《多環芳烴致胎兒神經管缺陷作用及氧化應激機制研究》是任愛國為項目負責人，北京大學為依託單位的面上項目。
基本介紹
- 中文名：多環芳烴致胎兒神經管缺陷作用及氧化應激機制研究
- 項目類別 ：面上項目
- 依託單位 ：北京大學
- 項目負責人：任愛國
科研成果 ,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Dietary Folate Intake Levels in Rural Women Immediately Before Pregnancy in Northern China | 期刊論文 | Meng, Qinqin，Zhang, Le，Liu, Jufen，Li, Zhiwen，Jin, Lei，Zhang, Yali，Wang, Linlin，Ren, Aiguo(*) |
2 | Plasma folate levels in early to mid pregnancy after a nation-wide folic acid supplementation program in areas with high and low prevalence of neural tube defects in china | 期刊論文 | Liu, Jufen，Gao, Lili，Zhang, Yali，Jin, Lei，Li, Zhiwen，Zhang, Le，Meng, Qinqin，Ye, Rongwei，Wang, Linlin，Ren, Aiguo(*) |
3 | Prevalence and trend of neural tube defects in five counties in Shanxi province of Northern China, 2000 to 2014 | 期刊論文 | Liu, Jufen，Zhang, Le，Li, Zhiwen，Jin, Lei，Zhang, Yali，Ye, Rongwei，Liu, Jianmeng，Ren, Aiguo(*) |
4 | Association between maternal single nucleotide polymorphisms in genes regulating glucose metabolism and risk for neural tube defects in offspring | 期刊論文 | Fu, Yunting，Wang, Lin-lin，Yi, Deqing，Jin, Lei，Liu, Jufen，Zhang, Yali，Ren, Aiguo(*) |
5 | Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects | 期刊論文 | Shanshan Li(#)，Linlin Wang，Yun Huang，Yuanyuan Wang，Caiyun Wang，Nicholas D.E. Greene，Aiguo Ren(*) |
6 | 神經管缺陷病理解剖結果與臨床報告的對比分析 | 期刊論文 | 王媛媛，靳蕾，劉菊芬，張亞黎，李智文，任愛國(*) |
7 | Apoptosis, Expression of PAX3 and P53, and Caspase Signal in Fetuses with Neural Tube Defects | 期刊論文 | Linlin Wang，Shanshan Lin，Deqing Yi，Yun Yuang，Caiyun Wang，Lei Jin，Jufen Liu，Yali Zhang，Aiguo Ren(*) |
8 | Organochlorine pesticide levels inmaternal serumand risk of neural tube defects in offspring in Shanxi Province, China: A case-control study | 期刊論文 | Wang, Bin(#)，Yi, Deqing，Jin, Lei，Li, Zhiwen，Liu, Jufen，Zhang, Yali，Qiu, Xinghua，Liu, Wenxin，Tao, Shu，Ren, Aiguo(*) |
9 | Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring | 期刊論文 | Liu, Jufen，Zhang, Yali，Jin, Lei，Li, Guoxing，Wang, Linlin，Bao, Yanping，Fu, Yunting，Li, Zhiwen，Zhang, Le，Ye, Rongwei，Ren, Aiguo(*) |
10 | Markers of macromolecular oxidative damage in maternal serum and risk of neural tube defects in offspring | 期刊論文 | Yuan, Yue，Zhang, Le，Jin, Lei，Liu, Jufen，Li, Zhiwen，Wang, Linlin，Ren, Aiguo(*) |
11 | Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis | 期刊論文 | Wang, Linlin(#)，Lin, Shanshan，Zhang, Ji，Tian, Tian，Jin, Lei，Ren, Aiguo(*) |
12 | Exposure of methyl mercury in utero and the risk of neural tube defects in a Chinese population | 期刊論文 | Jin, Lei，Liu, Ming，Zhang, Le，Li, Zhiwen，Yu, Jingru，Liu, Jianmeng，Ye, Rrongwei，Chen, Laiguo(*)，Ren, Aiguo(*) |
13 | Vitamin E Decreases the Incidence of Neural Tube Defects Induced by Benzo(a)pyrene in ICR Mice | 會議論文 | Ren, A. G.(#)(*)，Lin, S. S.，Wang, L. L.，Huang, Y. |
14 | Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population | 期刊論文 | Yi, Deqing(#)，Yuan, Yue，Jin, Lei，Zhou, Guodong，Zhu, Huiping，Finnell, Richard H.，Ren, Aiguo(*) |
15 | Expression of PAX3 and P53 in Human Fetuses with Neural Tube Defects | 會議論文 | Ren A(#)(*)，Yi D，Wang CY，Wang LL，Jin L，Liu JF，Zhang YL |
16 | Levels of Polycyclic Aromatic Hydrocarbons in Maternal Serum and Risk of Neural Tube Defects in Offspring | 期刊論文 | Wang, Bin(#)，Jin, Lei(#)，Ren, Aiguo(*)，Yuan, Yue，Liu, Jufen，Li, Zhiwen，Zhang, Le，Yi, Deqing，Wang, Lin-lin，Zhang, Yali，Wang, Xilong，Tao, Shu，Finnell, Richard H. |
17 | Plasma folate levels and associated factors in women planning to become pregnant in a population with high prevalence of neural tube defects | 期刊論文 | Ma, Rui，Wang, Linlin，Jin, Lei，Li, Zhiwen，Ren, Aiguo(*) |
18 | Tea consumption is not associated with reduced plasma folate concentration among chinese pregnant women | 期刊論文 | Liu, Jufen，Jin, Lei，Zhang, Yali，Zhang, Le，Li, Zhiwen，Wang, Linlin，Ye, Rongwei，Ren, Aiguo(*) |
19 | 葉酸預防神經管缺陷 | 期刊論文 | 任愛國(#)(*) |
20 | 胎兒中樞神經組織細胞凋亡與神經管缺陷關係的初探 | 期刊論文 | 王彩雲，林珊珊，易德青，王琳琳，靳蕾，任愛國(*) |
項目摘要
神經管缺陷(NTDs)是一類常見致死、致殘性先天缺陷，是影響出生人口素質的主要原因之一。NTDs的病因及發病機制尚未完全清楚。本課題組前期研究提示，多環芳烴(PAHs)可能與NTDs發病有關。本項目結合人體研究和動物模型，研究PAHs的致NTDs作用，檢驗氧化應激是否為PAHs的致畸機制。人體研究採用病例對照研究方法。病例為引產NTDs胎兒，對照為引產無缺陷胎兒。檢測肝組織內PAHs水平；中樞神經組織內氧化-抗氧化狀態、PAH-DNA加合物、生物大分子氧化損傷標誌、PAX3和p53基因及蛋白表達水平，及細胞凋亡水平，分析PAHs與NTDs的關係及氧化應激所起作用。通過孕鼠體內染毒和體外全胚胎培養，構建PAHs致NTDs動物模型，檢測胎鼠中樞神經組織內氧化-抗氧化狀態、DNA加合物、生物大分子氧化損傷標誌、Pax3和p53基因及蛋白表達水平，及細胞凋亡水平，揭示PAHs致NTDs分子機制。
