單自興

單自興，1945年12月生，教授，武漢大學化學與分子科學院博士生導師，研究方向為不對稱合成化學、元素有機化學、有機合成化學。

基本介紹

• 中文名：單自興
• 國籍：中國
• 出生日期：1945年12月
• 職業：導師、教授
• 主要成就：趙德傑, 單自興*，黃世文，湖北省自然科學二等獎(2000)
• 單位：武漢大學化學與分子科學院

教學情況

講授本科生課程："元素有機化學"，"精細合成技術"，"現代合白漿諒蘭成技術"

講授碩士研究生課程：,"元素有機化學進展","不對稱合成化學"，"手性化合物化學"

指導博士和碩士研究生近20多人

2000年以來主持的主要科研項目

1．新型手性雙官能Lewis酸催化的不對稱反應研究

國家自然科學基金, 2007.1-2009.12, 項目主持人

2．棄抹拒少新型手性催化劑的開發及在不對稱合成中的套用研究

國家蜜拳埋自然科學基金, 2004.1-2006.12, 項目主持人

3．固態超分子體系介入的不對稱反應研究

國家自然科學基金, 2000.1-2002.12, 項目主持夜講淋人

4．廣譜抗炎手性藥物(S)-(+)-布洛芬的製備方法學研究

湖北省科委重點科研項目,1998.1-2000.12, 項目主持人.

參加國家自然科學基金，國際合作項目等多項。

獲獎情況

有機硼化合物的製備、性質、結構表征及其在有機合成中的套用

趙德傑, 單自興*，黃世文，湖北省自然科學二等獎(2000) (*通訊聯繫人)

國際學術會議邀請報告：

Convenient Preparation of Enantiopure 1,1"-Bi-2-naphthols and Asymmetric Reactions Mediated by 1,1"-Bi-2-naphtholborane Derivatives

Zixing Shan，The Invited Lecture on the 15th International Symposium on Chirality (Chirality 2003; ISCD-15), 2003, Shizuoka, Japan.

專著

綠色精細化工導論， 貢長生，單潤疊記自興騙主旋等編著，化學工業出版社， 2005年第一版

2000年後授權的發明專利（六項）：

1．螯合手性硼酸酯及其製備方法和用途

單自興，劉德軍，褚運波，中國發明專利，ZL 03 1 18710.2 （2006）

2．100%ee的(R)- 或(S)-1,1¢-聯-2-萘酚的製備方法

單自興元凳，熊 英, 中國發明專利，ZL 200410012746.0 （2005）

3．L-(+)-2-氨基-1-對硝基苯基-1,3-丙二醇的酮縮合物的製備方法

單自興,萬波勇,王國平, 中國發明專利：ZL 00114346.8 (2004)

4．(S)-布洛芬的製備方法

單自興，萬波勇，中國發明專利：ZL 01106592.3 (2003)

5．一種(S)-布洛芬的製備方法

單自興，萬波勇，中國發明專利：ZL 01114245.6 (2003)

6．高對映純(R)-(+)-和(S)-(-)-1,1¢-聯-2-萘酚製備新方法

單自興,王國平,段 標,趙德傑，中國發明專利：ZL 93103325.x（2000）

正在審查中的發明專利五項（略）

發表論文

近年代表性論文 (2003-2006, SCI)：

1 Chiral Borate Esters in Asymmetric Synthesis 5: Asymmetric Reduction of Oxime Ethers Promoted by Chiral Spiroborate Esters with an O3BN Framework

Yunbo Chu, Zixing Shan, Dejun Liu, Nannan Sun, J. Org. Chem. 2006, 71(10)，3998

2 Chiral Diols: A New Class of Additives for Direct Aldol Reaction Catalyzed by L-proline

Yan Zhou, Zixing Shan, J. Org. Chem. 2006, accepted

3 Selective Oxidation of Polyfunctional 2-Amino-1,3-propanediol Derivatives

Zixing Shan and Guojian Lu, J. Org. Chem. 2004, 69(10), 3593

4 Chiral Borate Esters in Asymmetric Synthesis: 6. Hydrolytically Stable Tricoordinated Chiral Bicyclodiboronate Ester: Synthesis, Structure Characterization and Theoretical Investigation

