姜雙英，女，中國科學院大學專任教師。
基本介紹
人物經歷,教育背景,工作經歷,科研成果,專利成果,出版信息,科研項目,
人物經歷
教育背景
2011-09--2017-06 清華大學 博士
2007-09--2011-06 東北農業大學 學士
工作經歷
2020-01~現在, 中國科學院深圳先進技術研究院, 副研究員
2019-07~2020-01,中科院深圳先進技術研究院, 助理研究員
2017-08~2019-07,中國科學院深圳先進技術研究院, 博士後
科研成果
專利成果
[1] 李敏, 戴俊彪, 王洋, 姜青山, 羅周卿, 姜雙英. 基於DNA的數據存儲方法、數據恢複方法及終端設備. CN: CN112527736A, 2021-03-19.
[2] 戴俊彪, 姜雙英, 唐園瑋. 基於合成基因和釀酒酵母同源重組機制的分子克隆方法. CN: CN112175984A, 2021-01-05.
[3] 戴俊彪, 姜雙英, 蔡澤霖, 曾誠. 一種 rDNA 陣列的快速構建方法及其在人工調控 rDNA 拷貝數中的套用. 202311134312.7, 2023-09-05.
出版信息
發表論文
[1] Shuangying Jiang, Zhouqing Luo, Jie Wu, Kang Yu, Shijun Zhao, Zelin Cai, Wenfei Yu, Hui Wang, Li Cheng, Zhenzhen Liang, Hui Gao, Marco Monti, Daniel Schindler, Linsen Huang, Cheng Zeng, Weimin Zhang, Chun Zhou, Yuanwei Tang, Tianyi Li, Yingxin Ma, Yizhi Cai, Jef D. Boeke, Qiao Zhao, Junbiao Dai. Building a eukaryotic chromosome arm by de novo design and synthesis. NATURE COMMUNICATIONS. 2023, 14(1): http://dx.doi.org/10.1038/s41467-023-43531-5.
[2] Daniel Schindler, Roy SK Walker, Shuangying Jiang, Aaron N Brooks, Yun Wang, Carolin A Mller, Charlotte Cockram, Yisha Luo, Alicia Garca, Daniel Schraivogel, Julien Mozziconacci, Noah Pena, Mahdi Assari, Mara del Carmen Snchez Olmos, Yu Zhao, Alba Ballerini, Benjamin A Blount, Jitong Cai, Lois Ogunlana, Wei Liu, Katarina Jnsson, Dariusz Abramczyk, Eva GarciaRuiz, Tomasz W Turowski, Reem Swidah, Tom Ellis, Tao Pan, Francisco Antequera, Yue Shen, Conrad A Nieduszynski, Romain Koszul, Junbiao Dai, Lars M Steinmetz, Jef D Boeke, Yizhi Cai. Design, construction, and functional characterization of a tRNA neochromosome in yeast. CELL. 2023, 186(24): 5237-5253.e22, http://dx.doi.org/10.1016/j.cell.2023.10.015.
[3] Yue Shen, Feng Gao, Yun Wang, Yuerong Wang, Ju Zheng, Jianhui Gong, Jintao Zhang, Zhouqing Luo, Daniel Schindler, Yang Deng, Weichao Ding, Tao Lin, Reem Swidah, Hongcui Zhao, Shuangying Jiang, Cheng Zeng, Shihong Chen, Tai Chen, Yong Wang, Yisha Luo, Leslie Mitchell, Joel S Bader, Guojie Zhang, Xia Shen, Jian Wang, Xian Fu, Junbiao Dai, Jef D Boeke, Huanming Yang, Xun Xu, Yizhi Cai. Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast. CELL GENOMICS. 2023, 3(11): http://dx.doi.org/10.1016/j.xgen.2023.100364.
[4] Hu, Xin, Jiang, Shuangying, Xu, Feifei, Zeng, Cheng, Wang, Xiangxiang, Liu, Wei, Cheng, Aimin, Ma, Chengying, Gao, Ning, Zhao, Yuyu, Dai, Junbiao, Zhao, Guanghou. Engineering and functional analysis of yeast with a monotypic 40S ribosome subunit. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(6): http://dx.doi.org/10.1073/pnas.2114445119.
[5] Luo, Zhouqing, Yu, Kang, Xie, Shangqian, Monti, Marco, Schindler, Daniel, Fang, Yuan, Zhao, Shijun, Liang, Zhenzhen, Jiang, Shuangying, Luan, Meiwei, Xiao, Chuanle, Cai, Yizhi, Dai, Junbiao. Compacting a synthetic yeast chromosome arm. GENOME BIOLOGY[J]. 2021, 22(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780613/.
[6] Shuangying Jiang, Yuanwei Tang, liang xiang, Xinlu Zhu, Zelin Cai, Ling Li, Yingxi Chen, Peishuang Chen, Yuge Feng, Xin Lin, Guoqiang Li, SHARIF JAFAR, Junbiao Dai. Efficient de novo assembly and modification of large DNA fragments. Science China Life Sciences[J]. 2021
[7] Dai, Junbiao, Boeke, Jef D, Luo, Zhouqing, Jiang, Shuangying, Cai, Yizhi. Sc3.0: revamping and minimizing the yeast genome. GENOME BIOLOGY. 2020, 21(1): http://dx.doi.org/10.1186/s13059-020-02130-z.
[8] Jiang, Shuangying, Si, Tong, Dai, Junbiao. Whole-Genome Regulation for Yeast Metabolic Engineering. SMALL METHODSnull. 2020, 4(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000496824800001.
