周宏鈺，男，博士，廣州大學大灣區環境研究院教授，研究院書記。
基本介紹
- 中文名：周宏鈺
- 職業：教師
- 學位/學歷：博士
- 專業方向：基於人類細胞組合的污染物健康效應評價
- 任職院校：廣州大學大灣區環境研究院
個人經歷,研究方向,學術成果,
個人經歷
教育背景
2000.09 - 2004.06 山東大學化學與化學工程學院迎企犁，套用化學，學士。
2004.09 - 2009.06 山東大學藥學院，藥物化學，博士。
工作經歷
2009.09 - 2012.04 美國聖尤大兒童研究醫院，博士後。
2012.04- 2016.08 美國艾默里大學，博士後。
2016.09- 2018.09 暨南大學環境學院，研究員。
2018.10- 至今 廣州大學大灣區環境研究院，教授。
研究方向
基於人類細胞組合的污染物健康效應評價、基於PM2.5人工模型的大氣顆粒物致毒機制研究、環境污染物生物效應的構效關係及預測模型。
學術成果
1) 國家自然科學危漏戶基辣迎金重大研究計畫培育項目，選擇性治療耐藥腿敬境性肺癌的噻唑烷酮類小分子雄全試探針的設計、合成及體外抗癌活性研究與機制探討，已結題，參加。
2) 暨南大學培育與躍升計畫，金納米顆粒庫的快速高通量構建及其生物效淚盛格滲應，主持汽戒戲欠，結題。
3) 國家自然科學基金重大研究計畫培育項目，細顆粒物多組分混合暴露的聯合毒性機制研究，主持，進行中。
代表性論文：
1) Gou Y, Miao DD, Zhou M, Wang LJ, Zhou HY*, Su GX*. Bio-Inspired Protein-based nanoformulations for Cancer Theranostics. Front. Pharmacol.
2) Liu Y, Su GX, Wang F, Jia JB, Li SH, Zhao LL, Shi YL, Cai YQ, Zhu H, Zhao B, Jiang GB, Zhou HY*, Yan B*. Elucidation of the Molecular Determinants for Optimal Perfluorooctanesulfonate Adsorption Using a Combinatorial Nanoparticle Library Approach, Environ. Sci. Technol.
3) Su GX#, Zhou XF#, Zhou HY*, Li Y, Zhang XR, Liu Y, Cao DP, Yan B.* Size-Dependent Facilitation of Cancer Cell Targeting by Proteins Adsorbed on Nanoparticles. ACS Appl. Mater. Interfaces
4) Zhou HY, Qian WP, Uckun F. M, Wang LY, Wang A. Y, Chen HY, Kooby D, Yu Q, Lipowska M, Staley C. A, Mao H, Yang L* IGF1 Receptor Targeted Theranostic Nanoparticles forTargeted and Image-guided Therapy of Pancreatic Cancer. ACS Nano,
5) Zhou HY, Su GX, Jiao PF, Yan B.* Accelerating multifunctionalization of theranostic nanoparticles using multicomponent reaction. Chem. Eur. J.
6) Zhou HY, Jiao PF, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. J. Am. Chem. Soc.
7) Zhou HY, Li X, Lemoff A, Zhang B, Yan B.* Structural Confirmation and Quantification of Individual Ligands from the Surface of Multi-Functionalized Gold Nanoparticles. Analyst,
8) Du FF#, Zhou HY# (共同第一作者), Chen LQ, Zhang B, Yan B.* Structure Elucidation of Nanoparticle-Bound Organic Molecules By 1H NMR. TRAC-Trends Anal. Chem.
9) Zhou HY, Mu QX, Gao NN, Liu AF, Xing YH, Gao SL, Zhang Q, Qu GB, Chen YY, Liu G, Zhang B, Yan B.* A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Lett.
10) Zhou HY, Wu SH, Zhai SM, Liu AF, Sun Y, Li RS, Zhang Y, Ekins S, Swaan PW, Fang B, Zhang B, Yan B.* Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells. J. Med. Chem. (Highlighted by Drug Discovery Today, ).
5) Zhou HY, Su GX, Jiao PF, Yan B.* Accelerating multifunctionalization of theranostic nanoparticles using multicomponent reaction. Chem. Eur. J.
6) Zhou HY, Jiao PF, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. J. Am. Chem. Soc.
7) Zhou HY, Li X, Lemoff A, Zhang B, Yan B.* Structural Confirmation and Quantification of Individual Ligands from the Surface of Multi-Functionalized Gold Nanoparticles. Analyst,
8) Du FF#, Zhou HY# (共同第一作者), Chen LQ, Zhang B, Yan B.* Structure Elucidation of Nanoparticle-Bound Organic Molecules By 1H NMR. TRAC-Trends Anal. Chem.
9) Zhou HY, Mu QX, Gao NN, Liu AF, Xing YH, Gao SL, Zhang Q, Qu GB, Chen YY, Liu G, Zhang B, Yan B.* A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Lett.
10) Zhou HY, Wu SH, Zhai SM, Liu AF, Sun Y, Li RS, Zhang Y, Ekins S, Swaan PW, Fang B, Zhang B, Yan B.* Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells. J. Med. Chem. (Highlighted by Drug Discovery Today, ).
