周紹兵:科研成果,科研項目,發表論文,榮譽獎勵,科研團隊,

周紹兵，博士，西南交通大學材料科學與工程學院教授，教育部新世紀優秀人才，四川省學術和技術帶頭人，成都市突出貢獻優秀專家。2017年國家傑出青年科學基金建議資助。

研究方向是生物醫用高分子材料的合成及其在藥物控制釋放靶向製劑、形狀記憶智慧型材料和組織工程支架方面的套用基礎研究。1996年四川大學化學系獲學士學位,2003年於中國科學院成都有機化學研究所獲博士學位,2004年作為優秀人才引進到西南交通大學材材料先進技術教育部重點實驗室工作,建立了生物醫用高分子材料合成和藥物控制釋放製劑實驗室，2011年到美國哈佛大學作訪問學者。主持過國家自然科學基金項目6項,國家重大研究計畫子課題1項，教育部新世紀優秀人才基金1項，四川省傑出青年基金1項。

基本介紹

中文名：周紹兵
國籍：中國
職業：教授
主要成就：生物醫用高分子材料的合成

科研成果,科研項目,發表論文,榮譽獎勵,科研團隊,

科研成果

目前在Advanced Materials (影響因子17.49），Acs Nano(影響因子12.8),Advanced Functional Materials(影響因子11.82), Chemistry of Materials, Biomaterials, Journal of Controlled Release和Macromolecules等SCI收錄期刊發表文章100餘篇，文章SCI他引2000餘次,單篇最高SCI他引170次,合作出版外文專著1部(貢獻1章),作為第一發明人申請中國發明專利10餘項，7項獲得授權。2003年榮獲中國科學院院長優秀獎，2010年榮獲“第八屆詹天佑科學技術獎專項基金獎”,2011年榮獲“第十一屆四川省青年科技獎”。目前，任國際期刊American Journal of Materials Science and Technology副主編，國際期刊Advanced Materials Letter 編委,還擔任Advanced Materials (影響因子17.4),Angewandte Chemie International Edition (影響因子11.73)、Advanced Functional Materials (影響因子11.8）、Biomaterials(影響因子8.52)、Macromolecules、Journal of Controlled Release、Molecular Pharmaceutics等40餘種國際期刊評審人。

科研項目

1.國家自然科學基金面上項目，基於雙重回響聚合物膠束的抗腫瘤主動靶向給藥系統（21574105），項目經費：78萬元、起止年度：2016.1-2019.12。

2. 國家自然科學基金面上項目，具有三重形狀記憶功能的高分子表面微圖案及其與細胞作用機制（51373138），項目經費：82萬元、起止年度：2014.1-2017.12。

3. 高等學校博士學科點專項科研基金項目(博導類)，基於氫鍵作用的形狀記憶高分子表面微結構的研究（20120184110029）、項目經費：12萬元、起止年度：2013.1-2015.12

4. 國家自然科學基金面上項目，攜載藥物的可降解形狀記憶高分子器件的製備及其性能研究（50773065），項目經費：32萬元，起止年度：2008.1-2010.12。

5. 國家自然科學基金，具有溫敏性的磁靶向可降解聚合物抗腫瘤藥物膠束的研究（30970723），項目經費：37萬元，起止年度：2010.1-2012.12。

6.國家自然科學基金面上項目，聚醚-聚酸酐膠束的形貌調控及其對腫瘤細胞生長影響的研究（51173150），項目經費：60萬元，起止年度：2012.1-2015.12。

7.國家重大科學研究計畫（973計畫）子課題，生長因子在微納結構材料中的高活性固載及控釋2012CB933602, 項目經費：135萬元，起止年度：2012.1-2016.12。

