma tumorgenesis and stemness through regulating TAZstability. Cell Communication and signaling2018 Jul 3:16(1):37. doi: 10.1186/s12964-018-0250-1.
4.Shengchen Lin, Shuang Lu, Mentor Mulaj, Bin Fang, Tyler Keeley, Lixin Wan, Jihui Hao, Martin Muschol, Jianwei Sun* and Shengyu Yang*. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin . Journal of Biological Chemistry.2016 Dec 30;291(53):27323-27333.(*共同通訊作者)
5.Jaw-Yuan Wang#, Jianwei Sun#, Ming-Yii Huang, Ming-Feng Hou, Yu-Shiuan Wang, Yan Sun, Yao-Ting Tsai, Huifang He, Shengchen Lin, Shengyu Yang, and Wei-Chiao Chang. STIM1 Overexpression promotedColorectal Cancer Progression, Cell Motility and COX-2 Expression. Oncogene, 2015 Aug 13;34(33):4358-67. (#共同第一作者)
6. Jianwei Sun, Fujian Lu, Huifang He, Junling Shen, Jane Messina, Rahel Mathew, Dapeng Wang, Amod A. Sarnaik, Wei-Chiao Chang, Minjung Kim, Heping Cheng, and Shengyu Yang. STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion.Journal of Cell Biology. 2014 Nov 24, 207(4): 535-548. (同期JCB研究焦點評述: Mitch Leslie. Melanoma cells travel on calcium cycles. )
7．Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan and Shengyu Yang. GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion. Journal of Biological Chemistry. 2013 Dec 27;288(52):36971-82.
8. Jianwei Sun, Huifang He, Yin Xiong, Shuang Lu, Junling Shen, Anna Cheng, Wei-Chiao Chang,Ming-Feng Hou, Johnathan M. Lancaster, Minjung Kim and Shengyu Yang. Fascin Protein Is Critical for Transforming Growth Factor Protein-induced Invasion and Filopodia Formation in Spindle-shaped Tumor Cells. Journal of Biological Chemistry 2011, 286(45): 38865–38875.
