吳文學，男，博士，中國農業大學動物醫學院研究員、博士生導師。
基本介紹
- 中文名：吳文學
- 出生日期：1970年11月
- 畢業院校：中國農業大學
- 學位/學歷：博士
- 任職院校：中國農業大學
人物經歷,擔任職務,研究方向,學術成果,課題研究,發表論文,
人物經歷
1994年畢業於原北京農業大學(獸醫本科)，2002年獲中國農業大學博士學位。1994年畢業留校工作至今，2013-2014在美國哈佛醫學院做訪問學者。
擔任職務
現任教育部動物疫病快速診斷技術實驗室負責人、國家奶牛產業技術體系奶牛場生物安全與綜合防控崗位科學家、教育部新世紀優秀人才、中國獸藥典委員會委員、農業部獸藥評審專家、《中國獸醫雜誌》編委。
研究方向
畜禽傳染病免疫調控機理研究、傳染病診斷技術和疫苗研製。
學術成果
課題研究
先後主持或參加國家十三五重點研發專項、農業部公益性行業科研專項、國家科技支撐計畫、教育部新世紀優秀人才支持計畫、國家自然科學基金項目、農業部財政專項等40餘項，獲得國家發明專利8項、新獸藥證書1個。目前主持課題有：
[1]禽病高通量檢測技術及配套試劑與設備研究，國家“十三五”重點研發專項，275萬
[2]牛支原體抗體適體檢測技術與試劑盒的研製，國家“十三五”重點研發專項，77萬
[3]Cat L促進豬肺炎支原體感染後SIgA免疫應答的作用機制，國家自然基金，80萬
[4]寵物疫病快速診斷與疫苗研究與示範，農業部公益性行業科研專項，75萬
[5]國家奶牛產業技術體系，奶牛場生物安全與綜合防控崗位
發表論文
發表論文60餘篇(SCI論文20篇)。其代表論文有：
[1]Jiang F, He J, Navarro-Alvarez N, Xu J, Li X, Li P, Wu W. Elongation Factor Tu and Heat Shock Protein 70 Are Membrane-Associated Proteins from Mycoplasma ovipneumoniae Capable of Inducing Strong Immune Response in Mice. PLoS One, Aug 18;11(8):e0161170, 2016
[2]Zhou Y, Wu W*, Lindholt JS, Sukhova GK, Libby P, Yu X, Shi GP .Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms. Cardiovasc Res,Jul 1;107(1):98-107,2015
[3]Zhang Y, Yu Z, Jiang F, Fu P, Shen J, Wu W*, Li J. Two DNA aptamers against avian influenza H9N2 virus prevent viral infection in cells. PLoS One,Mar 31;10(3): e0123060, 2015
[4]Jiahe Li, Jixiang Zhang, Ning Zhang, Yuewei Zhang, Wenxue Wu*, Jinxiang Li. Development of a replicative plasmid for gene expression in Mycoplasma bovis. Journal of Microbiological Methods, Jan,2015
[5]Jian Xu, Da Teng, Fei Jiang, Yuewei Zhang, Saeed A. El-Ashrom, Hui Wang, Zhenhong Sun, Jinyan He, Junjun Shen, Wenxue Wu*, Jinxiang Li. Mycoplasma gallisepticum MGA_0676 is a membrane-associated cytotoxic nuclease with a staphylococcal nuclease region essential for nuclear translocation and apoptosis induction in chicken cells, Appl Microbio Biotechnol, Feb,2015
[6]Zhang Y,Chen H,Zeng X, Wang P, Li J, Wu W*. Levamisole enhances immunity in ducklings vaccinated against Riemerella anatipestifer. Microbiol Immunol,Aug; 58(8):456-62,2014
[7]Wang J, Sjöberg S, Tang TT, Oörni K, Wu W, Liu C, Secco B, Tia V, Sukhova GK, Fernandes C, Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP.Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta-Molecular Basis of Disease,Nov;1842(11):2174-83,2014
[8]Fu P,Sun ZH,Yu ZQ,Zhang YW,Shen JJ,Zhang HY,Xu W,Jiang F,Chen HL,Wu WX*. Enzyme Linked Aptamer Assay (ELAA),based on a competition format for rapid and sensitive detection of antibodies to Mycoplasma bovis in serum,Analytical Chemistry, 86(3):1701-1709, 2014
[9]Zhenhong Sun,Ping Fu,Kai Wei,Haiyan Zhang,Yuewei Zhang,Jian Xu,Fei Jiang,Xu Liu,Wei Xu,Wenxue Wu *. Identification of novel immunogenic proteins of Mycoplasma bovis and establishment of an indirect ELISA based on recombinant E1 beta subunit of the pyruvate dehydrogenase complex. PLoS One, 10;9(2):e88328,2014
[10]Yue-Wei Zhang,Hai-Yu Yan,Ping Fu,Fei Jiang,Yao Zhang,Wen-Xue Wu*,Jin-Xiang Li. Modified capillary electrophoresis based measurement of the binding between DNA aptamers and an unknown concentration target.Anal Bioanal Chem, 405(16):5549-55,2013
[11]Yin G, Qin M, Liu X, Suo J, Tang X, Tao G, Han Q, Suo X, Wu W*. An Eimeria vaccine candidate based on Eimeria tenella immune mapped protein 1 and the TLR-5 agonist Salmonella typhimurium FliC flagellin. Biochem Biophys Res Commun. Oct 25;440(3): 437-42,2013
[12]Jiahe Li,F. Chris Minion,Andrew C. Petersen,Fei Jiang,Sheng Yang,Panpan Guo, Jinxiang Li,Wenxue Wu*. Loop-mediated isothermal amplification for rapid and convenient detection of Mycoplasma hyopneumoniae,World J Microbiol Bioanal Chem, 29:607–616,2013
[13]Zhou M,Zhang G,Ren G,Gnanadurai CW,Li Z,Chai Q,Yang Y,Leyson CM, Wu W,Cui M,Fu ZF,Recombinant rabies viruses expressing GM-CSF or Flagellin are effective vaccines for both intramuscular and oral immunizations,PLoS One,8(5): e63384,2013
