工作經歷
在讀博士和博士後工作期間,參與了昆明動物研究所王文研究員主持的973計畫“重要家養動植物在人工選擇下進化的遺傳和基因組機制”,和973計畫“人工選擇與基因組進化”;及參與了EU FP7項目支持的3SR project和USDA支持的National Animal Genome Research Program。2013年11月作為高層次引進人才到西北農林科技大學動物科技學院工作。
工作學習經歷:
2002-2006年,復旦大學生命科學院理學學士;
2006-2011年,中國科學院昆明動物所遺傳學博士;
2011-2013年,澳大利亞聯邦科學院家畜產業所博士後;
2013-2015年,西北農林科技大學動物科技學院院副教授;
2015-至今, 西北農林科技大學動物科技學院教授。
研究領域與主要貢獻
通過分子進化和群體遺傳學理論,分析農業領域在組學時代產生的海量數據,找到在長期進化和人工選育過程中,決定關鍵農業性狀的主效基因/具體突變,並通過實驗解析其分子機制。特別關注反芻類家畜,其作為陸地上最主要的草食動物,研究其能高效利用不同生態地域飼草進行前胃發酵的遺傳成因。在基因輔助育種套用領域,作為主要完成人之一進行了世界上首個綿羊和山羊的參考基因組構建工作,並作為協調人以聯盟形式設計和定製了適用於研究中國綿羊群體和山羊群體的 SNP 晶片。
通過研究牛羊基因組變異與性狀關聯關係,解析出構成瘤胃壁的特異基因家族和反芻動物特有的脂類合成代謝途徑,部分解釋了瘤胃和羊毛脂產生的遺傳基礎,發表在2014年的Science 雜誌。通過創新生物信息學分析方法,用以解析基因組數據,在頂級的生物方法學雜誌 Nature Biotechnology (兩篇)發表論文,首次報告將光學圖譜用於基因組組裝和進行全基因組結構變異的關聯分析。將全世界黃牛新分為五個截然不同的血統來源,首次釐清了中國黃牛的血統來源,發表在 Nature communications 。找到兩個主效基因分別導致北京鴨通體雪白和生長速度增加15%同時飼料轉化效率提高6%,發表在 Nature communications 。
在2019年,通過比較不同類型的反芻動物基因組和多達270個轉錄組,發現羊角和鹿茸具有相似的基因表達模式,其特異高表達的基因主要募集來自在骨、皮膚、腦和睪丸組織表達的基因。這些角組織特異高表達基因,連同一些快速進化基因都參與了神經脊細胞遷移通路,從而從遺傳學角度首次提出反芻動物的角具有相同的細胞起源—頭部神經脊幹細胞,為反芻動物角具有單一的進化起源提供了遺傳學證據,為無角牛、羊的育種提供了理論基礎和關鍵靶基因,相關研究發表在 Science 雜誌。
總計發表SCI論文30餘篇,被引用1300餘次,其中以第一或通訊作者(含並列)在Science 、Nature Biotechnology、Nature Communications、Cell Research、Genome Biology 等學術期刊發表論文20篇。
參與項目和獲得獎勵
在讀博和博後工作期間,參與了973計畫“重要家養動植物在人工選擇下進化的遺傳和基因組機制”,和973計畫“人工選擇與基因組進化”;及參與了EU FP7項目支持的3SR project和USDA支持的National Animal Genome Research Program。引進西北農林科技大學後,獲得校引進人才科研啟動基金的資助、省人才經費和國家自然基金委面上項目資助。並獲得和入選如下獎勵或計畫:
獲得2014年度中國科學院優秀博士學位論文獎;
獲得2015年“陝西省科技新星”稱號;
入選2015年中組部“人才項目專家”青年人才;
入選2016年陝西省“百人計畫”創新人才;
獲得2018年“傑出青年農業科學家”稱號;
入選2018年“國家優秀青年科學基金項目”。
發表文章
以第一(#)或通訊作者(*)發表論文:
1. Wang Y, Zhang C, Wang N, ,…, Jiang Y*,Wang W*, Q Qiang*. Genetic basis of ruminant headgear and rapid antler regeneration. Science, 364, eaav6335(2019)(cover story)
2. Chen L#, Qiu Q#, Jiang Y#, ,…,Heller R, Wang W. Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits. Science, 364,eaav6202 (2019)(cover story)
3. Tian X, Li R, Fu W, …, Li M*, Jiang Y*. Building a sequence map of the pig pan-genome from multiplede novoassemblies and Hi-C data. SCIENCE CHINA Life Sciences (2019)
4. Chen H, Liu J, Wen J, …, Song W*, Sun Q*, Jiang Y* Frequent intra- and inter-species introgression shape the landscape of genetic variation in bread wheat. Genome Biology (2019)
5. Wang Y, Gao S, ZhaoY, …, Jiang Y*.Allele-specific expression and alternative splicing in horse×donkey and cattle×yak hybrids. ZOOLOGICAL RESEARCH (2019) (cover story)
6. Li C, Li M, Li X, , …, Jiang Y*,Hu S*. Whole-genome resequencing reveals loci associated with thoracic vertebrae number in sheep. Frontiers in Genetics 2019
7. Cao Y, Xu H, Li R, …, Luo J*, Jiang Y*. Genetic Basis of Phenotypic Differences Between Chinese Yunling Black Goats and Nubian Goats Revealed by Allele-Specific Expression in Their F1 Hybrids. Frontiers in Genetics 10:145.doi: 10.3389/fgene.2019.00145
8. Chen N, Cai Y, Chen Q,...,Jiang Y*, Lei C*. Whole-genome resequencing reveals world-wide ancestry and multiple adaptive introgression events of domesticated cattle in East Asia. Nature communications, 9 (1), 2337(2018)