8. 教育部新世紀優秀人才基金，蛋白和多肽類生物活性大分子控制釋放系統的研究（NCET-07-0719）項目經費：50萬元，2008.1-2010.12。

9. 四川省傑出青年科技基金，具有藥物控釋功能的可降解形狀記憶高分子器件的研究 (08ZQ026-040)，項目經費：12萬元，2008.1-2010.12。

10. 西南交通大學“楊華之星”項目，項目經費：30萬元，2009.9-2012.9。

發表論文

發表的SCI收錄論文目錄（註：* 表示通訊作者）

Jie Wang, Guang Yang, Xing Guo, Zhaomin Tang, Zhendong Zhong,Shaobing Zhou*,Redox-responsive polyanhydride micelles for cancer therapy, Biomaterials, 2014, 35, 3080-3090.
Ye Liu, Ying Li, Hongmei Chen, Guang Yang, Xiaotong Zheng,Shaobing Zhou*,Water-induced shape-memory poly(D,L-lactide)/microcrystalline cellulose composites, Carbohydrate Polymers,104 (2014) 101–108.
Xian Liu, Kun Zhao, Tao Gong, Jian Song, Chongyun Bao, En Luo, Jie Weng andShaobing Zhou*,Delivery of Growth Factors Using a Smart Porous Nanocomposite Scaffold to Repair a Mandibular Bone Defect, Biomacromolecules, 2014,15, 1019-1030.
Jinrong Li, Rong Fu, Long Li, Guang Yang, Shan Ding, Zhendong Zhong,Shaobing Zhou*,Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid, Pharm Res, DOI 10.1007/s11095-013-1266-2.
Long Li, Guang Yang, Jinrong Li, Shan Ding,Shaobing Zhou*,Cell behaviors on magnetic electrospun poly-d, l-lactide nanofibers，Materials Science and Engineering C 34 (2014) 252–261.
Lin Wang, Xifeng Yang, Hongmei Chen, Tao Gong, Wenbing Li, Guang Yang, andShaobing Zhou*,Design of Triple-Shape Memory Polyurethane with Photo-crosslinking of Cinnamon Groups, ACS Applied Materials & Interfaces, 2013, 5, 10520?10528.
Lin Wang, Xifeng Yang,Hongmei Chen, Guang Yang, Tao Gong, Wenbing Li andShaobing Zhou*，Multi-stimuli sensitive shape memory poly(vinyl alcohol)-graft-polyurethane，Polym. Chem., 2013,4, 4461-4468.
Shaobing Zhou*, Jing Fan, Sujit S. Datta, Ming Guo, Xing Guo and David A. Weitz*,Thermally Switched Release from Nanoparticle Colloidosomes, Advanced Functional Materials, 2013, 23, 5925–5929.
Tao Chen, Xing Guo,Aijun Zhao, Jie Wang,Chunli Shi andShaobing Zhou*，Morphological transition of self-assembled architectures from PEG-based ether-anhydride terpolymers，Soft Matter, 2013, 9, 3021-3031.
Wenbing Li, Tao Gong, Hongmei Chen, Lin Wang, Jinrong Li andShaobing Zhou*，Tuning surface micropattern features using a shape memory functional polymer，RSC Adv., 2013, 3, 9865–9874.
Hongmei Chen, Ye Liu, Tao Gong, Lin Wang, Keqing Zhao andShaobing Zhou*，Use of intermolecular hydrogen bonding to synthesize triple-shape memory supermolecular composites，RSC Adv., 2013, 3, 7048–7056.
Xing Guo, Chunli Shi, Jie Wang, Shubin Di,Shaobing Zhou*，pH-triggered intracellular release from actively targeting polymer Micelles，Biomaterials, 34 (2013) 4544-4554.
Zhao Zhang, Qianqian Qu, Jinrong Li, Shaobing Zhou*，The Effect of the Hydrophilic/Hydrophobic Ratio of Polymeric Micelles on their Endocytosis Pathways into Cells，Macromol. Biosci. 2013, 13, 789–798.
Shan Ding, Jinrong Li, Chao Luo, Long Li, Guang Yang andShaobing Zhou*，Synergistic e ff ect of released dexamethasone and surface nanoroughness on mesenchymal stem cell differentiation，Biomater. Sci., 2013, 1, 1091–1100.
Tao Gong,Wenbing Li, Hongmei Chen, Lin Wang, Shijun Shao,Shaobing Zhou*，Remotely actuated shape memory effect of electrospun composite nanofibers，Acta Biomaterialia 8(2012) 1248–1259.
