吳文武，男，1983年1月生，生物信息學博士，現為浙江農林大學林業與生物技術學院教授。
基本介紹
- 中文名：吳文武
- 國籍：中國
- 出生日期：1983年1月
- 職業：教師
研究方向,學習與工作經歷,教學工作,科研項目,論文與專著,
研究方向
研究主要涉及基因轉錄和調控、選擇性剪接、基因家族和生物演化等。
現階段，主要利用生物信息學手段，基於生物大數據對基因組、調控組和轉錄組等各組學進行研究，嘗試對生物表型下（如抗逆）的分子機制進行多層次多維度的解析
學習與工作經歷
2017/01—起 浙江農林大學林業與生物技術學院教授
2016/05—2017/01 浙江農林大學林業與生物技術學院副研究員
2014/11—2016/05 中科院上海植物逆境研究中心副研究員朱健康課題組
2012/10—2014/10 中科院上海生科院營養所博士後馮英課題組
2010/10—2011/09 中科院北京植物研究所聯合培養孔宏智課題組
2007/09—2012/09 西北農林科技大學博士研究生陶士珩課題組
教學工作
生物信息學
科研項目
1.2017 年浙江省科技廳重大科技專項，主要參與人
2.2015年國家自然科學基金青年科學基金主持
3.2014年中國博士後科學基金第7批特別資助主持
4.2013年中國博士後科學基金第54批面上資助主持
論文與專著
1.Wu W*, Zong J*, Wei N, Cheng I, Zhou X, Cheng Y, Chen D, Guo Q, Zhang B and Feng Y. (2017). CASH: A constructing comprehensive splice site method for detecting alternative splicing events. Brief Bioinform.DOI: 10.1093/bib/bbx034. IF= 8.399
2.Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z, Wu W and Feng Y. (2017). SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Cancer Res 77, 1168-1178.IF=8.556
3.Zhou X*, Wu W*, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H and Feng Y. (2014). Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Res 42, 4019-4030.IF= 9.202
4.Cheng J*, Xu Z*, Wu W*, Zhao L, Li X, Liu Y and Tao S. (2014). Training set selection for the prediction of essential genes. Plos One 9, e86805.IF= 3.057
5.Cheng J*, Wu W*, Zhang Y, Li X, Jiang X, Wei G and Tao S. (2013). A new computational strategy for predicting essential genes. BMC Genomics 14, 910.IF= 3.867
6.Wu W, de Folter S, Shen X, Zhang W and Tao S. (2011). Vertebrate Paralogous MEF2 Genes: Origin, Conservation, and Evolution. Plos One 6, e17334.IF= 3.057
7.Wu W, Huang X, Cheng J, Li Z, de Folter S, Huang Z, Jiang X, Pang H and Tao S. (2011). Conservation and Evolution in and among SRF- and MEF2-Type MADS Domains and Their Binding Sites. Mol Biol Evol 28, 501-511.IF= 13.649
8.Wu W, Shen X and Tao S. (2010). Characteristics of the CArG-SRF binding context in mammalian genomes. Mamm Genome 21, 104-113.IF= 2.078
9.Wang L, Li H, Zhao C, Li S, Kong L, Wu W, Kong W, Liu Y, Wei Y, Zhu JK and Zhang H. (2017). The inhibition of protein translation mediated by AtGCN1 is essential for cold tolerance in Arabidopsis thaliana. Plant Cell Environ 40, 56-68. IF= 6.169
10.Cheng Y, Luo C, Wu W, Xie Z, Fu X and Feng Y. (2016). Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol Cell Biol 36, 1628-1638. IF= 4.427
11.Zhan X, Qian B, Cao F, Wu W, Yang L, Guan Q, Gu X, Wang P, Okusolubo TA, Dunn SL, Zhu JK and Zhu J. (2015). An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses. Nat Commun 6, 8139.IF= 11.329
12.Zhou X, Li X, Cheng Y, Wu W, Xie Z, Xi Q, Han J, Wu G, Fang J and Feng Y. (2014). BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells. Nat Commun 5, 4581.IF= 11.329
13.Li H, Cheng Y, Wu W, Liu Y, Wei N, Feng X, Xie Z and Feng Y. (2014). SRSF10 Regulates Alternative Splicing and Is Required for Adipocyte Differentiation. Mol Cell Biol 34, 2198-2207.IF= 4.427
14.Li L, Guo Y, Wu W, Shi Y, Cheng J and Tao S. (2012). A comparison and evaluation of five biclustering algorithms by quantifying goodness of biclusters for gene expression data. Biodata Min 5, 8. IF= 1.640
15.Marsch-Martínez N, Wu W and de Folter S. (2011). The MADS symphonies of transcriptional regulation. Front. Plant Sci. 2, 26. IF= 4.495