Yan Zhou, Zixing Shan, Boshan Wang, Peng Xie, Organometallics 2006, 25 (20), 4917

5 Chiral Borate Esters in Asymmetric Synthesis 4: Chiral spiroborate esters catalyzed highly enantioselective direct aldol reaction

Yan Zhou, Zixing Shan, Tetrahedron, 2006, 62(10), 5692

6 Convenient Preparation of Enantiopure 1,1¢-Bi-2-anphthols via Inclusion Complexation of (1S,2S)-N-Benzyl-N,N-dimethyl- [1,3-dihydroxyl-1-(4¢- nitrophenyl)]-2-propylammonium Chloride

Ha Wuzu, Shan Zixing*，Tetrahedron: Asymmetry. 2006, 17, 854

7 (R)- or (S)-Bi-2-naphthol Assisted, L-Proline Catalyzed Direct Aldol Reaction

Yan Zhou, Zixing Shan, Tetrahedron: Asymmetry. 2006, 17(11)，1671

8 Synthesis of Spirobiindanes via Bis-cyclization Reaction of the 1,5-diaryl-3-pentanones Catalyzed by Heteropoly Acids

Kun.Lan, Zixin.Shan and Shao Fan, Tetrahedron Lett, 2006, 47, 4343

9 Highly Chemoselective Synthesis of 1,2,3,4,5-Pentasubstituted Cyclohexanols under Solvent-free Condition

Luo Xinxiang, Shan Zixing, Tetrahedron Lett. 2006, 47, 5623

10 Chiral Borate Esters in Asymmetric Synthesis 2: Asymmetric Borane Reduction of Prochiral Ketones in the Presence of a Chiral Spiroborate Ester

Liu D. J., Shan Z. X., Zhou Y., Qin J. G. Helv. Chim. Acta, 2004, 87(9), 2310.

11 A new and practical method for preparing enantiopure 1,1¢-bi-2-nanphthol ¾¾ resolution of racemic 1,1¢- bi-2-nanphthol using threo-(1S,2S)-2-amino-1-(4¢-nitrophenyl)-1,3-propanediol cyclohexanone condensate

Dejun Liu, Zixing Shan*, Fei Liu, Chunguang Xiao, Guojian Lu and Jingui Qin, Helv. Chim. Acta, 2003, 86(1), 157.

12 Chiral Borate Esters in Asymmetric Synthesis 1: The First Asymmetric Reaction Catalyzed by Chiral Spiroborate Esters with a O3BN Framework

Liu D. J., Shan Z. X., Qin J. G., Chin. J. Chem., 2004, 22(11), 1336

13 A rapid preparation, properties and structure of diastereomeric 1,1¢-bi-2-naphtholboric acid (S)-proline anhydrides

Zixing Shan*, Shimin Liu, Dejun Liu, Chin. J. Chem. 2003, 21(10), 1373

14 Preparation and Properties of Chiral Spiroborate Esters with a O3BN Framework

Zixing Shan, Yan Zhou, Dejun Liu, Wuzu Ha, Synth. React. Inorg. Metal-org. Nono-Metal Chem. 2005, 35(4), 275

15 手性硼酸酯介入的不對稱合成 3: 前手性亞胺在(R)-或(S)-1,1¢-聯-2-萘酚硼酸-(S)-脯氨酸衍生物存在下的不對稱催化還原

6．高對映純(R)-(+)-和(S)-(-)-1,1¢-聯-2-萘酚製備新方法

單自興,王國平,段 標,趙德傑，中國發明專利：ZL 93103325.x（2000）

正在審查中的發明專利五項（略）

發表論文

近年代表性論文 (2003-2006, SCI)：

1 Chiral Borate Esters in Asymmetric Synthesis 5: Asymmetric Reduction of Oxime Ethers Promoted by Chiral Spiroborate Esters with an O3BN Framework

