《周圍神經倍數擴增過程中神經功能重塑規律的研究》是殷曉峰為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：周圍神經倍數擴增過程中神經功能重塑規律的研究
- 項目類別 ：青年科學基金項目
- 依託單位 ：北京大學
- 項目負責人：殷曉峰
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | 供體神經同時修復供體神經和受體神經是否可以成為周圍神經損傷修復的新方法？ | 會議論文 | Yin, X. F.|Kou, Y. H.|Wang, Y. H.|Zhang, P. X.|Jiang, B. G.| |
2 | Hypothesis of peripheral nerve regeneration induced by terminal effectors | 期刊論文 | Jiang, Bao Guo|Yin, Xiao Feng|Zhang, Pei Xun|Han, Na|Kou, Yu Hui| |
3 | Different multiple regeneration capacities of motor and sensory axons in peripheral nerve | 期刊論文 | Peng Jianping|Yin Xiaofeng|Wang Yanhua|Wang Zhenwei|Kou Yuhui|Xu Chungui|Zhang Peixun|Jiang Baoguo| |
4 | Improved peripheral nerve regeneration with sustained release nerve growth factor microspheres in small gap tubulization. | 期刊論文 | Wang, Jiancheng|Zheng, Hua|Peng, Jianping|Kou, Yuhui|Xu, Chungui|An, Shuai|Yin, Xiaofeng|Zhang, Peixun|Jiang, Baoguo| |
5 | Morphological study on the collaterals developed by one axon during peripheral nerve regeneration | 期刊論文 | Yin, Xiao Feng|Kou, Yu Hui|Wang, Yan Hua|Zhang, Pei Xun|Zhang, Dian Yin|Fu, Zhong Guo|Zhang, Hong Bo|Jiang, Bao Guo| |
6 | Hedysari Extract Improves Regeneration after Peripheral Nerve Injury by Enhancing the Amplification Effect | 期刊論文 | Wang, Zhiyong|Zhang, Peixun|Kou, Yuhui|Yin, Xiaofeng|Han, Na|Jiang, Baoguo| |
7 | Can "Dor to Dor plus Rec Neurorrhaphy" by Biodegradable Chitin Conduit Be A New Method for Peripheral Nerve Injury? | 期刊論文 | Yin, Xiao Feng|Kou, Yu Hui|Wang, Yan Hua|Zhang, PeiXun|Zhang, Dian Yin|Fu, Zhong Guo|Zhang, Hong Bo|Jiang, Bao Guo| |
8 | The effect of a small gap sleeve suture at the distal anastomosis of a nerve graft on promoting nerve regeneration and functional recovery | 期刊論文 | Zhang, Zhenjun|Kou, Yuhui|Yin, Xiaofeng|Wang, Yanhua|Zhang, Peixun|Jiang, Baoguo| |
9 | Characteristics of peripheral nerve collateral multiplication and its potential use in neural trauma | 期刊論文 | Yin Xiao-feng|Kou Yu-hui|Zhang Pei-xun|Wang Yan-hua|Jiang Bao-guo| |
10 | The Electrophysiology Analysis of Biological Conduit Sleeve Bridging Rhesus Monkey Median Nerve Injury with Small Gap | 期刊論文 | Zhang, Peixun|Yin, Xiaofeng|Kou, Yuhui|Wang, Yanhu|Zhang, Hongbo|Jiang, Baoguo| |
11 | Maximum number of collaterals developed by one axon during peripheral nerve regeneration and the influence of that number on reinnervation effects | 期刊論文 | Jiang, Bao Guo|Yin, Xiao Feng|Zhang, Dian Yin|Fu, Zhong Guo|Zhang, Hong Bo| |
12 | Portion of a Nerve Trunk can be Used as a Donor Nerve to Reconstruct the Injured Nerve and Donor Site Simultaneously | 期刊論文 | Yin, Xiao Feng|Kou, Yu Hui|Wang, Yan Hua|Zhang, PeiXun|Zhang, Hong Bo|Jiang, Bao Guo| |
13 | Early sensory protection in reverse end-to-side neurorrhaphy to improve the functional recovery of chronically denervated muscle in rat: a pilot study. | 期刊論文 | Li, Qingtian|Zhang, Peixun|Yin, Xiaofeng|Han, Na|Kou, Yuhui|Jiang, Baoguo| |
14 | Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury | 期刊論文 | Yin, Xiao Feng|Fu, Zhong Guo|Zhang, Dian Yin|Jiang, Bao Guo| |
15 | Functional Recovery of Denervated Skeletal Muscle with Sensory or Mixed Nerve Protection: A Pilot Study | 期刊論文 | Li, Qing Tian|Zhang, Pei Xun|Yin, Xiao Feng|Han, Na|Kou, Yu Hui|Deng, Jiu Xu|Jiang, Bao Guo| |
項目摘要
嚴重周圍神經損傷是臨床實踐中的難點，研究發現周圍神經再生存在倍數擴增現象，即遠端再生的神經纖維數量可以大大超過損傷平面近端神經纖維的數量。本實驗室前期工作顯示，在遠端有足夠可長入空間的條件下，周圍神經再生倍數擴增極限的理論值為3.3，受區與供區神經纖維數量的比率影響倍數擴增率與重建效果。本課題將在前期工作的基礎上，進一步探討：1.影響倍數擴增的因素（不同神經平面擴增、二次級聯擴增、二期修復擴增對倍數擴增極限的影響）；2.倍數擴增的神經纖維在重建過程中的轉歸；3.遠端神經纖維倍數擴增後脊髓與腦中樞神經功能區數量及再分布變化的重塑規律。為利用倍數擴增效應修復周圍神經損傷中，供區神經的選取，重建方案的科學決策以及修復時機的選擇提供新的思路和實驗依據。
