姜伊鳴 博士,中山大學藥學院副教授,碩士生導師。研究方向為藥物代謝對生理和病理的調控作用、肝臟藥理與毒理及中藥開發的相關研究。2008至2018年在中山大學藥學院進行本科、碩士及博士學習,2017年受國際交流項目資助赴美國國立衛生研究院訪問學習。先後主持國家自然科學基金面上項目、國家自然科學基金青年項目、廣東省自然科學基金面上項目、廣州市科技計畫項目4項,參與國家重點研發計畫等國家級項目8項。研究成果共發表SCI論文30餘篇,其中一作10篇發表在Hepatology、British Journal of Pharmacology、Toxicological Sciences、Acta Pharmacologica Sinica、Chemico-Biological Interactions等知名學術刊物上。申請國家發明專利8項,已獲授權4項;2018年獲得中國藥理學會藥物代謝-劉昌孝人才獎。
基本介紹
人物經歷,科研項目,社會任職,代表性論文,
人物經歷
2008.09-2012.06,中山大學藥學院,藥學專業,獲學士學位
2012.09-2015.06,中山大學藥學院,藥學碩士專業,獲碩士學位
2015.09-2018.06,中山大學藥學院,藥理學專業,獲博士學位
2017.09-2017.12, 美國國立衛生研究院(NIH),訪問學習
2018.08-2021.08,中山大學藥學院,特聘副研究員
2021.09-,中山大學藥學院,副教授,碩士生導師
科研項目
- 國家自然科學基金面上項目,82173881,2022.01-2025.12,負責人。
- 國家自然科學基金青年項目,82003840,2021.01-2023.12,負責人。
- 廣東省自然科學基金面上項目,2019A1515010247,2019.10-2022.09,負責人。
- 廣州市科技基礎與套用基礎研究項目,202102020717,2021.04-2023.03,負責人。
- 國家自然科學基金面上項目,81973392,2020.01-2023.12,參與。
- 國家自然科學基金青年項目,81703599,2018.01-2020.12,參與。
- 國家自然科學基金青年項目,81703609,2018.01-2020.12,參與。
- 國家自然科學基金青年項目,81603185,2017.01-2019.12,參與。
- 國家自然科學基金面上項目,81573507,2016.01-2019.12,參與。
- 國家自然科學基金面上項目,81573489,2016.01-2019.12,參與。
- 國家自然科學基金面上項目,81373470,2014.01-2017.12,參與。
社會任職
廣東省藥理學會藥物代謝委員會委員
廣東省藥理學會臨床藥理委員會委員
代表性論文
- Yiming Jiang (姜伊鳴), Xinpeng Yao, Shicheng Fan, Yue Gao, Huizhen Zhang, Min Huang*, Huichang Bi*. Lipidomic profiling reveals triacylglycerol accumulation in the liver during pregnane X receptor activation-induced hepatomegaly.J Pharm Biomed Anal. 2020. DOI: 10.1016/j.jpba.2020.113851.
- Yiming Jiang# (姜伊鳴), Minghua Jin#, Jingkao Chen#, Jinwu Yan, Peiqing Liu, Meicun Yao, Weibin Cai, Rongbiao Pi*. Discovery of a novel niacin-lipoic acid dimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects. Eur J Pharmacol. 2020 Feb 5;868:172871.
- Yiming Jiang (姜伊鳴), Dechun Feng, Xiaochao Ma, Shicheng Fan, Yue Gao, Kaili Fu, Ying Wang, Jiahong Sun, Xinpeng Yao, Conghui Liu, Huizhen Zhang, Leqian Xu, Aiming Liu, Frank J. Gonzalez, Yingzi Yang, Bin Gao, Min Huang, Huichang Bi*. Pregnane X Receptor Regulates Liver Size and Liver Cell Fate via Yes-associated Protein Activation. Hepatology. 2019 Jan;69(1):343-358.
- Hang Zeng#, Yiming Jiang# (姜伊鳴,共同一作),Pan Chen, Xiaomei Fan, Dongshun Li, Aiming Liu, Xiaochao Ma, Wen Xie, Peiqing Liu, Frank J Gonzalez, Min Huang and Huichang Bi*, Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Br J Pharmacol. 2017 Apr;174(8):672-688.
- Huizhen Zhang#, Yiming Jiang# (姜伊鳴,共同一作), Jingjing Wu, Chuanqi Zheng, Xiaorong Ran, Dongshun Li, Min Huang, Huichang Bi*.Metabolic mapping of Schisandra sphenanthera extract and its active lignans using a metabolomic approach based on ultra high performance liquid chromatography with high-resolution mass spectrometry. J Sep Sci. 2017 Jan;40(2):574-586.
- Yiming Jiang# (姜伊鳴), Ying Wang#, Huasen Tan, Tao Yu, Xiaomei Fan, Pan Chen, Hang Zeng, Min Huang*, Huichang Bi*. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway. Acta Pharmacol Sin. 2016 Mar;37(3):382-9.
- Yiming Jiang# (姜伊鳴), Xiaomei Fan#, Ying Wang , Huasen Tan, Pan Chen, Hang Zeng , Min Huang*, Huichang Bi*. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chem Biol Interact. 2015 25;231:83-9.
- Ying Wang#, Yiming Jiang# (姜伊鳴,共同一作), Xiaomei Fan, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen, Min Huang, Huichang Bi*. Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways. Toxicol Lett. 2015 16;236(2):82-9.
- Yiming Jiang# (姜伊鳴), Xiaomei Fan#, Ying Wang, Pan Chen, Hang Zeng, Huasen Tan, Frank J. Gonzalez, Min Huang* and Huichang Bi*. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015 Jan;143(1):107-15.
- Xiaomei Fan#, Yiming Jiang# (姜伊鳴,共同一作), Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen,Aijuan Qu, Frank J. Gonzalez, Min Huang, and Huichang Bi*. Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.Drug Metab Dispos. 2014 Dec;42(12):1982-90.