Yunbo Chu, Zixing Shan, Dejun Liu, Nannan Sun, J. Org. Chem. 2006, 71(10)，3998

2 Chiral Diols: A New Class of Additives for Direct Aldol Reaction Catalyzed by L-proline

Yan Zhou, Zixing Shan, J. Org. Chem. 2006, accepted

3 Selective Oxidation of Polyfunctional 2-Amino-1,3-propanediol Derivatives

Zixing Shan and Guojian Lu, J. Org. Chem. 2004, 69(10), 3593

4 Chiral Borate Esters in Asymmetric Synthesis: 6. Hydrolytically Stable Tricoordinated Chiral Bicyclodiboronate Ester: Synthesis, Structure Characterization and Theoretical Investigation

Yan Zhou, Zixing Shan, Boshan Wang, Peng Xie, Organometallics 2006, 25 (20), 4917

5 Chiral Borate Esters in Asymmetric Synthesis 4: Chiral spiroborate esters catalyzed highly enantioselective direct aldol reaction

Yan Zhou, Zixing Shan, Tetrahedron, 2006, 62(10), 5692

6 Convenient Preparation of Enantiopure 1,1¢-Bi-2-anphthols via Inclusion Complexation of (1S,2S)-N-Benzyl-N,N-dimethyl- [1,3-dihydroxyl-1-(4¢- nitrophenyl)]-2-propylammonium Chloride

Ha Wuzu, Shan Zixing*，Tetrahedron: Asymmetry. 2006, 17, 854

7 (R)- or (S)-Bi-2-naphthol Assisted, L-Proline Catalyzed Direct Aldol Reaction

Yan Zhou, Zixing Shan, Tetrahedron: Asymmetry. 2006, 17(11)，1671

8 Synthesis of Spirobiindanes via Bis-cyclization Reaction of the 1,5-diaryl-3-pentanones Catalyzed by Heteropoly Acids

Kun.Lan, Zixin.Shan and Shao Fan, Tetrahedron Lett, 2006, 47, 4343

9 Highly Chemoselective Synthesis of 1,2,3,4,5-Pentasubstituted Cyclohexanols under Solvent-free Condition

Luo Xinxiang, Shan Zixing, Tetrahedron Lett. 2006, 47, 5623

10 Chiral Borate Esters in Asymmetric Synthesis 2: Asymmetric Borane Reduction of Prochiral Ketones in the Presence of a Chiral Spiroborate Ester

Liu D. J., Shan Z. X., Zhou Y., Qin J. G. Helv. Chim. Acta, 2004, 87(9), 2310.

11 A new and practical method for preparing enantiopure 1,1¢-bi-2-nanphthol ¾¾ resolution of racemic 1,1¢- bi-2-nanphthol using threo-(1S,2S)-2-amino-1-(4¢-nitrophenyl)-1,3-propanediol cyclohexanone condensate

Dejun Liu, Zixing Shan*, Fei Liu, Chunguang Xiao, Guojian Lu and Jingui Qin, Helv. Chim. Acta, 2003, 86(1), 157.

12 Chiral Borate Esters in Asymmetric Synthesis 1: The First Asymmetric Reaction Catalyzed by Chiral Spiroborate Esters with a O3BN Framework

Liu D. J., Shan Z. X., Qin J. G., Chin. J. Chem., 2004, 22(11), 1336

13 A rapid preparation, properties and structure of diastereomeric 1,1¢-bi-2-naphtholboric acid (S)-proline anhydrides

Zixing Shan*, Shimin Liu, Dejun Liu, Chin. J. Chem. 2003, 21(10), 1373

14 Preparation and Properties of Chiral Spiroborate Esters with a O3BN Framework

Zixing Shan, Yan Zhou, Dejun Liu, Wuzu Ha, Synth. React. Inorg. Metal-org. Nono-Metal Chem. 2005, 35(4), 275

15 手性硼酸酯介入的不對稱合成 3: 前手性亞胺在(R)-或(S)-1,1¢-聯-2-萘酚硼酸-(S)-脯氨酸衍生物存在下的不對稱催化還原