孫宏羽

孫宏羽，男，博士，湖南大學生物醫學工程學系教授，博士生導師。

基本介紹

• 中文名：孫宏羽
• 畢業院校：國立成功大學
• 學位/學歷：博士
• 專業方向：生物醫學工程
• 任職院校：湖南大學

人物經歷

教育經歷

博士國立成功大學 基礎醫學研究所 2004/9~2011/6

碩士國立成功大學 分子醫學研究所 2002/9~2004/6

學士國立中興大學動物系1998/9~2002/6

工作經歷

2018/09-今 湖南大學生物醫學工程學系 教授

2018/09-今 台灣成功大學分子醫學研究所 兼任助理教授

2011/08-2018/09 台灣成功大學醫學檢驗生物技術學系 博士後研究員

2016/11-2016/12 加拿大渥太華生物及微生物免疫學系 訪問博士後研究員

研究領域

主要從事脂蛋白/載脂蛋白代謝，肝炎病毒學，細胞生物學，分子病毒學及微生物致病機轉領域的科研工作。長期研究目標為探討載脂蛋白及脂蛋白調控胞內/外脂肪累積之分子機制，於肝炎病毒，代謝性疾病及細胞癌化之套用，具體工作目標包括載脂蛋白於脂肪酸及病毒誘發脂肪累積之機制，載脂蛋白於代謝相關疾病臨床顯著性，構築代謝相關疾病之載脂蛋白與脂肪體資料庫及尋找能夠預防或治療脂肪累積之小分子藥物。

學術成果

學術論文

1. Yu-Min Lin, Hung-Yu Sun, Wen-Tai Chiu, Hui-Chen Su, Yu-Chieh Chien,Lee-Won Chong, Hung-Chuen Chang, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao. Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation. Viruses, 2018 (Impact Factor 3.761)

2. Hung-Yu Sun*, Pin-Nan Cheng, Chiung-Ying Tseng, Wei-Jen Tsai, Yen-Cheng Chiu, Kung-Chia Young. Favoring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic hepatitis C virus infection. GUT, 2018. 67:1342-1350 (Impact Factor 17.016)

3. Peiju Tsai, Chun-Chieh Lin, Hung-Yu Sun, Jin-Ching Lee, Ting-Tsung Chang, Kung-Chia Young. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient’s viremia. Journal of Microbiology, Immunology and Infection. 2018. 51:446-455. (Impact Factor 2.094)

4. Hung-Yu Sun*, Chun-Chieh Lin, Pei-Ju Tsai, Wei-Jen Tsai, Jin-Ching Lee, Chiung-Wen Tsao, Pin-Nan Cheng, I-Chin Wu, Yen-Cheng Chiu, Ting-Tsung Chang, Kung-Chia Young. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cellular Microbiology, 2017. 19: e12673. (Impact Factor 4.41)

5. Yu-Min Lin, Bu-Chin Yu, Wen-Tai Chiu, Hung-Yu Sun, Yu-Chieh Chien, Hui-Chen Su, Shu-Yang Yen, Hsin-Wen Lai, Chyi-Huey Bai, Kung-Chia Young, Chiung-Wen Tsao. Fluoxetine regulates cell growth inhibition of interferon-&alpha. International Journal of Oncology, 2016. 49:1746-54. (Impact Factor 3.333)

6. Cheng-Hsun Ho, Huai-Chia Chuang, I-Chin Wu, Hung-Wen Tsai, Yih-Jyh Lin, Hung-Yu Sun, Kung-Chia Young, Yen-Cheng Chiu, Pin-Nan Cheng, Wen-Chun Liu, Tse-Hua Tan, Ting-Tsung Chang. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget, 2016. 7: 49765-49776

7. Chun-Chieh Lin, Peiju Tsai, Hung-Yu Sun, Mei-Chi Hsu, Jin-Ching Lee, I-Chin Wu, Chiung-Wen Tsao, Ting-Tsung Chang, Kung-Chia Young. Apolipoprotein J, a glucose up-regulated molecular chaperone stabilizes core and NS5A to promote infectious hepatitis C virus virion production, Journal of Hepatology, 2014; 61: 984-93. (Impact Factor 12.486)