Xiongjun Yu,Lin Wang,Maotao Huang,Tao Gong,Wenbing Li,Yaling Cao,Daijin Ji,Ping Wang,Jing WangandShaobing Zhou*,A shape memory stent of poly(ε-caprolactone-co-dl-lactide) copolymer for potential treatment of esophageal stenosis,Journal of Materials Science: Materials in Medicine,2012, 23,581-589.
Qi Zhou, Xing Guo, Tao Chen, Zhao Zhang, Shijun Shao, Chao Luo, Jinrong Li, and Shaobing Zhou*,Target-Specific Cellular Uptake of Folate-Decorated Biodegradable Polymer Micelles, J. Phys. Chem. B, 2011, 115 (43), pp 12662–12670.
Shijun Shao, Long Li, Guang Yang, Jingrong Li, Chao Luo, Tao Gong,Shaobing Zhou*,Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers,International Journal of Pharmaceutics ,2011,421,310– 320.
Shijun Shao,Shaobing Zhou*, Long Li, Jinrong Li, Chao Luo, Jianxin Wang, Xiaohong Li and Jie Weng,Osteoblast function on electrically conductive electrospun PLA/MWCNTs nanofibers,Biomaterials,2011,32,2821-2833.
Chi Huang, Yangbo Zhou, Zhaomin Tang, Xing Guo, Zhiyong Qian andShaobing Zhou*，Synthesis of multifunctional Fe3O4 core/hydroxyapatite shell nanocomposites by biomineralization，Dalton Trans., 2011,40, 5026-5031.
Yu Xiao, Tao Gong,Shaobing Zhou*，The functionalization of multi-walled carbon nanotubes by in situ deposition of hydroxyapatite，Biomaterials ，2010，31 ，5182-5190. （SCI, IF：6.646）
Chi Huang,Yangbo Zhou,Yong Jin,Xiaofeng Zhou,Zhaomin Tang, Xing Guo andShaobing Zhou*，Preparation and characterization of temperature-responsive and magnetic nanomicelles，J. Mater. Chem., 2011, 21 (15), 5660 – 5670.
Weijia Wang,Shaobing Zhou*, Laiyang Guo, Wei Zhi, XIaohong Li,Jie Weng,Investigation of endocytosis and cytotoxicity of poly-d,l-lactide -poly(ethylene glycol) nano/micro- particles in osteoblast cells, International Journal of Nanomedicine 2010:5 557–566.
Qiuxiang Su, Aijun Zhao, Hongsen Peng, andShaobing Zhou?，Preparation and Characterization of Biodegradable Electrospun Polyanhydride Nano/Microfibers，Journal of Nanoscience and Nanotechnology,2010. 10, 6369-6375.
Lin Sun, Chi Huang, Tao Gong,Shaobing Zhou*，A biocompatible approach to surface modification: Biodegradable polymer functionalized super-paramagnetic iron oxide nanoparticles，Materials Science and Engineering C，2010， 30，583–589
Weijia Wang,Shaobing Zhou*, Lin Sun, Chi Huang,Controlled delivery of paracetamol and protein at different stages from core–shell biodegradable microspheres,Carbohydrate Polymers, 79 (2010) 437–444.
Aijun Zhao，Shaobing Zhou*， Qi Zhou，Tao Chen，Thermosensitive Micelles from PEG-Based Ether-anhydride Triblock Copolymers，Pharm Res，2010，27，1627-1643.
Yu Xiao,Shaobing Zhou*, Lin Wang, Xiaotong Zheng, Tao Gong，Crosslinked poly(ε-caprolactone)/poly(sebacic anhydride) composites combining biodegradation, controlled drug release and shape memory effect，Composites: Part B41 (2010) 537–542.
Aijun Zhao, Qi Zhou, Tao Chen, Jie Weng,Shaobing Zhou*，Amphiphilic PEG-based ether-anhydride terpolymers: Synthesis, characterization, and micellization，Journal of Applied Polymer Science，2010,118（6）：3576–3585.
Weijia Wang, Shijun Shao, Chao Luo,Shaobing Zhou*,Chitosan hollow nanospheres fabricated from biodegradable poly-d,l-lactide-poly(ethylene glycol) nanoparticle templates,European Journal of Pharmaceutics and Biopharmaceutics, 76 (2010) 376–383.