[9] Luo, Zhouqing, Hoffmann, Stefan A, Jiang, Shuangying, Cai, Yizhi, Dai, Junbiao. Probing eukaryotic genome functions with synthetic chromosomes. EXPERIMENTAL CELL RESEARCHnull. 2020, 390(1): http://dx.doi.org/10.1016/j.yexcr.2020.111936.
[10] Braberg, Hannes, Echeverria, Ignacia, Bohn, Stefan, Cimermancic, Peter, Shiver, Anthony, Alexander, Richard, Xu, Jiewei, Shales, Michael, Dronamraju, Raghuvar, Jiang, Shuangying, Dwivedi, Gajendradhar, Bogdanoff, Derek, Chaung, Kaitlin K, Huttenhain, Ruth, Wang, Shuyi, Mavor, David, Pellarin, Riccardo, Schneidman, Dina, Bader, Joel S, Fraser, James S, Morris, John, Haber, James E, Strahl, Brian D, Gross, Carol A, Dai, Junbiao, Boeke, Jef D, Sali, Andrej, Krogan, Nevan J. Genetic interaction mapping informs integrative structure determination of protein complexes. SCIENCE[J]. 2020, 370(6522): 1294-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946025/.
[11] Shuangying Jiang, Shijun Zhao, Zelin Cai, Yuanwei Tang, Junbiao Dai. Synthetic yeast genomes for studying chromosomal features. CURRENT OPINION IN SYSTEMS BIOLOGY. 2020, 23: 1-7, http://dx.doi.org/10.1016/j.coisb.2020.09.001.
[12] Jiang, Shuangying, Dai, Junbiao. Inevitability or contingency: how many chromosomes do we really need?. SCIENCE CHINA-LIFE SCIENCES[J]. 2019, 62(1): 140-143, http://lib.cqvip.com/Qikan/Article/Detail?id=6100172052.
[13] Auxillos, Jamie Y, GarciaRuiz, Eva, Jones, Sally, Li, Tianyi, Jiang, Shuangying, Dai, Junbiao, Cai, Yizhi. Multiplex Genome Engineering for Optimizing Bioproduction in Saccharomyces cerevisiae. BIOCHEMISTRY[J]. 2019, 58(11): 1492-1500, http://dx.doi.org/10.1021/acs.biochem.8b01086.
[14] Cheng, Li, Liu, Chengxi, Jiang, Shuangying, Hou, Sha, Huang, Jinguo, Chen, Ziqing, Sun, Yangyang, Qi, Huan, Jiang, Hewei, Wang, Jingfang, Zhou, Yiming, Czajkowsky, Daniel M, Dai, Junbiao, Tao, Shengce. Cell Lysate Microarray for Mapping the Network of Genetic Regulators for Histone Marks. MOLECULAR & CELLULAR PROTEOMICS[J]. 2018, 17(9): 1720-1736, http://dx.doi.org/10.1074/mcp.RA117.000550.
[15] Zhang, Weimin, Zhao, Guanghou, Luo, Zhouqing, Lin, Yicong, Wang, Lihui, Guo, Yakun, Wang, Ann, Jiang, Shuangying, Jiang, Qingwen, Gong, Jianhui, Wang, Yun, Hou, Sha, Huang, Jing, Li, Tianyi, Qin, Yiran, Dong, Junkai, Qin, Qin, Zhang, Jiaying, Zou, Xinzhi, He, Xi, Zhao, Li, Xiao, Yibo, Xu, Meng, Cheng, Erchao, Huang, Ning, Zhou, Tong, Shen, Yue, Walker, Roy, Luo, Yisha, Kuang, Zheng, Mitchell, Leslie A, Yang, Kun, Richardson, Sarah M, Wu, Yi, Li, BingZhi, Yuan, YingJin, Yang, Huanming, Lin, Jiwei, Chen, GuoQiang, Wu, Qingyu, Bader, Joel S, Cai, Yizhi, Boeke, Jef D, Dai, Junbiao. Engineering the ribosomal DNA in a megabase synthetic chromosome. SCIENCE[J]. 2017, 355(6329): http://dx.doi.org/10.1126/science.aaf3981.
[16] Jiang, Shuangying, Liu, Yan, Xu, Caiyue, Wang, Yun, Gong, Jianhui, Shen, Yue, Wu, Qingyu, Boeke, Jef D, Dai, Junbiao. Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library. G3-GENES GENOMES GENETICS[J]. 2017, 7(12): 3857-3866, https://doaj.org/article/9b93a751e2e8436c81df0da79af1f8ed.
[17] Jiang, Shuangying, Liu, Yan, Wang, Ann, Qin, Yiran, Luo, Maoguo, Wu, Qingyu, Boeke, Jef D, Dai, Junbiao. Construction of Comprehensive Dosage-Matching Core Histone Mutant Libraries for Saccharomyces cerevisiae. GENETICS[J]. 2017, 207(4): 1263-1273, https://www.webofscience.com/wos/woscc/full-record/WOS:000417013900009.
科研項目
（ 1 ） 葡萄糖對組蛋白H4 K8 2-羥異丁醯修飾的調控機制研究, 主持, 國家級, 2019-01--2021-12
（ 2 ） 真核微生物基因組的人工設計與合成, 參與, 國家級, 2019-07--2024-06
（ 3 ） 釀酒酵母中新型rDNA陣列的設計合成與轉錄分析, 參與, 國家級, 2019-01--2021-12
（ 4 ） 第17條釀酒酵母染色體的合成及功能評價, 參與, 部委級, 2018-01--2019-12
（ 5 ） 釀酒酵母中組蛋白二羥異丁醯化修飾的調控機制研究, 主持, 國家級, 2018-01--2019-07
（ 6 ） 釀酒酵母rDNA組織形式的可塑性研究, 負責人, 地方任務, 2023-01--2025-12
