夏楊柳，女，博士，大連理工大學生命科學與藥學學院講師。
基本介紹
- 中文名：夏楊柳
- 畢業院校：中國科學院大連化學物理研究所
- 學位/學歷：博士
- 職業：教師
- 任職院校：大連理工大學生命科學與藥學學院
個人經歷,學術成果,榮譽獎項,
個人經歷
學習經歷
2009.09 － 2016.01 中國科學院大連化學物理研究所，生物化工專業，工學博士
工作經歷
2016.03－至今 大連理工大學生命與醫藥學院，講師
學術成果
已結題項目
1. 兒茶酚甲基化酶抑制劑類藥性最佳化及合作開發，參與人，國家國際科技合作專項項目，2012 - 2015，97萬
2. 香豆素兒茶酚類化合物的結構-代謝穩定性關係研究，參與人，國家自然科學基金，2011 - 2013，23.7萬
代表性論文
1. Xia Yang-Liu，Ge Guang-Bo，Wang Ping，Liang Si-Cheng，He Yu-Qi, Ning Jing, Qian Xing-Kai, Li Yan, Yang Ling. Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins. Drug Metabolism and Disposition. 2015
2. Xia Yang-Liu, Liang Si-Cheng, Zhu Liang-Liang, Ge Guang-Bo, He Gui-Yuan, Ning Jing, Lv Xia, Ma Xiao-Chi, Yang Ling, Yang Sheng-Li. Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin. Drug Metabolism and Pharmacokinetics. 2014
3. Wang Ping#, Xia Yang-Liu#, Yu Yang, Lu Jun-Xia, Zou Li-Wei, Feng Lei, Ge Guang-Bo, Yang Ling. Design, synthesis and biological evaluation of esculetin derivatives as anti-tumour agents. Rsc Advances. 2015
4. Xin Hong#, Xia Yang-Liu#，Hou Jie, Wang Ping, He Wei, Yang Ling, Ge Guang-Bo, Xu Wei. Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin. Journal of Pharmacy and Pharmacology. 2015
5. Si-Cheng Liang, Yang-Liu Xia, Jie Hou, Guang-Bo Ge, Jiang-Wei Zhang, Yu-Qi He, Jia-Yue Wang, Xiao-Yi Qi, Ling Yang. Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro: Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis. Journal of Pharmaceutical Sciences. 2016
6. 王梅玲, 夏楊柳, 楊夢麗, 吳大暢, 劉麗坤, 葛廣波, 楊凌, 侯潔. O-葡萄糖醛酸苷的生物合成研究進展. 中草藥. 2015
7. Lv Xia, Hou Jie, Xia Yang-Liu, Ning Jing, He Gui-Yuan, Wang Ping, Ge Guang-Bo, Xiu Zhi-Long, Yang Ling. Glucuronidation of bavachinin by human tissues and expressed UGT enzymes: Identification of UGT1A1 and UGT1A8 as the major contributing enzymes. Drug Metabolism and Pharmacokinetics. 2015
8. Zhu Liangliang, Xiao Ling, Xia Yangliu, Zhou Kun, Wang Huili, Huang Minyi, Ge Guangbo, Wu Yan, Wu Ganlin, Yang Ling. Diethylstilbestrol can effectively accelerate estradiol-17-O-glucuronidation, while potently inhibiting estradiol-3-O-glucuronidation. Toxicology and Applied Pharmacology. 2015
9. Liang Si-Cheng, Ge Guang-Bo, Xia Yang-Liu, Zhang Jiang-Wei, Qi Xiao-Yi, Tu Cai-Xia, Yang Ling. In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis. Journal of Pharmaceutical Sciences. 2015
10. He Guiyuan, Zhang Shixuan, Xu Liang, Xia Yangliu, Wang Ping, Li Shiyang, Zhu Liangliang, Xu Hongxi, Ge Guangbo, Yang Ling. C-8 Mannich base derivatives of baicalein display improved glucuronidation stability: exploring the mechanism by experimentation and theoretical calculations. RSC Advances. 2015
11. Sun Dongxue, Zhu Liangliang, Xiao Ling, Xia Yangliu, Ge Guangbo, Cao Yunfeng, Wu Yan, Yin Jun, Yang Ling. In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences. Xenobiotica. 2014
12. Guo Bin, Fang Zhongze, Yang Lu, Xiao Ling，Xia Yangliu, Gonzalez Frank J., Zhu Liangliang, Cao Yunfeng, Ge Guangbo, Yang Ling, Sun Hongzhi. Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases. Chemico-Biological Interactions. 2015
13. 楊剛, 朱亮亮, 呂俠, 吳大暢, 夏楊柳, 馬驍馳, 辛毅, 侯潔. Highly Efficient Preparation of Bisphenol A Glucuronide. Chemical Journal of Chinese Universities-Chinese. 2014
14. Dong Rui-Hua, Fang Zhong-Ze, Zhu Liang-Liang, Ge Guang-Bo, Li Xiao-Bao, Hu Cui-Min, Cao Yun-Feng, Xia Yang-Liu, Yang Ling, Liu Ze-Yuan. Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms. Xenobiotica. 2013
榮譽獎項
第一屆藥代動力學朝陽論壇傑出獎（2015年）
