《基於監測線粒體質控的發光金屬配合物探針設計》是張俊龍為項目負責人，北京大學為依託單位的面上項目。
基本介紹
- 中文名：基於監測線粒體質控的發光金屬配合物探針設計
- 項目類別：面上項目
- 項目負責人 ：張俊龍
- 依託單位 ：北京大學
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Introducing Metallosalens into Biological Studies: The Renaissance of Traditional Coordination Complexes | 期刊論文 | Yin, Hao-Yan(#); Tang, Juan; Zhang, Jun-Long(*) |
2 | Constructing a Catalytic Cycle for C-F to C-X (X = O, S, N) Bond Transformation Based on Gold-Mediated Ligand Nucleophilic Attack | 期刊論文 | Hu, Ji-Yun(#); Zhang, Jing; Wang, Gao-Xiang; Sun, Hao-Ling(*); Zhang, Jun-Long(*) |
3 | Aromaticity versus regioisomeric effect of beta-substituents in porphyrinoids | 期刊論文 | Yao, Yuhang(#); Rao, Yu; Liu, Yiwei; Jiang, Liang; Xiong, Jin; Fan, Ying Jie; Shen, Zhen(*); Sessler, Jonathan L(*); Zhang, Jun Long(*) |
4 | Fluorescence lifetime imaging of upper gastrointestinal pH in vivo with a lanthanide based near-infrared tau probe | 期刊論文 | Ning, Yingying(#); Cheng, Shengming; Wang, Jing Xiang; Liu, Yi Wei; Feng, Wei; Li, Fuyou(*); Zhang, Jun Long(*) |
5 | Synthesis, characterization and reactivity of trans-dihydroxy platinum(IV) porphyrins | 期刊論文 | Ning, Yingying(#); Yu, Yi; Liu, Yi-Wei; Zhang, Jing(*); Sun, Hao-Ling; Zhang, Jun-Long(*) |
6 | Luminescent metal salen complex as intracellular microviscosity fluorescent sensor | 期刊論文 | 尹昊琰(#); 唐娟; 張俊龍(*) |
7 | Unusual near infrared (NIR) fluorescent palladium(ii) macrocyclic complexes containing M-C bonds with bioimaging capability | 期刊論文 | Yao, Yuhang(#); Hou, Chun Liang; Yang, Zi Shu; Ran, Guangliu; Kang, Lei; Li, Cuicui; Zhang, Wenkai(*); Zhang, Jing; Zhang, Jun Long(*) |
8 | Gadolinium(III) Porpholactones as Efficient and Robust Singlet Oxygen Photosensitizers | 期刊論文 | Ke, Xian-Sheng(#); Ning, Yingying; Tang, Juan; Hu, Ji-Yun; Yin, Hao-Yan; Wang, Gao-Xiang; Yang, Zi-Shu; Jie, Jialong; Liu, Kunhui; Meng, Zhao-Sha; Zhang, Zongyao; Su, Hongmei; Shu, Chunying; Zhang, Jun-Long(*) |
9 | 具有癌細胞殺傷能力的主族金屬配合物及其製備和套用 | 專利 | 張俊龍(#)(*); 尹昊琰; 王炳武 |
10 | Near-infrared (NIR) lanthanide molecular probes for bioimaging and biosensing | 期刊論文 | Ning, Yingying(#); Zhu, Mengliang; Zhang, Jun Long(*) |
11 | Orthogonally arranged tripyrrin-BODIPY conjugates with an edge to plane mode | 期刊論文 | Hou, Chun Liang(#); Yao, Yuhang; Wang, Da; Zhang, Jing; Zhang, Jun Long(*) |
12 | A proof-of-concept application of water-soluble ytterbium(III) molecular probes in in vivo NIR-II whole body bioimaging | 期刊論文 | Ning, Yingying(#); Chen, Si; Chen, Hao; Wang, Jing Xiang; He, Shuqing; Liu, Yi Wei; Cheng, Zhen(*); Zhang, Jun Long(*) |