8. Jin-Ching Lee, Chin-Kai Tseng, Kung-Chia Young, Hung-Yu Sun, Shainn-Wei Wang, Wei-Chun Chen, Chun-Kuang Lin, Yu-Hsuan Wu. Andrographolide exerts anti-hepatitis C virus activity by upregulating heme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells. BRITISH JOURNAL OF PHARMACOLOGY, 2014; 171: 237-252. (Impact Factor 6.81)

9. Hung-Yu Sun*, Chun-Chieh Lin, Jin-Ching Lee, Shainn-Wei Wang, Pin-Nan Cheng, I-Chin Wu, Ting-Tsung Chang, Ming-Derg Lai, Dar-Bin Shieh, Kung-Chia Young. Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. GUT, 2013; 62:1193-1203. (Impact Factor 17.016)

10. Mei-Chi Hsu, Kuo-Ting Lee, Wei-Chiang Hsiao, Chih-Hsing Wu, Hung-Yu Sun, I-Ling Lin and Kung-Chia Young. The dyslipidemia-associated SNP on the APOA1/C3/A5 gene cluster predicts post-surgery poor outcome in taiwanese breast cancer patients: a 10-year follow-up study. BMC CANCER, 2013; 13:330. (Impact Factor 3.288)

11. M-C Hsu, C-S Chang, K-T Lee, H-Y Sun, Y-S Tsai, P-H Kuo, K-C Young and CH Wu. Central obesity in males affected by a dyslipidemia associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster. Nutrition & Diabetes, 2013; 3: e06. (Impact Factor 3.534)

12. Sun HY*, Ou NY, Wang SW, Liu WC, Cheng TF, Shr SJ, Sun KT, Chang TT, Young KC (2011) Novel Nucleotide and Amino Acid Covariation between the 5'UTR and the NS2/NS3 proteins of Hepatitis C Virus: Bioinformatic and Functional Analyses. PLoS One. 6: e25530 (Impact Factor 2.806)

13. Sun HY*, Chen SF, Lai MD, Chang TT, Chen TL, Li PY, Shieh DB, Young KC (2010) Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. Clin Chim Acta 411: 336-344. (Impact Factor 2.873)

國際論文

1. Chiung-Wen Tsao, Yu-Min Lin, Hung-Yu Sun, Kung-Chia Young, Yu-Chieh Chien, Wu-Tzu Feng. Anti-HCV effect of calcitriol via the newly protein synthesis and blockade of PPAR-g activity. 6th International Symposium on Infectious Disease and Signal Transduction/2016 Tawain-Japan Joint Symposium on Cell Signaling and Gene Regulation, Tainan, Taiwan (R.O.C), 2016 Oct 22-23.

2. Hung Yu Sun, Kung Chia Young. Lipoprotein lipase inhibits hepatitis C virus infection and reverses virus induced lipid accumulation through unsaturated fatty acid/CD36/PPARalpha signaling pathway. 23rd International Symposium on Hepatitis C Virus and Related Viruses. Kyoto, Japan. 2016 Oct 11-15. Oral presentation.

3. Tseng Chiung Ying, Hung Yu Sun, Wei Jen Tsai, Pin Nan Cheng, Yen Cheng, Chiu, Ting Tsung Chang, Kung Chia Young. The impacts of Zepatier or Harvoni treatment on plasma lipid profiles in chronic hepatitis C patients. 23rd International Symposium on Hepatitis C Virus and Related Viruses. Kyoto, Japan. 2016 Oct 11-15.

