孫寶發，男，漢族，1983.09月生。
學習經歷：
2002年9月-2006年7月 湖南科技大學 生物科學專業 理學學士學位
2006年9月-2009年7月 汕頭大學 生物化學與分子生物學專業 理學碩士學位
2009年9月-2013年1月 中國科學院動物研究所 動物學專業 理學博士學位
工作經歷：
2013年7月-2015年12月 中國科學院北京基因組研究所 助理研究員
2016年1月至今 中國科學院北京基因組研究所 副研究員
基本介紹
- 中文名：孫寶發
- 國籍：中國
- 民族：漢族
- 出生地：河北唐山
- 畢業院校：中國科學院動物研究所
- 職稱：副研究員
研究領域,獲獎及榮譽,主要成就,
研究領域
- 各種RNA甲基化的分布特徵及規律
- RNA甲基化對RNA加工代謝的調控
- RNA甲基化對多種生物學過程及疾病發生的調控機制
獲獎及榮譽
2016年 2016級中國科學院青年創新促進會會員
主要成就
承擔科研項目情況：
1.國家基金委面上項目，m5C 調控 mRNA 翻譯的功能研究， 2017/01-2020/12，在研，主持；
2.中科院人才項目，2016級青年創新促進會，2016/01-2019/12，在研，主持；
3.國家基金委青年科學基金項目，RNA mA甲基化修飾調控mRNA選擇性剪接機制研究，2015/01-2017/12，結題，主持；
4.國家基金委重大研究計畫，可逆化學修飾調控 lncRNA二級結構機制及其功能研究，2018/01-2021/12，在研，參加；
5.國家基金委重點項目，RNA mA 修飾甲基轉移酶複合物及其表觀調控因子鑑定和作用機制研究，2015.01-2019.12，在研，參加；
代表性論文：
"通訊作者以“*”標出，第一作者以”#”：
1. Chunxia Zhang#, Yusheng Chen#,Baofa Sun#, Lu Wang#, Ying Yang#, Dongyuan Ma, Wen Xiao, Yun-Gui Yang*, and Feng Liu*. m6A modulates haematopoietic stem and progenitor cell specification in vertebrates.Nature549(7671):273-276 (2017). (Highlighted in J Genet Genomics and Sci Signal.)
2. Xin Yang#, Ying Yang#,Bao-Fa Sun#, Yu-Sheng Chen#, Jia-Wei Xu#, Wei-Yi Lai#, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chun-Min Huang, Niu Huang, Gui-Bin Jiang, Yong-Liang Zhao, Hai-Lin Wang*, Ying-Pu Sun*, Yun-Gui Yang*. 5-methylcytosinepromotes mRNA export- NSUN2 as the methyltransferase and ALYREF as an m5C reader.Cell Res. 27(5):606-625 (2017). (Cell Res封面故事，入選Cell Res和Nat Sci Rev研究特色論文評論和F1000）
3. Kai Xu#, Ying Yang#, Gui-Hai Feng#,Bao-Fa Sun#, Jun-Qing Chen#, Yu-Fei Li, Yu-Sheng Chen, Xin-Xin Zhang, Chen-Xin Wang, Li-Yuan Jiang, Chao Liu, Ze-Yu Zhang, Xiu-Jie Wang, Qi Zhou*, Yun-Gui Yang*, Wei Li*. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation.Cell Res. 27(9):1100-1114 (2017). (Cell Res封面故事)
4. Ang Li#, Yu-Sheng Chen#, Xiao-Li Ping, Xin Yang, Wen Xiao, Ying Yang, Hui-Ying Sun, Qin Zhu, Poonam Baidya, Xing Wang, Devi Prasad Bhattarai, Yong-Liang Zhao,Bao-Fa Sun*, Yun-Gui Yang*. Cytoplasmic m6A reader YTHDF3 promotes mRNA translation.Cell Res. 27(3):444-447 (2017).
5. Peng Zhang#, Chunli Pei#, Xi Wang, Jinyi Xiang,Bao-Fa Sun, Yongsheng Cheng, Xiaolong Qi, Marco Marchetti, Jia-Wei Xu, Ying-Pu Sun, Bruce A. Edgar*, Zengqiang Yuan*. A balance of Yki/Sd activator and E2F1/Sd repressor complexes controls cell survival and affects organ size.Dev Cell43(5):603-617 (2017).
6. Ru Zheng#, Yue Li#, Huiying Sun#, Xiaoyin Lu,Bao-Fa Sun, Rui Wang, Lina Cui, Cheng Zhu, Hai-Yan Lin*, Hongmei Wang*. Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion.Reproduction153:35-48 (2017).
