姜曉宏，女，南京大學生命科學學院教授。
基本介紹
- 中文名：姜曉宏
- 專業方向：哺乳動物代謝性疾病的研究
- 職稱：副教授
- 任職院校：南京大學
學術兼職,研究方向,獲獎情況,科研成果,
學術兼職
江蘇省生理科學會青年工作委員。
研究方向
從事哺乳動物代謝性疾病的研究，尤其是肥胖導致的Ⅱ型糖尿病和心血管疾病。主要是從轉錄和轉錄後加工水平對線粒體的功能進行研究，從線粒體的生理功能到病理轉變的全新角度，解釋多種代謝性疾病潛在的分子生物學機制與聯繫。對各種代謝性疾病，尤其是肥胖引起的代謝綜合症，從回複線粒體功能，恢復機體能量平衡的角度尋找新的更有效治療途徑和藥物靶點。
（1）肥胖與2型糖尿病的分子機制
（2）心血管疾病的分子機制與治療
（3）腫瘤惡病質對機體代謝的影響及治療
獲獎情況
2011年，高等學校科學研究優秀成果獎自然科學一等獎
科研成果
代表性論文：
1. The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells. J Nutr Biochem. (2018) Jul; 57: 197-205. Hou D, He F, Ma L, Cao M, Zhou Z, Wei Z,Xue Y, Sang X, Chong H, Tian C, Zheng S, Li J, Zen K, Chen X, Hong Z, Zhang CY, Jiang X.
2. The Jun/miR-22/HuR regulatory axis contributes to tumorigenesis in colorectal cancer. Mol Cancer. (2018) Jan 19; 17(1):11. Liu Y, Chen X, Cheng R, Yang F, Yu M, Wang C, Cui S, Hong Y, Liang H, Liu M, Zhao C, Ding M, Sun W, Liu Z, Sun F, Zhang C, Zhou Z, Jiang, X, Chen X.
3. Characterization of serum miRNAs as molecular biomarkers for acute Stanford type A aortic dissection diagnosis. Sci Rep. (2017) Oct 20; 7(1):13659. Xu Z, Wang Q, Pan J, Sheng X, Hou D, Chong H, Wei Z, Zheng S,Xue Y, Zhou Q, Cao H, Zhang CY, Wang D, Jiang X.
4. Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16. Nature Communications. (2016) May 31; 7:11533. Ding H, Zheng S, Garcia-Ruiz D, Hou D, Wei Z, Liao Z, Li L, Zhang Y, Han X, Zen K, Zhang CY, Li J, Jiang X.
5. MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis. Atherosclerosis. (2015) Aug; 241(2):671-81. Xue Y, Wei Z, Ding H, Wang Q, Zhou Z, Zheng S, Zhang Y, Hou D, Liu Y, Zen K, Zhang CY, Li J, Wang D, Jiang X
6. Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression.Protein Cell. (2015) Jun;6(6):391-6.Li J, Zhang Y, Li D, Liu Y, Chu D, Jiang X, Hou D, Zen K, Zhang CY
7. Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance through inhibition of PTP1B.Diabetologia. (2014) Oct; 57(10):2145-54.Ding H, Zhang Y, Xu C, Hou D, Li J, Zhang Y, Peng W, Zen K, Zhang CY, Jiang X.
8. MicroRNA-495 induces breast cancer cell migration by targeting JAM-A. Protein Cell. (2014) Cao M, Nie W, Li J, Zhang Y, Yan X, Guan X, Chen X, Zen K, Zhang CY, Jiang X, Hou D
9. Directing RNase P-mediated cleavage of target mRNAs by engineered external guide sequences in cultured cells. Methods Mol Biol. (2014) 1103:45-56. Jiang X, Sunkara N, Lu S, Liu F. (專著)
10. Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reaction. J Biol Chem. (2014) Mar 21; 289(12):8432-41. Shi L, Zhang Q, Xu B, Jiang X, Dai Y, Zhang CY, Zen K
11. miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinasesignalling inhibitor 1. Eur J Cancer. (2014) Mar; 50(5):1013-24. Cao M, Hou D, Liang H, Gong F, Wang Y, Yan X,Jiang X, Wang C, Zhang J, Zen K, Zhang CY, Chen X.
12. The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus. PLoS Pathog. (2013) Aug; 9(8):e 1003525. Dai X, Yu X, Gong H,Jiang X, Abenes G, Liu H, Shivakoti S, Britt WJ, Zhu H, Liu F, Zhou ZH.
13. Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis.J Biol Chem. (2013) Aug 9; 288(32):23586-96. Li J, Zhang Y, Liu Y, Dai X, Li W, Cai X, Yin Y, Wang Q, Xue Y, Wang C, Li D, Hou D, Jiang X, Zhang J, Zen K, Chen X, Zhang CY.
14. Effective inhibition of cytomegalovirus infection by external guide sequences in mice. Proc Natl Acad Sci USA.(2012) Aug 7; 109 (32):13070-5. Jiang X, Gong H, Chen YC, Vu GP, Trang P, Zhang CY, Lu S, Liu F.
15. Ribonuclease P-mediated inhibition of human cytomegalovirus gene expression and replication induced by engineered external guide sequences. RNA Biol. (2012) Sep 9 (9):1186-95. Jiang X, Chen YC, Gong H, Trang P, Lu S, Liu F.
