史熊杰：武漢大學生命科學學院 副教授。主要從事膽固醇代謝平衡調控與代謝性疾病發生機理方面研究。2005年06月 武漢大學生物科學本科畢業。2014年07月任武漢大學生命科學學院副教授。
基本介紹
- 中文名：史熊杰
- 畢業院校：武漢大學
- 學位/學歷：博士
- 專業方向：生物化學
- 研究方向：膽固醇代謝
- 職稱：副教授
人物簡介,教育經歷,工作經歷,研究方向,代表論文,
人物簡介
史熊杰：武漢大學生命科學學院 副教授。
教育經歷
2005.09–2010.06 中國科學院水生生物研究所 博士
2001.09–2005.06 武漢大學生物科學 本科
工作經歷
2014.07 武漢大學生命科學學院 副教授
2014.03–2014.06 中國科學院水生生物研究所 訪問學者
2010.08–2013.10 美國匹茲堡大學藥學院 博士後
研究方向
（1）小腸膽固醇吸收的分子途徑；
（2）細胞內膽固醇動態運輸的分子機制；
（3）膽固醇代謝調控的信號轉導途徑和機理；
（4）膽固醇代謝的藥靶系統及新藥研發。
代表論文
1.Xiongjie Shi, Qiuqiong Cheng, Leyuan Xu, Jiong Yan, Mengxi Jiang, Jinhan He, Meishu Xu, Maja Stefanovic-Racic, Ian Sipula, Robert Martin O'Doherty, Shunlin Ren, Wen Xie. Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting HNF4α. Mol. Cell. Biol.2014. vol. 34 no. 3 485-497
2. Jinhan He, Bingfang Hu, Xiongjie Shi, Eric R Weidert, Peipei Lu, Meishu Xu, Min Huang, Eric E Kelley, Wen Xie. Activation of the Aryl Hydrocarbon Receptor Sensitizes Mice to Nonalcoholic Steatohepatitis by Deactivating Mitochondrial Sirtuin Deacetylase Sirt3. Mol. Cell. Biol. 2013, 33 (10) 2047-2055
3. ZhiminOu*, Xiongjie Shi*, Richard K Gilroy, LeventKirisci, Marjorie Romkes, Caitlin Lynch, Hongbing Wang, Meishu Xu, Mengxi Jiang, Songrong Ren, Roberto Gramignoli, Stephen C Strom, Min Huang, Wen Xie. Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver Diseases. Molecular Endocrinology 2013, 27 (1), 106-115. * Z.O. and X.S. contributed equally to this work.
4. Jie Gao, Jinhan He, Xiongjie Shi, Maja Stefanovic-Racic, Meishu Xu, Robert Martin O’Doherty, Adolfo Garcia-Ocana, Wen Xie. Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes. Diabetes 2012, 61 (6), 1543-1551.
5. Xiongjie Shi, Leo W. Y. Yeung, Paul K. S. Lam, Rudolf S. S. Wu, and Bingsheng Zhou. Protein Profiles in Zebrafish (Daniorerio) Embryos Exposed to PFOS. Toxicol. Sci. 2009, 110:334-40.
6. Xiongjie Shi, Chunsheng Liu, Guoqiao Wu, and Bingsheng Zhou. Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Chemosphere. 2009, 77:1010-8.
7. Xiongjie Shi, Yongbing Du, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicol Appl. pharmacol. 2008, 230: 23-32.
8. Xiongjie Shi, Chunsheng Liu, Yu Ke, Den Jun, Liqin Yu, Bingsheng Zhou. Progress of Toxicological Research on Environmental Endocrine Disruptors and Perspectives. Environ. Chem. (In Chinese), 2009, 21: 340-349.
9. Xiongjie Shi, Bingsheng Zhou. The Role of Nrf2 and MAPK Pathways in PFOS-induced Oxidative Stress in Zebrafish Embryos. Toxicol. Sci. 2010, 115:391-400.
10. Yanhong Wei, Xiongjie Shi, Hongxia Zhang, Jianshe Wang, Bingsheng Zhou, and Jiayin Dai. Combined effects of polyfluorinated and perfluorinated compounds on primary cultured hepatocytes from rare minnow (Gobiocyprisrarus) using toxicogenomic analysis. Aquat. Toxicol. 2009, 95:27-36.
11. Liqin Yu, Jun Deng, Xiongjie Shi, Chunsheng Liu, Ke Yu, and Bingsheng Zhou. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae. Aquat. Toxicol. 2009, doi:10.1016/j.aquatox.2009.10.022.
12. Jun Deng, Liqin Yu, Chunsheng Liu, Ke Yu, Xiongjie Shi, Leo W.Y. Yeung, Paul K.S. Lam, Rudolf S. S. Wu and Bingsheng Zhou. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquat. Toxicol. 2009, 93: 29-36.
13. Chunsheng Liu, Ke Yu, Xiongjie Shi, Jingxian Wang, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromisniloticus). Aquat. Toxicol. 2007, 82: 135-143.
14. M.K. So, Y. Miyake, W.Y. Yeung, Y.M. Ho, S. Taniyasu, P. Rostkowski, N. Yamashita,, Bingsheng Zhou, Xiongjie Shi, J.X. Wang, J.P. Giesy, H. Yu and P.K.S. Lam. Perfluorinated compounds in the Pearl River and Yangtze River of China. Chemosphere. 2007, 68: 2085-2095.15. Yongbing Du, Xiongjie Shi, Chunsheng Liu, Ke Yu and Bingsheng Zhou. Chronic effects of water-borne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: A partial life-cycle test. Chemosphere. 2009, 74: 723-9.
16. Jingxian Wang, Xiongjie Shi, Yongbin Du and Bingsheng Zhou. Effects of xenoestrogens on the expression of vitellogenin (vtg) and cytochrome P450 aromatase (cyp19a and b) genes in zebrafish (Daniorerio) larvae. J Environ Sci Health ATox Hazard Subst Environ Eng. 2011; 46(9):960-7.