Yu Xiao,Shaobing Zhou*, Lin Wang, and Tao Gong，Electro-active Shape Memory Properties of Poly(ε-caprolactone)/Functionalized Multiwalled Carbon Nanotube Nanocomposite，ACS Appl. Mater. Interfaces,2010,2(12), pp 3506–3514.
Hongsen Peng,Shaobing Zhou*,Jing Jiang, Tao Guo, Xiaotong Zheng, and Xiongjun Yu，Pressure-Induced Crystal Memory Effect of Spider Silk Proteins，J. Phys. Chem. B2009,113,4636–4641.
Xiongjun Yu,Shaobing Zhou*, Xiaotong Zheng, Yu Xiao and Tao Guo，Influence of in Vitro Degradation of a Biodegradable Nanocomposite on Its Shape Memory Effect，J. Phys. Chem. C,2009,113(41), pp 17630–17635.
Tao Guo,Shaobing Zhou*, Xiaotong Zheng and Jing Jiang,Modeling and Investigation of Interfacial Interaction between PLA and One Type of Deficient Hydroxyapatite,J. Phys. Chem. A,2009,113(25), pp 7112–7123.
Xiongjun Yu,Shaobing Zhou*, Xiaotong Zheng, Tao Guo, Yu Xiaoand Botao Song,A Biodegradable Shape Memory Nanocomposite with Dual-versatility of Thermal and Magnetic Field Sensitivity.Nanotechnology. 2009，20, 235702.
Xiaotong Zheng,Shaobing Zhou*,Yu Xiao, Xiongjun Yu, Xiaohong Li，Peizhuo Wu，Shapememoryeffectofpoly(D,L-lactide)/Fe3O4，nanocompositesby inductiveheatingofmagnetiteparticles，Colloidsand Surfaces B:Biointerfaces，71(2009),pp.67-72.
Lin Sun,Shaobing Zhou*, Weijia Wang, Xiaohong Li, Jianxin Wang, Jie Weng,Preparation and characterization of porous biodegradable microspheres used for controlled protein delivery,Colloids and Surfaces A: Physicochem. Eng. Aspects345 (2009) 173–181.
Xiaotong Zheng,Shaobing Zhou*, Yu Xiao, Xiongjun Yu, Bo Feng.In situ preparation and characterization of a novel Gelatin/ Poly(D,L-lactide)/ Hydroxyapatite nanocomposite.Journal of Biomedical Materials Research Part B: Applied Biomaterials. Volume91B, Issue1, Date:October 2009, Pages:181-190.
Shaobing Zhou*, Xiaotong Zheng, Xiongjun Yu,et al，Hydrogen Bonding Interaction of Poly(D,L-Lactide)/hydroxyapatite Nanocomposites，Chemistry of Materials, 2007，19（2），247 – 253.???
Jing Sun，Shaobing Zhou*,et al.,Synthesis and Characterization of Biocompatible Fe3O4 Nanoparticles,Journal of Biomedical Materials Research,Part A, 2007,80A(2), 333-341. （SCI, IF：2.5）
Xiaotong Zheng,Shaobing Zhou*, et al.,Shape memory properties of poly(D,L-lactide)/ hydroxyapatite composites，Biomaterials，2006，27（24），4288–4295.??? （2008年第4季度入選TOP25 Hottest Articles且排名第7）
Lin Sun,Shaobing Zhou*,Weijia Wang,Qiuxiang Su,Xiaohong LiandJie Weng,Preparation and characterization of protein-loaded polyanhydride microspheres, Journal of Materials Science: Materials in Medicine, 2009,20，2035-2042.
Shaobing Zhou*, Qiuxiang Su,et al，A novel in situ synthesis of dicalcium phosphate dehydrate nanocrystals in biodegradable polymer matrix，Materials Science and Engineering A，2006，430（1-2），341–345.
Shaobing Zhou*, Bing Song, Xiaohong Li,In vitro Degradation and Release profiles for Poly-dl-lactide Film Containing Paracetamol,Journal of Materials Science: Materials in Medicine,2007,18（8）1623-1626.
Xiaotong Zheng,Shaobing Zhou*, Xiongjun Yu, Xiaohong Li, Bo Feng, Shuxin Qu, Jie Weng，Effect of In vitro degradation of poly(D,L-lactide)/-tricalcium composite on its shape-memory properties，Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2008，Volume 86B Issue 1,Pages170–180.