9. Zhou Z, Li M, Cheng H,..., Hou S*, Jiang Y*. An intercross population study reveals genes associated with body size and plumage color in ducks. Nature communications,9,2648(2018)
10. Wang X, Liu J, Niu Y, ..., Huang X*, Jiang Y*, Chen Y*. Low incidence of SNVs and indels in trio genomes of Cas9-mediated multiplex edited sheep. BMC Genomics (2018), 19:397
11. Wang X, Zheng Z, Cai Y, Chen T, Li C, Fu W, Jiang Y*. CNVcaller: Highly Efficient and Widely Applicable Software for Detecting Copy Number Variations in Large Populations. GigaScience, 12.4, 6(12) (2017)
12. Dong Y, Zhang X, Xie M, …, Wang W*, Jiang Y* Reference genome of wild goat and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics (2015), 16:431
13. Chen H, Jiang Y*, Progress and Prospects in Domestic Animals and Breeding: a Review of Genomic Copy Number Variations. Biotechnology Bulletin (2015) 31(11): 35-42.
14. Li M, Zhou H, Pan X, …, Zi X*, Jiang Y*, Cassava foliage affects the microbial diversity of Chinese indigenous geese caecum using 16S rRNA sequencing[J]. Scientific Reports, 2017, 7.
15. Jiang Y#, Wang X#, Kijas J, Dalrymple B. Beta globin gene evolution in the ruminants: evidence for an ancient origin of sheep haplotype B. Animal Genetics (2015) 46:506–514
16. Zhou Z#, Jiang Y#, Wang Z#…, Wang W, Tian Z. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature biotechnology 23(4): 408-414 (ESI Highly Cited Papers) (2015)
17. Jiang Y#, Xie M#, Chen W#…, Wang W, Dalrymple B. The sheep genome illuminates biology of the rumen and lipid metabolism. Science 344: 1168-1172. (ESI Highly Cited Papers) (2014)
18. Dong Y#, Xie M#, Jiang Y#…, Wang J, Wang W, Sequencing and automated whole-genome optical mapping of the genome of a domestic goat. Nature Biotechnology 31(2): 135-141 (ESI Highly Cited Papers) (2013)
19. Jiang Y#, Li Y#, Lee W#, … ,Zhang Y, Wang W, Venom gland transcriptomes of two elapid snakes (Bungarus multicinctus and Naja atra) and evolution of toxin genes. BMC Genomics 12(1) (2011), 1-13.
20. Li D#, Dong Y#, Jiang Y#, … ,Wang W, A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Research 20(4),408-420. (2010)
學術報告
重要國際學術會議報告情況
1.“Comparative genomics analysis provides new insights to ruminant biology ” 9th ICG, Sep 9-12, 2014, Shenzhen, China
2.“Detection of large-scale variation among sheep, goat and cattle genomes” 34th ISAG, July 27-31, 2014, Xi'an, China
3.“The domestic sheep reference genome assembly” 33rd ISAG, July 15-20, 2012, Cairns, Australia
4.“The imprintome of a domestic sheep” 33rd ISAG, July 15-20, 2012, Cairns, Australia
5.“A reference genome of the domestic goat” 33rd ISAG, July 15-20, 2012, Cairns, Australia
6.“The quality of sheep reference genome, OAR v3.1” 5th 3SR Consortium Meeting, June 28-29, Alghero, Italy
7.“Sheep Genome Project: Gap Filling and Unbalanced Allelic Expression” PAG XX, Jan 14-18, 2012 San Diego, US.
8.“High-Resolution Analysis of Allelic Expression in Seven Sheep tissues”PAG XIX, Jan 15-19, 2011 San Diego, US.
9.“Sequencing and assembly of the sheep reference genome” PAG XIX, Jan 15-19, 2011 San Diego, US.
10.“The progress of sheep and goat genome assembly”1000 Genomes Project May 13-14, 2010, Shenzhen, China.