13 | Fluorescence Lifetime Imaging of Upper Gastrointestinal pH In Vivo with a Lanthanide Based Near-Infrared τ Probe | 期刊論文 | Yingying Ning(#); Shengming Cheng; Jingxiang Wang; Yi-Wei Liu; Wei Feng; Fuyou Li(*); Jun-Long Zhang(*) |
14 | Enhancing the reactivity of nickel(II) in hydrogen evolution reactions (HERs) by beta-hydrogenation of porphyrinoid ligands | 期刊論文 | Wu, Zhuo-Yan(#); Wang, Teng; Meng, Yin-Shan; Rao, Yu; Wang, Bing-Wu(*); Zheng, Jie(*); Gao, Song; Zhang, Jun-Long(*) |
15 | Highly near-IR emissive ytterbium(III) complexes with unprecedented quantum yields | 期刊論文 | Ji-Yun Hu(#); Yingying Ning; Yin-Shan Meng; Jing Zhang; Zhuoyan Wu; Song Gao(*); Jun-Long Zhang(*) |
16 | Cationic sulfonium functionalization renders Znsalens with high fluorescence, good water solubility and tunable cell-permeability | 期刊論文 | Tang, Juan(#); Xie, Da; Yin, Hao-Yan; Jing, Jing; Zhang, Jun-Long(*) |
17 | 發光金屬Salen配合物作為檢測細胞內微黏度的螢光成像探針 | 期刊論文 | 尹昊琰(#); 唐娟; 張俊龍 |
18 | A photoactivatable Znsalen complex for super-resolution imaging of mitochondria in living cells | 期刊論文 | Tang, Juan; Zhang, Mingshu; Yin, Hao-Yan; Jing, Jing; Xie, Da; *Xu, Pingyong; *Zhang, Jun-Long |
19 | Porpholactone Chemistry: An Emerging Approach to Bioinspired Photosensitizers with Tunable Near-Infrared Photophysical Properties | 期刊論文 | Ning, Yingying(#); Jin, Guo Qing; Zhang, Jun Long(*) |
20 | Manganese protoporphyrin IX reconstituted myoglobin capable of epoxidation of the C=C bond with Oxone (R) | 期刊論文 | Cai, Yuan-Bo(#); Yao, Si-Yu; Hu, Mo; Liu, Xiaoyun(*); Zhang, Jun-Long(*) |
21 | Synthesis, characterization and reactivity of trans-dihydroxy platinum(IV) porphyrins | 期刊論文 | Ning, Yingying(#); Yu, Yi; Liu, Yi-Wei; Zhang, Jing(*); Sun, Hao-Ling; Zhang, Jun-Long(*) |
22 | Bioinspired Orientation of β-Substituents on Porphyrin Antenna Ligands Switches Ytterbium(III) NIR Emission with Thermosensitivity | 期刊論文 | Ning Yingying(#); Ke Xian-Sheng; Hu Ji-Yun; Liu Yi-Wei; Ma Fang; Sun Hao-Ling; Zhang Jun-Long(*) |
23 | beta-Fluorinated porpholactones and metal complexes: synthesis, characterization and some spectroscopic studies | 期刊論文 | Hu, Ji-Yun(#); Wu, Zhuo-Yan; Chai, Ke; Yang, Zi-Shu; Meng, Yin-Shan; Ning, Yingying; Zhang, Jing; Zhang, Jun-Long(*) |
24 | Three bilindione isomers: synthesis, characterization and reactivity of biliverdin analogs | 期刊論文 | Wang, Jun-Fei(#); Ma, Fang; Sun, Hao-Ling; Zhang, Jing(*); Zhang, Jun-Long(*) |
項目摘要
線粒體作為細胞的能量工廠和信號轉導中心，對保證細胞正常生命活動起關鍵作用。因此線粒體質量控制(mitochondrial qualitycontrol，MQC)在維持細胞的生存和參與細胞死亡過程中顯得及其重要，在控制和治療衰老相關疾病、代謝性疾病、退行性疾病以及腫瘤等中具有重要意義。在本工作中，我們以Salen配體為基本骨架，通過調節金屬中心和配體結構，設計線粒體靶向的發光配合物。通過探測線粒體膜電位的變化，實時監控線粒體質控發生過程。這些發光分子還將用於線粒體內活性氧物種或者其他信號分子的研究特異性回響。在此基礎上，考察線粒體質控通路的信號轉導以及小分子干預過程，有助於我們理解線粒體質控的發生髮展和線粒體損傷相關疾病的病理機制。
