孫寶林，男，博士，中國科學技術大學教授、博士生導師。
基本介紹
- 中文名：孫寶林
- 畢業院校：密西根州立大學
- 學位/學歷：博士
- 專業方向：細菌病原體毒力基因的表達調控
- 任職院校：中國科學技術大學
- 職稱：中國科學技術大學教授
人物經歷,研究方向,科研項目,論文專著,
人物經歷
1986年牡丹江師範學院學士；
1989年中科院遺傳所碩士；
1999年密西根州立大學博士。
研究方向
1、細菌病原體毒力基因的表達調控
2、耐藥發生與轉移的調控機制
3、病原菌與宿主互作機制
科研項目
1. 中國科學院“百人計畫”專項，2004.01–2007.12，資助金額：270萬。
2. 國家“十一五”科技重大專項“愛滋病和病毒性肝炎等重大傳染病防治”子課題“結核病靶標研究”，2008.10–2011.05，資助金額：315萬。
3. 中國科學院知識創新工程“結核分枝桿菌致病機制、快速診斷和新型藥物研究”，2009.6–2011.05，資助金額：60萬。
4. 國家自然科學基金“金黃色葡萄球菌非編碼小RNA的功能解析”，2010.01–2012.12，資助金額：40萬。
5. 國家自然科學基金“金黃色葡萄球菌KdpDE二元信號轉導系統對致病性的調控研究”，2011.01–2013.12，資助金額：34萬。
論文專著
Xiong, M., Y. Bao, X. Yang, Y. Wang, B. Sun, and J. Wang (2012). Lipase-sensitive polymeric triple-layered nanogel for "on-demand" drug delivery.J. Am. Chem. Soc. 134:4355-4362.
Xue, T., Y. You, F. Shang, and B. Sun (2012). Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325. Med. Microbiol. Immunol. 201:81-92.
Xue, T., Y. You, D. Hong, H. Sun, and B. Sun (2011). The Staphylococcus aureus KdpDE two-component system couples extracellular K sensing and Agr signaling to infection programming.Infect. Immun. 79:2154-2167.
Zhao, L., T. Xue, F. Shang, H. Sun, and B. Sun (2010). Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence.Infect. Immun. 78:3506-3515.
Tao, L., X. Wu, and B. Sun (2010). Alternative sigma factor σ modulates prophage integration and excision in Staphylococcus aureus.PLoS Pathog. 6:e1000888.
Shang, F., T. Xue, H. Sun, L. Xing, S. Zhang, Z. Yang, L. Zhang, and B. Sun (2009). The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner.Infect. Immun. 77:2849-2856.
Huang, J., B. Sun, and X. Zhang (2010). Shewanella xiamenensis sp. nov., isolated from coastal sea sediment.Int. J. Syst. Evol. Microbiol. 60:1585-1589.
Huang, J., B. Sun, and X. Zhang (2010). Electricity generation at high ionic strength in microbial fuel cell by a newly isolated Shewanella marisflavi EP1.Appl. Microbiol. Biotechnol. 85:1141-1149.
Xue, T., L. Zhao, H. Sun, X. Zhou, and B. Sun (2009). LsrR binding-site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing.Cell Res. 19:1258-1268.
Wu, C. and B. Sun (2009). Identification of novel esterase from metagenomic library of Yangtze River.J. Microbiol. Biotechnol. 19:187-193.
Chu, X., H. He, C. Guo, and B. Sun (2008). Identification of two novel esterases from a marine metagenomic library derived from South China Sea.Appl. Microbiol. Biotechnol. 80:615-625.
Zhou, X., X. Meng, and B. Sun (2008). An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli.Cell Res. 18:937-948.
Ju, X., L. Zhao, and B. Sun (2007). Nitrogen fixation by reductively dechlorinating bacteria. Environ. Microbiol. 9:1078-1083.
Sun, B., B. M. Griffin, H. L. Ayala-del-Río, S. A. Hashsham, and J. M. Tiedje (2002). Microbial dehalorespiration with 1,1,1-trichloroethane. Science 298:1023-1025.
Sun, B., J. R. Cole, and J. M. Tiedje (2001). Desulfomonile limimaris sp. nov., an anaerobic dehalogenating bacterium from marine sediments. Int. J. Syst. Evol. Microbiol. 51:365-371.
Sun, B., J. R. Cole, R. A. Sanford, and J. M. Tiedje (2000). Isolation and characterization of Desulfovibrio dechloracetivorans sp. nov., a marine dechlorinating bacterium growing by coupling the oxidation of acetate to the reductive dechlorination of 2-chlorophenol.Appl. Environ. Microbiol. 66:2408-2413.