Shaobing Zhou*,Xianmo Deng,Hua Yang,Biodegradable copolymer of poly(ethylene glycol)-co-poly (ε-caprol actone):characterization and its use in controlled release system.Biomaterials,2003, 24(20), 3563-3570. （SCI, IF：5.196）
Shaobing Zhou,*Hongsen Peng,Xiongjun Yu, Xiaotong Zheng,Wenguo Cui, Zairong Zhang, Xiaohong Li,Jianxin Wang, Jie Weng,Wenxiang Jia,and Fei Li，Preparation and Characterization of a Novel Electrospun Spider Silk Fibroin/Poly(D,L-lactide) Composite Fiber,J. Phys. Chem. B.;2008; 112(36); 11209-11216.
Hongsen Peng,Shaobing Zhou*, Tao Guo, Yanshan Li, Xiaohong Li, Jianxin Wang, Jie Weng,In vitro degradation and release profiles for electrospun polymeric fibers containing paracetanol,Colloids and Surfaces B: Biointerfaces66 (2008), pp.206-212.
Shaobing Zhou*, Jing Sun, Lin Sun, Yanqin Dai, Liping Liu, Xiaohong Li, Jianxin Wang, Jie Weng, Wenxiang Jia, Zairong Zhang，Preparation and characterization of interferon-loaded magnetic biodegradable microspheres，Journal of Biomedical Materials Research Part B: Applied Biomaterials.Volume 87B, Issue 1, Date: October 2008, Pages:189-196.
Shaobing Zhou*, Xianmo Deng, Xiaohong Li,et al.,Investigation on a Novel Core-Coated Microspheres Protein Delivery System,Journal of Controlled Release,2001,75(1-2),27-36.??
Shaobing Zhou*,Xueyan Liao,Xiaohong Li,Xianmo Deng,et al.Poly-D,L-lactide-co-poly(ethylene glycol) microspheres as potential vaccine delivery systems.Journal of Controlled Release,2003，86(2-3)：195-205. (SCI, IF 4.01)
Xianmo Deng,Shaobing Zhou,Xiaohong Li,et al.,In vitroDegradation and Release profiles for Poly-dl-Lactide-poly(ethylene glycol) Microspheres Containing Human Serum Albumin.Journal of Controlled Release,2001, 71(2),165-173.
Shaobing Zhou*,Xianmo Deng,Shuiying He,Xiaohong Li,Wenxiang Jia, et al.,Study on biodegradable microspheres containing recombinant interferon.J.Pharm.Pharmacol.2002,54:1287-12192.
Shaobing Zhou*,Xianmo Deng,Xiaohong Li,et al., Investigation onPreparation and Protein Release of Biodegradable Polymer Microspheres as Drug DeliverySystem,Journal of Applied polymer science,2002,84,778-784.
Shaobing Zhou*,Xianmo Deng,In Vitro Degradation Characteristics of Poly-dl-lactide-poly(ethylene glycol) Microspheres Containing Human Serum Albumin.Reactive and functional polymer,2002,51,93-100.
Shaobing Zhou*, Xianmo Deng, Wenxiang Jia,et al.,Synthesis and characterization of biodegradable low-molecular-weight aliphatic polyesters and their use in protein delivery system,Journal of Applied polymer Sciences, 2004, 91(3), 1848–1856.
Shaobing Zhou*, Jinggang Xu,Xianmo Deng，et al.,Synthesis and Characterization of Biodegradable Poly(-caprolactone)- Polyglycolide-Poly(ethylene glycol) Monomethyl Ether Random Copolymer，Macromolecular Materials and Engineering，2004,289（6），576-580.
Shaobing Zhou*,Xueyan Liao, Xianmo Deng, Heming Li,et al.,Preparation and Characterization of Biodegradable Microspheres Containing Hepatitis B Surface Antigen,Macromolecular Bioscience,2004,4,(1)1, 47-52.
Yuan Yang, Li Liu,Shaobing Zhou*,et al.Novel Biodegradable Polymers as Gene Carriers.Macromol. Biosci.2004, 4, 1113–1117..