7. Wen Xiao#, Samir Adhikari#, Ujwal Dahal#, Yu-Sheng Chen#, Ya-Juan Hao#,Bao-Fa Sun#, Hui-Ying Sun, Ang Li, Xiao-Li Ping, Wei-Yi Lai, Xing Wang, Hai-Li Ma, Chun-Min Huang, Ying Yang, Niu Huang, Gui-Bin Jiang, Hai-Lin Wang, Qi Zhou, Xiu-Jie Wang, Yong-Liang Zhao, Yun-Gui Yang*. Nuclear m6A reader YTHDC1 regulates mRNA splicing.Mol Cell61(4):507-519 (2016).
8.Yixin Zhang, Na Li,Li Wang, Huiying Sun, Minyue Ma, Hui Wang, Xiaofei Xu, Wenke Zhang, Yingyu Liu, David S. Cram,Baofa Sun*,Yuanqing Yao*.J Assist Reprod Genet33(5): 637-645 (2016).
9.Baofa Sun#, Tong Li#, Jinhua Xiao, Li Liu, Peng Zhang, Robert W. Murphy, Shunmin He, Dawei Huang*. Contribution of multiple inter-kingdom horizontal gene transfers to evolution and adaptation of amphibian-killing chytrid,Batrachochytrium dendrobatidisFront Microbiol7:1360 (2016).
10. Guan Hong Wan*,Bao Fa Sun, Tuan Lin Xiong, Yan Kun Wang, Kristen E. Murfin, Jin Hua Xiao*, Da Wei Huang*. Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes.Front Microbiol7:1867 (2016).
11. Dong-Ya Cui, Xu-Bin Sun, Jia-Jia Wang, Peng Zhang,Bao-Fa Sun, Xiao-Wei Chen, Robert W. Murphy, Shun-Min He, Da-Wei Huang. Research on co-expression genes of a fig wasp.Progress in Biochemistry and Biophysics43(1): 83-89 (2016).
12.Bao-Fa Sun#,Yong-Xing Li#, Ling-Yi Jia, Li-Hua Niu, Robert W. Murphy, Peng Zhang, Shunmin He*, Da-Wei Huang*. Regulation of transcription factors on sexual dimorphism of fig wasps.Sci Rep5, 10696 (2015).
13.Bao-Fa Sun#, Tong Li#, Jin-Hua Xiao, Ling-Yi Jia, Li Liu, Peng Zhang, Robert W. Murphy, Shun-Min He, Da-Wei Huang*. Regulation of transcription factors on sexual dimorphism of fig wasps.Sci Rep5: 18676 (2015).
14. Ying Yang#,Bao-Fa Sun#, Wen Xiao, Xin Yang, Hui-Ying Sun, Yong-Liang Zhao, Yun-Gui Yang*. Dynamic m6A modification and its emerging regulatory role in mRNA splicing.Sci Bull60(1):21-32 (2015).
15. Tangliang Li, Yue Shi, Pei Wang, Luis Miguel Guachalla,Baofa Sun, Tjard Joerss, Yu-Sheng Chen, Marco Groth, Anja Krueger, Matthias Platzer, Yun-Gui Yang, Karl Lenhard Rudolph, Zhao-Qi Wang*. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.EMBO J34(12):1630-1647 (2015).
16. Xiu-Xia Wang,Bao-Fa Sun, Jiao Jiao, Ze-Chen Chong, Yu-Shen Chen, Xiao-Li Wang, Yue Zhao, Yi-Ming Zhou, Da Li*. Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia.Oncotarget6, 6535-6543 (2015).
17. Rui-Wu Wang*,Bao-Fa Sun, Yan Yang. Discriminative host sanction together with relatedness promote the cooperation in fig/fig wasp mutualism.J Anim Ecol84(4): 1133-1139(2015).
18. Rui-Wu Wang*,Bao-Fa Sun, Jun-Zhou He, Derek W. Dunn. Non-quantitative adjustment of offspring sex ratios in pollinating fig wasps.Sci Rep5:13057 (2015).