4. Wei Jen Tsai, Hung Yu Sun, Tseng Chiung Ying, Pin Nan Cheng, Yen Cheng, Chiu, Ting Tsung Chang, Kung Chia Young. Cultivated cell based evaluation of apolipoproteins with the treatment of direct acting antiviral agents against hepatitis C virus infection. 23rd International Symposium on Hepatitis C Virus and Related Viruses. Kyoto, Japan. 2016 Oct 11-15

5. Pin-Nan Cheng, Hung-Yu Sun, Chong-Ying Tseng, Wei-Jen Tsai, Yen-Cheng Chiu, Kung-Chia Young. Impacts of Direct-Acting Antiviral Agents on Plasma Lipid Profiles of Chronic Hepatitis C Patients. 5th APASL Single Topic Conference on Hepatitis C, Kaohsiung, Taiwan (R.O.C), 2016 June 10–12

6. Hung-Yu Sun, Pei-Ju Tsai, Chiung-Wen Tsao, Kung-Chia Young. Lipoprotein lipase liberates free fatty acids to inhibit hepatitis C virus infection and prevent lipid accumulation. 5th International Symposium on Infectious Disease and Signal Transduction/2015 Tawain-Japan Joint Symposium on Cell Signaling and Gene Regulation, Tainan, Taiwan (R.O.C), 2015 Nov 11-15.

7. Tsao, C.W., Lin, Y.M., Sun, H.Y., Young, K.C., Chien, Y.C., Feng, W.T. Anti-HCV effect of PK11195 via blockade of nitric oxide release. 5th International Symposium on Infectious Disease and Signal Transduction/2015 Tawain-Japan Joint Symposium on Cell Signaling and Gene Regulation, Tainan, Taiwan (R.O.C), 2015 Nov 11-15.

8. Hung-Yu Sun, Pei-Ju Tsai, Chiung-Wen Tsao, Kung-Chia Young. Lipoprotein lipase liberates free fatty acids exerting inhibitions of hepatitis C virus infection and lipid accumulation in hepatocytes. 10th Asia-Pacific Congress of Medical Virology 2015 (APCMV 2015) in conjunction with 12th Taipei International Conference on HIV/AIDS, Taipei, Taiwan (R.O.C), 2015 Oct 15-18.

9. Hung-Yu Sun, Chun-Chieh Lin, Pei-Ju Tsai, Chiung-Wen Tsao, Chih-Hsing Wu, Ting-Tsung Chang, Kung-Chia Young. Lipoprotein lipase inhibits HCV infection through free fatty acids-mediated PPARa pathway. 21th International Meeting on Hepatitis C Virus and Related Viruses, Banff, Canada, 2014 Sep 7-11.

10. Peiju Tsai, Chun-Chieh Lin, Hung-Yu Sun, Sung-Fang Chen, Yu-Wei Shiu, Kung-Chia Young. Establishment of Acute and Chronic Hepatitis C Virus Infections in Cell-Based Reporter System. 21th International Meeting on Hepatitis C Virus and Related Viruses, Banff, Canada, 2014 Sep 7-11.

11. Lin CC, Tsai PJ, Sun HY, Lee JC, Lai MD, Chang TT, Young KC. Apolipoprotein J is an essential host factor for the assembly of infectious hepatitis C virus particles. 20th International Meeting on Hepatitis C Virus and Related Viruses, Melbourne, Australia, 2013 Oct 6-10.

獎勵榮譽

2017 台灣肝病防治學術基金會肝病防治優秀論文獎

2017 成功大學-秀傳醫療體系學術合作研究計畫 共同主持人

執行計畫 ” 診斷治療及預防在病毒/代謝性/癌化肝臟疾病之轉譯套用:脂蛋白與載脂蛋白的新技術”

2017 台灣必治妥施貴寶股份有限公司代檢合作計畫

執行計畫 ”C型肝炎病毒定量代檢”

2016 成功大學醫學檢驗技術中心

執行代檢項目 ” 抗C型肝炎病毒藥物檢測 ”

執行代檢項目 ” C型肝炎病毒NS5A抗藥性相關變異株檢測 ”

執行代檢項目 ” 亞培C型肝炎病毒負荷量檢驗 ”

2014 國立成功大學醫學檢驗生物技術學系

病毒實驗室OHSAS 18000職業安全衛生管理系統認證

2014 國立成功大學醫學檢驗生物技術學系

病毒實驗室TOSHMS台灣職業安全衛生管理系統認證

2013 景凱生物科技股份有限公司代檢合作計畫

執行計畫 ”景凱藥物檢測”

2013 財團法人工業技術研究院代檢合作計畫