榮譽獎勵

2003年榮獲中國科學院院長優秀獎;
2010年榮獲“第八屆詹天佑科學技術獎專項基金獎”；
2011年榮獲“第十一屆四川省青年科技獎”；
2010年和2011年連續兩年被評為本科畢業設計優秀指導教師；
2014年被評為首屆“西南交通大學十佳研究生導師”榮譽稱號
2014年榮獲唐立新優秀學者獎
2014年榮獲四川省學術和技術帶頭人
2015年以第一完成人榮獲四川省科技進步獎（自然科學類）一等獎
在指導的研究生中, 其中8位研究生畢業論文獲四川省優秀碩士論文獎, 1位博士生畢業論文獲四川省優秀博士論文獎,16位研究生論文獲校優秀碩士論文。
祝賀楊光同學榮獲2015年度博士研究生國家獎學金，郭星、龔韜、唐昭敏三位同學榮獲2014年度“博士研究生國家獎學金”；趙坤榮獲2014年度“碩士研究生國家獎學金”。此前，龔韜榮獲2012年度“博士研究生國家獎學金”，郭星榮獲2013年度“博士研究生國家獎學金”.
研究生國家獎學金是由國家教育部、財政部設立，中央財政出資，用於獎勵普通高等學校中表現優異的全日制研究生，為發展中國特色研究生教育，促進研究生培養機制改革，提高研究生培養質量。博士研究生國家獎學金獎勵標準為每生每年3萬元；碩士研究生國家獎學金獎勵標準為每生每年2萬元。

科研團隊

博士後：劉顯
博士研究生：陳紅梅，王林，李龍，郭星，楊光，孫會麗，龔韜，唐昭敏，王毅
碩士研究生：史春麗，丁珊，楊希鳳，劉野，王傑，趙坤，屈倩倩，李丹，李瑩，狄淑斌，王文璽，周光亮，王毅，張累
已畢業研究生：鄭曉彤（博士），羅超，周洋波，陳濤，李文兵，李金絨，張釗，孫敬，蘇秋香，彭紅森，孫林，俞雄軍，郭濤，肖雨，王衛佳，趙艾軍，黃馳，周奇，邵仕軍課程教學
1.碩士生課程
(1)《高等生物材料》
(2)《藥物控制釋放與組織工程》
(3)《生物材料導論》
(4)《結構化學》
2.本科生課程
(1)《藥物控制釋放》
(2)《生物材料合成實驗技術》
招生信息
歡迎有化學,生物醫學工程,高分子材料,生物學,醫學,材料學或藥劑學等專業背景的學生保送和報考碩士,博士研究生。
同時長期招聘上述專業背景的博士後研究人員。
祝賀楊光同學榮獲2015年度“博士研究生國家獎學金”，郭星、龔韜、唐昭敏三位同學榮獲2014年度“博士研究生國家獎學金”；碩士研究生趙坤榮獲2014年度“碩士研究生國家獎學金”。此前，博士研究生龔韜榮獲2012年度“博士研究生國家獎學金”，博士研究生郭星榮獲2013年度“博士研究生國家獎學金”.
研究生國家獎學金是由國家教育部、財政部設立，中央財政出資，用於獎勵普通高等學校中表現優異的全日制研究生，為發展中國特色研究生教育，促進研究生培養機制改革，提高研究生培養質量。博士研究生國家獎學金獎勵標準為每生每年3萬元；碩士研究生國家獎學金獎勵標準為每生每年2萬元。

周紹兵