19. Xiao-Li Ping#,Bao-Fa Sun#, Lu Wang#, Wen Xiao#, Xin Yang, Wen-Jia Wang, Samir Adhikari, Yue Shi, Ying Lv, Yu-Sheng Chen, Xu Zhao, Ang Li, Ying Yang, Ujwal Dahal, Xiao-Min Lou, Xi Liu, Jun Huang, Wei-Ping Yuan, Xiao-Fan Zhu, Tao Cheng, Yong-Liang Zhao, Xinquan Wang, Jannie M Rendtlew Danielsen, Feng Liu*, and Yun-Gui Yang*. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.Cell Res24(2):177–189 (2014). （Natl Sci Rev研究特色論文）
20. Xu Zhao#, Ying Yang#,Bao-Fa Sun#, Yue Shi#, Xin Yang, Wen Xiao, Ya-Juan Hao, Xiao-Li Ping, Yu-Sheng Chen, Wen-Jia Wang, Kang-Xuan Jin, Xing Wang, Chun-Min Huang, Yu Fu, Xiao-Meng Ge, Shu-Hui Song, Hyun Seok Jeong, Hiroyuki Yanagisawa, Yamei Niu, Gui-Fang Jia, Wei Wu, Wei-Min Tong, Akimitsu Okamoto, Chuan He, Jannie M Rendtlew Danielsen, Xiu-Jie Wang, and Yun-Gui Yang*. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.Cell Res24(12): 1403-1419 (2014). （Cell Res研究特色論文）
21. Bailin Zhao #, Ying Yang #, Xiaoli Wang#, Zechen Chong, Ruichuan Yin, Shu-Hui Song, Chao Zhao, Cuiping Li, Hua Huang,Bao-Fa Sun, Danni Wu, Kang-Xuan Jin, Maoyong Song, Ben-Zhan Zhu, Guibin Jiang, Jannie M. Rendtlew Danielsen, Guo-Liang Xu, Yun-Gui Yang*, Hailin Wang*. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.Nucleic Acids Res42(3):1593-1605 (2014).
22. Xu Zhao#, Ying Yang#,Bao-Fa Sun, Yong-Liang Zhao, Yun-Gui Yang*. FTO and obesity: mechanisms of association.Curr Diabetes Rep14(5):486 (2014).
23. Peng Zhang, Xiaohui Si, Geir Skogerbo, Jiajia Wang, Dongya Cui, Yongxing Li, Xubin Sun, Li Liu,Baofa Sun, Runsheng Chen*, Shunmin He*, Da-Wei Huang*. piRBase: a web resource assisting piRNA functional study.Database (Oxford), 2014bau110 (2014).
24. Rui-Wu Wang*, Derek W. Dunn,Bao-Fa Sun. Discriminative host sanctions in a fig-wasp mutualism.Ecology95(5):1384-1393 (2014).
25.Bao-Fa Sun, Shun-Min He, Jin-Hua Xiao, Li Liu, Da-Wei Huang*. Multiple horizontal gene transfers and duplications in lepidopteran species.Insect Molecular Biology22 (1), 72-87 (2013).
26.Bao-Fa Sun, Jin-Hua Xiao, Shun-Min He, Li Liu, Da-Wei Huang*. Multiple interkingdom horizontal gene transfers in Pyrenophora and closely related species and their contributions to phytopathogenic lifestyles.PLoS ONE8 (3), e60029 (2013).
27. Jin-Hua Xiao#, Zhen Yue#, Ling-Yi Jia#, Xin-Hua Yang#, Li-Hua Niu#, Zhuo Wang#, Peng Zhang#,Bao-Fa Sun, Shun-Min He, Zi Li, Tuan-Lin Xiong, Wen Xin5, Hai-Feng Gu, Bo Wang, John H Werren, Robert W Murphy, David Wheeler, Li-Ming Niu, Guang-Chang Ma, Ting Tang, Sheng-Nan Bian, Ning-Xin Wang, Chun-Yan Yang, Nan Wang, Yue-Guan Fu, Wen-Zhu Li, Soojin V Yi, Xing-Yu Yang, Qing Zhou, Chang-Xin Lu, Chun-Yan Xu3, Li-Juan He, Li-Li Yu, Ming Chen, Yuan Zheng, Shao-Wei Wang, Shuang Zhao, Yan-Hong Li, Yang-Yang Yu, Xiao-Ju Qian, Yue Cai, Lian-Le Bian, Shu Zhang, Jun-Yi Wang, Ye Yin, Hui Xiao, Guan-Hong Wang, Hui Yu, Wen-Shan Wu, James M Cook*, Jun Wang* and Da-Wei Huang* Obligate mutualism within a host drives the extreme specialization of a fig wasp genome.Genome Biology14:R141 (2013).
28. Rui-Wu Wang*,Bao-Fa Sun, Qi Zheng, Lei Shi,Lixing Zhu. Asymmetric interaction and indeterminate fitness correlation between cooperative partners in the fig-fig wasp mutualism.Journal of the Royal Society Interface8(63):1487-1496 (2011).
29. Rui-Wu Wang*,Bao-Fa Sun, Qi Zheng. Diffusive coevolution and mutualism maintenance mechanisms in a fig-fig wasp system.Ecology91(5):1308-1016 (2010).
30. Rui-Wu Wang*,Bao-Fa Sun. Seasonal change in the structure of fig-wasp community and its implication for conservation.Symbiosis47:77-83 (2009).
31. Rui-Wu Wang#, Jo Ridley#,Bao-Fa Sun, Qi Zheng, Derek W. Dunn, James Cook, Lei Shi,Ya-Ping Zhang, Douglas W. Yu*. Interference competition and high temperatures reduce the virulence of fig wasps and stabilize a fig-wasp mutualism.PLoS ONE4(11):e7802 (2009).
